ライフサイエンスコーパス: clonal hematopoiesis

1 hape the genetic diversity of healthy blood (clonal hematopoiesis).

2 ion or chromosomal abnormality indicative of clonal hematopoiesis.

3 -forming unit colonies but not in those with clonal hematopoiesis.

4 eoplasms (MPN) characterized by multilineage clonal hematopoiesis.

5 polyclonal hematopoiesis and in 4 of 10 with clonal hematopoiesis.

6 identified in this subset with evidence for clonal hematopoiesis.

7 e myeloid skewing and mutations that lead to clonal hematopoiesis.

8 in myeloid malignancies and their precursor clonal hematopoiesis.

9 ts observed among genes also associated with clonal hematopoiesis.

10 most frequently mutated gene in age-related clonal hematopoiesis.

11 V600E mutation (P = .049) than those without clonal hematopoiesis.

12 were associated with DNMT3A and TET2 mutant clonal hematopoiesis.

13 sociation between cardiovascular disease and clonal hematopoiesis.

14 h identification of alterations arising from clonal hematopoiesis.

15 loid as well as lymphoid malignancies and in clonal hematopoiesis.

16 lls and demonstrate its utility for modeling clonal hematopoiesis.

17 lays an important role in the development of clonal hematopoiesis.

18 ions in genes not previously associated with clonal hematopoiesis.

19 y/mortality in individuals with age-related, clonal hematopoiesis.

20 genetic mechanism by which mutant p53 drives clonal hematopoiesis.

21 ts with cancer) had features consistent with clonal hematopoiesis.

22 2 gene in hematopoietic cell development and clonal hematopoiesis.

23 progenitor cells (HSPCs) and/or by promoting clonal hematopoiesis.

24 isorders in which recurrent mutations define clonal hematopoiesis.

25 ts with congenital neutropenia to assess for clonal hematopoiesis.

26 erved in hematological malignancies(1-3) and clonal hematopoiesis(4,5).

27 Clonal hematopoiesis, a common age-related phenomenon ma

28 Clonal hematopoiesis, a condition in which acquired soma

29 Clonal hematopoiesis, a condition in which individual he

30 tion not only to MPN, but also to JAK2 V617F clonal hematopoiesis, a more common phenomenon that may

31 that define myelodysplastic syndromes (MDS): clonal hematopoiesis, aberrant differentiation, peripher

32 n review the role played by mutant DNMT3A in clonal hematopoiesis, accompanied by its effect on immun

33 odysplastic syndromes and are also common in clonal hematopoiesis, acute myeloid leukemia, chronic ly

34 matopoiesis at the time of ABMT or developed clonal hematopoiesis after ABMT.

35 In 3 patients with clonal hematopoiesis analyzed by WES, we identified a so

36 imaging to investigate the interplay between clonal hematopoiesis and atherosclerosis in a longitudin

37 re subject to frequent missense mutations in clonal hematopoiesis and diverse neoplastic diseases.

38 Clonal hematopoiesis and hematologic neoplasms often fea

39 (PMF) are chronic diseases characterized by clonal hematopoiesis and hyperproliferation of terminall

40 translocation methylcytosine dioxygenase 2) clonal hematopoiesis and hypertension.

41 lore recent advances in the understanding of clonal hematopoiesis and its role in heart failure, emph

42 equencing data uncovers correlations between clonal hematopoiesis and lung cancer risk factors, ident

43 s and have a propensity for the evolution to clonal hematopoiesis and malignancy.

44 omising way to model the complex genetics of clonal hematopoiesis and myeloid disorders using CRISPR-

45 deficient mice to generate genetic models of clonal hematopoiesis and neoplasia.

46 DNMT3A-driven clonal hematopoiesis and, subsequently, periodontitis we

47 r disease-modifying drugs that can eradicate clonal hematopoiesis and/or prevent progression to more

48 re structural somatic variants indicative of clonal hematopoiesis, and are associated with aberrant l

49 Lynch syndrome, clonal hematopoiesis, and cervical intraepithelial neopl

50 identifies genetic variants correlated with clonal hematopoiesis, and highlights hundreds of potenti

51 hematopoietic defects associated with aging, clonal hematopoiesis, and MDS.

52 ene are the most common cause of age-related clonal hematopoiesis (ARCH) in older individuals, and ar

53 Age-related clonal hematopoiesis (ARCH) is characterized by age-asso

54 leukemia onset in the context of age-related clonal hematopoiesis (ARCH).

55 ol, which was termed in the past age-related clonal hematopoiesis (ARCH).

56 increasing frequency with which people with clonal hematopoiesis are discovered and the need for cou

57 sions of mutated hematopoietic cells, termed clonal hematopoiesis, are common in aging humans.

58 l hematopoiesis at the time of ABMT and that clonal hematopoiesis, as detected by the HUMARA assay, i

59 Our findings support the occurrence of clonal hematopoiesis-associated mutations as a widesprea

60 Indeed, several studies have now shown that clonal hematopoiesis associates with increased risk of a

61 at a significant proportion of patients have clonal hematopoiesis at the time of ABMT and that clonal

62 skewed XIP, and 10 of 78 (13.5%) either had clonal hematopoiesis at the time of ABMT or developed cl

63 Clonal hematopoiesis becomes increasingly common with ag

64 These data are consistent with clonal hematopoiesis being driven by a continuing risk o

65 ve resulted in highly sensitive detection of clonal hematopoiesis beyond these known driver genes.

66 nscriptional priming of DNMT3A-mutated human clonal hematopoiesis bone marrow progenitors.

67 his context, somatic alterations can promote clonal hematopoiesis by improving the competitive fitnes

68 Age-associated clonal hematopoiesis caused by acquired mutations in mye

69 e we study this phenomenon in the context of clonal hematopoiesis (CH) and the development of therapy

70 k factors that contribute to CHIP-associated clonal hematopoiesis (CH) are poorly understood.

71 Clonal hematopoiesis (CH) arises when a substantial prop

72 Clonal hematopoiesis (CH) arises when hematopoietic stem

73 Clonal hematopoiesis (CH) as a marker of cancer developm

74 Clonal hematopoiesis (CH) becomes more prevalent with ag

75 Chronic lymphocytic leukemia (CLL) and clonal hematopoiesis (CH) both commonly occur in elderly

76 Clonal hematopoiesis (CH) has been associated with a var

77 Clonal hematopoiesis (CH) has been associated with devel

78 Clonal hematopoiesis (CH) has emerged as an independent

79 the impact of germline genetic variation on clonal hematopoiesis (CH) in 731,835 individuals.

80 Recent studies identified nearly ubiquitous clonal hematopoiesis (CH) in AA patients.

81 The discovery of clonal hematopoiesis (CH) in older individuals has chang

82 studies have reported an association between clonal hematopoiesis (CH) in the infused PBSC product an

83 Clonal hematopoiesis (CH) increases inflammasome-linked

84 Clonal hematopoiesis (CH) is a molecular biomarker assoc

85 Clonal hematopoiesis (CH) is a phenomenon caused by expa

86 Clonal hematopoiesis (CH) is a premalignant condition th

87 Age-related clonal hematopoiesis (CH) is a risk factor for malignanc

88 Clonal hematopoiesis (CH) is a risk factor for the devel

89 Clonal hematopoiesis (CH) is an age-related condition pr

90 Clonal hematopoiesis (CH) is an aging-associated conditi

91 Clonal hematopoiesis (CH) is an aging-related hematologi

92 Clonal hematopoiesis (CH) is associated with age and an

93 Clonal hematopoiesis (CH) is characterized by the acquis

94 Clonal hematopoiesis (CH) is common among older people a

95 Clonal hematopoiesis (CH) is common in older persons and

96 Clonal hematopoiesis (CH) is defined as a single hematop

97 Clonal hematopoiesis (CH) is defined as clonal expansion

98 Clonal hematopoiesis (CH) is defined as the acquisition

99 Clonal hematopoiesis (CH) is defined by the expansion of

100 Clonal hematopoiesis (CH) is described as the outsized c

101 Clonal hematopoiesis (CH) is detectable in upwards of 20

102 asured within the hematopoietic compartment, clonal hematopoiesis (CH) is now recognized as a common

103 Clonal hematopoiesis (CH) is said to occur when a substa

104 at acquired hematologic mutations leading to clonal hematopoiesis (CH) may further increase vulnerabi

105 Clonal hematopoiesis (CH) of indeterminate potential (CH

106 Clonal hematopoiesis (CH) refers to the acquisition of s

107 Clonal hematopoiesis (CH) results from somatic genomic a

108 t that many treated patients have persistent clonal hematopoiesis (CH) that may not reflect residual

109 hly variable, ranging from clinically silent clonal hematopoiesis (CH) to leukemic progression.

110 Clonal hematopoiesis (CH) was detected in 19.7% and 27.7

111 Clonal hematopoiesis (CH) with acquired pathogenic varia

112 etic stem cell (HSC) mutations can result in clonal hematopoiesis (CH) with heterogeneous clinical ou

113 In exploratory analyses, we considered clonal hematopoiesis (CH) with variant allele fraction (

114 We hypothesized that clonal hematopoiesis (CH), a state in which somatic muta

115 most frequently mutated genes in age-related clonal hematopoiesis (CH), alongside DNA methyltransfera

116 Clonal hematopoiesis (CH), as evidenced by recurrent som

117 Clonal hematopoiesis (CH), the clonal expansion of a blo

118 Clonal hematopoiesis (CH), the expansion of hematopoieti

119 Clonal hematopoiesis (CH)-age-related expansion of mutat

120 Clonal hematopoiesis (CH)-associated genomic alterations

121 ss promote its relative expansion leading to clonal hematopoiesis (CH).

122 DNMT3A) is the most commonly mutated gene in clonal hematopoiesis (CH).

123 tionships between LOY, serum biomarkers, and clonal hematopoiesis (CH).

124 ng tissues, particularly evident in blood as clonal hematopoiesis (CH).

125 DNA repair or epigenetics frequently lead to clonal hematopoiesis (CH).

126 donations) to investigate the phenomenon of clonal hematopoiesis (CH).

127 nd and become detectable, now referred to as clonal hematopoiesis (CH).

128 This cfDNA sequencing approach revealed that clonal hematopoiesis constitutes a pervasive biological

129 This clonal hematopoiesis correlates with an increased risk o

130 However, clonal hematopoiesis does result in the accumulation of

131 Clonal hematopoiesis driven by mutations of DNMT3A (DNA

132 Clonal hematopoiesis driven by somatic heterozygous TET2

133 Clonal hematopoiesis driven by somatic mutations in hema

134 phenomenon marked by expansion of cells with clonal hematopoiesis driver mutations, has been associat

135 The acquisition of clonal hematopoiesis-driver mutations (CHDMs) occurs wit

136 zed in n=6 patients with HF harboring DNMT3A clonal hematopoiesis-driver mutations and n=4 patients w

137 es and T cells of patients with HF harboring clonal hematopoiesis-driver mutations in DNMT3A exhibit

138 ugh experimental studies suggest that DNMT3A clonal hematopoiesis-driver mutations may enhance inflam

139 Clonal hematopoiesis due to mutations in TP53 was presen

140 Conversely, clonal hematopoiesis due to mutations of CSF3R was prese

141 hematopoiesis, most individuals who acquire clonal hematopoiesis during aging will never develop MDS

142 A predisposition to clonal hematopoiesis had an autosomal dominant pattern o

143 , establishing the causal role of smoking in clonal hematopoiesis has been limited by observational s

144 Somatic mutations leading to clonal hematopoiesis have been described in IBMFSs, but

145 lly heterogeneous disorders characterized by clonal hematopoiesis, impaired differentiation, peripher

146 splastic lineages) from 67 patients revealed clonal hematopoiesis in 13 (50%) of 26 cases with MDS-PA

147 We found evidence of clonal hematopoiesis in 5 of 8 studied cases based on cl

148 f TCA established the presence or absence of clonal hematopoiesis in about 90% of female subjects.

149 We did not detect clonal hematopoiesis in any of the tested subjects.

150 HUMARA alleles, was reported as evidence of clonal hematopoiesis in approximately 30% of elderly wom

151 nality assays are suitable for evaluation of clonal hematopoiesis in elderly women.

152 This HUMARA at times indicated clonal hematopoiesis in healthy elderly women, thus prec

153 mosome genes (qTCA) and found no evidence of clonal hematopoiesis in healthy nonanemic elderly person

154 Moreover, mutations in BRCC36 are found in clonal hematopoiesis in humans.

155 understanding of the processes that promote clonal hematopoiesis in IBMFSs may inform clinical surve

156 Furthermore, we did not detect clonal hematopoiesis in more than 200 healthy nonelderly

157 age-specific enrichment, in part reflecting clonal hematopoiesis in older individuals.

158 ontinue to proliferate and expand, mimicking clonal hematopoiesis in patients postchemotherapy.

159 Here, we unravel increased clonal hematopoiesis in patients with iWM (61% vs 23% in

160 DNMT3A-driven clonal hematopoiesis in recipient mice promoted naturall

161 issue of Blood, Eskelund et al characterize clonal hematopoiesis in serial samples from persons with

162 been observed in AML and in individuals with clonal hematopoiesis in the absence of leukemic transfor

163 roliferative neoplasms (MPNs) and JAK2 V617F clonal hematopoiesis in the general population.

164 is sufficient to drive premature age-related clonal hematopoiesis in these inherited disorders.

165 second most commonly mutated gene linked to clonal hematopoiesis, in the hematopoietic cells of athe

166 es clinical considerations for patients with clonal hematopoiesis, including important points for hem

167 rdiovascular disease and are associated with clonal hematopoiesis, inflammation, and adverse vascular

168 Age-related clonal hematopoiesis is a common condition that is assoc

169 expected consequence of mutation-associated clonal hematopoiesis is an increased risk of hematologic

170 Clonal hematopoiesis is associated with low CD4 nadir, i

171 Clonal hematopoiesis is exceptionally common with human

172 Because clonal hematopoiesis is not deterministic of malignant t

173 The observed proportion of putatively clonal hematopoiesis is similar to the lifetime incidenc

174 al (CHIP), also referred to as aging-related clonal hematopoiesis, is defined as an asymptomatic clon

175 This outgrowth, called "clonal hematopoiesis," is highly prevalent in the elderl

176 discuss recent advances in our knowledge of clonal hematopoiesis, its relationship to malignancies,

177 emorial Sloan Kettering (MSK) and the Korean Clonal Hematopoiesis (KoCH) consortia, we show that CH i

178 vascular event in an individual patient with clonal hematopoiesis may be low, the possibility of futu

179 People with clonal hematopoiesis may come to clinical attention in a

180 e germline variants of genes associated with clonal hematopoiesis may increase the likelihood that an

181 ic morphology of blood and marrow cells, and clonal hematopoiesis, most individuals who acquire clona

182 CODEC detected genome-wide, clonal hematopoiesis mutations from single DNA molecules

183 Clonal hematopoiesis mutations in ECD were detected in c

184 , and highlights hundreds of potential novel clonal hematopoiesis mutations.

185 ns in TET2 occur frequently in patients with clonal hematopoiesis, myelodysplastic syndrome (MDS), an

186 BAX-mutated clonal hematopoiesis occurred independently of prior flu

187 Clonal hematopoiesis occurs normally, especially with ag

188 Clonal hematopoiesis of indeterminate potential (CHIP) a

189 Clonal hematopoiesis of indeterminate potential (CHIP) a

190 Clonal hematopoiesis of indeterminate potential (CHIP) a

191 mutations in the peripheral blood is termed clonal hematopoiesis of indeterminate potential (CHIP) a

192 Clonal hematopoiesis of indeterminate potential (CHIP) c

193 Clonal hematopoiesis of indeterminate potential (CHIP) c

194 Clonal hematopoiesis of indeterminate potential (CHIP) c

195 Clonal hematopoiesis of indeterminate potential (CHIP) d

196 Clonal hematopoiesis of indeterminate potential (CHIP) h

197 Clonal hematopoiesis of indeterminate potential (CHIP) h

198 Clonal hematopoiesis of indeterminate potential (CHIP) h

199 of somatic mutations in blood cell lineages, clonal hematopoiesis of indeterminate potential (CHIP) i

200 Clonal hematopoiesis of indeterminate potential (CHIP) i

201 Clonal hematopoiesis of indeterminate potential (CHIP) i

202 Clonal hematopoiesis of indeterminate potential (CHIP) i

203 Clonal hematopoiesis of indeterminate potential (CHIP) i

204 Clonal hematopoiesis of indeterminate potential (CHIP) i

205 Clonal hematopoiesis of indeterminate potential (CHIP) i

206 Clonal hematopoiesis of indeterminate potential (CHIP) i

207 Clonal hematopoiesis of indeterminate potential (CHIP) i

208 Clonal hematopoiesis of indeterminate potential (CHIP) i

209 Clonal hematopoiesis of indeterminate potential (CHIP) i

210 Clonal hematopoiesis of indeterminate potential (CHIP) i

211 Clonal hematopoiesis of indeterminate potential (CHIP) i

212 Clonal hematopoiesis of indeterminate potential (CHIP) i

213 Clonal hematopoiesis of indeterminate potential (CHIP) i

214 Clonal hematopoiesis of indeterminate potential (CHIP) i

215 Clonal hematopoiesis of indeterminate potential (CHIP) i

216 Clonal hematopoiesis of indeterminate potential (CHIP) i

217 Clonal hematopoiesis of indeterminate potential (CHIP) i

218 Clonal hematopoiesis of indeterminate potential (CHIP) i

219 Clonal hematopoiesis of indeterminate potential (CHIP) i

220 Clonal hematopoiesis of indeterminate potential (CHIP) i

221 Purpose Clonal hematopoiesis of indeterminate potential (CHIP) i

222 Clonal hematopoiesis of indeterminate potential (CHIP) m

223 Clonal hematopoiesis of indeterminate potential (CHIP) o

224 Clonal hematopoiesis of indeterminate potential (CHIP) p

225 Clonal hematopoiesis of indeterminate potential (CHIP) r

226 Clonal hematopoiesis of indeterminate potential (CHIP) r

227 lthough the cause of these t-MNs is unknown, clonal hematopoiesis of indeterminate potential (CHIP) v

228 Clonal hematopoiesis of indeterminate potential (CHIP) w

229 In patients with CKD, non-DNMT3A clonal hematopoiesis of indeterminate potential (CHIP) w

230 d dysplastic hematopoiesis can be considered clonal hematopoiesis of indeterminate potential (CHIP),

231 Age-related clonal hematopoiesis of indeterminate potential (CHIP),

232 logous process happens in a condition called clonal hematopoiesis of indeterminate potential (CHIP),

233 ns in hematopoietic cells, frequently called clonal hematopoiesis of indeterminate potential (CHIP),

234 Clonal hematopoiesis of indeterminate potential (CHIP),

235 Clonal hematopoiesis of indeterminate potential (CHIP),

236 Clonal hematopoiesis of indeterminate potential (CHIP),

237 Clonal hematopoiesis of indeterminate potential (CHIP),

238 Clonal hematopoiesis of indeterminate potential (CHIP),

239 Clonal hematopoiesis of indeterminate potential (CHIP),

240 Clonal hematopoiesis of indeterminate potential (CHIP),

241 Clonal hematopoiesis of indeterminate potential (CHIP),

242 Clonal hematopoiesis of indeterminate potential (CHIP),

243 Here we explore these patterns in clonal hematopoiesis of indeterminate potential (CHIP),

244 Clonal hematopoiesis of indeterminate potential (CHIP),

245 This phenomenon, termed clonal hematopoiesis of indeterminate potential (CHIP),

246 Clonal hematopoiesis of indeterminate potential (CHIP),

247 ith increased inflammatory responsiveness is clonal hematopoiesis of indeterminate potential (CHIP).

248 -lived trained immunity and the emergence of clonal hematopoiesis of indeterminate potential (CHIP).

249 iovascular risk factor has recently emerged: clonal hematopoiesis of indeterminate potential (CHIP).

250 tion sequencing (NGS) discovered age-related clonal hematopoiesis of indeterminate potential (CHIP).

251 critical as underscored by the incidence of clonal hematopoiesis of indeterminate potential associat

252 unotherapy outcomes to account for potential clonal hematopoiesis of indeterminate potential contamin

253 with a focus on the prevalence and impact of clonal hematopoiesis of indeterminate potential in patie

254 Clonal hematopoiesis of indeterminate potential is the p

255 Among individuals with JAK2 V617F clonal hematopoiesis of indeterminate potential or mCAs

256 In an adenine-induced CKD mouse model, Tet2-clonal hematopoiesis of indeterminate potential was link

257 es describe the emergence and prevalence of "clonal hematopoiesis of indeterminate potential" in aged

258 associated with hyperinflammatory responses (clonal hematopoiesis of indeterminate potential, CHIP),

259 stic boundaries between MDS, MDS/MPNs, sAML, clonal hematopoiesis of indeterminate potential, clonal

260 , acquired somatic mutations associated with clonal hematopoiesis of indeterminate potential, leukocy

261 In individuals carrying clonal hematopoiesis of indeterminate potential, myocard

262 ave been characterized as frequent events in clonal hematopoiesis of indeterminate potential, suggest

263 atients without MDS/AML also had evidence of clonal hematopoiesis of indeterminate potential-related

264 had T-cell clonality, and 8 of 12 (67%) had clonal hematopoiesis of indeterminate potential.

265 ng individuals with idiopathic cytopenias or clonal hematopoiesis of undetermined significance, the i

266 nt somatic genetic rescue (SGR) resulting in clonal hematopoiesis, of which 95% was maladaptive (mono

267 Future studies on the effect of clonal hematopoiesis on the HIV reservoir and non-AIDS-r

268 in hematopoietic stem and progenitor cells (clonal hematopoiesis or CH) are associated with advanced

269 e is often preceded by a premalignant state (clonal hematopoiesis or myelodysplastic syndrome).

270 hieve AML cure and the impact of preleukemic clonal hematopoiesis persistence in predisposing to seco

271 malignancy consistent with the concept that clonal hematopoiesis precedes stem cell malignancy.

272 ously illuminates the clonal architecture of clonal hematopoiesis/preleukemic and leukemic cells surv

273 a cross-sectional cohort study, we compared clonal hematopoiesis prevalence in PWH on stable antiret

274 ction, not drift, is the major force shaping clonal hematopoiesis, provide bounds on the number of he

275 Clonal hematopoiesis provides a glimpse into the process

276 Clonal hematopoiesis-related genetic alterations were id

277 herosclerosis is a cause or a consequence of clonal hematopoiesis remains a matter of debate.

278 These patients have BCR-ABL1-positive clonal hematopoiesis resembling a chronic myeloid leukem

279 Clonal hematopoiesis results from enhanced fitness of a

280 Clonal hematopoiesis results from somatic mutations in h

281 In contrast to mutations associated with clonal hematopoiesis (such as Tet2 deletion), the leukem

282 ors, a phenomenon we term tumor-infiltrating clonal hematopoiesis (TI-CH).

283 Here, we will review recent studies linking clonal hematopoiesis to altered immune function, inflamm

284 s drives disease evolution from asymptomatic clonal hematopoiesis to frank MDS, and, ultimately, to s

285 Factors that control the conversion from clonal hematopoiesis to MPN disease include inherited pr

286 d across a phenotypic continuum ranging from clonal hematopoiesis to myelodysplastic syndrome (MDS) a

287 ancies exist on a spectrum from asymptomatic clonal hematopoiesis to overt leukemia and exhibit subst

288 re, we developed ArCH, an Artifact filtering Clonal Hematopoiesis variant calling pipeline for detect

289 ation pattern (XIP) was 20% (21/104), and of clonal hematopoiesis was 3% (3/104).

290 Clonal hematopoiesis was a strong risk factor for subseq

291 ECD patients with clonal hematopoiesis were more likely to be older (P < .

292 screened included 40 regions known to drive clonal hematopoiesis when mutated and 64 novel candidate

293 al alterations (mCAs) represent two forms of clonal hematopoiesis where clones bearing expanded somat

294 rom normal, healthy elderly individuals with clonal hematopoiesis who are at increased risk of subseq

295 f ctDNA dynamics in EAC, taking into account clonal hematopoiesis with indeterminate potential (CHIP)

296 Emerging data also associate clonal hematopoiesis with other nonhematologic diseases.

297 n morphologic remission may continue to have clonal hematopoiesis with populations closely related to

298 Clonal hematopoiesis with somatic mutations is readily d

299 Clonal hematopoiesis with somatic mutations was observed

300 Assays that could reliably detect clonal hematopoiesis would therefore be extremely valuab