ライフサイエンスコーパス: clinical utility

1 , increasing interpretability and increasing clinical utility.

2 ticular emesis and nausea, have curbed their clinical utility.

3 Oncotype DX assay to assess for evidence of clinical utility.

4 n developing LRH-1 modulators with potential clinical utility.

5 there are multiple areas where this may have clinical utility.

6 approved for PCa, choline PET/CT may provide clinical utility.

7 dness-of-fit criteria, interpretability, and clinical utility.

8 sed measures could improve in robustness for clinical utility.

9 populations is now required to support their clinical utility.

10 eimer's disease) where PRS has or could have clinical utility.

11 icroscopy to analyze a blood smear, may have clinical utility.

12 ce side effects which could compromise their clinical utility.

13 ulations worldwide has greatly limited their clinical utility.

14 r is the fundamental obstacle preventing its clinical utility.

15 novel predictive score is needed to confirm clinical utility.

16 e MammaPrint assay to assess for evidence of clinical utility.

17 l outcomes suggest these agents have limited clinical utility.

18 anoma skin cancers, to demonstrate potential clinical utility.

19 mortality risk stratification with possible clinical utility.

20 sting in other disease cohorts to assess its clinical utility.

21 accuracy within 10 mm and could thus provide clinical utility.

22 reveals new molecular findings of uncertain clinical utility.

23 erial (vs other) infections would have great clinical utility.

24 index by balancing statistical accuracy with clinical utility.

25 vements to these mAbs to better ensure their clinical utility.

26 e receptor, a feature required for potential clinical utility.

27 tion of peptide vaccines from preclinical to clinical utility.

28 10-mL peripheral blood samples limits their clinical utility.

29 sents a diagnostic challenge that limits its clinical utility.

30 approved for PCa, choline PET/CT may provide clinical utility.

31 solely on self-report, would have tremendous clinical utility.

32 tensive rabbits, demonstrating potential for clinical utility.

33 lected through chart review and analyzed for clinical utility.

34 which is further enhanced by their potential clinical utility.

35 ion, storage, and analysis have hindered its clinical utility.

36 cted in blood-borne DNA, suggesting possible clinical utility.

37 ey are shown to have analytical validity and clinical utility.

38 of their molecular mechanisms and potential clinical utilities.

39 to define its therapeutic applicability and clinical utilities.

40 e for understanding pregnancy with potential clinical utilities.

41 anticipated to have broad translational and clinical utilities.

42 re the end points that are used to determine clinical utility?

43 tive and negative tests were rated as having clinical utility (42 of 45 [93%] and 112 of 156 [72%], r

44 To test for protein measurement, rather than clinical utility, a PD-L1 index tissue microarray, inclu

45 The performance, clinical utility (AII duration and survival), and cost-e

46 performance approached WHO TPP criteria for clinical utility among HIV-uninfected adults with presum

47 In the clinical utility analysis, we found 86% agreement (95% C

48 , the provision of a checklist increases the clinical utility and accessibility of these recommendati

49 ll operating characteristics and to identify clinical utility and areas of patient benefit.

50 This study investigated the clinical utility and combined yield of post-mortem genet

51 These validated data may be of great clinical utility and contribute to a personalized medica

52 The available data on clinical utility and cost-effective analysis for optimiz

53 Further research is needed to understand the clinical utility and cost-effectiveness of this approach

54 and when it should be performed to maximize clinical utility and cost-effectiveness.

55 The clinical utility and discovery potential of proteogenomi

56 In summary, clinicians perceived high clinical utility and low likelihood of harm with first-t

57 lity assurance and optimizations to maximize clinical utility and minimize alert fatigue.

58 essed, including understanding the potential clinical utility and optimal method to communicate perso

59 inical trials in pediatric PAH, although its clinical utility and prognostic value need to be further

60 Despite advances in the clinical utility and reliability of the Diagnostic Crite

61 biological probe for further determining the clinical utility and safety of pharmacological knockdown

62 cussion among frontline clinicians about the clinical utility and specific indications for testing.

63 a into model training will be crucial to the clinical utility and sustainability of machine learning-

64 We suggest that this analysis has clinical utility and that there is limited room for furt

65 oward potentially safer PAR4 antagonists for clinical utility and the development of tools such as ra

66 onmental processes to identify biomarkers of clinical utility and to develop novel targeted therapies

67 itional work is needed to prospectively test clinical utility and to develop PRPs for other populatio

68 of this tool to the clinic in 2004, further clinical utility and widespread adoption have been limit

69 CMR for MR assessment, highlight its current clinical utility, and recommend a standardized CMR proto

70 s work takes strides towards a pipeline with clinical utility, and the biomarkers identified further

71 cose-related effect on 1,5-AG, impacting its clinical utility as a diabetes biomarker in this subpopu

72 relapses in MOG-AAD patients, which may have clinical utility as a disease course biomarker and thera

73 ability of PD-MCI over time to determine its clinical utility as a marker of disease.

74 uggest that AKAP7 expression levels may have clinical utility as a prognostic biomarker for post-stro

75 -3p) associates with acute IS and might have clinical utility as an early diagnostic marker.

76 ing that these miRNA may have some potential clinical utility as biomarkers.

77 rystal microbalance (QCM) devices, have good clinical utility as fast diagnostic tools for the detect

78 NA-MENPs) across the BBB certainly will have clinical utility as future personalized nanomedicine to

79 ive studies were found to have evaluated the clinical utility, as defined by the guideline, of specif

80 of technical and biological validations and clinical-utility assessments, and the need to address im

81 Somatic mutations of established clinical utility (category I) were reported in 4 (3%) of

82 ing pathophysiology, are likely to have less clinical utility compared with approaches that combine t

83 Clinical utility data on HDT benefit in these patients a

84 of evidence that would support study of the clinical utility, describes the outcomes that should be

85 urrent antivirals for EBV have shown limited clinical utility due to low potency or high toxicity, le

86 conclusion, there is no strict definition of clinical utility for a TBT.

87 ly, there are no blood-based biomarkers with clinical utility for acute ischemic stroke (IS).

88 These tests may lack clinical utility for consumers wanting to understand the

89 Narrow and broad tests, however, lack clinical utility for different reasons.

90 The signature may have clinical utility for differentiating host systemic infla

91 from all other groups, suggesting potential clinical utility for identifying which NAAT- and toxin-p

92 ted screening tools to report calibration or clinical utility for improving health outcomes.

93 ed protein kinase phosphatase have potential clinical utility for management of periodontal inflammat

94 f histone-modifying enzymes have significant clinical utility for managing diseases such as cancer.

95 in an unbiased analysis of cfDNA, suggesting clinical utility for predicting chemotherapy response in

96 Genome sequencing has established clinical utility for rare disease diagnosis.

97 ur findings suggest that R-baclofen may have clinical utility for some of the core symptoms of human

98 ision curve analysis, the model demonstrated clinical utility for targeting preventative treatment, c

99 ombining ULK1/2 and PARP inhibition may have clinical utility for the treatment of TNBC.

100 ls suggesting that these approaches may have clinical utility for treatment or prevention of chronic

101 Our predictive models may have future clinical utility; for example, by anticipating the effec

102 tabilizing DNA-cleavage complexes, but their clinical utility has been compromised by resistance.

103 ne in type 2 diabetes is likely to have most clinical utility if it is based on an approach of using

104 ng echocardiography) have been shown to have clinical utility in a variety of settings.

105 ation of high frequency oscillations and its clinical utility in accurate pre-surgical assessment and

106 ole for DARPP-32 as a prognostic marker with clinical utility in breast cancer.

107 influences spermatogenesis and to assess its clinical utility in characterizing high-risk survivors a

108 identified genetic markers harbor potential clinical utility in characterizing high-risk survivors a

109 , likely due to bone turnover, which impairs clinical utility in children.

110 dysfunction associated with FGR and may have clinical utility in correctly identifying FGR among fetu

111 rate of phoria adaptation may have potential clinical utility in differentiating which patients may a

112 sory pathways and ondansetron has shown some clinical utility in disorders characterized by sensory a

113 NREM IEDs and suggests that HD-EEG may be of clinical utility in epilepsy surgery work-up.

114 ative accuracy may not yet be sufficient for clinical utility in FEP.

115 gement guidelines a real-time study of their clinical utility in FN is awaited.

116 e prospective studies and may have potential clinical utility in improving CVD risk classification.

117 ERK inhibitors may have clinical utility in overcoming resistance to MEK inhibit

118 nfectious disease suggests that G-1 may have clinical utility in patients with epithelial permeabilit

119 Conclusion: (18)F-FDG PET/CT has clinical utility in patients with UrC-ADC by identifying

120 The evidence for clinical utility in relation to five well-studied disord

121 case reports of phage therapy demonstrating clinical utility in resolving these otherwise intractabl

122 herefore, the MammaPrint assay does not have clinical utility in such patients.

123 the microfluidic platform, which could have clinical utility in the development of new anticancer ag

124 acid and acyl-carnitine profiles could hold clinical utility in the early diagnosis or clinical mana

125 e, these candidate biomarkers have potential clinical utility in the early identification of CS refra

126 This suggests that SP has limited clinical utility in the overall prevention of recurrent

127 laque, and suggest that this effect may have clinical utility in the prophylaxis of inflammatory athe

128 ncephalopathy), P7C3-A20 may have widespread clinical utility in the setting of neurodegenerative con

129 ars to be "lost in translation," we envision clinical utility in trial design, outcome prediction, an

130 antiviral activity against HEV in vitro but clinical utility in vivo is unknown.

131 se targets and the evidence supporting their clinical utility in youths.

132 Regarding clinical utility, increasing evidence points to a change

133 The clinical utility investigated by decision curve analysis

134 SMOLT's clinical utility is further demonstrated by developing a

135 regulates many biological processes, but its clinical utility is limited by its hypercalcemic effect.

136 uscle strength and hypertrophy; however, its clinical utility is limited by side effects such as card

137 Despite broad appreciation of their clinical utility, it has been unclear how vitamin B12 an

138 For clinical utility, it is highly desirable to identify com

139 in additional populations and to understand clinical utility, long-term efficacy, and safety of mult

140 markers of neurological damage with possible clinical utility, many of which whose presence in blood

141 all these factors, the data used to consider clinical utility must be derived from level I evidence s

142 To give this information clinical utility, new methods of detecting nucleic acid

143 The aim of this study was to evaluate the clinical utility of (18)F-JK-PSMA-7 for PET/CT imaging o

144 The clinical utility of (223)Ra has encouraged the developme

145 Overall, these results do not support the clinical utility of 5-HT2C agonists and 5-HT2A inverse a

146 This work aims to assess the clinical utility of a fiber-optic Raman spectroscopy wit

147 ased interest in understanding the potential clinical utility of a genetic predictor that might furth

148 The study examined the clinical utility of a molecular diagnosis and the cost-e

149 The concept of the clinical utility of a negative MBI result may be valid b

150 There is uncertainty about the accuracy or clinical utility of all potential screening tools.

151 se with carbapenemase activity, threaten the clinical utility of almost all beta-lactam antibiotics.

152 More work is also required to determine the clinical utility of amyloid imaging specifically in subj

153 porting the further evaluation and potential clinical utility of an effective heroin vaccine in treat

154 Conclusion: Our data demonstrate the clinical utility of an miRNA-based biomarker to support

155 ciparum malaria that threatens the long-term clinical utility of artemisinin-based combination therap

156 est that heparin might be used to expand the clinical utility of Avastin.

157 These data suggest clinical utility of baseline WBMRI in TP53 germline muta

158 is and degradation of proteins increases the clinical utility of biomarkers.

159 the first study to demonstrate the potential clinical utility of blood and CSF KLK8 as a biomarker fo

160 Future work will test the clinical utility of body composition monitoring for impr

161 adherence to these guidelines and assess the clinical utility of brain imaging.

162 Evidence increasingly supports the clinical utility of CCTA across various stages of CAD, f

163 scientific rationale for its role in AS, the clinical utility of circulating YKL-40 as a biomarker is

164 These findings highlight the possible clinical utility of CMSs and suggests that refinement of

165 Multiple studies are underway to assess the clinical utility of CTC and ctDNA in different settings

166 primary tumor; however, to realize the full clinical utility of ctDNA methylation detection via liqu

167 dy reveals the transcriptional landscape and clinical utility of eRNAs in cancer.

168 In this study, we evaluated the clinical utility of estimating tumor heterogeneity using

169 We also describe the clinical utility of exosomes.

170 Existing data regarding the clinical utility of extending antibiotic treatment follo

171 niques, however, show promise to improve the clinical utility of extracellular vesicle-based cancer d

172 Purpose To assess the clinical utility of ferumoxytol-enhanced MR angiography

173 To assess the clinical utility of FFPE-derived RNA, we performed ribo-

174 s, which limits the detail, specificity, and clinical utility of fMRI resting-state functional connec

175 etiology between phenotypes, to evaluate the clinical utility of genetic data for complex disease and

176 At present, the clinical utility of genetic risk prediction is still low

177 adjudication can increase significantly the clinical utility of genetic testing for patients with HC

178 We compared the clinical utility of GUM with traditional targeted metabo

179 Despite such clinical utility of HFOs, the spatial context and neuron

180 Nevertheless, the clinical utility of hospital-specific customized solutio

181 gnificant barrier to realizing the potential clinical utility of in vitro expansion.

182 The clinical utility of in vivo and in vitro assays remains

183 The clinical utility of inhibiting cytochrome P450 17A1 (CYP

184 The clinical utility of interferon-gamma release assays (IGR

185 herapeutic outcomes, but also maximizing the clinical utility of LDV and SOF combination regimens.

186 The clinical utility of limited-channel sleep studies (which

187 However, the analytical validity and clinical utility of liquid biopsies must be rigorously d

188 ongoing studies are evaluating the potential clinical utility of molecular subtyping.

189 ts and values essential to understanding the clinical utility of molecularly targeted therapies in on

190 onment and storage affects the phenotype and clinical utility of MSC-based products, and discuss the

191 ealthcare stakeholders are unclear about the clinical utility of NGS and are concerned it could be an

192 This study highlights the clinical utility of NGS testing for sRP cases, expands t

193 ated with Leigh syndrome and to validate the clinical utility of orphan protein characterization.

194 tive interpretations of p, and the potential clinical utility of p.

195 egy for cancer therapy, which may expand the clinical utility of PARP inhibitors.

196 view Board-approved pilot study, the initial clinical utility of PET/CT imaging with (18)F-JK-PSMA-7

197 This article discusses the current clinical utility of pharmacogenetic testing in the conte

198 To understand the clinical utility of plasma mNGS, we retrospectively revi

199 es and additional biomarkers will expand the clinical utility of predictive algorithms for pharmaceut

200 , this is the first study to demonstrate the clinical utility of predictive genetic testing for MYOC

201 This study aimed to examine the clinical utility of prolonged wireless reflux monitoring

202 ocognitive deficits and thus has a potential clinical utility of proper concussion assessment and man

203 These results highlight the potential clinical utility of PRSs for CHD as well as the need to

204 The existing evidence regarding the clinical utility of PRSs is considered across four diffe

205 d to confirm and better define the potential clinical utility of PV-CTCs in early-stage NSCLC.

206 e report results of clinician surveys of the clinical utility of rapid genomic sequencing (RGS).

207 e investigated the feasibility and potential clinical utility of rapid, high spatial resolution, near

208 The purpose of this study was to assess the clinical utility of real-time fluorescence imaging for i

209 In order to enhance the clinical utility of reporting segmental findings in clin

210 bstrate of RSNs and encourage testing of the clinical utility of resting-state connectivity in PET da

211 However, the clinical utility of RNA editing remains limited because

212 y reproducibility are required to expand the clinical utility of RNA-seq.

213 The clinical utility of routine electrocardiographic monitor

214 dy was conducted to test the feasibility and clinical utility of rWGS in acute cardiovascular care.

215 om the Fleischner Society and to analyze the clinical utility of screening chest radiography for asym

216 hese studies further highlight the potential clinical utility of serial ctDNA monitoring in patients

217 We assessed the clinical utility of serum neuronal exosomes as biomarker

218 The clinical utility of severe acute respiratory syndrome co

219 Our purpose was to evaluate and compare the clinical utility of simultaneously obtained quantitative

220 light recent studies assessing the potential clinical utility of specific molecular features for earl

221 elp improve the development, validation, and clinical utility of such DNAemia tests.

222 d neoangiogenesis and point to the potential clinical utility of targeting PRC1 in DNPC.

223 These data support the clinical utility of TBLC in interstitial lung disease di

224 d, taken together they greatly influence the clinical utility of testing.

225 We demonstrate the potential clinical utility of the approach in guiding therapeutic

226 mpatibility confirm the biodegradability and clinical utility of the device.

227 Analysis of the clinical utility of the effect size of plasma CXCL8 in h

228 Although the clinical utility of the identified loci remains to be de

229 Several illustrations of the clinical utility of the information obtained for improvi

230 display at video-rate speed are critical for clinical utility of the IVPA-US imaging technology.

231 itive and node-negative disease, evidence of clinical utility of the MammaPrint assay was only appare

232 rmed decision curve analysis to evaluate the clinical utility of the model by calculating its net ben

233 Future research should focus on the clinical utility of the models, particularly if their us

234 rring physicians were surveyed regarding the clinical utility of the MRI.

235 Decision curve analyses assessed the clinical utility of the nomogram.

236 utic approach, we demonstrated the potential clinical utility of the novel formulation as a safe and

237 greater than or equal to 2, may diminish the clinical utility of the quick Sequential Organ Failure A

238 This study aimed to examine the clinical utility of the radiographic evaluation of the b

239 primary lung cancer (IPLC) and evaluated the clinical utility of the risk prediction model for select

240 We end with case scenarios to illustrate the clinical utility of the website.

241 ity in circulation and cautioned against the clinical utility of their assessment.

242 We aimed to determine the real-world clinical utility of therapeutic drug monitoring in psori

243 ist could significantly expand the potential clinical utility of therapeutics targeting the kisspepti

244 ntional therapy are required to evaluate the clinical utility of these agents in the treatment of Ph-

245 humans and rodents has demonstrated that the clinical utility of these agents may not be limited to d

246 We sought to validate and examine the clinical utility of these measures in men after radical

247 To optimize the clinical utility of these measures, we aimed to quantify

248 tors in terms of understanding the potential clinical utility of these novel technologies.

249 We then discuss evaluations of the clinical utility of these scores, pertinent mechanistic

250 in in vitro and in vivo models, suggesting a clinical utility of these targeted therapies in patients

251 We aimed to investigate the clinical utility of these technologies by performing tar

252 esistance mutations are needed to ensure the clinical utility of these tools.

253 In addition, the practicability and clinical utility of this approach has also been demonstr

254 clinical observations, suggesting potential clinical utility of this approach.

255 tive validation is required to better assess clinical utility of this approach.

256 nt, whereas subsequent studies confirmed the clinical utility of this approach.

257 pective testing is required to determine the clinical utility of this assay, particularly for the dia

258 The potential clinical utility of this common laboratory test in predi

259 n = 21 CTCs/mL), demonstrating the potential clinical utility of this device.

260 g ototoxicity and nephrotoxicity, impact the clinical utility of this effective chemotherapy agent an

261 currently available data point to a relevant clinical utility of this imaging technique.

262 Next, we investigated the clinical utility of this model to detect focal white mat

263 Physiological and clinical utility of this newly identified interconnectio

264 cal outcomes trials are needed to assess the clinical utility of this novel approach to treat heart f

265 s and support the prognostic and therapeutic clinical utility of this pathway for patients.See relate

266 We aimed to compare the clinical utility of this subgroup-based approach for pre

267 DCC)-mediated internalization of Mn(2+), the clinical utility of this technique is limited by the cyt

268 To date, the evolutionary stability and thus clinical utility of this trade-off is unclear.

269 We explored the clinical utility of urinary dickkopf-3 (DKK3), a renal t

270 The clinical utility of using a 4-BRS for risk prediction an

271 These results support the potential clinical utility of using PFKFB3 inhibitors in combinati

272 verall these results are encouraging for the clinical utility of V565 in the treatment of IBD.

273 To assess the clinical utility of WBMRI in germline TP53 mutation carr

274 dence is lacking on the diagnostic yield and clinical utility of WES for pediatric renal transplant r

275 Our findings demonstrate the clinical utility of WES to identify causative mutations

276 The clinical utility of wPRx should be explored in prospecti

277 y trials' and have been believed to have low clinical utility other than that of establishing the adv

278 To inform its clinical utility, our strategy was adopted to track the

279 their clinical validity (phases 2 and 3) and clinical utility (phases 4 and 5) are incomplete.

280 In the context of genetic testing, clinical utility refers to the ability of a test to gene

281 tibiotic use and hospital admission, but its clinical utility requires validation in a prospective st

282 of events in the validation cohort, and the clinical utility restricted to decision-making threshold

283 In considering whether a TBT has clinical utility, several factors need to be considered:

284 Clinical utility surveys of MRI examinations were comple

285 ife-threatening prostate cancer with greater clinical utility than the current standard of care, syst

286 alysis indicated that this model has greater clinical utility than use of a nares surveillance cultur

287 diverse biological roles contribute to their clinical utility, the diversity of lipid structure and c

288 ultiple systems, which may provide immediate clinical utility to guide ablation.

289 nical studies to demonstrate and communicate clinical utility to payers and to set reasonable expecta

290 logy and fibrosis in murine PF, and may have clinical utility to treat human disease.

291 ssure regulation with age, thus, a potential clinical utility towards detection of fall proneness.

292 ccuracy (discrimination and calibration) and clinical utility using decision curve analysis.

293 on using Cox linear logistic regression, and clinical utility using decision curves.

294 DMDAC before onset of LV dysfunction and its clinical utility warrants further exploration.

295 To assess clinical utility, we compared the agreement and confiden

296 As a proof of concept for its clinical utility, we show that the NM-MRI signal correla

297 t broad-spectrum MMP inhibitors have limited clinical utility, which has spurred the development of i

298 Testing its clinical utility with The Cancer Genome Atlas data demon

299 es and organs, whereas some have promise for clinical utility within the next 5-10 yr.

300 ic guidance on how to define and demonstrate clinical utility would be valuable.