ライフサイエンスコーパス: clonality

1 e for these tests in a new R package called 'Clonality'.

2 nal, quantitative definition for determining clonality.

3 sequence-based PCR (rep-PCR) assessments of clonality.

4 ivity despite equivalent measures of overall clonality.

5 g to determine their resistance profiles and clonality.

6 arC allele combination, supporting its tight clonality.

7 ion, serum tryptase elevation, and mast cell clonality.

8 ne assay (HUMARA) has been used to determine clonality.

9 are such genomic profiles for an evidence of clonality.

10 ld gel electrophoresis was used to determine clonality.

11 as previously thought, from a difference in clonality.

12 ulated multinomial distribution based on IBC clonality.

13 meter, the oligoclonality index, to quantify clonality.

14 lthy subjects and patients showed restricted clonality.

15 on CDR3 length polymorphisms, have a limited clonality.

16 e of the desired mutation and to demonstrate clonality.

17 th America, where it is also associated with clonality.

18 f this subspecies and its apparent long-term clonality.

19 adicting widely held perceptions of obligate clonality.

20 nd the PIG-A gene was sequenced to determine clonality.

21 T-cell receptor gene rearrangement to detect clonality.

22 opeptidomes and intratumoral T cell receptor clonality.

23 not always sufficient to establish proviral clonality.

24 ected clones and a decline in overall T-cell clonality.

25 re reliable than mutations for demonstrating clonality.

26 uence typing (MLST) were performed to assess clonality.

27 cterize genetic relatedness and hence assess clonality.

28 of naive T cells unmasking underlying memory clonality.

29 ective, with concomitant low T-cell receptor clonalities.

30 ulted in a high discrimination rate of tumor clonality (77.3%; 75/97) in metachronous multiple lung c

31 in monitoring residual tumor and recurrence clonality after tumor resection.

32 However, clonality also results in the spatial expansion of the g

33 WGS analysis confirmed clonality among the ST-13578 population.

34 matopoiesis in 5 of 8 studied cases based on clonality analysis and presence of somatic genetic aberr

35 lymphoma from uveitis remains difficult, and clonality analysis may be either unsuccessful or mislead

36 ion, we performed whole-exome sequencing and clonality analysis of 72 urothelial carcinoma samples, i

37 Clonality analysis of array CGH data suggested that mult

38 Clonality analysis of this large data set further enable

39 nt a novel system and standards for accurate clonality analysis using 454 pyrosequencing.

40 Clonality analysis using X-chromosome inactivation patte

41 sequencing technology enable high-throughput clonality analysis via vector integration site (VIS) seq

42 Clonality analysis was performed using human androgen re

43 -associated mutations, exome sequencing, and clonality analysis, we demonstrate that JAK2V617I is lik

44 into one with infrequent genetic changes/low clonality and another with relatively higher clonality a

45 of high-avidity peripheral CTL with limited clonality and are able to contain acute and chronic infe

46 row, MC should be analysed for their number, clonality and c-Kit mutation.

47 Here, we investigate the clonality and cells of origin of regenerative nodules in

48 g deep sequencing; this allowed us to define clonality and clonal evolution patterns precisely at rel

49 No correlation was found between clonality and disease severity but in patients treated w

50 loss of heterozygosity (LOH), could evaluate clonality and distinguish second primary breast cancer f

51 characterize them and identify trends in DNA clonality and divergence.

52 fragments in the patients' blood can monitor clonality and evolving mutations as a surrogate for tumo

53 ange of ecosystems where both high levels of clonality and facilitation are expected to occur.

54 es novel evidence for interactive effects of clonality and facilitation between vascular and nonvascu

55 A correlation between clonality and JAK2V617F allelic ratio was demonstrated f

56 stigate the relationship between granulocyte clonality and JAK2V617F allelic ratio.

57 netic variation are incompatible with strict clonality and lack of genetic exchange.

58 ni-Urbani and Buser overlap index), relative clonality and Morisita's overlap index, as well as the i

59 We aimed to assess the clonality and mutation burden of individual crypts in co

60 clonality and another with relatively higher clonality and mutations impacting TpT dinucleotide.

61 have explored how - within the same system - clonality and positive plant-plant interactions might in

62 ification of an HES subset with T lymphocyte clonality and production of cytokines, particularly IL-5

63 likely to appropriately characterize isolate clonality and putative transmission events in the majori

64 a means of comparing the relative impact of clonality and recombination on fungal populations.

65 mor ploidy, allele-specific copy number, and clonality and represents this in an intuitive graph.

66 ion patterns while controlling for cell line clonality and sex.

67 Clonality and skewing of TCR repertoires were associated

68 he diffuse-type GCs show significantly lower clonality and smaller numbers of somatic and structural

69 patient HIV-1 evolution and to determine the clonality and structure of proviruses within expanded cl

70 the utility of RNA-seq for assessing T-cell clonality and T-cell antigen receptor (TCR) repertoire o

71 ons, providing insights into mutation rates, clonality and the genomic architecture and etiology of c

72 of the Ig repertoire provided measures of Ig clonality and the Ig phenotype.

73 kinetics, and the relationships between cell clonality and their functional phenotypes.

74 toimmune disease, the finding of CD8+ T cell clonality and trafficking implies participation in a dis

75 Strict fungal clonality and vertical transmission evidently have not p

76 ciency virus (HIV) infection and explore the clonality and viral specificity of the autoinvasive T ce

77 . anthracis virulence is associated with the clonality and virulence of plasmids pXO1 and pXO2.

78 across a range of mosaic event sizes, types, clonalities, and sequencing depths.

79 We describe the phenotype, clonality, and carbapenemase-encoding genes present in C

80 In this study, the origin, clonality, and function of these cells were investigated

81 esults reveal several genetic driver events, clonality, and mutational signatures associated with poo

82 e observe an increase in antigen reactivity, clonality, and pathogenicity of insulin-specific T cells

83 quence reads due to tumor heterogeneity, sub-clonality, and sequencing artifacts.

84 asmid transfers, and previous reports of its clonality are artifacts from the use of geographically a

85 In the long run, however, the effects of clonality are countered by recombination.

86 wo decades shows that both recombination and clonality are likely to contribute to the reproduction o

87 nd significantly greater increases in T-cell clonality as measured by T-cell receptor (TCR) sequencin

88 erent expressions of whole-animal vertebrate clonality (asexual organismal-level reproduction), both

89 f 190 female patients were informative for a clonality assay at the HUMARA locus; 80% of MMM, 75% of

90 We used a clonality assay based on quantitative expression of poly

91 sing a quantitative, transcriptionally based clonality assay, we reported X-chromosome-transcribed al

92 merase chain reaction (qPCR) transcriptional clonality assay.

93 cells without the need for a separate T-cell clonality assay.

94 hat the transcriptionally based X-chromosome clonality assays are suitable for evaluation of clonal h

95 Thus, these novel clonality assays are useful in the diagnosis and follow-

96 Transcriptional clonality assays of the engrafted human IM cells demonst

97 Clonality assays, based on X-chromosome inactivation, di

98 stologic type have different clonal origins, clonality assessment is essential to differentiate MPLCs

99 e entire workflow of IG/TR NGS assays for 1) clonality assessment, 2) minimal residual disease detect

100 countries to infer population structure and clonality at a global level.

101 cers in this cohort arose in persons who had clonality at the time of DNA sampling, more than 6 month

102 Pretreatment peripheral blood TCR clonality below the median was associated with improved

103 after serial transplantation, demonstrating clonality between each primary and passaged leukemia.

104 is known about their epitope specificities, clonality, binding affinities, epitopes, and neutralizin

105 t secondary responses are characterized by a clonality bottleneck that restricts the engagement of th

106 osttransplant PGNMID can change its apparent clonality by immunofluorescence supporting oligoclonal i

107 , EBV-encoded RNA in situ hybridization, and clonality by PCR of T-cell receptor gamma and immunoglob

108 ere analyzed for their T cell receptor (TCR) clonality by using anchored RT-PCR of all the TCRbeta lo

109 Clonality can be established by a lack of mosaicism in a

110 The signal of clonality can be interrupted by gene uptake and exchange

111 , suggesting that post-ICB peripheral CD8(+) clonality can provide information regarding long-term tr

112 s of SHM, Ag selection (including BASELINe), clonality (Change-O), and CSR.

113 emonstrated BubbleTree's utility in tracking clonality changes from patients' primary to metastatic t

114 Furthermore, T(FH) cells exhibited increased clonality compared with non-T(FH) cells from the same ly

115 5-fold greater density of T cells and higher clonality compared with normal breast.

116 rall T-cell infiltrate, but not the level of clonality, correlated with mRNA levels of key inflammato

117 analysis of peripheral T-cell phenotypes and clonality, cytokine production in mixed lymphocyte react

118 having the same clonality (SC) and different clonality (DC), respectively.

119 se of the "semiclonal model" or of "epidemic clonality," demonstrating occasional bouts of clonal pro

120 well as providing a clinical useful tool for clonality detection and minimal residual disease monitor

121 Clonality detection based on X-chromosome inactivation p

122 ion of CD5(+)B220(dull) cells (judged by BCR clonality) did not seem to be accelerated by APRIL; both

123 acter isolates to determine epidemiology and clonality during infectious outbreaks.

124 n addition, to maximize the detection of low-clonality events in probands, we applied a trio-based mo

125 re features with Th17 cells, with shared TCR clonality, expression of RORC2 and CCR6 and response to

126 (i) the proposed way to distinguish epidemic clonality from PCE may be faulty and (ii) the evidence o

127 In this model, occasional clonality generates linkage disequilibrium in the short

128 mbined analyses of two signatures for mutant clonality, HPRT mutation, and T-cell receptor beta CDR3

129 nce: HR = 0.30, 95% CI 0.12-0.72, P = 0.007; clonality: HR = 3.32, 95% CI 1.38-7.94, P = 0.007).

130 Phenotypic clonality identifies the clonal population by the expres

131 ts for three markers of B-cell activation or clonality: immunoglobulin free light chains (FLCs), solu

132 The 5 TCAs were used to examine clonality in 46 female patients along with assays for er

133 Th1 clonality in AA, investigated by high-throughput sequenc

134 in TCRbeta repertoire diversity and reduced clonality in both CP groups versus controls.

135 pregnancy, robustly increased TCR repertoire clonality in both peripheral Tcon and Treg.

136 ysregulation, we reinvestigated the issue of clonality in elderly women.

137 Sexual reproduction and clonality in eukaryotes are mostly seen as exclusive, th

138 bate on the relative significance of sex and clonality in eukaryotes is confounded by not appropriate

139 s, serum erythropoietin levels, establishing clonality in female subjects using assays employing X-ch

140 te their cell type, receptor expression, and clonality in individual mice.

141 ctious virions, providing a viral measure of clonality in infected cells.

142 tificial nuclear transfer; intergenerational clonality in nature via parthenogenesis and gynogenesis;

143 eral processes can produce the appearance of clonality in populations that undergo frequent recombina

144 cell receptor sequencing revealed increased clonality in radiation-treated tumors.

145 n acute dengue patients, with higher overall clonality in secondary infection.

146 An increase in clonality in systemic lupus erythematosus and Crohn's di

147 irulence, and reforms longstanding theory on clonality in trypanosomatid parasites.

148 In the present article we examine clonality in virus evolution.

149 0.39, 95% CI 0.26-0.57, P = 1.3e-06) and the clonality index (HR = 2.13, 95% CI 1.44-3.15, P = 0.0002

150 Higher values of clonality index (lower diversity) were not associated wi

151 95% CI 0.78-0.93, P = 0.0002; HR per log2 or clonality index = 1.16, 95% CI 1.03-1.31, P = 0.016).

152 We measured both the quantity and clonality index of T cells by means of T-cell receptor (

153 However, the clonality index was associated with prognosis only in th

154 through a novel combinatorial method, named clonality inference in tumors using phylogeny (CITUP), t

155 present there is no compelling evidence that clonality influences the position or function of interne

156 l and peripheral blood T cell receptor (TCR) clonality inform clinical outcomes in urothelial carcino

157 Clonality is a pervasive feature of sessile organisms, b

158 Clonality is associated with the recent emergence of a m

159 rophilia particularly if evidence of myeloid clonality is lacking.

160 In this review, we address how tumor clonality is measured using next-generation sequencing (

161 knowledge concerning tumor heterogeneity and clonality is needed to determine the impact of targeted

162 This finding demonstrated that clonality is not predictive of an interneuron's ultimate

163 ng, it is not always clear how evaluation of clonality is performed, and is it not known what the rel

164 Timely detection of HCC recurrence and its clonality is required to implement salvage therapies app

165 Thus, clonality is the standard evolutionary mode for viruses

166 is contribution to the prognosis of sFLCr or clonality, it was found that the sFLCr does not identify

167 t a variably dynamic process of shifting CTL clonality lagging in tandem with viral evolution and sug

168 ulations are highly clonal and that the high clonality likely resulted from epidemic expansion of imp

169 itatively assess how seeding density affects clonality loss so that experimental protocols can be opt

170 now the method implemented in our R package Clonality, making available an easy and fast way to esti

171 n can stabilise these hybrids, but pervasive clonality may have a profound impact on the distribution

172 Thus, EBV clonality may reflect selection for a TR number that opt

173 The most commonly used phenotypic clonality methods are based on the X-chromosome inactiva

174 clonotypes, which may be contributing to the clonality observed during chronic viral infections.

175 'Trailer-end clonality' occurs despite predictions of host immunologi

176 United States were also analyzed to examine clonality of a specific MLVA type.

177 Affinity and clonality of allergen-specific IgE antibodies are import

178 Clonality of C. acnes isolates from deep specimens from

179 An analysis of the clonality of cardiac progenitor cells (CPCs) and myocyte

180 ion 3 sequencing) were used to determine the clonality of CD8(+) T lymphocytes taking part in the rec

181 The clonality of colitis-associated neoplasia has not been f

182 Extreme clonality of CTL expansions seen in LGL leukemia makes i

183 h included modifications in the presence and clonality of driver mutations associated with GBM.

184 The specificity of recombination and the clonality of each mutant were confirmed by PCR, sequenci

185 The presence or absence of mutations and the clonality of each mutation were determined for each mark

186 ae species in Argentina, and we contrast the clonality of epidemic V. cholerae with the background di

187 determining region 3) sequence to assess the clonality of epitope-specific CD8(+) T lymphocytes gener

188 To study the clonality of flagellin-reactive CD4 cells in Crohn patie

189 ompared the peripheral-blood CD34 count, the clonality of granulocytes and platelets in peripheral bl

190 Here we analyzed the clonality of HIV-1-infected cells using high-throughput

191 ion in severe combined immunodeficient mice, clonality of lung metastasis was dependent on cell numbe

192 heterozygosity analysis, we investigated the clonality of mature teratoma and its relationship to oth

193 he simple fluorescence method of determining clonality of metastases described here can allow large-s

194 Previous methods to determine clonality of metastasis used karyotype or molecular anal

195 al, such as the divergence times and genetic clonality of metastatic lineages.

196 esolution analysis allowed us to measure the clonality of methylation in individual tumors and gain i

197 However, to date no study assessing clonality of multiple primaries has been conducted in me

198 Mutation significance and estimated clonality of mutations determined the most likely MSI ta

199 establish how negative selection shapes the clonality of neoantigens in a growing cancer by construc

200 clonal populations and emphasize the lack of clonality of nontypable (NT) H. influenzae isolates.

201 challenging previously held views about the clonality of obligate intracellular bacteria.

202 T-cell clonality of peripheral T-cell lymphoma (PTCL) is routin

203 We studied the clonality of phyllodes tumors from six patients who unde

204 We also analyzed transcript clonality of rat TCR-Valpha5, an ortholog of the dominan

205 We confirmed the clonality of selected transformants by Southern blot hyb

206 ed genomic DNA cannot be used to analyze the clonality of some streptococci containing Phi10394.4 and

207 nique allows for a direct examination of the clonality of sparse cell populations such as HSCs.

208 Little is known about the clonality of Staphylococcus epidermidis in the United St

209 if next-generation sequencing (NGS) revealed clonality of strains.

210 While screening the clonality of Streptococcus pyogenes isolates from an out

211 (Ig) gene rearrangements are used to define clonality of suspected B-lineage malignancy in tissue sa

212 tekeeping founder mutations, and explore the clonality of synchronous lesions to look for field effec

213 nostic value of T-cell abundance and Simpson clonality of TCR variants adjusting by sex, age, tumor l

214 orbicula to test the hypothesis of long-term clonality of the androgenetic species.

215 dy was aimed at disclosing the diversity and clonality of the anti-Dsg3 response, as well as whether

216 The clonality of the experimental metastasis model depended

217 tations as a marker of clonal expansion, the clonality of the gastric unit and show how mutations exp

218 Spectratyping analysis showed restricted clonality of the identified TCR Vbetas.

219 er their evolutionary landscape by inferring clonality of the individual mutation events.

220 robial antigens in early life determines the clonality of the mature B-1 B cell repertoire and ensuin

221 To assess clonality of the MRSA isolates causing SSTI and BSI duri

222 The sudden emergence and clonality of the outbreak suggest that this strain may b

223 and serotype HS:1,8, further indicating the clonality of the related isolates from different host sp

224 The clonality of the T-cell repertoire from p53 knockout and

225 was found in peripheral lymphoid organs, the clonality of the TCR-BV8 and BV14 T cells that migrate t

226 To determine clonality of the thymocytes, we used degenerate RT-PCR t

227 PFGE showed marked clonality of the U.S. isolates, with differences between

228 ism for the selective pressure that leads to clonality of these B-cell clusters and opens the possibi

229 To study the clonality of this response, we analyzed 22 MOG35-55-spec

230 The presence and extent (clonality) of genomic instability, as assessed by mutati

231 vantage on standard vertebrate reproduction, clonality offers fresh perspectives on the evolutionary

232 Clonality often defines the diseased state in hematology

233 The impact of bacterial clonality on infections caused by Staphylococcus aureus

234 on provides no insight into the influence of clonality on interneuron development because the entire

235 The extent to which any negative effects of clonality on mating success might be offset by the posit

236 ood but these do not necessarily reflect the clonality or differentiation of cells within tissue.

237 nalyses of the T-cell receptor Vbetas showed clonality or the presence of a very restricted number of

238 xpansion of stem cells, but determination of clonality over many decades is restricted by epigenetic

239 Resistant tumors displayed a complex clonality pattern suggesting the emergence of several re

240 Deep digital sequencing revealed diverse clonality patterns in both never-smokers and smokers.

241 floc" that avoid exploitation by maintaining clonality pay an ecological cost when rare, often leadin

242 udy, we conducted a longitudinal analysis of clonality, phenotype, and function to define the charact

243 s of the Colombian Pacific coast to evaluate clonality, population structure and linkage disequilibri

244 Increased TCR clonality positively correlated with increased CD8(+) PB

245 in otherwise disease-free BM, and whether BM clonality predicted higher risk of progression.

246 The Clonality R package is a practical tool to assess the cl

247 M algorithm is a preferable approach for our clonality random-effect model.

248 Genotypic clonality relies on somatic mutations to mark the clonal

249 T cells, T-cell functional response, and TCR clonality, represents possible additional mechanisms of

250 ses (66.7%) were assessed as having the same clonality (SC) and different clonality (DC), respectivel

251 s estimated by a modified Gini-Simpson index clonality score.

252 Our results indicate that clonality serves to increase sexual fitness when it is a

253 ive allelic systems to recombination genes ("clonality/sexuality machinery") to escape recombinationa

254 Analysis of clonality showed that all of these cases represented the

255 Analyses of clonality, somatic mutations, and gene expression in the

256 ini Index and cluster sizes quantify the BCR clonality status and are robust to sampling and sequenci

257 Modern clonality studies have confirmed the multipotent stem-ce

258 skewing has recently been suggested by XCIP clonality studies in aging hematopoietic cells.

259 HTLV-1 clonality studies revealed the presence of multiple clon

260 Observed Microviridae clonality suggests recovery of bloom-terminating viruses

261 pients of the same donor and reflected donor clonality, supporting a deterministic, clone-size-based

262 Clonality testing identified involvement of bone marrow,

263 ombining XCIP clonality testing with genetic clonality testing to identify clonal populations with ye

264 research applications include combining XCIP clonality testing with genetic clonality testing to iden

265 Errors in interpreting clonality tests arise from stochastic, genetic, and cell

266 newly activated naive cells of considerable clonality that persisted in the circulation for several

267 Despite clonality, the Sca-1 outliers had distinct transcriptome

268 nsions can serve as surrogate markers of CTL clonality to assess clonal kinetics in T-LGLL.

269 ght chain ratio (sFLCr) and bone marrow (BM) clonality to define more sCR.

270 Using mutation clonality to infer time of onset, we find that while age

271 ell populations include cellular conditions, clonality, transcriptional circuitry and chromatin modif

272 Self-incompatibility, clonality, tree size and proximity to the mother tree we

273 globulin A (IgA) vasculitis by analysing BCR clonality, use of immunoglobulin heavy-chain variable re

274 ework, BubbleTree, to characterize the tumor clonality using next generation sequencing (NGS) data.

275 Analysis of tumor clonality using X-linked inactivation assays in a patien

276 genesis and kleptogenesis; intragenerational clonality via polyembryony; and what in effect qualifies

277 Plasma cell clonality was analyzed by flow cytometry, immunohistoche

278 Tumor clonality was assessed by analyses of mitochondrial DNA.

279 Clonality was assessed by laser capture of multiple cell

280 Clonality was assessed by repetitive sequence-based PCR

281 Clonality was demonstrated by eBURST analysis and standa

282 Clonality was demonstrated by following cytochrome c oxi

283 abeta, but its expression level was high and clonality was detected in a TCRgammadelta expressing tum

284 Among those tested, Clonality was identified for its robustness as a key met

285 e ability to form colonies, an indication of clonality, was restricted to the aldehyde dehydrogenase

286 data on survival, plasmid copy numbers, and clonality, we developed a model predicting virulence.

287 To increase our ability to detect clonality, we developed simple TCA for detecting the tra

288 By mapping T cell receptor clonality, we find that responding patients have more la

289 Regardless of clonality, we found that MCPyV status was concordant for

290 To study antigen-specific T cell clonality, we have developed a method that allows select

291 orrelations between granulocyte and monocyte clonalities were greatest, followed by correlations betw

292 ons, endogenous erythroid colony growth, and clonality were investigated in 51 children.

293 on of high pretreatment peripheral blood TCR clonality with elevated PD-L1 IC staining in tumor tissu

294 ors in WT and Pd-1-/- mice displayed reduced clonality with emergence of immune escape clones.

295 e inflamed joint share T-cell receptor (TCR) clonality with Th17 cells, suggesting a shared clonal or

296 and breast, confounding assessment of tumor clonality with traditional X-inactivation studies.

297 TS from reinfection, despite a high level of clonality within and among individuals, giving insights

298 d each genome to be unique, implying limited clonality within prokaryoplankton populations.

299 Additionally, we observed evidence of clonality within the EAC cases; specifically, 22 of 25 E

300 ticolor Cre-dependent marker system to trace clonality within the tumor microenvironment to show that