ライフサイエンスコーパス: clonal expansion

1 major contributors to explain heterogeneous clonal expansion.

2 hat loss of Pkd1, Kmt2d, and Arid1a promoted clonal expansion.

3 ls without prior GC experience or detectable clonal expansion.

4 distinct basal activation, proliferation and clonal expansion.

5 onfers a growth advantage to tumor cells for clonal expansion.

6 69, CD25, CD154, NUR77), IL-2 production, or clonal expansion.

7 low-affinity B cell clones for proliferative clonal expansion.

8 y safely tolerated but also advantageous for clonal expansion.

9 mphocyte development, facilitating leukaemic clonal expansion.

10 equilibrium between immune surveillance and clonal expansion.

11 st of melanocytic nevi in vivo termed stable clonal expansion.

12 er progenitors is further proposed to impact clonal expansion.

13 d perturbed EC function without the need for clonal expansion.

14 and loss of progenitor function, leading to clonal expansion.

15 lignant transformation and peripheral T cell clonal expansion.

16 ctions as an essential regulator of neoblast clonal expansion.

17 f Ag affinity selection in Ab maturation and clonal expansion.

18 s of cancer cells during the early stages of clonal expansion.

19 mphocytes either remain tolerized or undergo clonal expansion.

20 ed to be a secondary consequence of leukemic clonal expansion.

21 adipogenesis, during the process of mitotic clonal expansion.

22 ve horizontal spread of mcr-1 rather than by clonal expansion.

23 act provirus, transcribed HIV, and displayed clonal expansion.

24 the geometry of tumor growth are crucial for clonal expansion.

25 c mutations, their selection, and subsequent clonal expansion.

26 Adult cancers often arise from premalignant clonal expansions.

27 tant IDH1 and 2HG are not required for later clonal expansions.

28 cile RT017 that contain multiple independent clonal expansions.

29 s evaluated, and evidence for antigen-driven clonal expansions.

30 are, we observed widespread millimeter-scale clonal expansions.

31 quisition of oncogenic mutations and grow by clonal expansion(1,2).

32 enced preadipocytes exhibit enhanced mitotic clonal expansion accompanied by reduced levels of p27 as

33 individuals and variability in the sizes of clonal expansions across genes.

34 tory cytokines are required to drive NK cell clonal expansion, additional stimulatory signals control

35 ignal strength is critical for CD8(+) T cell clonal expansion after Ag stimulation.

36 alignant cells confirmed the report of rapid clonal expansion after PD-1 blockade in these patients,

37 TORC1-haploinsufficient B cells have reduced clonal expansion, AID expression, and capacities to yiel

38 an ongoing process of positive selection and clonal expansion akin to what occurs in cancer, but with

39 ugh persistent antigen exposure favors their clonal expansion and accumulation of mutations, which fu

40 In addition to increased clonal expansion and acquisition of effector functions,

41 s assess adequate nutrient supply to support clonal expansion and adaptive immune responses.

42 Selected B cells undergo clonal expansion and affinity maturation in the GC dark

43 This BCR profile is indicative of clonal expansion and affinity maturation.

44 are also attractive tools for understanding clonal expansion and clonal competition in cancer.

45 , GPR56(+) TEMRA cells have higher levels of clonal expansion and contain the majority of virus-speci

46 ions of mutations that synergized to promote clonal expansion and dominance.

47 d, with an additional 2-4 weeks required for clonal expansion and downstream functional characterizat

48 T cells are known to scale their clonal expansion and effector cytokine response accordin

49 ulation, T cells exit quiescence to initiate clonal expansion and effector differentiation.

50 ns and the factors that influence subsequent clonal expansion and emergence of disease.

51 ess features of adaptive immunity, including clonal expansion and establishment of long-lived memory

52 etic mutations through a stepwise process of clonal expansion and evolution.

53 compartments in which B cells undergo rapid clonal expansion and express activation-induced cytidine

54 e infected cells that persist have undergone clonal expansion and frequently have proviruses integrat

55 uences, after an optional step that includes clonal expansion and functional characterization.

56 ta) is abolished, thereby inhibiting mitotic clonal expansion and further adipocyte differentiation.

57 memory CD8 T cells was coupled with impaired clonal expansion and higher PD-1 re-expression upon seco

58 poietic stem or progenitor cells can lead to clonal expansion and imbalanced blood cell production.

59 We found that Runx3 deficiency limited clonal expansion and impaired upregulation of cytotoxic

60 ve immune response, lymphocytes must undergo clonal expansion and induce a survival program that enab

61 Furthermore, their clonal expansion and infiltration into nonlymphoid tissu

62 spleen and liver and often subsequent local clonal expansion and intraparenchymal localization of T-

63 ET2-deficient cells was sufficient for their clonal expansion and led to a marked increase in atheros

64 class II-restricted CD8(+) T cells underwent clonal expansion and mediated killing of HIV-infected ce

65 , Rsad2-deficient NK cells were defective in clonal expansion and memory formation following exposure

66 ytes that exhibit adaptive features, such as clonal expansion and memory, during viral infection.

67 possessing functional basal cells capable of clonal expansion and multilineage differentiation.

68 lly, we show increasing B cell accumulation, clonal expansion and mutational frequency from the cecum

69 vectors, which are sometimes associated with clonal expansion and oncogenesis.

70 However, the timing and relative order of clonal expansion and other types of genomic alterations,

71 The mechanisms involved in clonal expansion and persistence need to be defined to e

72 an advantage to mutant cells, driving their clonal expansion and potentially leading to leukemia.

73 tion of the NLRP3 inflammasome, which drives clonal expansion and pyroptotic cell death.

74 ion or amplification of IDH1 was followed by clonal expansion and recurrence at a higher grade.

75 n, suggesting extensive and serial rounds of clonal expansion and selection.

76 eolar lung organoid (BALO) model that allows clonal expansion and self-organization of FACS-sorted br

77 We analyzed IgG repertoire diversity, clonal expansion and somatic hypermutation in cells from

78 matic mutations and directly visualizing the clonal expansion and spread of oncogenes.

79 ypes revealed coupling of tumor recognition, clonal expansion and T cell dysfunction marked by clonal

80 omb repressive complex 2 deficiency impaired clonal expansion and TE cell differentiation, but minima

81 t-7 expression in activated T cells enhances clonal expansion and the acquisition of effector functio

82 , cell death exists as a checkpoint to limit clonal expansion and to terminate unrestrained responses

83 ingle-cell RNA sequencing, which demonstrate clonal expansion and unique functional states of B cells

84 t, subsets of CD62L(lo) eTregs showed higher clonal expansion and were more highly interrelated than

85 CMV exposure elicits massive CD8(+) T cell clonal expansions and diminishes the cytotoxic T cell re

86 These MAbs were the result of clonal expansions and had significant levels of somatic

87 Widespread B cell clonal expansions and immunoglobulin subclass switch eve

88 opsy sample, a fundamental step to determine clonal expansions and their evolutionary trajectories.

89 B-cell responses result in clonal expansion, and can occur in a variety of tissues.

90 ndergo somatic hypermutation, affinity-based clonal expansion, and differentiation to produce plasma

91 s, their connection to T cell activation and clonal expansion, and their variability across patients.

92 ergone minimal somatic mutation with limited clonal expansion, and three bound the receptor-binding d

93 R Vdelta1 cells were oligoclonal, suggesting clonal expansion, and upon repeated CHMI, showed diminis

94 l tissue distant from the cancer, reflecting clonal expansions, and the underlying mutational process

95 es, and across lymphocyte subsets; to detect clonal expansion; and to detect the recruitment of new c

96 mutations in hematopoietic cells leading to clonal expansion are commonly acquired during human agin

97 How long-lasting T-B interactions and B cell clonal expansion are regulated by antigen presentation r

98 Clonal expansions are rare, being detected once every 36

99 g in-vivo lineage tracing data we quantified clonal expansion as well as proliferation and differenti

100 introductions into the hospital followed by clonal expansion associated with transmission.

101 tly, in East Asia and the USA, but underwent clonal expansion at different times.

102 rom cell lines generated by a barrier bypass-clonal expansion (BBCE) protocol.

103 ll transcriptomic analyses revealed distinct clonal expansions between cell states, with CD4(+)CD8alp

104 analyses of bilateral tumors indicated that clonal expansions can evolve before the divergence of le

105 he reservoir, which is maintained in part by clonal expansion, can be measured using quantitative vir

106 ETAA1 deficiency decreased clonal expansion cell autonomously within the responding

107 exhibited biased VH use, V(D)J mutation, and clonal expansion comparable to antigen-binding cells.

108 delta1 and distinguished by highly localized clonal expansions, consistent with the nonrecirculating

109 We show that drift-driven clonal expansions cooperate with faster HSC cycling in y

110 tions, and TCR repertoire analysis indicated clonal expansions, distinct repertoire characteristics a

111 identified in different subjects, suggesting clonal expansion driven by a common antigen.

112 ntral memory cells undergoing antigen-driven clonal expansion during ART.

113 mutations may persist after therapy, lead to clonal expansion during hematologic remission, and event

114 14 patients); most, however, did not undergo clonal expansion during ponatinib treatment and, moreove

115 We find that clonal expansions during a perinatal time window leave a

116 ssibility of identifying and tracking B cell clonal expansions during adaptive immune responses.

117 We also show the consistency of clonal expansion dynamics between bulk alpha and beta re

118 adoptive cell transfer approaches to profile clonal expansion, effector function, and recruitment of

119 xtant resistant organisms belong to a single clonal expansion event.

120 Clonal expansion following high-LET radiation exposure w

121 Developing B lymphocytes undergo clonal expansion following successful immunoglobulin hea

122 a computational method called the multistage clonal expansion for EAC (MSCE-EAC) screening model that

123 Clonal expansions have differentiated from a naive to ef

124 rom the fundamental immunological process of clonal expansion, highlighting the parallels between inn

125 Our results indicate that clonal expansions highly contribute to the persistence o

126 and that the KDM5s are necessary for mitotic clonal expansion in 3T3-L1 cells, indicating that KDM5 K

127 The hiEndoPCs show clonal expansion in culture and give rise to hepatocytes

128 Overall, our studies demonstrated B cell clonal expansion in human cardiac allografts with CAV.

129 s study provides a broad view of macroscopic clonal expansion in human tissues, thus serving as a fou

130 relationship between expression profiles and clonal expansion in iNKT or MAIT cells, highly expanded

131 Here, we summarize the evidence for clonal expansion in innate lymphocytes, which has primar

132 imes in L1 and L2, but only once followed by clonal expansion in L3.

133 ubject to iterative re-activation cycles and clonal expansion in lymphoid tissues.

134 luencing relapse risk occur at initiation of clonal expansion in neuroblastoma and rhabdomyosarcoma,

135 reveals a unique origin in Asia, followed by clonal expansion in NPC-endemic regions.

136 er alterations that undergo selection-driven clonal expansion in NSCLC.

137 cquisition of somatic mutations that lead to clonal expansion in regenerating haematopoietic stem cel

138 1 and optimal cell cycling needed for T-cell clonal expansion in response to antigenic activation.

139 acquisition of somatic mutations that drive clonal expansion in the absence of cytopenias and dyspla

140 n binding affinity failed to support further clonal expansion in the GC.

141 ry cell fate without significantly affecting clonal expansion in the germinal center (GC).

142 , we show that UNG deficiency reduces B cell clonal expansion in the germinal center in mice and bloc

143 Results showed robust B cell clonal expansion in the graft but not in the blood for a

144 ies are required to characterize the role of clonal expansion in the persistence of replication-compe

145 Anti-insulin B cells undergo clonal expansion in vivo and emerge as IgM(+) and IgM(-)

146 distribution or the underlying mechanism of clonal expansion in vivo.

147 Despite finding no evidence of clonal expansions in an aged, epitope-specific TCR reper

148 clustered in 42,670 clones, revealing major clonal expansions in each of these subsets.

149 Despite higher TCR clonal expansions in HAM/TSP patients, no disease-specif

150 3 cases studied (61%), we found premalignant clonal expansions in morphologically normal kidney tissu

151 habeta analyses of MAIT cells revealed large clonal expansions in older adults and tissues that rival

152 of CD8(+) Tem diversity due to CMV-specific clonal expansions in reactivating patients.

153 This review discusses the age-related clonal expansions in the human HSPC pool, which was term

154 tral evolutionary forces that participate in clonal expansions; in that work we have also shown that

155 The PLCOm2012, Bach, and Two-Stage Clonal Expansion incidence models had the best overall p

156 In some cases, clonal expansion is driven by HIV proviral DNA integrate

157 es were genetically diverse, suggesting that clonal expansion is involved in dissemination of FQ(R) C

158 B cell clonal expansion is vital for adaptive immunity.

159 The roles distinct B cell subsets play in clonal expansion, isotype switching, and memory B cell d

160 We found that clonal expansion largely depends on the location of a cl

161 lso exhibit adaptive characteristics such as clonal expansion, longevity, self-renewal, and robust re

162 Paradoxically, clonal expansion may also be enhanced by HIV expression

163 We propose that CD8 T-cell clonal expansion may be a correlative biomarker to enabl

164 ntegrated readout of DNA damage, repair, and clonal expansion, may be informative markers of UV expos

165 In turn, increased NSPC migration and clonal expansion might be a consequence of growth in the

166 The two-stage clonal expansion model we propose is based on the thesis

167 iability of the two-, three-, and four-stage clonal expansion models given age-specific cancer incide

168 Multistage clonal expansion (MSCE) models are a class of continuous

169 Clonal expansion not only serves to amplify the number o

170 epends on the specific mutant allele driving clonal expansion, number of mutations, mutant allele bur

171 hematopoietic differentiation mimicking the clonal expansion observed in essential thrombocythemia a

172 Clonal expansions occur in the persistent HIV reservoir

173 resistance from single cells, mimicking the clonal expansion of a resistant lineage following mutati

174 tectable by bulk sequencing only in cases of clonal expansion of a single cancer cell bearing the mut

175 rols and found that PSA immunization induced clonal expansion of a small subset of suppressive CD4(+)

176 more, exposure to high-LET radiation induced clonal expansion of a subset of progenitor cells in the

177 events from the Americas but not from local clonal expansion of a successful clone.

178 ed strong infiltration of CD8(+) T cells and clonal expansion of activated CD8(+) effector T cells wi

179 Clonal expansion of B cell chronic lymphocytic leukemia

180 lammatory process, as well as activation and clonal expansion of B cells.

181 hat miR-17-92 expression is required for the clonal expansion of both virus-specific Th1 and TFH cell

182 disease in several cancer types, indicating clonal expansion of cancer cells as tumor progression pr

183 t were completely identical, consistent with clonal expansion of CD4+ T cells harboring intact HIV-1.

184 ith ICT increases T(h)1 subsets and promotes clonal expansion of CD8 T cells and subsequent regressio

185 ramework for understanding the regulation of clonal expansion of CD8 T cells by subthreshold TCR sign

186 tor beta-chains in purified T cells revealed clonal expansion of CD8 T cells, which occurred in blood

187 l expansion and T cell dysfunction marked by clonal expansion of CD8(+)CD39(+) T cells, which co-expr

188 expression in two dogs may have been due to clonal expansion of cells harboring integrated vectors.

189 nd are probably, as in adults, maintained by clonal expansion of cells infected before ART initiation

190 Clonal expansion of cells with ALV integrations driving

191 Moreover, the compliant matrix potentiated clonal expansion of CMs that involves multiple cell divi

192 -mediated cytopenias and is characterised by clonal expansion of cytotoxic CD3+ CD8+ lymphocytes.

193 mice, L-selectin proteolysis promoted early clonal expansion of cytotoxic T cells resulting in an 8-

194 hat antibiotic selection pressure results in clonal expansion of existing resistant strains.

195 be mutated in elderly individuals along with clonal expansion of hematopoiesis that confers an increa

196 hole blood-derived DNA in humans showed that clonal expansion of hematopoietic cells with somatic mut

197 of indeterminate potential (CHIP) refers to clonal expansion of hematopoietic stem cells attributabl

198 dom lineage tracing to localize and quantify clonal expansion of hepatocytes in normal and injured li

199 Infections due to clonal expansion of highly virulent bacterial strains ar

200 Clonal expansion of HIV-1-infected cells in peripheral b

201 These results identify potential drivers of clonal expansion of HIV-1-infected cells in vivo.

202 at integration may influence persistence and clonal expansion of HIV-infected cells after cART is int

203 at ART reduces HIV-infected T cells and that clonal expansion of HIV-infected cells maintains viral p

204 mory T cells, and most recently appreciated, clonal expansion of HIV-infected cells.

205 In vivo clonal expansion of HIV-infected T cells is an important

206 ARCH is defined as the gradual, clonal expansion of HSPCs carrying specific, disruptive,

207 oad, but there was a significant increase in clonal expansion of HTLV-1-infected lymphocytes in coinf

208 auses mixed cryoglobulinemia (MC) by driving clonal expansion of IgM(+)CD27(+) B cells.

209 Clonal expansion of individually sorted cells re-establi

210 uman genome is thought to play a role in the clonal expansion of infected cells and HIV persistence.

211 nces in the 2 compartments are the result of clonal expansion of infected cells or a viral genetic bo

212 Thus, HIV replication in lymphoid tissue, clonal expansion of infected cells, and recirculation of

213 tance are proliferative processes that drive clonal expansion of infected cells.

214 B cell-specific Fcmr(-/-) mice lacked robust clonal expansion of influenza hemagglutinin-specific B c

215 , however, there is growing evidence for the clonal expansion of innate lymphocytes, particularly in

216 Clonal analysis revealed clonal expansion of Kim1+ cells, indicating that acutely

217 ty of the HIV-1 reservoir by stimulating the clonal expansion of latently infected CD4+ T cells.

218 ed that homeostatic T cell proliferation and clonal expansion of latently infected T cells due to vir

219 ng and immunohistochemical analyses revealed clonal expansion of Lkb1-deficient myofibroblast-like ce

220 Clonal expansion of lower-avidity T-cell clonotypes depe

221 Multiple myeloma (MM) is characterized by clonal expansion of malignant plasma cells in the bone m

222 s a heterogeneous disease characterized by a clonal expansion of mast cells in various organs.

223 LFA-1 blockade significantly suppressed the clonal expansion of minor histocompatibility antigen-spe

224 Clonal expansion of mitochondrial DNA (mtDNA) deletions

225 d clonal haematopoiesis, or the asymptomatic clonal expansion of mutated blood cells in the elderly,

226 In contrast, a dramatic clonal expansion of Mx1(+) SCs allows extensive contribu

227 erhans cell histiocytosis (LCH) is caused by clonal expansion of myeloid precursors that differentiat

228 t it is unknown if somatic mutations promote clonal expansion of non-malignant cells in the setting o

229 Interestingly, we find that in vivo clonal expansion of P. gingivalis-specific Th cells and

230 Hh/Gli1 activation resulted in clonal expansion of phenotypically defined granulocyte m

231 t chain AL amyloidosis, are characterized by clonal expansion of plasma cells which produce a vast am

232 e hypothesis that antibiotic use selects for clonal expansion of preexisting resistant bacterial stra

233 a very early event, likely essential for the clonal expansion of preneoplastic hepatocytes to HCC, wh

234 d since 1998 was caused by the emergence and clonal expansion of progenitor strains, with macrolide r

235 ndrome coronavirus 2 (SARS-CoV-2) led to the clonal expansion of SARS-CoV-2-specific CD8(+) and CD4(+

236 This approach is effective for the clonal expansion of single human cells and for basal cel

237 tical sets of env sequences, consistent with clonal expansion of some infected cells, were more frequ

238 nd 1 in the tumor microenvironment, enhanced clonal expansion of T cells, decreased PD-1 expression o

239 eporter revealed continued proliferation and clonal expansion of terminally differentiated acinar cel

240 ctly with TH17 cells in situ and revived the clonal expansion of TH17 cells both ex vivo and in vivo,

241 We detect different clonal expansion of the adaptive immune system in distan

242 the integrated viral DNA contributes to the clonal expansion of the infected cells.

243 ral replication cycle, but not in inhibiting clonal expansion of the infected host cells.

244 forded a glimpse into these processes by the clonal expansion of the malignant cell.

245 ethylation profiling, demonstrated nonlinear clonal expansion of the original tumors and identified o

246 that disease flares were associated with the clonal expansion of the S. aureus population, occurring

247 pregulation of YAP/TAZ leads to uncontrolled clonal expansion of the SOX2+ PSCs and disruption of the

248 s after sublethal irradiation results in the clonal expansion of the surviving stem cells and the eve

249 ytes with LOY and provides insights into why clonal expansion of these cells may occur.

250 genome duplications allowing replication and clonal expansion of these complex rearranged molecules.

251 cted c-MYC+ B cells from apoptosis, allowing clonal expansion of this population, providing an explan

252 study whether ipilimumab treatment leads to clonal expansion of tissue-reactive T cells.

253 sion of BRAF(V600E) in mouse EMPs results in clonal expansion of tissue-resident macrophages and a se

254 Re-activation and clonal expansion of tumor-specific antigen (TSA)-reactiv

255 Lymphomas arise from clonal expansions of B, T, or NK cells at different stag

256 -predisposed strain of mice, as evidenced by clonal expansions of cells carrying an activated oncogen

257 l analysis during regeneration reveals local clonal expansions of hepatocyte stem/progenitors at inju

258 Clonal expansions of millimetres in diameter occurred in

259 Clonal expansions of mutated hematopoietic cells, termed

260 mly integrating vectors, which may result in clonal expansion, oncogenic transformation, variegated t

261 e a characteristic of clonal cell selection, clonal expansion, or both.

262 In contrast to the normal colon, where clonal expansions outside the confines of the crypt are

263 hat activated CD4(+) T cells, at the peak of clonal expansion, persistently downregulated their TCR e

264 proteins, was upregulated during the T cell clonal-expansion phase, followed by inhibition of the tr

265 However, single-cell clonal expansion produces heterogeneous methylomes, thus

266 uced apoptosis and permits significant B-CLL clonal expansion regardless of the clone's BCR mutation

267 s with a selective advantage, leading to the clonal expansions responsible for dominant genetic disea

268 beta-catenin in DCs or blocking IL-10 after clonal expansion similarly led to reduced CD8(+) T cells

269 mechanisms by which proviral integration and clonal expansion sustain the HIV reservoir.

270 KG2C(+) NK cells led to significantly larger clonal expansions than the cenB-encoded KIR2DL2 (p = 0.0

271 This suggests inherent limits to clonal expansion that act to diversify the T cell respon

272 enables them to overtake the tissue through clonal expansion that causes, but also relies on, the ki

273 driven by a continuing risk of mutations and clonal expansions that become increasingly detectable wi

274 agnostic specimens, consistent with dramatic clonal expansions that came to dominate the transformati

275 short punctuated bursts, followed by stable clonal expansions that form the tumor mass.

276 ssive somatic genetic changes and consequent clonal expansions that lead to cancer(1).

277 ichment of CD133+ cells by controlling their clonal expansion through the Wnt-regulator FZD8.

278 early private alterations and not from later clonal expansions, thus exposing the profile of the prim

279 g CD117(+) ECs underwent four generations of clonal expansion to enrich hyperproliferative ECs.

280 ounder cells subsequently undergoing massive clonal expansion to form occlusive neointimal lesions.

281 Also, tonic signaling and clonal expansion, two important functions mediated by th

282 opulation of radiotolerant RSCs that undergo clonal expansion under severe stress.

283 an innate-like low cytotoxic state, with low clonal expansion, unlike the classical exhausted state o

284 b as a repressor of Rag transcription during clonal expansion using Abelson murine leukemia virus-tra

285 Clonal expansion via reprogramming also enables the disc

286 ichment of CD133+ cells by controlling their clonal expansion via the Wnt-regulator FZD8.

287 The degree of clonal expansion was correlated with the titer of HBV su

288 n compared to MS and HC, increase of the TCR clonal expansion was inversely correlated with the diver

289 Clonal expansions were also present in each donor, stron

290 These clonal expansions were defined by somatic mutations shar

291 Blocking mTORC1 prior to growth prevented clonal expansion, whereas blockade after cells reached p

292 e cells provides insight into the process of clonal expansion which is fundamental to our understandi

293 phylogenetic analysis of spatial features of clonal expansion, which shows congruent patterns of geno

294 s that are acquired early in evolution drive clonal expansions, which increase the chances of acquiri

295 the elderly grows to accommodate CMV-driven clonal expansions while preserving its underlying divers

296 thus serving as a foundation for associating clonal expansion with environmental factors, aging, and

297 tients demonstrated a correlation of the TCR clonal expansion with HTLV-I proviral load.

298 elayed wound healing accompanied by impaired clonal expansion within the wound area.

299 a chain sequences show pronounced CD8 T cell clonal expansions within the joints.

300 Krt8(+) mammary luminal cells leads to their clonal expansion without directly affecting their lumina