ライフサイエンスコーパス: clinical observation

1 was open-minded, exploratory, comprehensive, clinical observation.

2 cted practices supported by common sense and clinical observation.

3 ormalities are evident from both parents and clinical observation.

4 ders have been defined by expert opinion and clinical observation.

5 y limited and has largely been obtained from clinical observation.

6 as confirmed by pathology, bacteriology, or clinical observation.

7 fe without improving survival, compared with clinical observation.

8 is" has been recently coined to describe the clinical observations.

9 , these models do not entirely reproduce the clinical observations.

10 s, which is consistent with experimental and clinical observations.

11 This direct causality is incompatible with clinical observations.

12 mortality, which is consistent with current clinical observations.

13 nation in numeric simulations, referenced to clinical observations.

14 A (10%) and G (90%), which is in accord with clinical observations.

15 ning, and show a remarkable coincidence with clinical observations.

16 nt mice that have recapitulated and informed clinical observations.

17 ts vs. several decades of animal studies and clinical observations.

18 l of blood clot dissolution, as well as with clinical observations.

19 previously defined in vitro measurements and clinical observations.

20 are parameterised to qualitatively reproduce clinical observations.

21 imate (NHP) model of SSIOAC and reported our clinical observations.

22 ls, in vitro human cell culture systems, and clinical observations.

23 blood and bone marrow and to correlate with clinical observations.

24 th of susceptible virus, explaining puzzling clinical observations.

25 y provides a molecular explanation for these clinical observations.

26 heightened interoception, described in some clinical observations.

27 respectively, accurately reflecting previous clinical observations.

28 gap between data from animal pain models and clinical observations.

29 them seems to fully account for the reported clinical observations.

30 frequently occurs through epidemiological or clinical observations.

31 alities in this study and no Ramizol-related clinical observations.

32 that recapitulated important aspects of the clinical observations.

33 to collect participants' characteristics and clinical observations.

34 odelling associated with SND agreed with the clinical observations.

35 ion predicted by simulation agreed well with clinical observations.

36 Similar to clinical observations, a robust vaginal polymorphonuclea

37 Two models have been forged on the basis of clinical observations: a first model proposes that the r

38 The flow of ideas from clinical observations about essential tremor, to their t

39 results provide a bridge between the current clinical observations about resection for temporal lobe

40 of PTGR2 in gastric cancer, but also provide clinical observations affirming the significance of PTGR

41 Consistent with clinical observations, all metreleptin signaling pathway

42 gies-based on viral load, CD4 cell count, or clinical observation alone-for determining when to switc

43 We stress the continuing relevance of clinical observations amid the increasing molecular comp

44 In addition to a number of very compelling clinical observations, an extensive body of extremely su

45 Our evidence of clinical observation and blood parameters showed no sign

46 nical benefit after 6 wk of therapy based on clinical observation and CT response by World Health Org

47 the pathogenesis of CHIKV infection through clinical observation and with animal models.

48 Clinical observations and animal models have provided th

49 Here, we summarise the published clinical observations and biology underlying tumours wit

50 Clinical observations and complete blood counts (CBC) we

51 In vitro studies confirm these clinical observations and demonstrate an anti-HIV replic

52 Clinical observations and epidemiologic studies suggest

53 Through clinical observations and experimental models of AlloSCT

54 f concept for our approach, we recapitulated clinical observations and identified the EGFR L858R as t

55 Clinical observations and laboratory evidence link bone

56 Clinical observations and laboratory models of IBMFSs su

57 acy of treatment, determined on the basis of clinical observations and microbiologic tests, was asses

58 Recent clinical observations and molecular studies have created

59 s of death are unknown, but a combination of clinical observations and pathological findings suggests

60 Over the past decade, clinical observations and ray-tracing models have greatl

61 classes, elucidating previously unexplained clinical observations and suggesting new drug reposition

62 t candidates, the validation of research and clinical observations and the generation of unanticipate

63 rministic model has some deviations from the clinical observations and the growth term value is not w

64 However, investigations relevant to clinical observations and the natural history of the dis

65 e current work are consistent with published clinical observations and the results of previous clinic

66 Our prior clinical observations and those of other investigators s

67 nds in cancer, with reference to instructive clinical observations and translational approaches.

68 itionally, the diagnosis was mainly based on clinical observations and treatment options were confine

69 ng probability and risk of TKR compared with clinical observations and two binary outcome prediction

70 ne cell profiles demonstrated alignment with clinical observations and validated the correlation of T

71 the molecular mechanisms underpinning these clinical observations, and identify relevant epigenetic

72 understanding of renal physiology, reported clinical observations, and individual experiences.

73 the importance of basic research, chairside clinical observations, and population-based studies in d

74 Based on reported clinical observations, and studies of mouse models of CM

75 olecular biology studies, animal models, and clinical observations, and the potential of new therapie

76 ellular and molecular mechanisms behind this clinical observation are unclear.

77 Recent clinical observations are also changing how HLH is conce

78 Neuroimaging, neurophysiological and clinical observations are consistent with either or both

79 These clinical observations are well established, but the unde

80 id hormone action has been informed by these clinical observations as well as by animal models and ha

81 rstanding the molecular details underpinning clinical observations as well as to aid in the design of

82 Clinical observations, as well as data obtained from the

83 Consistent with our clinical observations, BRF1 overexpression in a Pten-def

84 hemianopia in humans is well recognized from clinical observation but the findings in acquired lesion

85 l. provide a potential explanation for these clinical observations by examining IL-17C-driven psorias

86 Our findings support clinical observations by providing evidence that lack of

87 creased levels of bound fatty acids, and all clinical observations can be rationalized by this molecu

88 Our work highlights how clinical observations can lead to the generation of a mo

89 roduce diverse sets of experimental data and clinical observations concerning the temporal sensitivit

90 Clinical observations corroborate previously reported cl

91 These clinical observations, coupled with important scientific

92 We also used clinical observation data from nationally representative

93 Based on clinical observations, data from accessible GWAS and exp

94 riguing example of such crosstalk comes from clinical observations dating from the 1930s: Patients wh

95 ear extinction suggests that, in accord with clinical observations, DBS could augment the effectivene

96 However, our clinical observations do not support this premise.

97 Similar to clinical observations, drug efficacy is variable across

98 driven by discoveries in animal studies and clinical observations (eg, oestrogen, calcitonin, and te

99 A preponderance of preclinical data and clinical observations established p38alphaMAPK as a brai

100 Clinical observations established that IL-12/23p40 is in

101 CLL) from its early stage and worsens during clinical observation, even in absence of disease progres

102 ersonality, and social psychology as well as clinical observations, expansions of the original cognit

103 Several mechanisms referenced to clinical observations explained termination of AF to sin

104 Common sense and clinical observation fail for several reasons: incomplet

105 loss of volume in the articular cartilage, a clinical observation first described in polio patients a

106 superior and inferior quadrants, supporting clinical observations for RNFL thinning in glaucoma.

107 Evidence from clinical observation (funduscopy) suggested that retrogr

108 The clinical observation has been made that there might be a

109 A long-standing clinical observation has been the delay between GC admin

110 similar in both groups despite the fact that clinical observation has consistently found evidence of

111 Clinical observation has long held that TBI can accelera

112 Translational research informed by clinical observations has the greatest potential for the

113 accumulation of patient reports, as well as clinical observations, has belatedly led to an interest

114 giographic intervention, serial imaging, and clinical observation have also changed over the years.

115 These clinical observations have been theoretically linked to

116 Although many experimental and clinical observations have implicated gut microbiota in

117 Clinical observations have linked tobacco smoking with i

118 underlying mechanisms responsible for these clinical observations have not been fully delineated.

119 While clinical observations have suggested that insulin action

120 her with neuroanatomical, brain imaging, and clinical observations, have recontextualized the cerebel

121 gingivalis) in a manner consistent with the clinical observations (i.e., LPS upregulated Wnt5a and d

122 Epidemiologic and clinical observations identify obesity as an important r

123 rize the anatomy of the His bundle and early clinical observations, implantation techniques and avail

124 Clinical observations implicate a role of eosinophils in

125 Clinical observations imply that female cocaine addicts

126 role of serendipity coupled with meticulous clinical observation in drug development in medicine was

127 tion resulting in acanthosis is an important clinical observation in patients with atopic dermatitis,

128 lated objects has been hypothesized based on clinical observation in PTSD, but the neural mechanisms

129 The model's predictions accurately mimic clinical observations in ascites, including the magnitud

130 We review important new clinical observations in chronic pancreatitis made in th

131 We review important new clinical observations in chronic pancreatitis made in th

132 We review selected important clinical observations in chronic pancreatitis reported i

133 PURPOSE OF REVIEW: We review important new clinical observations in chronic pancreatitis reported i

134 p a diagnostic toolbox to capture and report clinical observations in double-blind placebo-controlled

135 New clinical observations in ESCS include (1) torpedo-like,

136 d cancer progression while, in contrast with clinical observations in humans, anti-RANKL therapy full

137 Here, we review clinical observations in offspring, noting that offsprin

138 This mimics clinical observations in patients with exacerbations, wh

139 Clinical observations in these patients have varied from

140 etinal regions yielded results comparable to clinical observations in those regions.

141 Clinical observations included visual acuity, retinal de

142 logy have been accompanied by some important clinical observations including increased rates of C. di

143 can explain a number of previously published clinical observations including latent reservoir size an

144 However, clinical observations indicate a spectrum of anorectal d

145 Recently, additional clinical observations indicate that AAG patients may als

146 ent survival are poorly understood; however, clinical observations indicate that EBOV viremia may be

147 ression and are consistent with our previous clinical observations indicating that certain TMPRSS2/ER

148 ms (Autism Diagnostic Interview-Revised) and clinical observation instrument (Autism Diagnostic Obser

149 However, the mechanism underlying this clinical observation is not fully understood.

150 The cellular basis of this clinical observation is unknown.

151 A theory for estimating Theta from scaled clinical observations is developed, and the hypothesis i

152 common discrepancy between experimental and clinical observations is the use of nonphysiologically r

153 Based on clinical observations, it is more appropriate in most ca

154 Clinical observations link respiratory virus infection a

155 Despite these clinical observations, little is known regarding the eff

156 Clinical observation may also serve as an adjunct to ini

157 Consistent with clinical observations, miR-1269a significantly increases

158 Here we report the clinical observation of 3 MCL patients with symptomatic

159 Finally, our findings may explain a past clinical observation of a GABAA-R PAM reducing HbA1c lev

160 In work arising from the clinical observation of a patient with ALK fusion-positi

161 ine to control ongoing pain, consistent with clinical observation of BTP.

162 a potential mechanistic explanation for the clinical observation of early adverse events to SSRI tre

163 Clinical observation of HR during anti-PD-1/anti-PD-L1 t

164 y providing mechanistic explanations for the clinical observation of immune dysfunction and tolerance

165 s is remarkable and may explain the reported clinical observation of improved HSCT outcome with young

166 After an initial clinical observation of isolated cases of pyridoxal-5'-p

167 non-small cell lung cancer, as implicated by clinical observation of mixed ADC and SCC pathologies in

168 The clinical observation of reduced ROP severity in prematur

169 a mechanistic explanation that supports the clinical observation of superiority of HMA over cytarabi

170 These findings are relevant to clinical observations of altered metabolic signaling in

171 From SPA surveys, we identified 22 519 clinical observations of children younger than 5 years w

172 , celiac disease, CD, and UC, which supports clinical observations of comorbidity.

173 ociate those mechanical findings with common clinical observations of disc fatigue and damage.

174 Despite clinical observations of enhanced bone healing in patien

175 The clinical observations of exposed bone revealed that most

176 Together, our findings link clinical observations of glucose uptake with a pathologi

177 ctors and vascular occlusions, replicate key clinical observations of ischemia and macular edema in t

178 These findings are consistent with several clinical observations of luminal breast cancer sub-types

179 Clinical observations of migraine headache symptoms in p

180 The data set contained 24,756 direct clinical observations of outpatient sick-child visits ac

181 Clinical observations of patients with central vision lo

182 These nerve-dependent phenotypes mimic clinical observations of patients with nerve damage resu

183 Sporadic clinical observations of periodontal regeneration treatm

184 Based on clinical observations of peripartum cardiomyopathy patie

185 ey provide a mechanistic explanation for the clinical observations of reduced albuminuria with atrase

186 l groups, which again is consistent with the clinical observations of reduced numbers of dendritic sp

187 In our clinical observations of severe generalized recessive dy

188 Our data support the clinical observations of strong RPE fluorescence, increa

189 Clinical observations of the apparently random responsiv

190 us pathogenetic mechanisms and important new clinical observations of the disease course provide fres

191 ion has been substantially altered by recent clinical observations of thyroid signaling defects in sy

192 een the underlying molecular biology and the clinical observations of tumor (18)F-FDG accumulation in

193 However, recent preclinical and clinical observations of tumor initiation or recurrence

194 The strongest evidence for this derives from clinical observations of tumor regressions upon antivira

195 This finding is in accordance with clinical observations of zoster virus reactivation from

196 fen resistance, which is consistent with the clinical observation on the association of ER-alpha36 ex

197 se results provide the optical basis for two clinical observations on keratoconus: (1) optical perfor

198 We detail clinical observations on VH in five macular degeneration

199 nireview examines both the basic science and clinical observations over the past 20 years to show how

200 pathy (AAG) including serological diagnosis, clinical observations, pathophysiology, and treatment.

201 Clinical observations point to immune defects in GD beyo

202 their reconciliation with epidemiologic and clinical observations poses a major challenge.

203 n this Review, we provide an overview of the clinical observations, preclinical experiments and clini

204 Hemodynamic and clinical observations provide direction toward additiona

205 btypes that are difficult to discern through clinical observations, providing impetus for deeper inve

206 Additional parameters, including clinical observations, radiographs, viral load in blood,

207 Nevertheless, these clinical observations raise the possibility for an ABC-D

208 ls, have led to claims that common sense and clinical observation, rather than RCTs, should be the pr

209 These findings reconcile preclinical and clinical observations regarding the development of morph

210 ely common, but the etiology underlying this clinical observation remains elusive.

211 However, the mechanism underlying this clinical observation remains largely unknown.

212 We review selected important clinical observations reported in 2012.

213 Clinical observations reveal that an augmented pace of T

214 Clinical observations revealed that a robust vaginal pol

215 nostic algorithm based on the combination of clinical observations, RT-qPCR in multiple diagnostic sp

216 Based on clinical observations, sensory over-responsivity is hypo

217 Clinical observations show that CD31 expression is alter

218 Clinical observations show that the relationship between

219 Clinical observations showing significantly less acute a

220 These data are consistent with clinical observations showing that n-3 PUFA and SSRI hav

221 ng a prodrome requires techniques other than clinical observation such as monitoring endophenotypes t

222 Clinical observations suggest a relatively specific effe

223 Clinical observations suggest a role for donor MICA anti

224 Clinical observations suggest an even higher risk during

225 Because clinical observations suggest conventional sodium channe

226 Clinical observations suggest that anaphylaxis is more c

227 Animal studies and clinical observations suggest that epilepsy is associate

228 Preclinical and clinical observations suggest that even following the de

229 Although clinical observations suggest that humans with amygdala

230 Clinical observations suggest that local inflammation is

231 Clinical observations suggest that loss of MC4R function

232 Clinical observations suggest that most cancers metastas

233 Clinical observations suggest that patients with age-rel

234 Clinical observations suggest that RT may expand the the

235 Basic and clinical observations suggest that the caudal hypothalam

236 Clinical observations suggest that the development of SM

237 Clinical observations suggest that the monomorphic varia

238 However, recent clinical observations suggest that the survival of patie

239 Clinical observations suggest that there is individual v

240 Clinical observations suggest that VZV-specific T cell i

241 microbiome of atopic patients and to review clinical observations suggesting that atopic patients mi

242 he results of this study are consistent with clinical observation, suggesting the usefulness of pharm

243 ns in these affected genes was predictive of clinical observations, suggesting potential clinical uti

244 Clinical observation suggests that early acute respirato

245 Clinical observation suggests that HIV progress more rap

246 This effect was in line with clinical observations, supporting a correlation between

247 mized to postoperative IS (control group) or clinical observation (test group) at a single-center ter

248 mpared to B. multivorans, which supports the clinical observation that B. cenocepacia is more virulen

249 efense, offer a possible explanation for the clinical observation that coagulase-negative staphylococ

250 The clinical observation that discontinuation of treatment c

251 iomagenesis, functionally substantiating the clinical observation that EGFR-positive GBMs from patien

252 This finding might help us understand the clinical observation that patients with atopic dermatiti

253 This study confirmed our clinical observation that patients with CS suffer from c

254 This finding was corroborated by clinical observation that PER2 down-regulation was assoc

255 In conjunction with the clinical observation that rare coding GLRB gene mutation

256 This dynamic analysis supports the clinical observation that the majority of vein grafts pr

257 ervable and predictable link with the common clinical observation that the posterior region of the di

258 e to in vivo irradiation are consistent with clinical observation that therapeutic ionizing radiation

259 lts support a potential mechanism underlying clinical observations that allergic sensitization is ass

260 In addition, the model supports the clinical observations that antibiotic treatment quickly

261 ome chronically infected in combination with clinical observations that antibody responses after blad

262 th protective alleles, coupled with detailed clinical observations that EvC and BPI do not occur in t

263 cal microbiota transplantation and summarize clinical observations that have implicated the intestina

264 hus chronic exposure give credibility to the clinical observations that MI can be an important cause

265 Our findings provide the rationale for clinical observations that relate atopy with a lower ris

266 When data were required from both parent and clinical observation, the specificity of the DSM-5 crite

267 Consistent with clinical observations, the allodynia was unaffected by a

268 Based on clinical observations, the speed of adduct formation, sk

269 anagement of dacryocystitis is based on only clinical observation Therefore, this study attempted to

270 Together with our clinical observations, this supports the need to optimiz

271 ational psychiatry accounts have linked this clinical observation to difficulties in making flexible

272 pathogenesis of AMD, having progressed from clinical observations to epidemiologic observations and

273 ative nature of therapeutic development from clinical observations to in vitro, in vivo, and clinical

274 Clinical observations uncovered the importance of autoim

275 We retrospectively report our clinical observations using 4 different treatment activi

276 Clinical observations, viral loads, immune responses, an

277 s, Kuhn's method of unfettered, exploratory, clinical observation was substandard, haphazard, even me

278 Although evidence from clinical observations was indirect, there is close corre

279 ning the underlying molecular basis for this clinical observation, we find that KSHV infection select

280 Working from this clinical observation, we find that wild-type mtsR functi

281 Based on this clinical observation, we investigated the potential of p

282 Starting with this clinical observation, we sought to model neonatal ABOi o

283 To investigate this clinical observation, we subjected lupus-prone MRL/lpr a

284 To explore mechanisms underlying these clinical observations, we backcrossed an established pso

285 Inspired by these clinical observations, we examined the anticancer potent

286 In agreement with clinical observations, we found that both genetic and bo

287 Based on clinical observations, we have previously shown in a mur

288 Based on clinical observations, we hypothesized that low condylar

289 Based on recent clinical observations, we hypothesized that the Hedgehog

290 Based on several clinical observations, we investigated the association b

291 Based on clinical observations, we systematically investigated wh

292 Based on these clinical observations, we wished to determine whether Gr

293 , classic pressure-flow physiology explained clinical observations well, with a coefficient of determ

294 oxicities occurred, and no treatment-related clinical observations were made in any of the studies.

295 Clinical observations were performed after grafting.

296 Clinical observations were recorded during hospitalizati

297 the activities of these compounds along with clinical observations, where available.

298 reveals mutational signatures predictive of clinical observations, which may serve as a powerful pro

299 early detection and the need for correlating clinical observations with multimodal imaging, particula

300 nditioned fear and PTSD derives largely from clinical observations, with limited empirical work on th