ライフサイエンスコーパス: clonal selection

1 e to therapy has led to a Darwinian model of clonal selection.

2 ir prognostic significance and mechanisms of clonal selection.

3 on sites with multiple breakpoints, implying clonal selection.

4 Cx43 were generated by gene transfection and clonal selection.

5 cells as a source of genetic plasticity and clonal selection.

6 al composition), most probably the result of clonal selection.

7 -gal) was generated by gene transfection and clonal selection.

8 ent and the interaction of this process with clonal selection.

9 through the process of clonal variation and clonal selection.

10 tolerance is receptor selection rather than clonal selection.

11 tic mutations, which then directly influence clonal selection.

12 actions between somatic mutation, ageing and clonal selection.

13 to the cytokine, potentially contributing to clonal selection.

14 lations, indicating mechanisms distinct from clonal selection.

15 vaccination strategy that drives further TCR clonal selection.

16 of spontaneous somatic variants to grapevine clonal selection.

17 a deterministic, clone-size-based model for clonal selection.

18 ifferentiated CD4(+) effector T cells during clonal selection.

19 level from the same parental source without clonal selection.

20 revealed a focused repertoire suggestive of clonal selection.

21 genic cycles of mutation, proliferation, and clonal selection.

22 affinity and stability are optimized during clonal selection.

23 asts then mature into centrocytes to undergo clonal selection.

24 mportance of apoptosis in GC homeostasis and clonal selection.

25 multiple cycles of mutation acquisition and clonal selection.

26 c cell death in the regulation of CD4 T cell clonal selection.

27 ather than to random methylation followed by clonal selection.

28 c factors in the microenvironment may foster clonal selection.

29 structure, 2) alterations in cell number, 3) clonal selection, 4) metabolic differentiation, and 5) h

30 for understanding cell state transitions and clonal selection advantages for metastatic cancer cells.

31 drogen-independent cells that are poised for clonal selection after androgen-deprivation therapy.

32 es two subsequent rounds of transfection and clonal selection after each transfection.

33 well as for effective strategies to improve clonal selection against age related deterioration.

34 ion, leading to the conclusion that negative clonal selection against mutator clones is unlikely to b

35 ccumulation of somatic mutations followed by clonal selection akin to Darwinian evolution.

36 , genetic diversity provides a substrate for clonal selection and a source of therapeutic escape.

37 Display of antigen on FDCs is critical for clonal selection and affinity maturation of activated B

38 hese results suggest a revised vision of how clonal selection and affinity maturation operate in resp

39 Further genomic characterization of clonal selection and cancer in populations from around t

40 FRA-1 perspective supporting the notion that clonal selection and cell plasticity represent two sides

41 germinal center (GC) formation and regulate clonal selection and differentiation of memory and antib

42 cytes that respond rapidly to stress without clonal selection and differentiation.

43 biology, including antibody-antigen binding, clonal selection and effector functions.

44 in the absence of a better understanding of clonal selection and evolution.

45 -resident and migratory DCs was required for clonal selection and expansion of CD4(+) T cells after s

46 ent and natural antibody are interdependent: clonal selection and expansion of CD5+ B-1 cells is depe

47 products of inflammation, may play a role in clonal selection and expansion of CLL B cells.

48 However, it remains unclear if clonal selection and expansion of PCs follow any determi

49 of the T-cell line, suggesting a non-random clonal selection and expansion of T-cell clones that rec

50 xpress acquired antigen receptors or undergo clonal selection and expansion when stimulated.

51 and epigenetic diversification, followed by clonal selection and expansion.

52 s phenotypic assay of gene knockouts without clonal selection and expansion.

53 from the heterogenic population without any clonal selection and expansion.

54 ic mutational burden, mutational signatures, clonal selection and frequency of driver mutations in al

55 ancer has a major impact on the detection of clonal selection and genetic drift from both bulk and si

56 resistance has frequently been attributed to clonal selection and immunoediting, comparisons of paire

57 applied to experimental tumor data to study clonal selection and infer evolutionary history.

58 Quantification of clonal selection and inference of fitness landscapes of

59 rther underscoring the importance of BlpC in clonal selection and its role as a selfish element.

60 cell stressors are a recognized mechanism of clonal selection and leukemogenesis in bone marrow failu

61 trics can enhance yerba mate quality through clonal selection and optimized agricultural practices.

62 Whole-exome sequencing detected clonal selection and outgrowth of the acquired resistant

63 the laboratory mouse, little is known about clonal selection and population dynamics of the haematop

64 o 25 mmol/l glucose for 35 days induces both clonal selection and reversible dinucleotide repeat expa

65 e lymphocytes and may frame new questions of clonal selection and self tolerance.

66 Proteins of the BCL-2 family regulate clonal selection and survival of lymphocytes, and are fr

67 iPSC stage, generate master cell lines after clonal selection, and faithfully promote differentiation

68 of contemporary views on immune recognition, clonal selection, and immunological self-tolerance.

69 nstrated that this process is independent of clonal selection, and represents an EZH2-mediated epigen

70 ry immune response when somatic mutation and clonal selection are still in progress.

71 her, these findings implicate antigen-driven clonal selection as a major factor in HIV-1 persistence,

72 ired over a short period of time followed by clonal selection, as opposed to ongoing evolution.

73 s, demonstrates that ruxolitinib induces RAS clonal selection both in a JAK/STAT wild-type and hyper-

74 develops as a result of somatic mutation and clonal selection, but quantitative measures of selection

75 tent with a model where JAK2(V617F) promotes clonal selection by conferring TNFalpha resistance to a

76 reagents using the miniaturized platform for clonal selection by destructive assay versus conventiona

77 eneity in real-time gene expression, enables clonal selection by flow cytometry, and forms a basis fo

78 Here, we analyze cancer evolution and clonal selection by jointly considering mutational and t

79 ce that luminal cell translocation may drive clonal selection by promoting either the death or the ex

80 e acidity induced by glycolysis reveals that clonal selection can stabilize glycolysis even when ener

81 Early passage WTPDX show evidence of clonal selection, clonal evolution and enrichment of bla

82 expanded, but whether affinity maturation by clonal selection continues through the course of chronic

83 Mutagenic processes and clonal selection contribute to the development of therap

84 Whereas clonal selection controls cell death or survival in resp

85 er, our results suggest that therapy-induced clonal selection could be already present at the MRD sta

86 lly linked with highly distinct B and T cell clonal selection, diversification, and differentiation.

87 ing on the acquisition of somatic mutations, clonal selection, driver mutation cooperation, and tumor

88 f random, stochastic methylation followed by clonal selection due to a proliferative advantage caused

89 progression of tumors, cancer cells undergo clonal selection due to a variety of genetic and microen

90 Although these may in part be due to clonal selection during adaptation to tissue culture, ou

91 which is only slowly reshaped by fluctuating clonal selection during adult life.

92 This phenomenon may be critical in clonal selection during carcinogenesis.

93 inical trials were used to evaluate RNASEH2B clonal selection during olaparib treatment.RESULTSShallo

94 The forces that govern clonal selection during the genesis and maintenance of s

95 Current models attribute T cell clonal selection during the immune response to T-cell re

96 AR mutations exhibited clonal selection during treatment, including an increase

97 f cancer that is not subject to the blunting clonal selection effects that reduce the efficacy of oth

98 cal memory imply that Ab diversification and clonal selection exist in cartilaginous fish.

99 pecific to that antigen are enriched through clonal selection, expansion, and somatic hypermutation.

100 A genes are targeted by somatic mutations as clonal selection factors potentially impairing cellular

101 treatment in three cancer types, supporting clonal selection following anticancer therapy.

102 ssion resulted in chromosomal aberration and clonal selection for cells with c-myc amplification and

103 cells that escaped senescence had undergone clonal selection for faster proliferation and extensive

104 of heterozygosity at defined regions during clonal selection for growth advantage define the minimal

105 of TCR usage, which indicates strong T-cell clonal selection for peptide recognition.

106 e suppressive micro-environments and elicits clonal selection for survival and proliferative expansio

107 ype patterns of newborn twins suggested that clonal selection for TCRDV is independent of genetic bac

108 d that point mutations, indel formation, and clonal selection form a robust tripartite system for ant

109 ted that acquired PARPi resistance arose via clonal selection from an intrinsically unstable and hete

110 This regulation compartmentalizes clonal selection from receptor selection.

111 2 and IFN-gamma production is independent of clonal selection, functional avidity maturation, and the

112 erving cell-cell interactions and minimizing clonal selection, GBOs maintain the cellular heterogenei

113 ogenous genes in cells that do not allow for clonal selection has been challenging.

114 Clonal selection has been proposed as a pathogenetic mec

115 onses to abnormal environmental signals, and clonal selection have all been hypothesized to play a ro

116 ced-fitness" mutations may mediate "negative clonal selection," i.e., selective elimination of premal

117 telomere attrition becomes an instrument for clonal selection in advanced age, with splicing factor m

118 This suggests a lack of strong clonal selection in Barrett's and that the malignant pot

119 Our results suggest the importance of clonal selection in endocrine therapy resistance of brea

120 Many B cells undergo apoptosis during B cell clonal selection in GCs.

121 ty depends on rapid B cell proliferation and clonal selection in germinal centers (GCs) and declines

122 n-specific patterns of genomic mutations and clonal selection in haematopoietic cells on the basis of

123 gest that this mechanism is also critical to clonal selection in MPN.

124 nostic and MRD tumor cells, revealed greater clonal selection in patients with standard-risk CAs, hig

125 While clonal selection in response to particular antigens has

126 The data suggest a nonrandom clonal selection in T-LGL, possibly driven by a common a

127 The extent of somatic mutation and clonal selection in the human bladder remains unknown.

128 existing premalignant myeloid clones undergo clonal selection in the setting of nonmyeloablative HSCT

129 Most models of clonal selection in the Th cell compartment favor TCR af

130 eated P. falciparum infection drove waves of clonal selection in the Vd1(+) T cell receptor repertoir

131 examine how B cell receptor affinity affects clonal selection in thymus-independent type 2 (TI-2) imm

132 D8 + T cell infiltration and T cell receptor clonal selection in virus-positive tumors.

133 models results from an iterative process of clonal selection in vitro and/or in vivo.

134 ide experimental access to the mechanisms of clonal selection in vivo.

135 en that somatic hypermutation and subsequent clonal selection increase antigen-antibody specificity a

136 Following these checkpoints, clonal selection induces a host-specific DH reading fram

137 Clonal selection initially is promiscuous, activating ce

138 The process of clonal selection is a central feature of the immune syst

139 Clonal selection is central to immune function, but it i

140 among epithelium and stroma, but subsequent clonal selection is driven by factors, which appear to b

141 However, simple clonal selection is inadequate to describe the late rela

142 epithelium can change the transformation and clonal-selection landscape, permitting the fixation of s

143 Somatic hypermutation and clonal selection lead to B cells expressing high-affinit

144 after radiotherapy could be associated with clonal selection leading to tumor regrowth at the treatm

145 mathematical analysis is applied to negative clonal selection, leading to the conclusion that negativ

146 Clonal selection leads to the development of T-cell lymp

147 strating that Bcl-xL and apoptosis influence clonal selection/maintenance for affinity maturation.

148 induced changes in gene expression, and that clonal selection may partially explain the change in mes

149 ogether, clonal heterogeneity and age-driven clonal selection may underlie the perplexing diversity o

150 Here, we investigate whether clonal selection might contribute to this phenotype chan

151 tic and not determined by a distinct step of clonal selection necessary for survival from the acute r

152 In all patients, clonal selection occurred rapidly, within 1-3 treatment

153 In both cases, clonal selection occurred within immature cell populatio

154 Tetrachimeric mice show clonal selection occurs during development with further

155 d with ivosidenib combination therapy, rapid clonal selection occurs within the first treatment cycle

156 e dominant clone at recurrence arose through clonal selection of a pre-existing minor clone present a

157 Clonal selection of a T cell for use in the immune respo

158 cancers is a stochastic process resulting in clonal selection of aggressively expanding cells with al

159 ary proteins contributed to accumulation and clonal selection of antigen-experienced CD4+ T cells at

160 e Ab responses to DNA are dependent upon the clonal selection of B cells expressing particular H and

161 Here, we report that clonal selection of CD4(+) T cells is also extrinsically

162 stability in the absence of ATM function and clonal selection of cells harboring alterations within t

163 of CpG island methylation could result from clonal selection of cells having growth advantages due t

164 Since replicational stress leads to clonal selection of cells with p53 mutations, our result

165 cellular origin of high affinity IgE and the clonal selection of high affinity memory B cells into th

166 We conclude that clonal selection of INS-1 cells allows isolation of cell

167 No evidence of clonal selection of lentiviral vector-transduced T cells

168 daptive immunity by providing the ground for clonal selection of lymphocytes with the appropriate ant

169 when concepts of neonatal immune tolerance, clonal selection of lymphocytes, and "forbidden clones"

170 ory cytokine that has been implicated in the clonal selection of neoplastic cells.

171 ignant lesion and the features that underpin clonal selection of one particular integrant remain poor

172 These results suggest that clonal selection of recurrent mutations found in cancer

173 ent and mesenchymal phenotype may arise from clonal selection of tumor cells that have acquired the p

174 In all 15 cases examined, clonal selection on engraftment was observed in both pri

175 g common hematological traits influence both clonal selection on somatic mutations and the subsequent

176 This may be a result of either clonal selection or selective activation in the pathogen

177 bly through a role in somatic hypermutation, clonal selection, or both.

178 tudies characterize a BCR-dependent negative clonal selection pathway that has been co-opted by a com

179 esults, the fitness function of the previous clonal selection phase is inferred to be directional and

180 ion is critical to the development of T-cell clonal selection, possibly from immune competition secon

181 Clonal selection preceded treatment failure by months to

182 A candidate mechanism for the apparent clonal selection pressure exerted by the sulfone against

183 T cells surviving the clonal selection process emigrate from the thymus to the

184 The nature of the clonal selection process is unclear, and to address this

185 owed to be an appropriate tool to assist the clonal selection process of 'Tempranillo'.

186 Ultimately, this reconceptualization of the clonal selection process suggests a quantitative, testab

187 autoantibodies are derived from a restricted clonal selection process.

188 eir activation by cognate antigen during the clonal selection process.

189 bled from microarray-eluted material without clonal selection produced only 30% less protein than seq

190 The immunological process of clonal selection requires a rapid burst in lymphocyte pr

191 e not the only sites for the affinity-driven clonal selection responsible for the maturation of humor

192 ancies identified as evolving neutrally, all clonal selection seemingly occurred before the onset of

193 t arose from the application of mutagenesis, clonal selection techniques, and media optimization to s

194 ronment is an important driving force in the clonal selection that leads to invasive and metastatic d

195 This phenomenon is reflected by the clonal selection that occurs during Ab-MLV-mediated tran

196 The success of these events is driven by clonal selection, the potential of metastatic cells to d

197 Clonal selection theories postulate that lymphocyte fate

198 The clonal selection theory first proposed by Macfarlane Bur

199 tion originated as a critical element of the clonal selection theory of antibody formation in order t

200 The clonal selection theory states that B lymphocytes produc

201 undation of modern immunology, including the clonal selection theory, antigen receptor diversity, imm

202 e implications of these new findings for the clonal selection theory, self-tolerance, and immunodomin

203 Contrary to the general precepts of the clonal selection theory, several recent studies have pro

204 cells undergo class switch recombination and clonal selection to generate high affinity neutralizing

205 acteristic of T cells that was eliminated by clonal selection to protect the host from autoimmune pat

206 ed animals, however, appears to preclude the clonal selection typically observed in human ATLL, which

207 EM simulates tumor populations under somatic clonal selection using an agent-based framework.

208 howed that all patients treated with HDM had clonal selection, whereas a static progression was obser

209 of random missegregation are outbalanced by clonal selection, which is dictated by the chromosomal l

210 e conditions favoring overgrowth resulted in clonal selection, which with added Ras or MEK oncogenes

211 FDCs) is essential for B cell activation and clonal selection within germinal centers.

212 lonal expansion, genetic diversification and clonal selection within the adaptive landscapes of tissu

213 rations in the epigenome might contribute to clonal selection, yet the extent to which the chromatin