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1 r growth rate as effectively as the standard clinical dose.
2  than that observed in humans at the maximal clinical dose.
3 tion dose to one half and one quarter of the clinical dose.
4 nistrations at 4 times the anticipated human clinical dose.
5 PV4 effectively in patients from a low daily clinical dose.
6 duce immune activation at safe and tolerable clinical doses.
7 ut did not resolve renal injury at practical clinical doses.
8  and bupivacaine) were added to solutions in clinical doses.
9 ial for renal and hepatic OAT2 inhibition at clinical doses.
10  their correct syntenic murine loci to model clinical dosing.
11 ncy CAR-T cell products meeting criteria for clinical dosing.
12              This report demonstrates that a clinical dose (1 mg/kg/day) of 13-cis-RA in mice signifi
13 sed favorable properties and a predicted low clinical dose (2 mg twice daily).
14  fasted or normally fed mice at the standard clinical dose 30 micromol/kg, both 3,4,3-LI(1,2-HOPO) an
15 heart (n=6) preparations by applying HIFU at clinical doses (4-16 W).
16 ia social dosing was nearly 4 fold that from clinical dosing alone and did not vary by delivery mode.
17  absorbed based on solubility at an expected clinical dose and represents a valuable parameter to the
18 y doses of drugs and X-rays to 2-6% of their clinical doses and efficiently spares normal cells.
19 om the haemopoietic properties that occur at clinical doses and which, at the highest doses, might le
20 cing adverse effects in the normal organs at clinical doses, and optimal clinical doses balancing eff
21 normal organs at clinical doses, and optimal clinical doses balancing efficacy/safety as determined b
22 ting disorders, the drug was administered at clinical doses, both in vivo and in vitro, to rat dorsal
23 wever, the time requirement for synthesis of clinical doses can hinder patient throughput because of
24 coadministration of lapatinib or imatinib at clinical doses could result in a significant increase in
25                                     At their clinical doses, current antipsychotic agents share the p
26   STAR-guided ML models can directly predict clinical dose/efficacy/safety from five features to desi
27 nd are identical to those used currently for clinical dose estimates for beta-particle emitters.
28 (ADR) and informed predictions about optimal clinical doses, expected performance of standard doses a
29 openic murine pneumonia model with simulated clinical dosing exposures was used to validate our quant
30 tween 1991 and 2006 and classified them into clinical (dose-finding trials) and statistical trials (m
31 y relevant to tumor response during standard clinical dose-fractionated radiation therapy.
32 nt susceptible sub-population (S1) with this clinical dose given (i) over 24 h for mcr-negative isola
33                                 The standard clinical dosing group received doses individualized to c
34                                 However, the clinical dose is approximately 250-1000 times lower than
35                        Ionizing radiation at clinical dose levels activates both pro- and anti-prolif
36 ed for more than 4 seconds in spiral mode at clinical dose levels.
37 dic reactor capable of synthesizing a single clinical dose of (89)Zr-labeled antibody.
38 oing are highly sensitive to disruption by a clinical dose of 13-cis-RA.
39 icacy relationships resulted in an estimated clinical dose of 350-400 mg twice daily.
40                                          The clinical dose of 4-HPR, however, is limited by residual-
41 aging was performed once after 1 week with a clinical dose of a macrophage-specific iron oxide-based
42 ination of Intralipid with half the standard clinical dose of Abraxane reduces the tumor growth rate
43                     At one-tenth the current clinical dose of contrast agent, and following a single
44 ays starting after the final dose of CCl(4) (clinical dose of gadoxetate disodium is 0.25 mmol/kg).
45 monstrate that in vivo HA degradation with a clinical dose of hyaluronidase impairs mCRC tumorigenesi
46 Treatments with GSK-3 inhibitors including a clinical dose of lithium to rats with thoracic spinal co
47  were also scanned after pretreatment with a clinical dose of the aromatase inhibitor letrozole.
48 ered in SAB synthesis for the preparation of clinical doses of (211)At-labeled radiopharmaceuticals.
49 or appropriate formulations and dilutions of clinical doses of 90Y immunopharmaceuticals immediately
50 tor dial setting for accurate calibration of clinical doses of 90Y preparations.
51  behavioural effects of fetal treatment with clinical doses of betamethasone and dexamethasone; (2) d
52                   These results predict that clinical doses of bupivacaine would decrease the peak an
53 enfluramine (DF) in human subjects receiving clinical doses of DF and to determine whether human brai
54  a mouse model to investigate the effects of clinical doses of etoposide on the induction of chromoso
55                             Animals received clinical doses of FTC/TAF (n = 6) or TAF (n = 9) orally
56 ial drug amodiaquine inhibited infection but clinical doses of hydroxychloroquine and other antiviral
57  a basic science finding (acute tolerance to clinical doses of methylphenidate) into clinical applica
58 e data indicate that while mothers receiving clinical doses of sertraline experience substantial bloc
59 l studies, nearly half of those who received clinical "doses" of the HealtheRx shared their informati
60 ff-targets determining efficacy in tumors at clinical doses, on/off-target-driven tissue/cell selecti
61 y, along with physicochemical properties and clinical dose provide useful DILI predictivity.
62 sus controls), and caused less bleeding than clinical-dose r-tPA (P<0.001).
63 ation, causing more embolus dissolution than clinical-dose r-tPA alone (P<0.001) or alpha2-antiplasmi
64 e extent for X-ray reference irradiations at clinical dose rates.
65  due to physiologic motion when delivered at clinical dose rates.
66 T 719 treatment was compared with a standard clinical dose regimen of 25 mg/kg/day 5-FU/leucovorin gi
67 ltiple-dose ADC regime, which replicates the clinical dose regimen standard, with a single-dose regim
68 models to evaluate the effects of long-term, clinical dosing regimens of these drugs on the relative
69 d can be studied over longer timescales with clinical dosing regimens that are more relevant to human
70 P and adenosine beyond currently recommended clinical doses resulted in a significant increase in cor
71                    CT irradiation at typical clinical doses results in oversensing of ICRMDs in the m
72 smaller scale that is required for animal or clinical doses/sampling.
73  than that of bortezomib administered on its clinical dosing schedule.
74 ug residence and transit times, important to clinical dose scheduling, have not yet been defined.
75  paramagnetic ion concentration in a typical clinical dose) showed persistent (up to at least 2 hours
76 ntibiotic concentrations (when available) in clinical dosing software, which uses pharmacokinetic/pha
77 f these particles released approximately two clinical doses spaced a month apart.
78  maintenance OIT, which has implications for clinical dosing strategies.
79                            This could affect clinical dose tailoring, especially in children.
80 nical trial simulations are used to identify clinical doses that achieve these kill rates in children
81 d mice that, when delivered at the same high clinical dose, the human IFN-alpha14 subtype has very po
82 uantify information spread via social versus clinical dosing then conducted information diffusion exp
83 opioid use, which prevents understanding the clinical dose threshold level that increases the risk of
84 es of these predictions relative to measured clinical doses to ease translation of new PET radiotrace
85     The computer software is applicable as a clinical dosing tool to optimize tacrolimus exposure and
86 l LNP that delivers mRNA to Kupffer cells at clinical doses; unlike most LNPs, this LNP does not pref
87                                              Clinical doses were able to be prepared and passed all q
88 and vinorelbine seem to correlate with their clinical doses, where vincristine with the highest overa