ライフサイエンスコーパス: clonally

1 e is eliminated and the other is transmitted clonally.

2 Nostoc, and that each appears to be evolving clonally.

3 different modalities are largely segregated clonally.

4 abundant IgM which, together with SIgM from clonally affiliated PCs, recognized mucus-embedded comme

5 onal spectrum at the whole-genome level of a clonally aged population and uncovered phenotypic variat

6 We established a nuclear transfer method to clonally amplify the genomes of neurons from adult mice

7 A single mutant expands clonally and finally replaces the wild-type population o

8 ded direct evidence of a parallel boost of 2 clonally and functionally related B-cell subsets of shor

9 therapies and persist in patients, diversify clonally and serve as reservoirs to drive relapse, recur

10 Each symplasmatum develops clonally and stochastically from a single bacterium into

11 le independent NSCLC cohorts, occurring both clonally and subclonally.

12 Clonally arrayed sequenced collections of bacterial stra

13 In a PCR tube, millions of clonally barcoded beads are used to uniquely barcode lon

14 the most abundant clonal genotypes, even in clonally complex and rapidly evolving cases.

15 led the anti-BK virus antibody repertoire as clonally complex with respect to immunoglobulin sequence

16 Single secretory cells clonally dedifferentiated into multipotent stem cells wh

17 ata also show that the CD4+ T cells that are clonally deleted experienced only slightly stronger T-ce

18 and hydrophobic amino acids in CDR3beta, and clonally deletes TCRs with cysteines in their CDR3 pepti

19 cytes at single cell resolution, we isolated clonally derived adipocytes from stromal vascular fracti

20 nt intestinal cellular pool, we transplanted clonally derived BMSCs into fetal sheep.

21 ibition of MET kinase activity from a single clonally derived cancer cell line.

22 Two distinct and clonally derived CCs, CC1 and CC2, were used for this st

23 Using clonally derived colonic epithelia, we show that toxins

24 onal HSCs over 1 month, although analysis of clonally derived cultures suggests that there is conside

25 tions in vitro or transplantation into mice, clonally derived EP cells differentiate into numerous en

26 t alternative histological phenotypes can be clonally derived from a common cell of origin.

27 However, through clonally derived help, this population acquired a polyfu

28 pared with autologous control erythroblasts, clonally derived JAK2V617F-positive erythroblasts from M

29 Analysis of clonally derived JAK2V617F-positive erythroblasts from M

30 In addition, clonally derived KO pNSCs and dNSCs displayed impaired p

31 Clonally derived PECAM1(+) tumour cells coalesce to form

32 d drug sensitivity and marker segregation in clonally derived second-generation progeny, and identifi

33 lodysplastic syndromes and secondary AML are clonally derived.

34 esis, we developed a mathematical model of a clonally descended bacterial population undergoing HDT t

35 aled the frequent within-host coexistence of clonally descended cells that differed in their MGE infe

36 ating single-cell proteome measurements with clonally determined lymphoid, neutrophilic/monocytic, an

37 equences, and suggests that the formation of clonally developing clusters may often be the first step

38 Yet when competed directly, clonally developing snowflake yeast rapidly displaced ag

39 be uniform, favoring the role of peripheral, clonally directed antitumor immunity as a key mediator o

40 ecently formed and long-lived PCs drawn from clonally disparate precursors.

41 ablasts that re-emerge in these subjects are clonally distinct and exhibit enhanced somatic hypermuta

42 hat foreign Ag-specific nTregs and Tconv are clonally distinct and that foreign Ag-specific nTreg pop

43 nity, Plumlee et al. (2013) demonstrate that clonally distinct CD8 T cells have the ability to genera

44 ng microenvironment, and cooperation between clonally distinct cell populations, can contribute to th

45 derived parts of the heart, neck muscles are clonally distinct from these muscles and define a third

46 led that individual tumour foci can arise as clonally distinct lesions with no shared driver gene alt

47 These clonally distinct MDSC overproduce hematopoietic suppres

48 The activation states are clonally distinct, stable across cell division and devel

49 ILCs lack clonally distributed antigen receptors characteristic of

50 The interaction between clonally distributed inhibitory receptors and their acti

51 compete for binding to TNF, the response is clonally diverse and involves multiple epitopes on adali

52 an intrinsic functional property acquired by clonally diverse B cells.

53 heral blood plasmablasts are normally highly clonally diverse but the antibodies they encode are appr

54 with resulting transcriptional phenotypes in clonally diverse cancer populations.

55 es highlight the roles of recently expanded, clonally diverse CD4(+) T cells and innate effectors in

56 For these clonally diverse metastases, under typical metastasis gr

57 e-MHC ligand and thereby the generation of a clonally diverse public T cell response to CMV.

58 ve capacity, allowing aged muscle to mount a clonally diverse, albeit diminished, response to injury.

59 The resulting clonally enriched ECs behaved like ECs, as measured by i

60 ways; and (iv) APOBEC-induced mutagenesis is clonally enriched in chemotherapy-treated urothelial car

61 best of our knowledge, the first report that clonally enriched primitive ECs promote occlusive pulmon

62 ified two previously unrecognized subsets of clonally, epigenetically, functionally, phenotypically a

63 Myeloid leukemia in Down syndrome (ML-DS) clonally evolves from transient abnormal myelopoiesis (T

64 The dynamics of genetic diversity in large clonally evolving cell populations are poorly understood

65 cterial pathogens currently rely on tracking clonally evolving lineages.

66 During immune responses, B lymphocytes clonally expand and undergo secondary diversification of

67 We recently showed that ductal cells clonally expand as self-renewing liver organoids that re

68 y of hematopoietic tissue and the ability to clonally expand hematopoietic progenitors in vitro has p

69 ntracellular lifestyle during which bacteria clonally expand into multicellular bacterial communities

70 f the TCR to an antigen-MHC complex, T cells clonally expand to establish an immune response.

71 n to generate supereffector CD8 T cells that clonally expand to greater levels, survive longer, and p

72 Autoreactive B cells clonally expand, isotype switch, and mutate--properties

73 ages, this conversion strategy can generate clonally expandable cell populations with a variety of p

74 NSCs are clonally expandable, genetically stable, and easily tran

75 , antigen-specific PD1(+)ICOS(+) cTfh subset clonally expanded after booster immunization whose frequ

76 itat, could, in principle, lead to localized clonally expanded aggregates composed of one or a few ta

77 patients with Goodpasture disease display a clonally expanded alpha3135-145-specific CD4(+) T-cell r

78 T cells in old brains are clonally expanded and are generally distinct from those

79 t PD-1-expressing T(RM) cells in tumors were clonally expanded and enriched for transcripts linked to

80 Furthermore, these PCs were clonally expanded and showed signs of affinity maturatio

81 Patient-specific iPSCs were then generated, clonally expanded and validated.

82 OCBs are locally produced by clonally expanded antigen-experienced B cells and theref

83 FACS-sorted adult human ductal cells clonally expanded as spheres in culture, while retaining

84 Clonally expanded blood cells that contain somatic mutat

85 Clonally expanded CD19(+)CD27(+)CD20(-)CD38(hi) plasmabl

86 that induction generates successive waves of clonally expanded CD4(+), CD8(+) and gammadelta(+) T cel

87 These results show that clonally expanded CD4(+)T cells can be a reservoir of in

88 -1 DNA sequences that were derived from such clonally expanded CD4+ T cells constituted 62% of all an

89 compatibility complex library of some of the clonally expanded CD8(+) T cells inhibit disease by supp

90 sequencing in a third cohort, we discovered clonally expanded CD8(+) T(EMRA) cells in the cerebrospi

91 sequencing of 2752 CSF cells, we identified clonally expanded CD8+ T cells, plasmablasts, and, to a

92 y dramatically shortening the time to obtain clonally expanded cell colonies.

93 It is not known if any of the clonally expanded cells carry replication-competent prov

94 clouds our assessment of the degree to which clonally expanded cells harbor infectious viruses, and t

95 Clonally expanded cells make up a large and increasing f

96 archival origin among highly differentiated, clonally expanded cells.

97 About 40% of the integrations were in clonally expanded cells.

98 nd BACH2; many of these integrations were in clonally expanded cells.

99 We measured the size of clonally expanded deletions in 62 small and 60 large ind

100 en individual iPSC lines from each tissue or clonally expanded fibroblasts carried an elevated load o

101 Clonally expanded G-allele(+) T cells exhibit an unconve

102 of the fact that subclonal SE mutations are clonally expanded in B cell lymphomas, our studies also

103 n normal esophagus (NE) or BE and were later clonally expanded in BE or in EAC.

104 rring even in histologically NE cells may be clonally expanded in esophageal adenocarcinogenesis.

105 are preferentially enriched and potentially clonally expanded in hepatocellular carcinoma (HCC), and

106 lthough germline TCRs were more abundant and clonally expanded in patients with OS, nongermline seque

107 ermore, isolated Lgr5(+) hepatoblasts can be clonally expanded in vitro into embryonic liver organoid

108 SF B cells are driven to an inflammatory and clonally expanded memory and plasmablast/plasma cell phe

109 idogenic Ig light chain (LC) secreted from a clonally expanded plasma cell.

110 LCs are secreted from clonally expanded plasma cells, generally as disulfide-l

111 tasis from a class 1B UM is infiltrated with clonally expanded plasma cells, indicative of antibody-m

112 her T cells infiltrating AAA lesions contain clonally expanded populations of T cells, we amplified b

113 At time points 1 and 2, such clonally expanded populations were found predominantly i

114 A shortcoming of this model is that clonally expanded precursor lesions do not always belong

115 could be populations of infected cells that clonally expanded prior to and/or during ART, some of wh

116 verse repertoires of healthy individuals and clonally expanded repertoires from individuals with chro

117 clear transfer, Hazen et al. (2016) examined clonally expanded single neurons for mutations and found

118 to that of the host gene, the proportion of clonally expanded sites, and the proportion located with

119 The data indicate that dividing clonally expanded T cells contain defective proviruses a

120 Clonally expanded T cells represented the majority of al

121 In contrast to nonexpanded T cells, clonally expanded T cells showed characteristics of acti

122 ; ii) T-cell repertoire was restricted; iii) clonally expanded T cells were present in all patients.

123 V(D)J analysis shows clonally expanded T cells, indicating that they are capa

124 ave A68/NP(145)(+)CD8(+) memory T cells with clonally expanded TCRalphabetas, while low-responders di

125 de screens to demonstrate the specificity of clonally expanded TCRs in the cerebrospinal fluid of pat

126 The authors identified an enrichment of clonally expanded Th1 cells containing intact HIV-1 prov

127 fresh RCCs showed that EM T cells were more clonally expanded than CM or naive T cells, and the clon

128 clones in a typical stem cell library can be clonally expanded to billions of cells in a few weeks wh

129 system in MS, with a notable contribution of clonally expanded TRM-like CD8+ cells.

130 also accurately identifies the repertoire of clonally expanded tumor-reactive cells and reveal a dual

131 Sequencing the clonally expanded Vh7 revealed signs of somatic hypermut

132 s selectively expressed on highly activated, clonally expanded, but phenotypically exhausted CD8+ T c

133 ve) hERM cells derived by fluorometry can be clonally expanded, can grow organoids, and express the m

134 We hypothesized that clonally expanded, class-switched IgG4-positive B cells

135 ecognition are selectively retained, but not clonally expanded, during aging.

136 Clonally expanded, HIV-1-infected cells were detectable

137 tifiers (UMIs) that allowed for screening of clonally expanded, individually tagged cells.

138 +) T cells from Mtb-infected CBA/J mice were clonally expanded, preferentially expressing T cell rece

139 ppressed, and positively selected thymocytes clonally expanded, resulting in a small thymus with a he

140 Clonally expanded, somatically hypermutated IgM+ and IgG

141 imab were predominately isotype-switched and clonally expanded, whereas the inverse was true for B ce

142 iple cytotoxic CD4(+) T cell states that are clonally expanded.

143 nd also at the inflamed site, where they are clonally expanded.

144 remained highly stable as the tumour masses clonally expanded.

145 d genes, rapidly produce cytokines, and have clonally expanded.

146 d cells in patients on long-term therapy are clonally expanded; in some cases the integrated viral DN

147 Some of these CD4(+)T cells are clonally expanded; most of the proviruses are defective.

148 maturation in normal and malignant skin and clonally-expanded antibodies in melanoma, support the in

149 l signature present in acutely activated and clonally-expanded T cells that become committed to the m

150 These clonally expanding populations of HIV-infected cells may

151 ular disease, these studies suggest that the clonally expanding SMC may represent a translational tar

152 plore the structural features that allow the clonally expressed TCR to functionally engage with multi

153 ues, occasionally caught in the act of being clonally fixed in the adjacent tumors.

154 ocytosis or thrombocytosis, can be initiated clonally from a single cell carrying JAK2-V617F.

155 regation (GPR-1) provides a germline derived clonally from a single parental gamete.

156 d HSCs and analyses of their perpetuation in clonally generated progeny HSCs have now provided defini

157 ephrogenesis demonstrates that Troy(+) cells clonally give rise to tubular structures that persist fo

158 inizing and modeling microscopically tracked clonally growing populations before and after a semi-let

159 ial to control myeloma and other genetically/clonally heterogeneous cancers.

160 sTR probabilistically classifies isolates as clonally heterogeneous or mixed by using a model of tand

161 Cancers are often clonally heterogeneous, and the detection of subclonal m

162 ng clinical applications which often rely on clonally-homogeneous cell populations.

163 Each of the huge number of clonally independent B cells expresses a unique set of I

164 We confirm that the tumours are clonally independent, having distinct somatic single-nuc

165 utations (SNPs) in aligned pairs distinguish clonally inherited regions from regions where either gen

166 .IMPORTANCE The MCPyV genome was found to be clonally integrated in 80% of cases of Merkel cell carci

167 Merkel cell carcinomas (MCCs) that harbor a clonally integrated Merkel cell polyomavirus (MCV) genom

168 op and self-organize into cardiac tissues by clonally isolating and expanding second heart field card

169 c dermatitis are significantly less mutated, clonally less focused, and less indicative of Ag selecti

170 In contrast, clonally marked mature hepatocytes demonstrated the abil

171 X2 and strongly for NANOG, can be propagated clonally on either Matrigel or gelatin, and are morpholo

172 ctivating mutation, which is somatically and clonally present in almost all patients through the enti

173 We show that two morphs clonally produced by the aphid Paracletus cimiciformis d

174 The BCSP clonally produces chondrocytes (cartilage-forming) and o

175 r persistence, but the contribution of these clonally proliferating cells to the rebounding virus is

176 een blueberry root transcriptomes from eight clonally propagated blueberry plants of cultivar 'Emeral

177 Genetic progress in this clonally propagated crop can be accelerated through the

178 As a clonally propagated crop, cassava is especially vulnerab

179 Domestication of clonally propagated crops such as pineapple from South A

180 a one-step operation in the domestication of clonally propagated crops.

181 asexual domestication trajectories in other clonally propagated crops.

182 olistic view of the genome organization of a clonally propagated diploid species and provides insight

183 e study population was a large collection of clonally propagated F1 hybrid lines of Populus that satu

184 rom grapes (Vitis vinifera ssp. vinifera), a clonally propagated perennial crop, to address three ong

185 Whole-genome sequencing of clonally propagated rearrangements identified random pat

186 espread genotyping makes cassava a model for clonally propagated root and tuber crops in the developi

187 rieties in farmers' fields, using cassava, a clonally propagated root crop widely grown in the tropic

188 ommon East Asian tree species introduced and clonally propagated since prehistoric times across the P

189 served in a number of species, especially in clonally propagated species.

190 ts are underway to transform the crop from a clonally propagated tetraploid into a seed-propagated, i

191 cp-17-carrying Oceanic paper mulberries are clonally propagated, our data concur with expectations o

192 existence of eukaryotes is best described by clonally propagating cell lines with episodic sex trigge

193 The majority of sites were clonally pure or composed of clones from a single phylog

194 In this study, we assessed two clonally purified E. chaffeensis mutants with insertions

195 at possess the BCR-ABL1(+) translocation and clonally recombined VDJ regions.

196 As a consequence, nestmates are almost clonally related (r = 0.996).

197 nowledge, we found that a restricted pool of clonally related B cells participated in robust bidirect

198 The target antigen or antigens of these clonally related B cells remain unknown; our work contin

199 point to a CSF antigen-driven activation of clonally related B cells that shape the intrathecal immu

200 enhanced transcriptional similarity between clonally related B cells, as well as distinct transcript

201 lusters that might represent the most active clonally related B-cell populations.

202 Cases 2 and 3 were designated as clonally related based on overlapping copy number altera

203 pe with the same amino acid replacement were clonally related by descent.

204 nd that each ASC isotype contained a unique, clonally related CDR3 repertoire.

205 and greater transcriptional complexity than clonally related cell types in the central and periphera

206 However, clonally related cells often share SHMs which have been

207 anocytes spread throughout skin as fields of clonally related cells that are invisible to the naked e

208 th apoptosis and differentiation initiate in clonally related clusters.

209 Hence, clonally related composite lymphomas are elegant models

210 ple clones were detected with 16 clusters of clonally related CRAB.

211 For patients with clonally related DLBCL, induction therapy with either an

212 Clonally related enteric neurons exhibit synchronous act

213 Moreover, in the absence of TBR2, clonally related excitatory neurons become more laterall

214 Here, we show that clonally related excitatory neurons in the developing hi

215 Clonally related excitatory neurons maintain a coherent

216 terize the cell types and circuit diagram of clonally related excitatory neurons, we performed multi-

217 is of lineage trees constructed from sets of clonally related Ig sequences.

218 cell development and concomitantly elicited clonally related IgA(+) plasma cells in the small intest

219 tools to address this question, finding that clonally related inhibitory interneurons dispersed widel

220 ther analysis of the spatial distribution of clonally related interneurons and demonstrate that inter

221 puter simulation, Sultan et al. suggest that clonally related interneurons are "not randomly disperse

222 ic retroviral barcode labeling, we find that clonally related interneurons can be widely dispersed wh

223 Moreover, the regional distribution of clonally related interneurons exhibits a clear clusterin

224 As such, it is likely that clonally related interneurons have considerable flexibil

225 Two previous studies suggest that clonally related interneurons originating from individua

226 es and propose a new interpretation, whereby clonally related interneurons would be considered cluste

227 ly by short-lived PCs with repopulation from clonally related memory B cells.

228 Similarly to TG2-specific PCs, clonally related memory IgA B cells of blood showed lowe

229 osits that the ontogenetic columns formed by clonally related neurons migrating along the same radial

230 label neuronal progenitors and observed that clonally related neurons receive synaptic input from olf

231 Mutations common to tumors and clonally related PanIN2 and PanIN3 lesions were identifi

232 transformation and cell-cell killing within clonally related populations, as the consequences of int

233 solates, we were able to investigate whether clonally related Pseudomonas aeruginosa inhabiting diffe

234 sequence to improve the ability to identify clonally related sequences.

235 ding of RNA polymerase II in these adjacent, clonally related stem cells within intact Drosophila bra

236 that MM composes 4 hierarchically organized, clonally related subpopulations, which, although phenoty

237 ) were more abundant in humans than mice and clonally related to a large repertoire of memory IgM(+)

238 ese phenotypically resembled GCTfh, and were clonally related to a resting PD1(+)ICOS(-) CD4(+) memor

239 evealed an Env-IM cross-reactive Ab that was clonally related to a subsequent vaccine-induced gp41-re

240 revealed that ST459 isolates from Canada are clonally related to colonizing and invasive ST459 organi

241 The sequences clonally related to known antibodies with binding affini

242 monstrate that the trapezius muscle group is clonally related to myocardium at the venous pole of the

243 onstrated the Houston patient isolates to be clonally related to one another but distantly related to

244 n environmental clade (ST3, N = 17 isolates) clonally related to the pandemic O3:K6 complex and a cli

245 ed with a very poor outcome, especially when clonally related to the preexisting CLL, the mechanisms

246 The resultant cells were clonally related to the primary leukemic blasts but rese

247 80% of DLBCL cases in patients with CLL are clonally related to the underlying CLL, and the median s

248 eloped acute myeloid leukemia (AML) that was clonally related to their B-ALL, a novel mechanism of CD

249 In clonally related tumors, chromosomal copy number changes

250 s M. abscessus subspecies abscessus and were clonally related within each patient.

251 Abs from these subsets were clonally related, suggesting a common origin.

252 ivergent Poncirus accessions are found to be clonally related, supporting a previous conjecture that

253 majority of serotype IV isolates (89%) were clonally related, tetracycline-, erythromycin-, and clin

254 pressing cTfh and tonsillar GCTfh cells were clonally related.

255 of B cells; half of the IgVH sequences were clonally related.

256 atients, different bands comprising OCBs are clonally related.

257 mas and Hodgkin's lymphomas, the tumours are clonally related.

258 suggesting that the individual mAbs are not clonally related.

259 Air and clinical isolates were found to be clonally related.

260 asis of the other, i.e. where the tumors are clonally related.

261 lls, proliferate to expand a small number of clonally relevant lymphocytes, differentiate to antibody

262 tion of loblolly pine (Pinus taeda) that was clonally replicated at three sites in the southeastern U

263 a quantitative trait mapping experiment in a clonally-replicated full-sibling family of loblolly pine

264 lity, but can be more accurately assessed in clonally-replicated plantings where each genotype is rep

265 ent Bmi1(+) ISCs dramatically proliferate to clonally repopulate multiple contiguous crypts and villi

266 last populations at diagnosis and were fully clonally represented at relapse, identifying these rare

267 enotyping of the diagnostic biopsy to detect clonally represented somatic tumor mutations and is a re

268 e developmental plasticity, allowing them to clonally reproduce and to repair tissues following wound

269 antigen-presenting cells in that they have a clonally restricted antigen-specific receptor, the B cel

270 binding to endothelial protein C receptor, a clonally restricted autoantigen, with minimal CDR1, CDR2

271 Clonally restricted hematopoiesis is associated with an

272 These lymphomas were heavily infiltrated by clonally restricted T cells and frequently downregulated

273 Unlike GC B cells, which are clonally restricted, T(FH) cells distributed among all G

274 daptate" biology: an integration of adaptive clonally-restricted specificities, innate tissue-sensing

275 We hypothesized that clonally selected ECs expressing the progenitor marker C

276 ept suggests that unchecked proliferation of clonally selected precursors of endothelial cells (ECs)

277 ity promotes structural alterations that are clonally selected to drive tumor development.

278 Although VCGs reproduce clonally, significant diversity exists within VCGs.

279 ing Tfh cells that are transcriptionally and clonally similar to germinal center Tfh cells.

280 (Saccharomyces cerevisiae) to develop either clonally ("snowflake"; Deltaace2) or aggregatively ("flo

281 cogenic mutation could bias this process and clonally spread the mutation throughout the stem cell po

282 ommunity of hundreds of nuclei and reproduce clonally through large multinucleated spores.

283 and could enable the maintenance of hybrids clonally through seed propagation(5,6).

284 We clonally trace thousands of cells from cancers, linking

285 Here, we used expressed DNA barcodes to clonally trace transcriptomes over time and applied this

286 Clonally transmissible cancers are somatic cell lineages

287 ntrast, the remaining 20% of patients have a clonally unrelated DLBCL and have a prognosis similar to

288 arly, the probability of harboring multiple, clonally unrelated fields at the time of diagnosis was f

289 sequencing confirmed the presence of a STIC clonally unrelated to 1 case of UEC, and NGS of the othe

290 ases engender a new myeloid neoplasm that is clonally unrelated to the recipient's original AML.

291 bined B-cell non-Hodgkin lymphomas are often clonally unrelated.

292 malaria parasite Plasmodium falciparum show clonally variant expression regulated at the epigenetic

293 A peculiar case of clonally variant genes are the 2 nearly identical clag3

294 together, our findings support the idea that clonally variant genes facilitate the adaptation of para

295 -infected erythrocytes, is a major family of clonally variant targets of naturally acquired immunity

296 lciparum Ags are extraordinarily diverse and clonally variant, which likely contribute to the ineffic

297 c multicellular collectives, or they develop clonally via mother-daughter cellular adhesion.

298 ghly motile and a fraction of HSCs expanding clonally within spatially restricted domains.

299 ture, melanin-producing melanocytes expanded clonally within the epidermis before losing their differ

300 later divisions in the DLN could self-renew, clonally yielding a TCF1-silenced daughter cell as well