ライフサイエンスコーパス: clonal evolution

1 reased BCR signaling, CLL proliferation, and clonal evolution.

2 ts to a model most consistent with divergent clonal evolution.

3 rom 59 patients demonstrated highly frequent clonal evolution.

4 A can allow real-time sampling of multifocal clonal evolution.

5 t of cancer microenvironment and the role of clonal evolution.

6 that persistent lymphocytes do not represent clonal evolution.

7 iscriminant value for identifying cases with clonal evolution.

8 ntial role of ALK mutations in neuroblastoma clonal evolution.

9 apoptosis, promote differentiation, or drive clonal evolution.

10 did not, suggesting that treatment promotes clonal evolution.

11 somal abnormalities and their changes during clonal evolution.

12 tterns of nonexpressed genes to characterize clonal evolution.

13 h intra-individual chromatin variability and clonal evolution.

14 ions may coevolve rather than compete during clonal evolution.

15 hich may cause genomic instability and drive clonal evolution.

16 role of this region in disease phenotype and clonal evolution.

17 role of this region in disease phenotype and clonal evolution.

18 cells protected them from TNF-alpha-induced clonal evolution.

19 ession may be more likely to experience such clonal evolution.

20 of genome variations that accumulate during clonal evolution.

21 (range, 10-135 months); 4 patients (11%) had clonal evolution.

22 ting ability and suppresses the tendency for clonal evolution.

23 ions confers a strong advantage during tumor clonal evolution.

24 hogenesis of stem cell diseases and leukemic clonal evolution.

25 responses to therapy, mutational burden, and clonal evolution.

26 ntial for enabling malignant progression and clonal evolution.

27 ace of disease progression and the extent of clonal evolution.

28 e of positive selection and neutral drift in clonal evolution.

29 marked resistant clones selected during the clonal evolution.

30 s the only clinical variable associated with clonal evolution.

31 ide and copy number variants along the tumor clonal evolution.

32 or blood vessels follow a pattern of dynamic clonal evolution.

33 rates, which drive relapse by Darwinian-type clonal evolution.

34 ignant cells acquire a CSC phenotype through clonal evolution?

35 to 70 years), median time from diagnosis to clonal evolution 14 months (range, 0 to 145 months), and

36 ch an approach can potentially help to avert clonal evolution, a major cause of therapeutic resistanc

37 evaluated for the suppression of cytogenetic clonal evolution after therapy, the cytogenetic response

38 Fifteen patients had clonal evolution alone (AP-CE), 32 had AP features but n

39 However, the dynamic nature of clonal evolution, along with potential fitness costs and

40 Clonal evolution analyses suggest that the composition a

41 Clonal evolution analysis indicates that myeloid related

42 risingly, this work indicates that PNH has a clonal evolution and architecture strikingly similar to

43 es are frequent in AML and permit tracing of clonal evolution and architecture.

44 nancies are usually examined after extensive clonal evolution and carry many mutations, obscuring the

45 Chronic inflammation may both initiate clonal evolution and catalyze its expansion from early d

46 n the phenomenon of heterogeneity in cancer--clonal evolution and cell plasticity.

47 Here, we traced the clonal evolution and characterized the genetic features

48 inactive genes is indicative of a protracted clonal evolution and consequently, increased risk for tu

49 rnatively, autoimmune diseases could promote clonal evolution and disordered bone marrow growth, prom

50 The temporal relationship between clonal evolution and drug exposure suggests that EPAG ma

51 age WTPDX show evidence of clonal selection, clonal evolution and enrichment of blastemal gene expres

52 tic targeting in breast cancer and implicate clonal evolution and expansion of cancer stem-like cells

53 and noncellular elements) and the concept of clonal evolution and heterogeneity have emerged as impor

54 apid autopsy have provided insights into the clonal evolution and heterogeneity of cancer.

55 cer-related deaths, but the natural history, clonal evolution and impact of treatment are poorly unde

56 ostically significant CNAs accumulate during clonal evolution and include gains of 1q21 and deletions

57 Clonal evolution and intratumoral heterogeneity drive ca

58 esistance mechanism against immortalization, clonal evolution and malignant progression.

59 t on the mechanisms associated with leukemic clonal evolution and may fundamentally change approaches

60 Clonal evolution and outgrowth of cellular variants with

61 These genes may provide insights to the clonal evolution and progression of breast cancer and hi

62 and the impact of mutation chronology on the clonal evolution and progression of CNL.

63 ve helped to understand the genetic basis of clonal evolution and relapse and the role of inherited g

64 poptosis, with a higher probability of tumor clonal evolution and resistance.

65 Sequential sample analysis shows clonal evolution and selection of the malignant driving

66 istance to systemic treatment as a result of clonal evolution and selection.

67 aintained by niches that allow for stem cell clonal evolution and selection.

68 Intraclonal variation, followed by clonal evolution and the appearance of a second clone ov

69 -tumour genetic heterogeneity resulting from clonal evolution and the emergence of subclonal tumour p

70 al-time and noninvasive approach to tracking clonal evolution and the emergence of treatment-resistan

71 ith intrinsic chromosomal instability, favor clonal evolution and the frequent emergence in their tee

72 in a cohort of 197 MPN patients and followed clonal evolution and the impact on clinical outcome.

73 ims being to dampen chronic inflammation and clonal evolution and thereby also diminish concurrent di

74 nitors could serve as reservoirs for further clonal evolution and thereby contribute to therapeutic r

75 r results support a role of the epigenome in clonal evolution and uncover new candidate pathways asso

76 Evidence for clonal evolution and/or polyclonal secondary kinase muta

77 d: 100 in chronic phase (15 with cytogenetic clonal evolution) and five in accelerated phase.

78 ns, are associated with genomic instability, clonal evolution, and chemoresistance in chronic lymphoc

79 cts are associated with genomic instability, clonal evolution, and chemoresistance in chronic lymphoc

80 A for the identification of DLBCL mutations, clonal evolution, and genetic mechanisms of resistance.

81 matic mutations address tumor heterogeneity, clonal evolution, and mechanisms of resistance to guide

82 telomere length was associated with relapse, clonal evolution, and mortality.

83 nse but was associated with risk of relapse, clonal evolution, and overall survival.

84 ntage of abnormal metaphases, longer time to clonal evolution, and presence of other accelerated-phas

85 ms and risk stratification tools, studies of clonal evolution, and prospective trials are needed to i

86 ing of the key drivers of tumor development, clonal evolution, and recurrence, and aided precision me

87 development of "premature atherosclerosis," clonal evolution, and second cancer in patients with MPN

88 modulation of disease tempo, disease burden, clonal evolution, and tumor microenvironment in SMM rema

89 t on the selective pressures driving somatic clonal evolution are explored.

90 tinct cancer subclones, many aspects of this clonal evolution are poorly understood, including the di

91 The two main manifestations of clonal evolution are strong linkage disequilibrium (LD)

92 AR-indifferent' cell state through divergent clonal evolution as a mechanism of treatment resistance

93 Age more than 10 years at time of HSCT, clonal evolution as an indication for transplantation, p

94 iagnosed early-stage CLL or the frequency of clonal evolution as determined by interphase FISH.

95 In conclusion, in patients with clonal evolution as the sole criterion of disease accele

96 at a median interval of 36 months, to study clonal evolution at single-cell resolution.

97 ease after relapse, which is associated with clonal evolution at the cytogenetic level.

98 isotypes suggested ongoing switch events and clonal evolution at the M-PC level.

99 We show that whereas clonal evolution can be summarized as a tree, reticulate

100 Markers of clonal evolution can be used to determine patient risk f

101 Patients with cytogenetic clonal evolution can respond to IFN-alpha therapy, and t

102 Cytogenetic clonal evolution (CE) is a known poor prognostic factor

103 loid leukemia (AML) arises through multistep clonal evolution characterized by stepwise accumulation

104 As clonal evolution could allow Bcr-Abl independent prolife

105 ber changes combined with different modes of clonal evolution create extensive somatic genome diversi

106 mal metaphases (cutoff, 24%), longer time to clonal evolution (cutoff, 24 months), other accelerated-

107 A prognostic classification for cytogenetic clonal evolution defined three groups with complete resp

108 s are frequent in PNH, suggesting a stepwise clonal evolution derived from a singular stem cell clone

109 reatment, are commonly visualized in various clonal evolution diagrams, visual analytics methods that

110 Multiple genetic events and subsequent clonal evolution drive carcinogenesis, making disease el

111 ated that early HSC pools were permissive to clonal evolution driven by drift.

112 s generally thought to result from branching clonal evolution driven by random mutations that accumul

113 oftware includes functionalities to simulate clonal evolution due to the emergence of driver mutation

114 nct senescence barriers to permit unfettered clonal evolution during cancer development: (1) stress-

115 e understanding of genetic heterogeneity and clonal evolution during cancer progression.

116 Clonal evolution during disease progression and therapy

117 Continued clonal evolution during disease progression is an import

118 Eighteen patients experienced clonal evolution during follow-up.

119 Among 73 patients assessable for clonal evolution during stable chronic phase, those who

120 lowing monitoring of disease progression and clonal evolution during therapy.

121 immune infiltration that reflect the tumor's clonal evolution during treatment.

122 may sequentially accumulate during stem cell clonal evolution either through drift (passenger mutatio

123 ylogenetic analysis demonstrated the lack of clonal evolution for African strains which conclusively

124 mia of Down syndrome (DS-AMKL) is a model of clonal evolution from a preleukemic transient myeloproli

125 cing on bone marrow samples and investigated clonal evolution from clonal haemopoiesis to the develop

126 AP crypt diversity is consistent with slower clonal evolution from enhanced stem cell survival, eithe

127 This study aimed to discover if clonal evolution from heterozygous to homozygous mutatio

128 Clonal evolution from lower to higher risk implicated th

129 There is evidence for a distinct clonal evolution from metaplasia to dysplasia in the hum

130 diagnostic and relapse neuroblastomas showed clonal evolution from the diagnostic tumor, with a media

131 hieved a complete suppression of cytogenetic clonal evolution had a median survival of 66 months, wit

132 Patients showing clonal evolution had significantly shorter survival afte

133 Recent studies aimed at defining patterns of clonal evolution have revealed that serial tumors in som

134 lution (HEM-AP), and 24 had AP features plus clonal evolution (HEM-AP + CE).

135 P-CE), 32 had AP features but no evidence of clonal evolution (HEM-AP), and 24 had AP features plus c

136 l diversity are the cancer stem cell and the clonal evolution hypotheses.

137 and functional interrogation of preleukemic clonal evolution, identifying mitochondrial function and

138 nsplanted before the age of 10 years, before clonal evolution (ie, myelodysplastic syndrome or acute

139 Because AML is likely preceded by clonal evolution in "preleukemic" hematopoietic stem cel

140 dies uncovered that neutral evolution shapes clonal evolution in a significant proportion of solid ca

141 To better understand clonal evolution in AML, we sequenced the genomes of M3-

142 or role for epigenetic mechanisms in driving clonal evolution in B-ALL and identifies novel pathways

143 We conclude that AID accelerates clonal evolution in BCR-ABL1 ALL by enhancing genetic in

144 We present a cellular automaton model of clonal evolution in cancer aimed at investigating the em

145 resolution view of genetic heterogeneity and clonal evolution in cancer.

146 astatic melanomas supports a linear model of clonal evolution in cancer.

147 ted and whole-exome sequencing and described clonal evolution in cases for whom paired CHIP and thera

148 od, Rossi et al provide further evidence for clonal evolution in chronic lymphocytic leukemia (CLL) a

149 Our study thus uncovers patterns of clonal evolution in CLL, providing insights into its ste

150 The prognostic significance of clonal evolution in CML is not uniform and is related to

151 characterize genomic architecture and infer clonal evolution in eight tumour biopsies and nine plasm

152 f which, TNFalpha, can induce BM failure and clonal evolution in Fancc-deficient mice.

153 evolution, as illustrated by simulations of clonal evolution in hematopoietic stem cells.

154 constitutes a new paradigm for the study of clonal evolution in human cancers.

155 To evaluate the functional impact of clonal evolution in individual patients, we differentiat

156 Clonal evolution in longitudinal samples mainly occurred

157 , we present current concepts on the role of clonal evolution in lymphoid and myeloid leukemia as a d

158 We propose that clonal evolution in micropathogens be defined as restrai

159 erstanding of the molecular events governing clonal evolution in MPNs, the cell-intrinsic and -extrin

160 To study clonal evolution in myeloproliferative disorders, we use

161 rvival genes in cancer cell integrity during clonal evolution in non-small cell lung cancer (NSCLC).

162 usion, our study reveals novel insights into clonal evolution in NPM1mut AML.

163 H gene replacement as a mechanism generating clonal evolution in one group.

164 he biology of stem and progenitor cells, and clonal evolution in patients with myeloproliferative neo

165 To address the role of clonal evolution in relapsed NPM1-mutated (NPM1mut) AML,

166 High-dose Cy does not prevent relapse or clonal evolution in SAA.

167 es provides new opportunities for addressing clonal evolution in solid cancers, in particular those w

168 specially regarding secondary malignancies), clonal evolution in the absence of significant BM dyspla

169 le-agent clinical efficacy may be limited by clonal evolution in the advanced leukemic phase of this

170 umor provides data to analyze the process of clonal evolution in the population of cells that give ri

171 dysplasia and provide functional support for clonal evolution in these mice.

172 rated or blast phase on treatment, including clonal evolution, in the nilotinib groups than in the im

173 2%) achieved some suppression of cytogenetic clonal evolution; in 41 patients (46%), the suppression

174 Serial sampling reveals diverse patterns of clonal evolution, including linear evolution, differenti

175 The rate of clonal evolution increased with duration of follow-up wi

176 Clonal evolution is a key feature of cancer progression

177 Drug resistance mediated by clonal evolution is arguably the biggest problem in canc

178 Clonal evolution is believed to be a main driver for pro

179 Our results indicate that clonal evolution is more complex than predicted by linea

180 Although clonal evolution is most often conceived of as driven by

181 y cause a malignant phenotype and continuous clonal evolution is often linked to tumor progression.

182 nd that--outside secondary lymphoid tissues--clonal evolution is retarded by diminished BCR-signaling

183 This niche succession or crypt clonal evolution is similar to the clonal succession of

184 in addition to the Philadelphia chromosome (clonal evolution) is considered by many to be a feature

185 , abnormal metaphases < 16%, and interval to clonal evolution < or = 24 months) had an estimated medi

186 f the molecular and genetic pathways driving clonal evolution may inform surveillance and risk strati

187 Revealing the clonal evolution mechanisms in the metastatic transition

188 del for explaining intratumor diversity, the clonal evolution model, has recently been challenged by

189 umoral heterogeneity can be explained by the clonal evolution model, whereby growth advantageous muta

190 Both the hierarchical cancer stem cell and clonal evolution models have been invoked to help explai

191 Clonal evolution occurred among 10% of ZAP-70-negative a

192 Clonal evolution occurs during the course of chronic lym

193 These data support a model in which minimal clonal evolution occurs in the metastatic tumor cell pop

194 The course of clonal evolution of 2 related clones in the blood of a p

195 of abnormal metaphases, time to cytogenetic clonal evolution of 24 months or less, and absence of ot

196 Here we explore the clonal evolution of a form of childhood precursor-B cell

197 wn how induction chemotherapy influences the clonal evolution of a patient's nonleukemic hematopoieti

198 Clonal evolution of a tumor ecosystem depends on differe

199 formalize the problem of reconstructing the clonal evolution of a tumor using single-nucleotide muta

200 light these recent reports investigating the clonal evolution of acute leukemia genomes and discuss t

201 Further evidence of clonal evolution of ALK-mutated cells was provided by es

202 Our results explain the genetic basis for clonal evolution of an ETV6-RUNX1 preleukemic clone to p

203 oblastic leukemia (B-ALL) results from oligo-clonal evolution of B-cell progenitors endowed with init

204 Here we study the clonal evolution of barcoded glioblastoma cells in an un

205 eity indicated genetic divergence during the clonal evolution of breast cancer, particularly at the t

206 These alterations promote the clonal evolution of cancer cells via the accumulation of

207 s quantitative insights into the genomic and clonal evolution of cancer.

208 r numbers of tumors should cast light on the clonal evolution of cancers in space and time.

209 Interestingly, clonal evolution of CD5(+)B220(dull) cells (judged by BC

210 ng, suggesting that mosaicism as a result of clonal evolution of cells harboring somatic mutations is

211 The clonal evolution of cells with extra copies of 1q sugges

212 EMBLEM, we define the genetic and epigenomic clonal evolution of hematopoietic stem cells and their p

213 mmon genetic alterations observed during the clonal evolution of high grade malignant gliomas.

214 underlying pathogenic role of MLL-PTD in the clonal evolution of human leukemia, which should facilit

215 Clonal evolution of Ig V regions, expression of activati

216 The persistence and dynamic clonal evolution of leukemia-initiating cells and preleu

217 int, and have potential implications for the clonal evolution of malignancies.

218 sting that the chaperone is required for the clonal evolution of melanomas and other tumors that depe

219 man cancers can aid our understanding of the clonal evolution of metastasis and provide a realistic m

220 nct PILs, which is evidence for the separate clonal evolution of multiple pancreatic neoplasms within

221 In addition, the results indicate that the clonal evolution of mutations that are seen within later

222 uired genomic instability and the subsequent clonal evolution of neoplastic cells with variable patte

223 tionary clades and supported a predominantly clonal evolution of NTHi, with the majority of genetic i

224 iversity of O55:H7 and better understand the clonal evolution of O157:H7, we fully sequenced EPEC O55

225 ecise monitoring of engraftment and revealed clonal evolution of oncogenic cells during the progressi

226 Here we investigate ITH and clonal evolution of papillary renal cell carcinoma (pRCC

227 nt variability in the mutational profile and clonal evolution of pediatric AML from diagnosis to rela

228 in human tissues have been used to trace the clonal evolution of progenitor cells in diseased states.

229 that this mutation was an early event in the clonal evolution of resistance.

230 ow genome variations might accumulate during clonal evolution of somatic cell populations, including

231 prognosis, suggesting that they occur during clonal evolution of the disease.

232 y U-CLL and M-CLL cells could be involved in clonal evolution of the disease.

233 presentation and at relapse suggesting that clonal evolution of the IgH locus is unusual in this dis

234 by providing a more detailed picture on the clonal evolution of the tumor.

235 environment-facilitated clonal expansion and clonal evolution of tumor cell populations.

236 ually described as tumor progression, or the clonal evolution of tumor cell populations.

237 he need for novel therapies and suggest that clonal evolution or decreasing platelet counts while on

238 ity to some cancers beyond that explained by clonal evolution or environmental differences.

239 rved across treatment may result from either clonal evolution or geographically disparate sampling of

240 at primary response end point and/or time of clonal evolution or longest follow-up.

241 23 months earlier--findings consistent with clonal evolution or multifocal disease.

242 ls; (2) colony-forming units (CFUs) revealed clonal evolution or multiple independent clones in indiv

243 ogenetic aspects of tumor evolution, such as clonal evolution over time and clonal response to treatm

244 To track clonal evolution over time, we included all available fo

245 the evolutionary process and the dynamics of clonal evolution over time.

246 We show that clonal evolution patterns are heterogeneous in individua

247 ells at each site, we also proposed distinct clonal evolution patterns between primary and metastatic

248 ndings of novel co-occurring alterations and clonal evolution patterns can be served as predictive bi

249 41 and DAXX) in AML, we also found two major clonal evolution patterns during AML relapse: (1) the fo

250 ing; this allowed us to define clonality and clonal evolution patterns precisely at relapse.

251 ed using whole-exome sequencing to infer the clonal evolution patterns.

252 iteria that we have proposed for predominant clonal evolution (PCE).

253 state cancer is due to time-dependent cancer clonal evolution (potentially induced by radiation damag

254 ng the timeline of mutations contributing to clonal evolution, pre- and postnatally.

255 e patients have other signs of acceleration, clonal evolution predicts lower response rates and a sho

256 only one of six without treatment) underwent clonal evolution, predominantly involving subclones with

257 may realize its invasive potential through a clonal evolution process driven by definable microenviro

258 Tumorigenesis is a clonal evolution process that is initiated from single c

259 integrated investigations of spatial ITH and clonal evolution provide an important molecular foundati

260 ically occult, altered stem cell turnover or clonal evolution rates may be detected by measuring the

261 ulate more alterations from slower stem cell clonal evolution rather than increased error rates.

262 Our method effectively characterizes clonal evolution, reassortment, and recombination in RNA

263 tations at progressive disease (PD), and the clonal evolution remain underinvestigated.

264 se to lenalidomide and the drug's effects on clonal evolution remain unknown.

265 Here, we show the clonal evolution structure in 15 myelofibrosis (MF) pati

266 However, evidence for various forms of clonal evolution suggests that B-CLL clones may be more

267 Clonal evolution that leads to emergence of a dominant m

268 Here we emphasize a view of clonal evolution that stresses natural selection over de

269 The classic tumor clonal evolution theory postulates that cancers change o

270 nk4a); and (ii) provide an in vitro model of clonal evolution through successive dysfunction of Rb an

271 By taking into account clonal evolution through time-dependent analysis, the ge

272 oid lineage, characterized by cytopenias and clonal evolution to acute myeloid leukemia (AML).

273 ded overall response, survival, relapse, and clonal evolution to myeloid cancer.

274 les AID-induced hypermutation and propagates clonal evolution toward malignant follicular lymphoma.

275 Postnatally acquired mutations then drive clonal evolution toward overt leukemia.

276 roup (*p = 0.018), indicative of a shortened clonal evolution treated sulindac.

277 case, disease progression is associated with clonal evolution, typically defined by the expansion or

278 However, the dynamics of clonal evolution underpinning carcinogenesis remain poor

279 Clonal evolution underpins all facets of adaptive immuni

280 Monitoring tumor burden and clonal evolution using sequencing provides advantages ov

281 The median survival time following clonal evolution was 19 months.

282 Clonal evolution was analyzed after 4 cycles of treatmen

283 Clonal evolution was defined as the presence of karyotyp

284 Similarly, using SNP-A, earlier clonal evolution was found in 4 of 7 AA patients followe

285 The probability of clonal evolution was higher in patients in the first qua

286 Later in life, clonal evolution was suppressed by stabilizing selection

287 on receptor chromosomes (RCs) and subsequent clonal evolution, we analyzed specimens from 86 patients

288 Minor subclones and/or clonal evolution were also observed, thus potentially li

289 Rates of relapse and clonal evolution were similar to our historical experien

290 resources for the tumour, this gives rise to clonal evolution where only the fittest cells survive.

291 -tumoral heterogeneity (ITH) could represent clonal evolution where subclones with greater fitness co

292 wth regulation and drive successive waves of clonal evolution, whereas a far greater number are funct

293 iated with the addition of new mutations and clonal evolution, which is shaped, in part, by the chemo

294 Ninety patients with CML and cytogenetic clonal evolution who received IFN-alpha-based regimens w

295 s aiming to understand the mechanisms of HSC clonal evolution will benefit from this new approach to

296 trated that AID and RAG1-RAG2 drove leukemic clonal evolution with repeated exposure to inflammatory

297 The software simulates clonal evolution with the emergence of driver and passen

298 ls revealed a pattern of nonlinear, parallel clonal evolution, with distinct subclones within pre-MDS

299 cterized by linear and branching patterns of clonal evolution, with the latter including convergent e

300 ity during therapy demonstrated differential clonal evolution within tumors and putative selection ag