ライフサイエンスコーパス: clinical investigation

1 rgeting its methyltransferase activity under clinical investigation.

2 y that remains unexplained following routine clinical investigation.

3 of low-dose aspirin in T1DM warrant further clinical investigation.

4 stomosis and hyperbaric oxygen therapy merit clinical investigation.

5 for TP53- or ATM-defective CLL that warrants clinical investigation.

6 as well as for targeting CD83+ AML, warrants clinical investigation.

7 commercially available (in Europe) or under clinical investigation.

8 nologic checkpoint blocking antibodies begin clinical investigation.

9 idering compounds at various stages of (pre-)clinical investigation.

10 ially cost-effective, candidates for further clinical investigation.

11 ising, novel antimicrobial agent that merits clinical investigation.

12 than the MTD regimen, justifying its further clinical investigation.

13 inhibitor of the target or pathway is under clinical investigation.

14 s of promising antitumor therapies in active clinical investigation.

15 ment of MLL-rearranged leukemia and is under clinical investigation.

16 ibitors (NRTIs) is an important strategy for clinical investigation.

17 nts in the last decade and highlight ongoing clinical investigation.

18 or beta-blockers in PH that warrants further clinical investigation.

19 outcomes and identify areas requiring future clinical investigation.

20 otherapeutics for cancer and many more under clinical investigation.

21 acokinetics, and adolescent compliance merit clinical investigation.

22 implications of these investigators' role in clinical investigation.

23 mitations of RF ablation and warrant further clinical investigation.

24 network, threatening the cause of legitimate clinical investigation.

25 eutics as well as the nanotherapeutics under clinical investigation.

26 ome to reach this goal and the next steps in clinical investigation.

27 activity are currently in advanced stages of clinical investigation.

28 modifying therapy for PD and support further clinical investigation.

29 ective in reducing pain and warrants further clinical investigation.

30 fficient potency and acceptable toxicity for clinical investigation.

31 sis of the four metabolites in a large-scale clinical investigation.

32 ombinant chaperoning-based vaccine to future clinical investigation.

33 e need for detailed further experimental and clinical investigation.

34 a nuanced understanding of epidemiology and clinical investigation.

35 Soluble Dll4 is thus a candidate for clinical investigation.

36 pilot study suggests important new areas for clinical investigation.

37 e ASCI started a new journal, the Journal of Clinical Investigation.

38 rategies for optimal training, staffing, and clinical investigation.

39 s, show antitumor efficacy and are now under clinical investigation.

40 ts potential as a prototype virus for future clinical investigation.

41 lar targeted therapies under preclinical and clinical investigation.

42 tions--the annual meeting and The Journal of Clinical Investigation.

43 icantly attenuated systemic IRI and warrants clinical investigation.

44 ety of new targets are available for further clinical investigation.

45 herapeutic rescue strategies currently under clinical investigation.

46 ictal activity, aiding both experimental and clinical investigation.

47 the first selective CDK7 inhibitor to enter clinical investigation.

48 cell and gene therapies are currently under clinical investigation.

49 been made in translating this technology for clinical investigation.

50 sion and providing a clear rationale for its clinical investigation.

51 and the flagship of the American Society for Clinical Investigation.

52 inumab might be possible and warrant further clinical investigation.

53 le isotopically labeled ones, even for adult clinical investigation.

54 otent non-bile acid FXR agonist currently in clinical investigation.

55 dextrin, a promising therapy currently under clinical investigation.

56 CRC mouse models for genetic studies and pre-clinical investigation.

57 t also demonstrate functional utility in pre-clinical investigations.

58 sibility to apply the QD-based biosensor for clinical investigations.

59 n of F8-IL4 is currently being developed for clinical investigations.

60 gression and regression in basic science and clinical investigations.

61 sy, thereby overcoming critical obstacles to clinical investigations.

62 multicenter efforts to conduct the necessary clinical investigations.

63 in glioblastoma through both preclinical and clinical investigations.

64 available at the end of synthesis for use in clinical investigations.

65 further validated in large-scale prospective clinical investigations.

66 rokinetic assays for possible application in clinical investigations.

67 ional glioblastoma classification for future clinical investigations.

68 against PC that warrants further in vivo and clinical investigations.

69 rphologies consistent with those reported in clinical investigations.

70 decades has emerged as a result of organized clinical investigations.

71 monly used for epidemiological, forensic and clinical investigations.

72 acy observed in pre-clinical and small-scale clinical investigations.

73 linical trials and to summarize results from clinical investigations.

74 s essential to guiding the design of further clinical investigations.

75 ress in this field and priorities for future clinical investigations.

76 in cancer with several new drugs undergoing clinical investigations.

77 dasatinib, laying the groundwork for future clinical investigations.

78 from research and design to pre-clinical and clinical investigations.

79 an be applied to educational, scientific, or clinical investigations.

80 to their ability to augment experimental and clinical investigations.

81 applicable to a wide range of biological and clinical investigations.

82 time-both of which are necessary for future clinical investigations.

83 ide a new foundation for future research and clinical investigations.

84 n provide a basis for further biological and clinical investigations.

85 devices that have been approved or are under clinical investigations.

86 Despite extensive clinical investigations, a standard systemic therapy for

87 tely, current implementations, in animal and clinical investigations, activate both afferent and effe

88 history, examination and routinely available clinical investigations) against a new 'gold standard' f

89 This has translated to clinical investigations aimed at the safe and controlled

90 ro and in vivo, establishing a rationale for clinical investigation and further motivation to underst

91 , age, and other reproductive information in clinical investigation and gene association studies of N

92 he past 20 years has spurred an explosion of clinical investigation and growing intensity of informat

93 e Duke-UNC Editorial Board of the Journal of Clinical Investigation and have had the privilege of pub

94 al myocardial function have also evolved for clinical investigation and hold the promise of enhanced

95 Generally, the tension between clinical investigation and individual care can be framed

96 13 patients for up to 37 years, extended the clinical investigation and monitoring to living relative

97 most notably targeting tau, currently under clinical investigation and one approved in May 2020.

98 Finally, we propose future avenues of clinical investigation and potential therapeutic approac

99 toxic effects encountered and anticipated in clinical investigation and practice with antiangiogenic

100 anagement of COVID-19 will require basic and clinical investigation and public health and clinical in

101 9 has advanced to clinical investigation and successfully suppressed postp

102 emergency medical services for streamlining clinical investigations and accurate triage, use of prec

103 contradictory results compared to those from clinical investigations and animal models.

104 Most of these enzymes are currently under clinical investigations and if successful will potential

105 perspective to use stochastic pacing during clinical investigations and in patients with implanted p

106 asures of myocardial strain and synchrony in clinical investigations and in practice; data are limite

107 This finding compels additional clinical investigations and pharmacovigilance directed t

108 Scientists Association, American Society of Clinical Investigation, and Association of American Phys

109 s mild AD in a large, multisite, prospective clinical investigation, and this signature appears to pr

110 e prospective studies (IDE [S-ICD System IDE Clinical Investigation] and EFFORTLESS [Boston Scientifi

111 The institutional review board for clinical investigations approved the protocols for each

112 l trials, and human data from several of the clinical investigations are compared with results from m

113 Clinical investigations are focused on development of ef

114 Further clinical investigations are needed to determine its clin

115 Encouraging results from some of these clinical investigations are summarized in this review.

116 205 identification, currently under phase II clinical investigation, are described herein.

117 up to 4 weeks or longer, supporting further clinical investigation as a potential once-monthly subcu

118 ostimulatory saponin that is currently under clinical investigation as an adjuvant in various vaccine

119 n Hh pathway inhibitor (HPI) currently under clinical investigation as an anticancer agent.

120 Chk1 kinase inhibitors are currently under clinical investigation as potentiators of cytotoxic chem

121 biosynthesis inhibitors are currently under clinical investigation as treatments for respiratory and

122 ate hepatitis C virus antiviral therapies in clinical investigation as well as the associated clinica

123 dy suggests that ROR1 merits preclinical and clinical investigations as a novel target for mAb-based

124 onic lipids, which have been broadly used in clinical investigations, as an alternative to ionizable

125 years ago, in 1909, the American Society for Clinical Investigation (ASCI) held its first annual meet

126 The American Society for Clinical Investigation (ASCI), a nonprofit honorary soci

127 Urine is considered an ideal biofluid for clinical investigation because it is obtained noninvasiv

128 ra (MVA) is a useful viral-based vaccine for clinical investigation, because of its excellent safety

129 t at the stage where it can enter widespread clinical investigations, because the technology is stabl

130 Clinical investigation, blinded to lyso-Gb3 results, rev

131 Research Council Scale) and associated with clinical investigations (brain magnetic resonance imagin

132 Genetic predictive testing and clinical investigation by imaging from neck to pelvis wa

133 tments of Ophthalmology and their associated clinical investigation centers.

134 (ABSORB Clinical Investigation, Cohort B [ABSORB B]; NCT00856856

135 fer preclinical rationale warranting further clinical investigation combining HDACi with EGFR and HER

136 This clinical investigation demonstrated that the concurrent

137 Many clinical investigations depend on participant self-repor

138 After extensive clinical investigation, direct sequencing and mutation a

139 Clinical investigations discovered that levels of patien

140 Given the vast research and clinical investigation efforts dedicated to advancing bo

141 ns and ESR1 gains deserving urgent dedicated clinical investigation, especially in the context of end

142 tissues has led to the rapid development of clinical investigations exploring their anti-inflammator

143 ing mechanisms are poorly defined, with most clinical investigations focused on humoral autoimmunity

144 tase enzyme (BACE1) are under preclinical or clinical investigation for Alzheimer's disease (AD).

145 tein kinases (MAPKs) that is currently under clinical investigation for human malignancies.

146 r coronary in-stent restenosis and are under clinical investigation for lesions without prior stent i

147 , facilitates improved screening and focused clinical investigation for PH diagnosis and management.

148 and adolescents <=21 years of age undergoing clinical investigation for suspected Lyme disease.

149 nd a number of therapeutic options are under clinical investigation for the management of patients wi

150 sue-derived cells (hUTC) are currently under clinical investigation for the treatment of geographic a

151 Smoothened (SMO) inhibitors are under clinical investigation for the treatment of several canc

152 ry arterial hypertension and have been under clinical investigation for the treatment of several othe

153 giogenesis and has since undergone extensive clinical investigation for the treatment of various soli

154 he novel Hsp90 inhibitor XL888 is undergoing clinical investigation for use in conjunction with the r

155 more than 80 others are currently undergoing clinical investigations for a range of solid tumours and

156 Nevertheless, clinical investigations for atherosclerosis still focus

157 ffers a novel combination regimen for future clinical investigations for prevention of prostate cance

158 using the standard World Health Organization clinical-investigation form for viral hemorrhagic fevers

159 Our clinical investigations further indicate that high tumor

160 on-like peptide-1 (GLP-1), and the target of clinical investigation, gastric inhibitory polypeptide (

161 tions due to S. maltophilia warrants further clinical investigation given its potent in vitro activit

162 Human satellite cells are scarce; therefore, clinical investigation has been limited.

163 use and in vitro cell systems, together with clinical investigations, has provided insight into the m

164 Clinical investigations have suggested that repression o

165 Experimental and clinical investigations have tested the hypothesis that

166 Clinical investigations highlight the increased incidenc

167 history of DCM occurred in 11% (n=12) while clinical investigations identified familial DCM in a tot

168 ng founders when they created the Journal of Clinical Investigation in 1924.

169 geting arginine is safe and warrants further clinical investigation in arginine-dependent cancers.

170 privation combined with antifolates warrants clinical investigation in ASS1-negative urothelial and r

171 Therefore, epigenetics is a key area of clinical investigation in diagnosis, prognosis, and trea

172 of MEK1/2 and CDK4/6 is currently undergoing clinical investigation in NRAS-mutant melanoma.

173 BAY 1895344 is currently under clinical investigation in patients with advanced solid t

174 minal infusion of AAV2-GDNF and suggest that clinical investigation in PD patients is warranted.

175 In contrast, Vitamin D, another drug under clinical investigation in PDAC, induces distinct transcr

176 prostate cancer models and, therefore, merit clinical investigation in this setting.

177 The results were compared with subsequent clinical investigations in human volunteers.

178 ing pharmacological profile supports further clinical investigations in hypertriglyceridemic subjects

179 Research and clinical investigations in psychiatry largely rely on th

180 More than 20 years ago clinical investigations in the immunotherapy of cancer r

181 l proof-of-principle to repurpose l-NAME for clinical investigations in treatment of PDACs and possib

182 Clinical investigations included electro-oculography, fu

183 Clinical investigations included eye examination with co

184 Clinical investigations included fundus photography, opt

185 Clinical investigations included visual field testing, f

186 om LSC would enable important scientific and clinical investigation including the possibility of purg

187 ity and longevity of NK cells are also under clinical investigation, including cytokine-based agents,

188 approaches that are in preclinical or early clinical investigation, including modified protein immun

189 Recent clinical investigations indicate that anthracycline-base

190 Randomized clinical investigation indicates that ACEI and a BP goal

191 mulating evidence from both experimental and clinical investigations indicates a tight interaction be

192 these trials and have warranted intense pre-clinical investigation into defining the tendencies of d

193 (TRIUMPH I: Double Blind Placebo Controlled Clinical Investigation Into the Efficacy and Tolerabilit

194 This article describes the first clinical investigation into the medical and technical as

195 further study, including epidemiological and clinical investigations into laxative prescriptions cons

196 Our findings indicate further need for clinical investigations into the effects of OLZ, but not

197 Clinical investigations involving patients with ANDV han

198 However, further rigorous clinical investigation is necessary in order to prove th

199 Additional comprehensive and disciplined clinical investigation is needed to carefully characteri

200 Innovative basic and clinical investigation is urgently needed to improve tre

201 atinine are observed postoperatively, timely clinical investigation is warranted to maximize renal re

202 Further clinical investigation is warranted.

203 to antitumor effects to be gauged in future clinical investigations justified by our findings.

204 This edition of the Journal of Clinical Investigation marks the transition to a new edi

205 alignancies and pediatric-specific issues in clinical investigation may make translating genomic disc

206 , the most readily available human cells for clinical investigation, may provide a powerful tool for

207 Parallel clinical investigation of 6 patients with IWC revealed a

208 tumor uptake (~56% injected dose/g) warrants clinical investigation of [(89)Zr]Zr-DFO-scFv-Fc-CD44 as

209 s of these immunotherapies have prompted the clinical investigation of additional therapies that modu

210 , we applied our model to data obtained in a clinical investigation of an allogeneic whole-cell thera

211 tic cholesterol metabolism, which led to the clinical investigation of ASBT inhibitors as lipid-lower

212 These results warrant the clinical investigation of ATO for tumors with activated

213 derscore the potential of proteogenomics for clinical investigation of breast cancer through more acc

214 , the present data do not support additional clinical investigation of combined paclitaxel/bevacizuma

215 omach volume, and could be a useful tool for clinical investigation of diabetes and other pancreas pa

216 cells and provide the rationale for further clinical investigation of DIM.

217 HER2-amplified breast cancers, rationalizing clinical investigation of dual mTORC1/2 kinase inhibitor

218 Results will inform clinical investigation of EGFR-targeting therapeutics in

219 Clinical investigation of evobrutinib is ongoing in seve

220 Our results support the clinical investigation of FTC/TAF for PrEP.

221 rgeted clinical-grade CCR2 imaging probe for clinical investigation of heart diseases.

222 cancers expressing AR-V7, supporting further clinical investigation of HSP90 inhibitors in malignanci

223 d they offer a mechanistic rationale for the clinical investigation of Jak and STAT3 inhibitors as th

224 itoneal space provide a strong basis for the clinical investigation of LSPD.

225 erience generated by laboratory research and clinical investigation of lymphokine-activated killer ce

226 des have brought an accelerating pace to the clinical investigation of new molecular targeted agents,

227 ene-driven lymphomas, and this work supports clinical investigation of NKT cell-based immunotherapy i

228 Further clinical investigation of PARP-1 inhibitors is warranted

229 The study was conducted in the Center for Clinical Investigation of Quinze-Vingts National Ophthal

230 These findings warrant further clinical investigation of selumetinib plus docetaxel in

231 t of PI3K inhibitors, and strategies for the clinical investigation of such drugs in hormone receptor

232 These results warrant the clinical investigation of suicidal CD44v6-targeted T cel

233 ertension Study (n = 811), a cross-sectional clinical investigation of systematic differences between

234 TACE inhibitor and continues to obstruct the clinical investigation of TACE activity.

235 Clinical investigation of TDT 067 for the topical treatm

236 with the parent antibody, supporting further clinical investigation of the co-administration dosing s

237 Clinical investigation of the manifestations observed in

238 dontal health and disease, paving the way to clinical investigation of the possibility of using the W

239 with DLD; (3) recommend methods for further clinical investigation of the remaining infants, who are

240 ifferent experimental models, leading to the clinical investigation of the TGF-beta inhibitor LY21572

241 Our results warrant the clinical investigation of this combination therapy in pa

242 umors via a variety of mechanisms, prompting clinical investigation of this potentially promising tre

243 Overall, our data support the clinical investigation of this therapy in TNBC.

244 rends in DTI applications for biomedical and clinical investigation of various brain diseases and dis

245 nd retrospective analyses ranging from small clinical investigations of 42 participants to large, mul

246 esents a novel PET radiotracer to facilitate clinical investigations of anti-GD2 immunotherapies and

247 itizes tumors, providing a new rationale for clinical investigations of As(2)O(3) in irradiation prot

248 inding is relevant to future preclinical and clinical investigations of cell transplantation and the

249 eomics and may be of value in biological and clinical investigations of cervical carcinogenesis.

250 k that will be valuable for experimental and clinical investigations of diverse physiological process

251 ween animal groups in toxicology studies and clinical investigations of liver disease.

252 dies exploring xenobiotic hepatotoxicity and clinical investigations of liver disease.

253 serve as a translatable biomarker for future clinical investigations of muscarinic agents, and bear m

254 Clinical investigations of novel drugs and biological ag

255 SCCs from HIV-positive patients and support clinical investigations of PD-1/PD-L1 checkpoint blockad

256 Background Clinical investigations of shock in cardiac intensive ca

257 Although clinical investigations of the RV have been focused on t

258 widespread problem in this tumor, prompting clinical investigations of the use of FGFR1 inhibitors f

259 y and will inform additional preclinical and clinical investigations of these constructs.

260 We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infe

261 elopment and are either in various phases of clinical investigation or have received marketing author

262 e, and stem cell delivery is still under pre-clinical investigation or in clinical trials.

263 Clinical investigations provide evidence that N-BP inhib

264 Clinical investigations reveal the overexpression of spe

265 Future clinical investigations should evaluate intervening on t

266 Larger clinical investigations should include remodeling metric

267 A wealth of experimental and clinical investigations show that individual differences

268 ysician-scientists, the American Society for Clinical Investigation spring meetings are the backdrop

269 New clinical investigations suggest that CD may be caused by

270 Preclinical and clinical investigations suggest that phenylalanine ammon

271 isorder deepens through basic laboratory and clinical investigations, swift implementation of new eff

272 public health emergency, multi-institutional clinical investigation systems must be in place to rapid

273 epatitis and to illustrate the principles of clinical investigation that can be applied broadly to ot

274 Fortunately, clinical investigations that have assessed the efficacy

275 otics are described, along with the types of clinical investigations that have been done.

276 Rather than relying on well conducted clinical investigations, the Food and Drug Administratio

277 trategy of NRF2 activation sought by intense clinical investigation therefore appears to have also un

278 gested by pathology studies and confirmed by clinical investigations, these results are not surprisin

279 overy Institute and the American Society for Clinical Investigation, this clinical advance has depend

280 l significant obstacles that require further clinical investigation through international collaborati

281 riate etiologic evaluation and comprehensive clinical investigation to define the range of anomalies

282 The apelin-APJ system merits further clinical investigation to determine its role in cardiova

283 highly effective ROS1 inhibitor, and further clinical investigation to evaluate its potential therape

284 Our findings warrant onward clinical investigations to examine the clinical efficacy

285 reason why it is important to continue with clinical investigations to give more clarity about the o

286 This emphasized the importance of clinical investigations to identify familial DCM.

287 Our results may help guide future clinical investigations to promote functional axon regen

288 nticoagulants and warfarin have also entered clinical investigation, to address the issue of preexist

289 portion of OD patients despite the extensive clinical investigation used to assign each patient to th

290 Our findings prompt prospective clinical investigations using BH3-mimetics combined with

291 result in a fundamental change in how human clinical investigation was conducted, with the eventual

292 sfunction affecting the prefrontal cortex in clinical investigations, we targeted prefrontal cortex i

293 Clinical investigations were not contributory.

294 Clinical investigations were performed in 109 DCM index

295 Methods and Results Clinical investigations were routinely performed in DCM

296 This work provides a foundation for clinical investigations whereby lymphedema etiogenesis a

297 e, and provided potential CNS biomarkers for clinical investigation with the compound, including phar

298 Clinical investigations with CSC marker follow-up as a m

299 These observations warrant clinical investigations with selected BLCA patients.

300 These therapies are in various stages of clinical investigation, with some successes noted in cli