ライフサイエンスコーパス: clonic

1 ed awareness versus focal to bilateral tonic-clonic.

2 tic consequences of focal to bilateral tonic-clonic.

3 /12), myoclonic (5/12) and generalized tonic-clonic (1/12) or atonic (1/12) seizures.

4 history of generalised-onset seizures (tonic-clonic 99.6%; myoclonic 38.8%; absence 37.2%).

5 ximately half of patients, and include tonic-clonic, absence, and myoclonic seizures, including statu

6 also associated with more prehospital tonic-clonic activity (22.7% vs 4.2%; P < .001) and cardiopulm

7 physiological sparse and pathological tonic-clonic activity may coexist in the same cortical network

8 how that the highest synchrony occurs during clonic ADs, consistent with the idea that specific circu

9 sent study examined the neuronal network for clonic AGS in GEPR-3s by microinjecting a competitive NM

10 upport a critical role for NMDA receptors in clonic AGS modulation.

11 The brainstem nuclei of the clonic AGS network are identical to those subserving ton

12 re implicated as requisite components of the clonic AGS network, and these data support a critical ro

13 ver, the requisite involvement of AMG in the clonic AGS network, which is not seen in tonic AGS, is s

14 The neuronal network for clonic AGS remains to be investigated.

15 xhibiting tonic AGS, and GEPR-3s, exhibiting clonic AGS.

16 differences between focal to bilateral tonic-clonic and focal impaired awareness for a marker validat

17 aired awareness and focal to bilateral tonic-clonic and may account for the more negative prognostic

18 enetetrazole (PTZ)-induced generalized tonic-clonic and myoclonic seizure incidence and severity.

19 or learning difficulty, occurrence of tonic-clonic and non-tonic-clonic seizures in the 3 months bef

20 iors that were bilateral or unilateral tonic-clonic and nonconvulsive in this model.

21 izure approximately 20 s after injection was clonic and showed no EEG changes.

22 ts important mechanistic differences between clonic and tonic forms of AGS.

23 e-like seizures but decreased propensity for clonic and tonic seizures.

24 Susceptibility to clonic and tonic-clonic flurothyl-induced seizures posit

25 llenged with flurothyl and the threshold for clonic and tonic-clonic seizures was determined.

26 Thresholds for flurothyl-induced clonic and tonic-clonic seizures were determined.

27 loped seizures (primarily generalized, tonic-clonic, and atonic) that began on average at 6.8 months

28 types, including absence, generalised tonic-clonic, and complex partial seizures, converge on the sa

29 nic, clonic, tonic-atonic, generalised tonic-clonic, and focal with clearly observable motor signs),

30 ure began 3-4 min after injection, was tonic-clonic, and had EEG spike-wave activity.

31 haracterized by myoclonic, generalized tonic-clonic, and in 30% of patients, absence seizures.

32 ralised tonic-clonic, complex partial, focal clonic, and infantile spasms.

33 l tonic, generalised tonic-clonic, bilateral clonic, atonic, or focal to bilateral tonic-clonic) per

34 ne rats (GEPR-3s) exhibits generalized onset clonic audiogenic seizures (AGS), but following repetiti

35 clonic but decreases susceptibility to tonic-clonic bicuculline seizures in intact male rats.

36 efined as bilateral tonic, generalised tonic-clonic, bilateral clonic, atonic, or focal to bilateral

37 he model and in humans, the time between two clonic bursts increased exponentially from the start of

38 t prenatal morphine exposure does not affect clonic but decreases susceptibility to tonic-clonic bicu

39 ultiple forms of epilepsy (generalized tonic-clonic, complex partial, absence seizures), including re

40 TBC1D24 mutations included generalised tonic-clonic, complex partial, focal clonic, and infantile spa

41 -47 sec), seizure-like bursts with tonic and clonic components occurred spontaneously (53%) or in res

42 perhaps contributing to the limbic and tonic-clonic components of the observed epileptic phenotype.

43 onsciousness during focal to bilateral tonic-clonic consist of paradoxical increases in cortical acti

44 e first stage 6 seizure or generalized tonic-clonic convulsion (GTC).

45 eceptor antagonist CGP 35348 prevented tonic-clonic convulsions and significantly enhanced survival o

46 This compound did not cause tonic-clonic convulsions in mice, had a good pharmacokinetic p

47 ugh mice toxicity studies, we observed tonic-clonic convulsions in several mice at high doses.

48 This was manifested by (1) generalized tonic-clonic convulsions with multiple failings, which were el

49 nkgotoxin-5-glucoside cause poisoning, tonic-clonic convulsions, and neurotoxic effects.

50 ion between oral automatisms and generalized clonic convulsions.

51 -18 years with partial and generalised tonic-clonic epilepsy were identified by population screening.

52 Susceptibility to clonic and tonic-clonic flurothyl-induced seizures positively correlated

53 terminal value of the log-linear fit of the clonic frequency decrease was correlated with the presen

54 ed awareness and 50 focal to bilateral tonic-clonic from 41 patients.

55 tic marker CD68 and focal to bilateral tonic-clonic generalized seizure history.

56 rile seizures consisted of generalized tonic-clonic, generalized tonic, generalized atonic, simple pa

57 ized by a combination of myoclonic and tonic-clonic (GTC) seizures.

58 Subject 3 had atonic onset followed by clonic hand/arm flexion.

59 ocortical and entorhinal networks show tonic-clonic-like events, but the main hippocampal territories

60 Thresholds for minimal clonic, maximal tonic, or psychomotor (partial) seizures

61 ularis oculi (OO) spasms and 18 patients had clonic OO spasms) and 8 patients with IB were included i

62 titive, rhythmic burst discharges, either as clonic or spike-wave activity, again mediated both by in

63 clonic, atonic, or focal to bilateral tonic-clonic) per 28 days in each 4-week period of an 8-week h

64 ow voltage fast activity onset, tonic phase, clonic phase and postictal suppression.

65 activation of PV(+) interneurons during the clonic phase generated excitatory GABAergic responses in

66 logical network hyperexcitability during the clonic phase of seizures.

67 ncreased exponentially from the start of the clonic phase of the seizure.

68 an initial tonic phase, followed by a longer clonic phase that is characterized by rhythmic bouts of

69 ons reduced the occurrence of ADs during the clonic phase.

70 ctivity analysis of focal to bilateral tonic-clonic revealed sustained increases in cortical firing r

71 seizure (1.3 [1.1 to 1.6]), and first tonic-clonic seizure (1.5 [1.2 to 1.8]).

72 onsive to fenfluramine was generalized tonic-clonic seizure (120 of 263 [46%]), with a decrease in fr

73 th new-onset seizure was a generalized tonic-clonic seizure (72 [33%]).

74 gh risk of SUDEP (with >=1 generalised tonic-clonic seizure [GTCS] per year), low risk of SUDEP (no h

75 lete and reversible blockade of only the F&F clonic seizure behavior was induced by AP7 (1 and 7.5 nm

76 Only 17 of these had a tonic-clonic seizure during follow-up.

77 ents with different focal to bilateral tonic-clonic seizure histories.

78 ere was an increase in the flurothyl-induced clonic seizure threshold (anticonvulsant effect) in the

79 ere was an increase in the flurothyl-induced clonic seizure threshold after an E injection alone whil

80 ction alone while there was a reduced tonic--clonic seizure threshold in the presence of both hormone

81 ctrical stimulation until the first forelimb clonic seizure was induced.

82 can provide notification of an ongoing tonic-clonic seizure, or peace of mind in the absence of notif

83 f eclampsia, as defined by a witnessed tonic-clonic seizure.

84 he experienced a witnessed generalized tonic-clonic seizure.

85 our institution, she had a generalized tonic-clonic seizure.

86 to first seizure of any type and first tonic-clonic seizure.

87 urring during, or immediately after, a tonic-clonic seizure.

88 on phase of the experiment, only generalized clonic seizures ("forebrain seizures") were expressed.

89 rile seizures (7/29, 25%), generalized tonic-clonic seizures (5/29, 17%), and focal-onset seizures (3

90 10 suppressed minimal clonic seizures (6 Hz mouse model) without typical rotar

91 myoclonus (all patients), generalized tonic-clonic seizures (all patients) and complex partial seizu

92 n to sound stimuli-induced generalized tonic-clonic seizures (audiogenic reflex seizures) and is a va

93 y (JAE), and epilepsy with generalized tonic clonic seizures (EGTCS).

94 ocal epilepsy, with focal to bilateral tonic-clonic seizures (FBTCS+) a more severe form of the disor

95 (JME), one predisposing to generalized tonic-clonic seizures (GTCS) and a second to myoclonic seizure

96 zed with the algorithm: 25 generalized tonic-clonic seizures (GTCSs) from 11 patients, and 19 episode

97 partial seizures (PSZ) and generalized tonic-clonic seizures (GTSZ) with and without structural heart

98 le childhood epilepsy with generalized tonic-clonic seizures (ICEGTC), which bears similarity to SMEI

99 impaired awareness seizures (FIAS) and tonic-clonic seizures (TCS) over 6.5 months.

100 ice) exhibited spontaneous generalized tonic-clonic seizures (which occurred in the absence of cardia

101 epilepsy and epilepsy with generalized tonic-clonic seizures alone.

102 prefrontal cortex are associated with tonic-clonic seizures and a normal survival rate.

103 res, and 1 had 4 witnessed generalized tonic-clonic seizures and approximately 30 suspected generaliz

104 ers manifesting with action myoclonus, tonic-clonic seizures and ataxia.

105 poral lobe epilepsy, and epilepsy with tonic-clonic seizures and cognitive regression.

106 timated lifetime number of generalized tonic-clonic seizures and functional cluster membership was as

107 Moreover, incidence of tonic clonic seizures and hindlimb extension were reduced in w

108 epilepsy with early onset, generalized tonic-clonic seizures and juvenile lethality by 3 weeks of age

109 hildhood absence epilepsy, generalized tonic clonic seizures and the epileptic encephalopathy, Dravet

110 frequent myoclonic jerks, generalized tonic-clonic seizures and, less commonly, absences.

111 Generalized tonic-clonic seizures are among the most dramatic physiologica

112 Focal to bilateral tonic-clonic seizures are associated with lower quality of lif

113 mes in which generalized myoclonic and tonic-clonic seizures are expressed.

114 Generalised tonic-clonic seizures are the greatest risk factor for SUDEP;

115 s of GABA metabolism, and one in which tonic-clonic seizures associate with increased central nervous

116 , neurological insult, total number of tonic-clonic seizures before randomisation, seizure type and t

117 7-11.1], history of focal to bilateral tonic-clonic seizures before surgery (aHR 1.6, 95% CI 0.9-2.8)

118 ifference in occurrence of generalized tonic-clonic seizures between groups was 0.3% (95% CI = +/-8.6

119 , and all homozygotes exhibited lethal tonic-clonic seizures by mid-third week.

120 g the networks involved in generalized tonic-clonic seizures can provide insights into mechanisms of

121 ed early onset spontaneous generalized tonic-clonic seizures concurrent with a significant reduction

122 Tonic-clonic seizures developed spontaneously after 5 months o

123 e with EEG abnormality were at risk of tonic-clonic seizures during follow-up compared with 16% of th

124 ining three had infrequent generalized tonic-clonic seizures during nocturnal sleep.

125 ted with afebrile focal or generalized tonic-clonic seizures during the first to second year of life;

126 Fewer generalized clonic seizures failed to reliably produce changes in se

127 ltered if (1) a minimum of eight generalized clonic seizures had been expressed, and (2) a minimum of

128 ion, decreased spontaneous generalized tonic-clonic seizures in a model of temporal lobe epilepsy, an

129 ic hyperactivity immediately following tonic-clonic seizures in DS mice, which leads to lethal bradyc

130 astic behaviors and eventually induces tonic-clonic seizures in rodents.

131 ty, occurrence of tonic-clonic and non-tonic-clonic seizures in the 3 months before pregnancy, previo

132 miR-335-5p increased susceptibility to tonic-clonic seizures in the pentylenetetrazol seizure model,

133 seizures are at low risk of subsequent tonic-clonic seizures in the period of time to which therapeut

134 ivation after focal motor to bilateral tonic-clonic seizures in the striatum, globus pallidus externu

135 fects of treatment on the frequency of tonic-clonic seizures in those patients with such pre-randomis

136 pothalamic brain sites following generalized clonic seizures induced by kainic acid.

137 greater latency and lower incidence of tonic-clonic seizures induced by pentylenetetrazol (PTZ; 70 mg

138 ent episodes of unprovoked generalized tonic-clonic seizures lasting 2-3 minutes that spontaneously r

139 ent episodes of unprovoked generalized tonic-clonic seizures lasting 2-3 minutes that spontaneously r

140 aired awareness and focal to bilateral tonic-clonic seizures may also help us to understand their dif

141 SPECT from 59 secondarily generalized tonic-clonic seizures obtained during epilepsy surgery evaluat

142 (JME), epilepsy with only generalized tonic-clonic seizures occurring either randomly during the day

143 e absence epilepsy, five patients with tonic-clonic seizures on awakening and 30 control subjects had

144 epsy and two out of five patients with tonic-clonic seizures on awakening, but in none of the 30 cont

145 le absence epilepsy, and epilepsy with tonic clonic seizures only under the sole heading of idiopathi

146 Because generalised tonic-clonic seizures precede most cases of SUDEP, patients mu

147 onsciousness during focal to bilateral tonic-clonic seizures remain unclear.

148 Daily flurothyl-induced generalized clonic seizures resulted in a progressive decrease in bo

149 MP6s but not GCaMP6f in the DG induces tonic-clonic seizures several weeks after viral injection.

150 six patients experiencing generalized tonic-clonic seizures showed marked improvement, three showed

151 rter latencies to onset of generalized tonic-clonic seizures than controls.

152 used in the MESS study are greater for tonic-clonic seizures than they are for partial seizures.

153 fractory partial-onset and generalized tonic-clonic seizures that acts as a selective negative allost

154 h the remaining 7-12% comprising generalized clonic seizures that transition into brainstem seizures.

155 ine, and he continued to have frequent tonic-clonic seizures throughout his life.

156 reasing latency of pilocarpine-induced tonic-clonic seizures upon in vivo coelenterazine administrati

157 in is unusually sensitive to recurrent tonic-clonic seizures upon routine handling and to seizures in

158 othyl and the threshold for clonic and tonic-clonic seizures was determined.

159 igated by metabolic sources of carbon; tonic-clonic seizures were also suppressed by alpha-amino-3-hy

160 impaired awareness, focal to bilateral tonic-clonic seizures were characterized by deeper loss of con

161 holds for flurothyl-induced clonic and tonic-clonic seizures were determined.

162 Preoperative focal to bilateral tonic-clonic seizures were independently associated with seizu

163 es conferring a low threshold to ECT minimal clonic seizures were mapped to the telomeric region of m

164 Tonic-clonic seizures were observed in HAGS animals, while LAG

165 of aged apoE4 TR mice had more severe tonic-clonic seizures which occasionally progressed to tonic e

166 All had generalized tonic-clonic seizures with onset associated with fever, consis

167 normal early development, generalized tonic-clonic seizures with onset at 5-10 years of age, and pro

168 e of the normoglycemic rats, developed tonic-clonic seizures within 12h after ischemia.

169 " (HP: 0011172; p = 2.1 x 10(-5)) and "focal clonic seizures" (HP: 0002266; p = 8.9 x 10(-6)), STXBP1

170 aired awareness, or focal to bilateral tonic-clonic seizures) from baseline analysed in the modified

171 its acoustically triggered generalized tonic-clonic seizures, and often times the EEG, recorded with

172 sease patients present with myoclonus, tonic-clonic seizures, and progressive declines in cognitive a

173 died prematurely following generalized tonic-clonic seizures, and they were equally susceptible to th

174 caused low seizure threshold, sporadic tonic-clonic seizures, brain enlargement and ectopic neurons i

175 age between oral automatisms and generalized clonic seizures, by measuring changes in mRNA expression

176 t paradigm, pentylenetetrazole-induced tonic-clonic seizures, exclude the possibility that the geneti

177 ncreased latencies to forelimb clonus, tonic clonic seizures, hindlimb extension, and death compared

178 sitive histories of focal to bilateral tonic-clonic seizures, including both remote (none for >1 year

179 icate that the higher the frequency of tonic-clonic seizures, the higher the risk of SUDEP; furthermo

180 Wildtypes developed severe tonic-clonic seizures, whereas knockouts had mild seizure acti

181 zures recorded, the majority are generalized clonic seizures, with the remaining 7-12% comprising gen

182 used by kainic acid, in the absence of tonic-clonic seizures.

183 havioral endpoints of epileptogenesis, tonic-clonic seizures.

184 ffective control of focal to bilateral tonic-clonic seizures.

185 t week 3 to 4 of life from generalized tonic-clonic seizures.

186 nique capacity to initiate generalized tonic-clonic seizures.

187 at a mean age of 42 days from massive tonic-clonic seizures.

188 notype consisting of 3/sec absence and tonic-clonic seizures.

189 in focal-to-bilateral and generalized tonic-clonic seizures.

190 ve in managing partial and generalized tonic-clonic seizures.

191 c, myoclonic, absence, and generalised tonic-clonic seizures.

192 ife and overt myoclonic or generalised tonic-clonic seizures.

193 ines displayed spontaneous generalized tonic-clonic seizures.

194 arrays during three focal to bilateral tonic-clonic seizures.

195 y active during periods of generalized tonic-clonic seizures.

196 in patients who experience generalized tonic-clonic seizures.

197 generalized myoclonic and/or bilateral tonic-clonic seizures.

198 nic seizures and relatively infrequent tonic-clonic seizures.

199 approximately 30 suspected generalized tonic-clonic seizures.

200 rogressively severe myoclonus and rare tonic-clonic seizures.

201 ures and to pentylenetetrazole induced tonic-clonic seizures.

202 rred immediately following generalized tonic-clonic seizures.

203 d with the tonic phases of generalized tonic-clonic seizures.

204 le childhood epilepsy with generalized tonic-clonic seizures.

205 ly involved in secondarily generalized tonic-clonic seizures.

206 ions and for impaired consciousness in tonic-clonic seizures.

207 seizures, required ASIC1a to interrupt tonic-clonic seizures.

208 ced threshold to electrically evoked minimal clonic seizures.

209 The first 2 subjects had tonic or clonic semiology with rare secondary generalization.

210 ing hemiclonic, hemitonic, generalized tonic-clonic, simple partial (stereotyped episodes of epigastr

211 in patients with IB and in BSP patients with clonic spasms but not in BSP patients with tonic spasms.

212 BR in patients with IB and in patients with clonic spasms, but not in patients with tonic spasms.

213 ed by multiple transitions between tonic and clonic states.

214 The treatment of tonic-clonic status epilepticus is usually divided into three

215 seizures were defined as hemiclonic, tonic, clonic, tonic-atonic, generalised tonic-clonic, and foca

216 , the addictive component of tobacco, induce clonic-tonic seizures in animals.

217 These include the tonic-clonic transition, slow advance of clinical semiology an

218 oactivity, myoclonic jerks, continuous tonic-clonic), which correlated with regional cFOS expression.