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1 tegrin and DLL1 and were highly adhesive and clonogenic.
6 nal cancer cell lines reduced cell invasion, clonogenic ability, and epithelial-mesenchymal transitio
7 significantly inhibited their proliferation, clonogenic ability, and invasiveness by suppressing extr
8 litaxel-induced senescence, with the loss of clonogenic ability, and the induction of senescence-asso
11 that persistent HGF treatment stimulates the clonogenic activity of ICAM1-positive luminal progenitor
12 used by two mechanisms: (1) decreases in the clonogenic activity of the stem cells and in the endocri
13 ll divisions demonstrates that the increased clonogenic activity resides within the undivided fractio
14 ibited enhanced cell proliferation, elevated clonogenic activity, accelerated anchorage-independent g
19 cally defined as undifferentiated and highly clonogenic ALDH(+)/CD49f(+)/EpCAM(+) luminal progenitors
20 en directly from patients as well as in vivo clonogenic ALL xenograft cells, destroyed the in vivo cl
21 igh nuclear membrane fluctuations are highly clonogenic and also exhibit gene, protein, and functiona
22 apable of propagating tumor growth in both a clonogenic and an orthotopic serial transplantation assa
23 epressed miR, is inhibitory to Ewing Sarcoma clonogenic and anchorage-independent cell growth, even a
24 ing Sarcoma, and that its depletion inhibits clonogenic and anchorage-independent growth in multiple
27 Consistently, Pten silencing exacerbated the clonogenic and invasive potential of Tp53-deficient bone
28 We found PIP4K2A to be essential for the clonogenic and leukemia-initiating potential of human AM
30 ization by GPx2 is essential for maintaining clonogenic and metastatic capacity, but also for the gen
34 essing cells in adult sheath tissues possess clonogenic and multipotent properties comparable to thos
40 In addition, purified Axin2(lacZ) cells were clonogenic and self-renewing in culture in a Wnt-depende
41 human DF-derived epithelial cells possessed clonogenic and sphere-forming capabilities, as well as e
42 nstrate that Notch3 is expressed in a highly clonogenic and transiently quiescent luminal progenitor
43 th the highest Wnt activity exhibited higher clonogenic and tumorigenic potential than pCCSCs with th
46 ulfiram-induced toxicity was investigated by clonogenic assay after treatment of human SK-N-BE(2c) ne
50 tional dose rate radiation using a classical clonogenic assay in murine pancreatic cancer cell lines.
51 this, radiation sensitivity, as measured by clonogenic assay of cultured murine (GL261) and human (U
53 n two lung cancer cell lines and performed a clonogenic assay to examine their role in cell prolifera
61 nd/or radiation that were not apparent in 2D clonogenic assays but that may significantly influence t
64 Radiosensitivity parameters determined by clonogenic assays of mCRC cell lines HT-29 and DLD-1 aft
66 forming unit (BFU-E and CFU-E) colonies, the clonogenic assays that quantify early and late erythroid
67 ive clustering and guide-gene selection, and clonogenic assays to delineate hierarchical genomic and
68 ation, decreased colony-forming potential in clonogenic assays, and delayed disease onset in a mouse
69 cing, FACS purification, and robust in vitro clonogenic assays, have changed our view of their roles
70 low cytometry, cell-sorting, and single-cell clonogenic assays, we identified Lin(-)CD34(+)CD38(+)CD4
72 g unit MK cell numbers twofold vs control in clonogenic assays, without substantially modifying MK ma
77 effectively targeted and eliminated in vivo clonogenic BPL xenograft cells, even at femtomolar-picom
79 geting miR-126 in LSCs and LPs reduced their clonogenic capacity and eliminated leukemic cells, again
80 ate, stem/progenitor cell marker content and clonogenic capacity in the explants but also had the opp
81 cell marker (p63alpha and ABCG2) content and clonogenic capacity in the explants but had opposite eff
82 ncNB1 knockdown abolishes neuroblastoma cell clonogenic capacity in vitro and leads to neuroblastoma
83 CCA cells inhibited their proliferation and clonogenic capacity in vitro, and suppressed tumor xenog
87 lted in chromosomal imbalances and increased clonogenic capacity of liver progenitor cells (LPCs) and
88 rescence-based screen, reduced viability and clonogenic capacity of melanoma cell lines and increased
90 apamycin (mTOR) with rapamycin increases the clonogenic capacity of primary human oral keratinocytes
91 se-3 by a compound, NSC321205, increases the clonogenic capacity of primary oral keratinocytes and ca
92 , a noncleavable isoform of HuR promotes the clonogenic capacity of primary oral keratinocytes and de
93 ted by functional analysis, hPFCs harbor the clonogenic capacity of PSC cultures and emerge prior to
95 ysplasia proliferated less, showed decreased clonogenic capacity, and formed fewer capillary-like net
96 tendon stem cell marker CD146 and exhibited clonogenic capacity, as well as multilineage differentia
101 POR reduced SN30000 reductive metabolism and clonogenic cell death and similarly reduced sensitivity
102 dose rate irradiation more potently induces clonogenic cell death than conventional dose rate irradi
104 3K inhibitor BKM120, as evidenced by reduced clonogenic cell growth and three-dimensional (3D) sphero
108 of p16 on radiosensitivity was determined by clonogenic cell survival and tumor growth delay assays.
113 published high-throughput and high accuracy clonogenic cell-survival data for therapeutic scanned pr
114 rectly sorted (uncultured) or a single-cell (clonogenic) cell population from primary tissue can diff
115 hnology for the generation of 'libraries' of clonogenic cells from 1-mm-diamter endoscopic biopsy sam
117 nin alone results in the formation of highly clonogenic cells that are nonmotile and prone to undergo
118 ls represent a highly enriched population of clonogenic cells--notably, the isolated cells exhibited
120 e reversion of EMT, the loss of TIC-mediated clonogenic colony formation, and the loss of cell motili
121 consistent with a decrease in the number of clonogenic colony-forming unit-fibroblasts within the BM
126 ucosal damage occurs through decline in stem/clonogenic epithelial cell loss mediated by microvascula
128 Hep3B and Huh7) increased tumor cell growth, clonogenic formation, migration and invasion, whereas kn
129 c ALL xenograft cells, destroyed the in vivo clonogenic fraction of ALL blast cells, and, at nontoxic
130 ockdown breast cancer cells, suggesting that clonogenic function is served by either CRD-BP isoform.
131 strate the cloning and propagation of highly clonogenic, 'ground state' stem cells of the human intes
132 ells (LT-HSC) in vitro resulted in dispersed clonogenic growth and expression of genes involved in mi
133 inhibits cellular growth, wound healing and clonogenic growth and induces apoptosis of H295R cells i
136 HCC models showed reduced proliferation and clonogenic growth behavior following TGF-beta stimulatio
138 specifically induced cell death and reduced clonogenic growth in BMSC-adherent myeloma cell lines, a
141 knockdown of beta-catenin also abrogates the clonogenic growth of AE(+) mouse HSPCs and human leukemi
145 uced pronounced apoptosis in and reduced the clonogenic growth of multiple AML lines and primary AML
146 allopian tube secretory epithelial cells and clonogenic growth of ovarian cancer cells overexpressing
147 icacy of PI3K/mTOR inhibition in suppressing clonogenic growth of ovarian cancer cells with GAB2 over
151 cle with strongly enhanced and Wnt-dependent clonogenic growth potential compared to virtually identi
153 IIIc suppressed apoptotic activity, enhanced clonogenic growth, and induced disintegration of the blo
154 be a mediator of mutant p53 GOF activity in clonogenic growth, architectural tissue remodeling, migr
155 the impairment of anchorage-independent and clonogenic growth, consistent with an oncogenic function
160 otoxicity, without adversely affecting human clonogenic hematopoietic progenitors in vitro, or murine
161 bolism pathways induces oxidative stress and clonogenic killing in HNSCCs and this strategy may be us
162 8 years) are significantly more sensitive to clonogenic killing mediated by platinum-based chemothera
165 epithelial-to-mesenchymal transition to form clonogenic, long-term, self-renewing MSC-like cells.
166 , and demonstrate that this subset of highly clonogenic luminal progenitors is required for mammary g
167 to CD105(+)CD90(+)CD73(+)CD31(-) multipotent clonogenic mesodermal precursors, which can be isolated
168 associated with changes in the frequency of clonogenic MM cells and the progression-free survival of
169 rging strategy targeting mature and immature clonogenic myeloma cell populations in the autograft.
170 e and human, did not adversely impact either clonogenic or multilineage differentiation potential, in
172 -inhibitor-induced multinucleated cells fail clonogenic outgrowth, and high percentages of multinucle
174 herapy, because the preleukemic early thymic clonogenic population needs to be eradicated and its dis
175 ividual cells correlates with differences in clonogenic potential and lineage-specific differentiatio
176 lation within Met-pos neurospheres displayed clonogenic potential and long-term self-renewal ability
178 uced with BCR-ABL1 display slowed growth and clonogenic potential as compared to Fyn wild-type BCR-AB
179 ts or with hepatocyte growth factor restored clonogenic potential in low Wnt activity colon cancer ce
181 highest in cells with high Wnt activity and clonogenic potential of cells with low Wnt activity were
183 ET bromodomain inhibitor (+)-JQ1 reduced the clonogenic potential of FA patient HSPCs but rescued phy
184 fter uptake, and maintained the survival and clonogenic potential of HSPCs, presumably by preventing
185 17F) inactivation/downregulation and impairs clonogenic potential of Jak2(V617F) cell lines and PV bu
186 bsence of IL2Rgamma completely abrogated the clonogenic potential of JAK3(A572V), as well as the tran
187 trongly triggered apoptosis and impaired the clonogenic potential of leukemic, but not normal, CD34(+
192 thermore, dinaciclib potently suppressed the clonogenic potential of relapsed NRI AMLs in vitro and p
196 ant, is per se sufficient to confer a B-cell clonogenic potential to the viral protein and modulate,
198 mostly quiescent and associated with higher clonogenic potential when cocultured with BM stromal cel
199 eases cellular viability, proliferation, and clonogenic potential while not altering the proliferatio
200 diated DNA damage response, attenuated their clonogenic potential, abrogated camptothecin (CPT)-induc
202 ignificantly inhibited the proliferation and clonogenic potential, and induced apoptosis of drug-resi
203 including androgen deprivation, exhibit high clonogenic potential, and possess long-term tumor-propag
204 -ErbB receptor inhibitor, diminished growth, clonogenic potential, anoikis resistance and induced apo
205 sufficient to reduce malignant cell growth, clonogenic potential, glucose consumption, lactate secre
206 in these cell lines reduced cell growth and clonogenic potential, whereas inhibition of miR-223 incr
217 : 1) increased drug resistance; 2) increased clonogenic potential; 3) activation of both Wnt and Hedg
219 rogenitor cells, observing GFP expression in clonogenic progenitor colonies and peripheral blood leuk
220 inhibitor, LY-294002, caused a reduction in clonogenic progenitor number in HPIP-expressing CD34(+)
223 ion of miR-28 impairs cell proliferation and clonogenic properties of BL cells by modulating several
226 gs establish quiescent cells as an effective clonogenic reserve and provide a motivation for investig
227 human neuroblastomas and is required for the clonogenic self-renewal and tumorigenicity of human neur
228 and non-SP cells, where transitions between clonogenic states are modulated by exosome-mediated Wnt
229 liferation rates, and greater induction of a clonogenic, stem-like cell population compared with fema
232 olonged growth inhibition as well as reduced clonogenic survival (loss of reproductive capacity) but
236 ds to an increase in apoptosis and decreased clonogenic survival and again correlates with APAK expre
242 adiosensitization was evidenced by decreased clonogenic survival and increased DNA double-strand brea
244 accelerated cellular proliferation, improved clonogenic survival and reduced apoptosis, all of which
245 (IR) and etoposide treatment, as assessed by clonogenic survival and short-term proliferation assays.
246 Match oligonucleotides significantly reduced clonogenic survival and upregulated the DNA damage marke
247 In addition, TIMP1 played a role in tumor clonogenic survival and vascular density, while TIMP1 in
248 rix metalloproteinase expression, as well as clonogenic survival and viability during exposure to flu
251 d AH63 as supra-additive radiosensitisers by clonogenic survival assays and isobologram analyses.
255 ved glioblastoma cell lines, we confirmed by clonogenic survival assays that GSCs were significantly
256 spectively, induced significant decreases in clonogenic survival compared to either drug alone in FaD
257 ro cell lines treated with (177)Lu-DOTATATE, clonogenic survival decreased and gammaH2AX foci increas
259 cess selected for 22Rv1-cells with increased clonogenic survival following subsequent radiation expos
260 tion as seen by decreased cell viability and clonogenic survival in all pancreatic cancer cell lines
261 1 was obligatory for AR-dependent growth and clonogenic survival in both hormone-dependent PC and cas
262 bining MnPs and AscH- synergized to decrease clonogenic survival in human pancreatic cancer cells.
263 d EIF1AX proteins promoted proliferation and clonogenic survival in LGSC cells, providing the first e
264 PSMA-specific cellular uptake and decreased clonogenic survival in PSMA+ PC3 PIP cells and caused si
265 s, targeting MUC1-C inhibited the growth and clonogenic survival of both trastuzumab-resistant cells.
268 bitor or dominant-negative N17Rac1 abrogates clonogenic survival of HFR-selected breast cancer cells
269 F2 knockdown on proliferation, motility, and clonogenic survival of HIF2-dependent tumor cells in vit
272 AT3 knockdown on proliferation, motility and clonogenic survival of tumor cells in vitro is phenocopi
273 ls were treated by cisplatin and T2AA, their clonogenic survival was significantly less than that of
274 time, the cellular bioenergetic function and clonogenic survival were largely restored in some cells.
277 ed H2A histone family member X staining) and clonogenic survival were tested in PSMA-positive (PSMA+)
278 exhibited increased DNA damage and decreased clonogenic survival when compared with PSMA- PC3 flu cel
279 oxygen species levels, rate of apoptosis and clonogenic survival, and growth in immune and nonimmune
280 transcription of DNAPK and RAD54, increases clonogenic survival, and increases resolution of DNA dou
281 nhancing glioblastoma cell proliferation and clonogenic survival, as synemin RNA interference decreas
282 a significant reduction in growth rate, and clonogenic survival, coinciding with the degree of knock
283 lted in radiosensitivity, as seen by reduced clonogenic survival, enhanced apoptotic activity and enh
284 /= 50 nM) significantly decreased viability, clonogenic survival, migration, and invasion of glioblas
285 verified the compounds by in vitro assays of clonogenic survival, proliferation, and migration and in