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1 les after exposure to oral contraceptives or clomiphene.
2 nresponsive to the induction of ovulation by clomiphene.
3 min would increase the ovulatory response to clomiphene.
4 ificantly in the 25 women given placebo plus clomiphene.
5 d with gonadotropin but not as compared with clomiphene.
6 mulative live births than those who received clomiphene (103 of 374 [27.5%] vs. 72 of 376 [19.1%], P=
8 ificantly from the rate with gonadotropin or clomiphene (42 of 192, 22%; P=0.15) or clomiphene alone
9 ion rate was higher with letrozole than with clomiphene (834 of 1352 treatment cycles [61.7%] vs. 688
11 eening effort using this approach identified clomiphene, a widely used fertility drug, as one such co
12 in or clomiphene (42 of 192, 22%; P=0.15) or clomiphene alone (8 of 85, 9%; P=0.44) but was lower tha
14 common, unique region on HSA; cis- and trans-clomiphene also appeared to interact at a unique site, a
18 herapy group (P<0.001 for metformin vs. both clomiphene and combination therapy; P=0.31 for clomiphen
19 to the observed suppressive interactions of clomiphene and in turn reveals aspects of the biology th
22 he binding that takes place between the drug clomiphene and the protein human serum albumin (HSA).
23 ompetition experiments between cis- or trans-clomiphene and various site-selective probes indicated t
25 min ovulated spontaneously or in response to clomiphene, as compared with 3 of the 26 women (12 perce
26 and 25 women in the placebo group were given clomiphene because they did not ovulate spontaneously du
27 ous site-selective probes indicated that the clomiphene-binding region is the same as the proposed ta
30 ith the polycystic ovary syndrome to receive clomiphene citrate plus placebo, extended-release metfor
34 ulate spontaneously were then given 50 mg of clomiphene daily for five days while continuing to take
35 to interact at a unique site, although trans-clomiphene displayed additional direct competition with
39 men, in a 1:1 ratio, to receive letrozole or clomiphene for up to five treatment cycles, with visits
40 arin-azapropazone site of HSA, and cis/trans-clomiphene gave positive allosteric effects caused by th
41 e metformin group (21.7%) than in either the clomiphene group (39.5%, P=0.002) or the combination-the
43 oup [31.8%] and 30 of 103 pregnancies in the clomiphene group [29.1%]) or twin pregnancy (3.4% and 7.
44 e rate of multiple pregnancy was 6.0% in the clomiphene group, 0% in the metformin group, and 3.1% in
45 h rate was 22.5% (47 of 209 subjects) in the clomiphene group, 7.2% (15 of 208) in the metformin grou
47 nd in these studies that both cis- and trans-clomiphene have 1:1 interactions at a common binding reg
48 he association equilibrium constants for the clomiphene/HSA system, with beta-cyclodextrin being used
54 nancy, including the use of fertility drugs (clomiphene [n = 33 835], gonadotropins [n = 57 136], gon
55 ndings suggest that relatively little of the clomiphene-NTD association is mediated through the pathw
57 men (90 percent) who received metformin plus clomiphene ovulated (mean peak serum progesterone concen
59 rates with standard therapy (gonadotropin or clomiphene) (P=0.003) or gonadotropin alone (P<0.001) bu
62 coprotein (GP)-bearing pseudoviruses; three (clomiphene, sertraline, and toremifene) were more potent
68 prove the water solubility of cis- and trans-clomiphene without affecting the nature of their binding