ライフサイエンスコーパス: clinical effect

1 ssel concentration will result in a relevant clinical effect.

2 l cytokines was not associated with a marked clinical effect.

3 despite limited and conflicting data on its clinical effect.

4 ), and CY pretreatment had no immunologic or clinical effect.

5 ce that would account for the specificity of clinical effect.

6 unction through which sibutramine exerts its clinical effect.

7 mology to endogenous TPOs, studies confirmed clinical effect.

8 iting the target has little correlation with clinical effect.

9 and the other failed to show any beneficial clinical effect.

10 th placebo-treated forearms did not show any clinical effect.

11 ention or delay of diabetes would have major clinical effect.

12 ull spectrum of neurovascular injury and its clinical effect.

13 t to detect biases that can have significant clinical effect.

14 entrations and may contribute to bupropion's clinical effects.

15 ed significant study heterogeneity and small clinical effects.

16 des of signal interference did not result in clinical effects.

17 ns may contribute to the drugs' differential clinical effects.

18 jury, and this acidosis may have detrimental clinical effects.

19 ognitive effects may underlie their positive clinical effects.

20 tes that are traceable to pharmacological or clinical effects.

21 ri primary outcome measures of cognitive and clinical effects.

22 the brain circuitry hypothesized to mediate clinical effects.

23 ct biological effects that may have variable clinical effects.

24 istence are crucial to achieving the desired clinical effects.

25 g replication early is sufficient to achieve clinical effects.

26 chanism of action that may contribute to its clinical effects.

27 aled that the K422T mutation per se had mild clinical effects.

28 ols and molecules with the potential to have clinical effects.

29 opontine nucleus regions may differ in their clinical effects.

30 ust be administered at high doses to observe clinical effects.

31 ify the relation between amyloid removal and clinical effects.

32 nants of methotrexate's pharmacokinetics and clinical effects.

33 exate plasma concentration is related to its clinical effects.

34 romodulatory effect thus resulting in larger clinical effects.

35 ems may contribute to isoflurane's important clinical effects.

36 gs are known to have opposing behavioral and clinical effects.

37 ief Psychiatric Rating Scale (BPRS) assessed clinical effects.

38 treatment was not evaluable due to negative clinical effects.

39 triction causes malnutrition and has adverse clinical effects.

40 evels on basophils contrast with more modest clinical effects.

41 mogenic Scn5a+/- hearts in parallel with its clinical effects.

42 Scn5a+/- murine hearts that recapitulate its clinical effects.

43 assessed for their physical, biological, and clinical effects.

44 ent pharmacopoeia tests, but provoke adverse clinical effects.

45 tor antagonists can strongly impact on their clinical effects.

46 ate markers of performance to correlate with clinical effects.

47 ization activity in direct relation to their clinical effects.

48 thus influencing their biological action and clinical effects.

49 and promoting their survival and consequent clinical effects.

50 evodopa, particularly doses at threshold for clinical effects.

51 fic functional properties leading to similar clinical effects.

52 NMDAR) channel-blocking drugs with divergent clinical effects.

53 amine and help to explain their differential clinical effects.

54 l antiretroviral therapy have similar 4-year clinical effects.

55 ntrations of anesthetics required to achieve clinical effects.

56 ell time on threat, which partially mediated clinical effects.

57 he results demonstrate target engagement and clinical effects.

58 , which may contribute to its behavioral and clinical effects.

59 to be administered at high doses to observe clinical effects.

60 concentrations may translate into beneficial clinical effects.

61 nd-name and generic medications have similar clinical effects?

62 PRGF platelet concentrate failed to augment clinical effects achieved with the xenograft alone in tr

63 Among patients with asthma, the clinical effect and relative contribution of maternal sm

64 Based on the positive clinical effect and the ELA profile of GCF, it can be su

65 States, but little is known regarding their clinical effects and biokinetic distribution with long-t

66 Poor correlation between clinical effects and drug levels likely accounts for thi

67 This study evaluates the clinical effects and pathophysiologic basis of hypotherm

68 get of rapamycin (mTOR), has produced robust clinical effects and revolutionised the treatment of met

69 activity to better understand its potential clinical effects and role in disease prevention.

70 To assess the clinical effects and safety of the recombinant human LAL

71 ous studies evaluating the pharmacologic and clinical effects and safety profiles of these drugs in p

72 mones, because they have shown only a modest clinical effect, and are often used in combination with

73 ne effects will persist and reliably predict clinical effects, and by the challenge in interpreting t

74 genetic variation with the highest potential clinical effects, and uncertainty about clinically repor

75 n injury, where patterns of damage and their clinical effects are heterogeneous.

76 to the cardiovascular system, data on their clinical effects are lacking.

77 ences of treatment and their relationship to clinical effects are not well understood.

78 widely prevalent in all communities yet its clinical effects are poorly understood and often overloo

79 its metabolite 1-hydroxymidazolam, the major clinical effects are thus likely caused by midazolam its

80 The reasons for this, including clinical effect, are unclear.

81 earch is needed to assess the durability and clinical effect as well as long-term safety.

82 ge base supporting the safety and beneficial clinical effects associated with EECP, this therapy can

83 loited therapeutically to circumvent adverse clinical effects associated with IFN therapy.

84 to treat depression and to examine specific clinical effects associated with serious outcomes.

85 nological mechanisms underlie the beneficial clinical effects associated with the induction of HMW-MA

86 odegenerative environment and exert powerful clinical effects; at least a portion of these effects ma

87 ilot studies have shown significant positive clinical effects, but, thus far, no large randomized tri

88 enzodiazepine (BZ) anxiolytics mediate their clinical effects by enhancing the effect of gamma-aminob

89 b monotherapy is not having any demonstrable clinical effects by reducing the EGFR-positive pool of C

90 C5a activation fragment (C5aR1), a striking clinical effect can be realized.

91 ay between-group analyses of covariance) and clinical effects (clinically significant improvement) we

92 equivalence with no detectable difference in clinical effects, confirming that US Food and Drug Admin

93 d APOBEC3 may have beneficial or detrimental clinical effects depending on how they affect the bindin

94 Differential clinical effects depending on timing of initiation, unde

95 e in human beings or animals to show adverse clinical effects due to the gadolinium deposition in the

96 ement of FEV(1) may not exert any meaningful clinical effect during tidal breathing.

97 release formulation produced no cognitive or clinical effect either in non-smokers or smokers.

98 Owing to the rapid and robust clinical effects, electroconvulsive therapy (ECT) repres

99 The study provides evidence of enhanced clinical effects for patients receiving active ABMT.

100 Beneficial clinical effects have been demonstrated with the additio

101 However, only modest clinical effects have been observed, possibly because of

102 mechanisms by which these agents exert their clinical effects have, until recently, remained unclear.

103 oxyglucose PET tracers that have a potential clinical effect in oncology.

104 d blood kinetics, biochemical responses, and clinical effects in 5 adult men and 5 adult women who vo

105 significant, anti-eosinophil and beneficial clinical effects in adult patients with active, corticos

106 gainst one melanoma subtype may have adverse clinical effects in another.

107 to mite allergens associated with favorable clinical effects in atopic dermatitis patients.

108 dynamically superior to IPC of the foot, its clinical effects in claudicants remain undetermined.

109 Data on the epidemiology and clinical effects in community-dwelling elderly persons a

110 the anti-CD40L Ab 5c8, demonstrated positive clinical effects in patients with autoimmune diseases; h

111 ion frequency in a manner reminiscent of its clinical effects in persons with PD.

112 n awake and anesthetized individuals and its clinical effects in the ischemia/reperfusion setting.

113 nts directed at amyloid-beta will have major clinical effects in the later stages of the disease.

114 ate that T-cell mosaicism may have different clinical effects in WAS.

115 prevent relapse and mediate other beneficial clinical effects including control of infections without

116 ther with the other results, may explain why clinical effect is lost if SLIT is discontinued at this

117 This limited added clinical effect may justify the use of a protocol combin

118 of the explanation for its observed positive clinical effects may be the stimulation of angiogenesis.

119 s each decrease susceptibility to CAIA, with clinical effects most pronounced in C5aR-deficient mice.

120 Although some have shown modest clinical effects, most have not been effective.

121 In control subjects, neither positive clinical effects nor cerebral blood flow decreases were

122 To examine the clinical effect of 14-3-3zeta overexpression in advanced

123 This is the first evidence of a clinical effect of a neuromodulatory intervention in the

124 bdominal fluid protein loss and evaluate the clinical effect of accounting for abdominal fluid nitrog

125 his phase 3 trial, we aimed to determine the clinical effect of adding IMA901 to sunitinib, the stand

126 While the phenotype and true clinical effect of AMR remain to be better defined, the

127 Data on the results and clinical effect of an invasive risk stratification strat

128 We report the clinical effect of B7-H1 in RCC patients with a median o

129 PubMed was searched for publications on the clinical effect of brain stimulation in dystonia up thro

130 We aimed to quantify the clinical effect of carbapenem resistance on mortality an

131 Purpose To analyze the clinical effect of continuous dose monitoring and patien

132 Q3) What is the clinical effect of DAPT in stable patients who are >1 ye

133 ormed donor KIR genotyping and evaluated the clinical effect of donor KIR genotype and donor and reci

134 tion have a high degree of predictability of clinical effect of dopaminergic drugs on motor symptoms

135 erotonin in behavioral regulation and on the clinical effect of drugs for depression.

136 e to hyperuricemia and hypertension, but the clinical effect of fructose reduction on blood pressure

137 Epidemiology, risk factors, and clinical effect of infections by multiresistant bacteria

138 The epidemiology and clinical effect of inherited chromosomally integrated HH

139 anted and were unable to maintain satisfying clinical effect of inrathecally infused baclofen.

140 is study aimed to evaluate the incidence and clinical effect of jaundice in critically ill patients w

141 the mechanism responsible for the beneficial clinical effect of lipid-lowering therapies.

142 ding the molecular mechanisms underlying the clinical effect of lithium and myo-inositol-mediated ske

143 rant microRNA (miRNA) profiles; however, the clinical effect of miRNA expression has not previously b

144 The clinical effect of MiStent sirolimus-eluting stent compa

145 rovides preliminary evidence of the positive clinical effect of multiparametric MR imaging-directed I

146 The clinical effect of MYD88 mutation activating the nuclear

147 The clinical effect of newer-generation drug-eluting stents

148 The beneficial clinical effect of NK-cell alloreactivity has not been u

149 er 18 months of randomised follow-up and the clinical effect of open access to pressure information f

150 We review the most recent evidence for the clinical effect of PARP inhibition in breast and ovarian

151 rstanding is limited regarding the long-term clinical effect of persistent CMV infection in immunocom

152 s and/or IL-6R antibodies might increase the clinical effect of platinum-based chemotherapy in otherw

153 med to assess the feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing a

154 trial is not sufficient to advocate the true clinical effect of PRF on recession treatment with CAF +

155 To evaluate the clinical effect of procedure duration on AST when either

156 sis that ADCC plays an important role in the clinical effect of rituximab at the level of the effecto

157 The clinical effect of routine intracoronary thrombus aspira

158 The clinical effect of routine oxygen therapy in patients wi

159 her studies are warranted to investigate the clinical effect of targeting CDC7 in metastatic melanoma

160 a mechanistic explanation for the remarkable clinical effect of the anti-CD20 mAbs in a representativ

161 The clinical effect of the observed lumen and vessel remodel

162 and treatment devices will have the profound clinical effect of their cardiological predecessors will

163 ive cytogenetic audit to assess the probable clinical effect of these proposed policy changes.

164 The national burden and clinical effect of this novel presentation of MRSA disea

165 However, the clinical effect of this SNP in LAP is ethnicity dependen

166 The clinical effect of this would ultimately result in a red

167 RIs, and may be a potential substrate of the clinical effect of treatment.

168 The goal of this study was to evaluate the clinical effect of using (90)Y-edotreotide to treat symp

169 daily living; however, information about the clinical effect of various strategies of cognitive rehab

170 f for abnormal is placed should indicate the clinical effect of wrong results.

171 randomized clinical trial is to evaluate the clinical effects of a Lactobacillus rhamnosus SP1-contai

172 he purpose of this study was to evaluate the clinical effects of a long-term calorie-restriction (CR)

173 ly standardized instruments to determine the clinical effects of a preseasonal, ultra-short-course bo

174 microscope may have utility in assessing the clinical effects of a small interfering RNA (siRNA)-base

175 e, the aim of this study was to evaluate the clinical effects of a toothpaste containing 0.3% triclos

176 understanding the underlying biology of the clinical effects of AC medications.

177 dies are recommended to better determine the clinical effects of adjunctive AZM in patients who smoke

178 ations are ideally suited for studies on the clinical effects of alleles that are rare in general pop

179 med a phase I study assessing the safety and clinical effects of AMD3100 in patients with multiple my

180 The clinical effects of amphetamine are quite variable, from

181 es related to AMR, focusing on epidemiology, clinical effects of AMR, discovery of novel agents to tr

182 e actions could contribute to some important clinical effects of anaesthetics.

183 open trials have demonstrated the beneficial clinical effects of aspirin desensitization (AD) in pati

184 ective study to determine the biological and clinical effects of bariatric surgery in patients with N

185 rosteroids, the role of neurosteroids in the clinical effects of BDZs is unknown.

186 The results advance the knowledge on the clinical effects of bupropion as an antidepressant.

187 pathways that likely underpin the beneficial clinical effects of calcitriol in patients with SR asthm

188 DA-DKP, which could account for some of the clinical effects of cHSA.

189 ing these elements, may underlie some of the clinical effects of clozapine.

190 ilable data concerning the immunological and clinical effects of CMVIG after heart or lung transplant

191 ng the utility of this strategy to index the clinical effects of CNVs.

192 s suggest the need to carefully evaluate the clinical effects of combination chemotherapies that inco

193 This may account for the superior clinical effects of combination LABA/corticosteroid trea

194 ing on cancer cell biology and emphasise the clinical effects of continued smoking in patients with c

195 Recent research suggests that some clinical effects of coxibs, selective inhibitors of cycl

196 se findings help clarify the immunologic and clinical effects of CTLA-4 antibody blockade in previous

197 animal models are clearly needed to explain clinical effects of DBS in TRD.

198 Curiously enough, clinical effects of DD did not strictly correlate with C

199 ered one of the key mechanisms mediating the clinical effects of deep brain stimulation on motor symp

200 inical trials that compared the metabolic or clinical effects of different protein intakes in adult c

201 ed trials are needed to fully assess the net clinical effects of drug-eluting stents compared with ba

202 The beneficial clinical effects of eplerenone (as observed in the main

203 R-type Ca(2+) channels may contribute to the clinical effects of general anesthesia.

204 The clinical effects of gluten-sensitive enteropathy with vi

205 cat)/K(0.5)(h)) and exhibits the most severe clinical effects of hypoglycemia.

206 how a recipient's repertoire influences the clinical effects of induction therapy.

207 To explore the clinical effects of inflammation associated with vascula

208 lated tracheobronchitis wherein the positive clinical effects of infliximab are demonstrated.

209 ntrol and muscle metabolism, biochemical and clinical effects of insulin treatment in the severely bu

210 sible explanation of how the well-recognized clinical effects of ketogenic diets can alter human beha

211 We examined physiological and clinical effects of l-methylfolate, the fully reduced an

212 We aimed to examine the clinical effects of low-level kinase domain mutations id

213 ome of the salutary electrophysiological and clinical effects of mineralocorticoid antagonists in myo

214 iated human adipocytes and muscle.RESULTSThe clinical effects of mirabegron treatment included improv

215 er, uptake 2, in the brain will speed up the clinical effects of norepinephrine reuptake inhibitor an

216 To examine the clinical effects of NT5C2 mutations in relapsed ALL, we

217 ationship between asthma and obesity and the clinical effects of obesity in children with asthma.

218 dy sought to assess the pharmacokinetics and clinical effects of oral BG9928 in heart failure (HF) pa

219 Despite the common occurrence and frequent clinical effects of peritumoral cysts in the central ner

220 es all the benefits of fish consumption, and clinical effects of plant-derived n-3 PUFA.

221 al is to clinically evaluate and compare the clinical effects of potassium-titanyl-phosphate (KTP) la

222 nd studied the impact of aspirin dose on the clinical effects of prasugrel.

223 ic trial revealed variable, but predictable, clinical effects of prefrontal tDCS combined with CBT fo

224 ps in knowledge regarding the biological and clinical effects of recurrent genomic aberrations or gen

225 atic review to summarize the preclinical and clinical effects of resistant starch, which may help gui

226 ting clinical trials that aim to measure the clinical effects of restorative therapies after stroke.

227 examined the psychological, behavioral, and clinical effects of risk scanning with the Navigenics He

228 We examined the antimicrobial and clinical effects of scaling and root planing (SRP) with

229 ignalling may play a key role in stabilizing clinical effects of SCIT.

230 non-small-cell lung cancer (NSCLC), but the clinical effects of SFK inhibition in NSCLC are unknown.

231 mechanisms of atherogenesis and thrombosis, clinical effects of smoking and benefits of cessation, a

232 methods with which to assess and refine the clinical effects of stimulation.

233 The known and potential clinical effects of such antibodies are discussed.

234 essure ulcer risk and studies evaluating the clinical effects of such models.

235 ADCY9 genotype is materially relevant to the clinical effects of the CETP inhibitor anacetrapib.

236 r the development of new drugs to hamper the clinical effects of the disease.

237 p between the serotonin transporter gene and clinical effects of the selective serotonin reuptake inh

238 clinical trial is to evaluate the adjunctive clinical effects of the systemic administration of ornid

239 better understanding of the biochemical and clinical effects of the therapies in development bear di

240 tionship of this boost to age paralleled the clinical effects of the vaccine observed during the effi

241 However, the clinical effects of these abnormalities cannot be determ

242 ditional studies are needed to determine the clinical effects of these divergent responses.

243 The clinical effects of these mutations are short stature, a

244 The clinical effects of these therapies are variable and oft

245 ance of this potentiation for the beneficial clinical effects of this combination of agents and the d

246 immense diversity coupled with differential clinical effects of this diversity suggest that an effec

247 ost-gut microbial relationship, what are the clinical effects of this shift in relationship?

248 dditional studies to further investigate the clinical effects of this treatment.

249 The clinical effects of TIPS have been confirmed, however, n

250 , Placebo Controlled Study of the Short Term Clinical Effects of Tolvaptan in Patients Hospitalized f

251 tentially unique molecular, physiologic, and clinical effects of too much sitting (inactivity physiol

252 Clinical effects of transcranial electrical stimulation

253 The clinical effects of treatment with beta-adrenoceptor (be

254 ptable toxicity; the rapid onset and adverse clinical effects of tumor flare represent a significant

255 rmed a double-blind, cross-over trial of the clinical effects of ustekinumab in 104 patients with mod

256 ctive of this study was to explore the broad clinical effects of varying iron status.

257 original concern focused on exacerbation of clinical effects of vitamin B-12 deficiency and its role

258 The long-term clinical effects of wartime traumatic brain injuries (TB

259 types of protein (animal and soy) has little clinical effect on cardiovascular disease risk factors,

260 ected against IL-23p19 or IL-12/23p40 had no clinical effect on established inflammatory skin disease

261 savings could potentially have a substantial clinical effect on resource use and patient throughput.

262 ma medication, and had a positive, long-term clinical effect on rhinoconjunctivitis symptoms and medi

263 reatment decisions at the point of care, and clinical effect on tuberculosis-related morbidity.

264 ic responses that may contribute to observed clinical effects on coronary artery disease and blood pr

265 a-2a interferon (IFN-alpha2a) has beneficial clinical effects on human T-cell leukemia virus type 1 (

266 ained-release green tea gel and to study its clinical effects on patients with chronic periodontitis

267 have immunomodulatory and thereby beneficial clinical effects on the overall skin condition, as well

268 nt in EMD may be responsible for some of its clinical effects, or that amelogenin alone may not trigg

269 outcomes were identified (disease activity, clinical effects, pain, early morning stiffness duration

270 INTERPRETATION: Clinical effects ranged from seemingly not clinically im

271 Statistical (analysis of covariance) and clinical effects (reliable change index) were tested in

272 These data are consistent with the useful clinical effects reported with compounds that can augmen

273 ts and RPC cases, marijuana source and type, clinical effects, scenarios, disposition, and length of

274 Body scheme alteration was the only clinical effect showing a lateralization, as they were e

275 Treatment of KI mice with PPIs had a clear clinical effect, showing a reduction in inflammatory man

276 Clinical effect size was moderate to large with high pro

277 The observed clinical effect size was within one standard deviation o

278 of statins may account for their beneficial clinical effect: Statins decreased the migration of leuk

279 erspective on study results that ignores the clinical effects the study was conducted to measure.

280 Despite its high prevalence and clinical effect, the neurobiological substrates underlyi

281 lude a definitive statement about safety and clinical effect, these results provide the basis for lar

282 veals a spectrum of outcomes ranging from no clinical effect, to risk factors for disease, to both lo

283 but also important differences in regards to clinical effects, toxicity and patient populations in wh

284 ations vs non-R882 mutations showed opposite clinical effects-unfavorable for R882 on RFS (all: hazar

285 These data reveal that PUFA may exert their clinical effects via their capacity to regulate the expr

286 Clinical effect was evaluated by retrospective chart rev

287 However, proof of a clinical effect was lacking until the publication of thr

288 The clinical effect was larger in children with more severe

289 This clinical effect was lost in Treg-depleted mice, demonstr

290 This clinical effect was most prominent in low-distress BCSs.

291 This clinical effect was not restricted to a few of the teste

292 Clinical effect was noted as early as 1 week after initi

293 es, and the method he used to discover their clinical effects was open-minded, exploratory, comprehen

294 o 7.00 mg/L, which corresponds to an optimal clinical effect, was identified.

295 Trophic mechanisms of observed clinical effects were explored with molecular and cellul

296 The greatest clinical effects were observed with the 22.5 mg and 75 m

297 precise dose-responses of physiological and clinical effects, whether fish oil provides all the bene

298 TMS-treated patients showed positive clinical effects, which were indicated by a reduction in

299 escription medications may result in serious clinical effects with potential life-threatening complic

300 made solely by metagenomic NGS had a likely clinical effect, with 7 of 13 guiding treatment.