ライフサイエンスコーパス: clonotype

1 5 GP33(+) clonotypes; ~20 versus ~7 GP276(+) clonotypes).

2 160 clonotypes) and memory CD8 T cells (~160 clonotypes).

3 ed E. coli, from 35 different clonal groups (clonotypes).

4 at were comparable to those of the effective clonotype.

5 equences based on their CDR3 sequence or V3J clonotype.

6 tributing to the selection of the public TCR clonotype.

7 ecific peptide/MHC ligation of the alphabeta clonotype.

8 epitope may optimally induce related B cell clonotypes.

9 r without overrepresentation of specific TCR clonotypes.

10 ong behavior of CMV- and EBV-specific T cell clonotypes.

11 ents identified no additional cross-reactive clonotypes.

12 CDR3 motifs, and a high frequency of public clonotypes.

13 rare, found in only one of seven VH1-46 IgG clonotypes.

14 ogenic neoantigens and tumor-reactive T cell clonotypes.

15 r repertoires comprising exclusively private clonotypes.

16 he major part of the differences among these clonotypes.

17 tted uninhibited accumulation of low-avidity clonotypes.

18 3s that group into 30 distinct antibody V(H) clonotypes.

19 by length-matched Ag-specific CD8(+) T-cell clonotypes.

20 d proliferation (LIP) of two distinct T cell clonotypes.

21 ease disproportionally affects low-frequency clonotypes.

22 for cross-recognition compared with dominant clonotypes.

23 nes per response, of both public and private clonotypes.

24 ocess, conditioned on non-extinction of both clonotypes.

25 the numbers of T cells belonging to the two clonotypes.

26 structural role for the TCRA chain for these clonotypes.

27 + T responses, each composed of multiple TCR clonotypes.

28 stribution of T cells toward lower-frequency clonotypes.

29 al contained between 9 and 17 million B cell clonotypes.

30 oire and increased presence of long sequence clonotypes.

31 xhausted counterpart (~40 versus ~15 GP33(+) clonotypes; ~20 versus ~7 GP276(+) clonotypes).

32 These 53 clones expressed 47 unique clonotypes, 8 of which encoded proinsulin-specific T-cel

33 ximately 100 antibody clonotypes, with three clonotypes accounting for >40% of the response.

34 influenza vaccine, with boosted pre-existing clonotypes accounting for approximately 60% of the respo

35 this donor comprised 24 persistent antibody clonotypes, accounting for 72.6% +/- 10.0% of the anti-C

36 enrichment (or diminution) of particular TCR clonotypes across all challenged animals.

37 To evaluate the dynamic nature of T cell clonotypes across time, we utilized several binary simil

38 ssential for the maintenance of low-affinity clonotypes after protein vaccination but was not suffici

39 TRAV29 clonotypes also proved cross-restricted, but conferred r

40 ertoires display highly dynamic yet distinct clonotype alterations.

41 er extended to investigate the transition of clonotypes among different biological compartments.

42 A sequencing (scRNAseq) and longitudinal TCR clonotype analysis to identify a unique transcriptional

43 were dispensable for the development of this clonotype and had negligible impact on the polyclonal Tr

44 itution included both adoptively transferred clonotypes and endogenous clonotypes not detected in the

45 Additionally, we extracted and compared BCR clonotypes and found that each ASC isotype contained a u

46 Moreover, the flow of Ig clonotypes and inter-tissue repertoire similarities acro

47 GlcNAc-reactive B-1 clonotypes and serum antibodies were reduced in germ-fre

48 y IgM(+) B cells were related to some IgA(+) clonotypes and switched to IgA in response to T cell-ind

49 patients with a characteristic trajectory of clonotypes and traceability over the disease course.

50 NA sequencing procedures for identifying TCR clonotypes and transcript phenotypes in individual T cel

51 broader in both GP33-specific effector (~160 clonotypes) and memory CD8 T cells (~160 clonotypes).

52 arthritis model to determine the frequency, clonotype, and specificity of T cells that infiltrate ar

53 subpopulation of universally shared antibody clonotypes, and an exceptional overall diversity of the

54 rior Ag exposure, inferred from expanded TCR clonotypes, and essential phenotypic properties in their

55 er C127 expression compared with subdominant clonotypes, and TCR avidity positively correlates with P

56 sms: 1) functional improvement of persisting clonotypes; and 2) recruitment of particular clonotypes

57 t the persistence of numerous BM plasma cell clonotypes ( approximately 2%) identifiable at all point

58 Moreover, mAbs bearing this clonotype are autoreactive against CD4 T cells and inhib

59 Dominant clonotypes are characterized by higher PD-1 expression a

60 Some public clonotypes are dependent on the gut microbiota and encod

61 Clonotypes are grouped on the basis of pathogen selectiv

62 such expansion, ensuring that the remaining clonotypes are optimized for continued protection.

63 nd sequencing indicated that distinct T-cell clonotypes are preferentially increased in the CNS compa

64 reservoir cells is heavily biased: expanded clonotypes are present in all individuals, account for t

65 may maintain TCR diversity and that dominant clonotypes are sensitive to antigen even after dramatic

66 Dominant clonotypes are shown to overlap among multiple recurrenc

67 most likely due to the fact that IgE and IgG clonotypes are widely shared in patients with nasal poly

68 te that the specificity of individual T cell clonotypes arises not only from TCR residues that create

69 ns for the number of cells belonging to each clonotype as well as a linear Fokker-Planck equation for

70 e emergence of high-avidity Melan-A-specific clonotypes as a surrogate marker of treatment efficacy.

71 for clonal neoantigens confirmed correct TCR clonotype assignments based on high-throughput TCRBV CDR

72 Hierarchical clustering of public clonotypes associated with dietary gluten exposure ident

73 served increased abundance of tumor-enriched clonotypes at 2 wk postradiation compared with pretreatm

74 en by preferential expansion of high avidity clonotypes at the expense of their low avidity counterpa

75 obust direct single-guide RNA capture and to clonotype-aware multimodal phenotyping of cancer samples

76 As the two clonotypes become more similar in terms of the self-anti

77 R3, and a remarkable sharing of one dominant clonotype between individual old mice, implying operatio

78 single-cell RNA-seq revealed sharing of TCR clonotypes between these Treg cell populations, potentia

79 lates, reveal that effective and ineffective clonotypes bind to the terminal portions of the peptide-

80 al susceptibility varied substantially among clonotypes but was consistent across different locations

81 bsets were composed mostly of a few dominant clonotypes, but there was slightly more breadth and dive

82 ing strongly focused on a few high-frequency clonotypes by adulthood.

83 These results show that CD-associated clonotypes can be identified and that common gluten asso

84 E. coli, subspecies-level identification by clonotyping can be used to significantly improve empiric

85 action (<5%) of peripheral blood plasmablast clonotypes (CD3(-)CD14(-)CD19(+)CD27(++)CD38(++)CD20(-)T

86 and TRBV2 public motifs (>30%) and of public clonotypes characteristic of high-affinity TCRs.

87 oires, we observed that germline-encoded TCR clonotypes, characteristic of neonatal infection, persis

88 with distinct T cell antigen receptor (TCR) clonotypes, characterized by superior control of HIV-1 r

89 PP GCs from different mice expand public BCR clonotypes (clonotypes that are shared between many mice

90 using graph theory, with the cross-reactive clonotypes connecting the different HLA-A2 peptides reco

91 To evaluate the TCR clonotype contribution to CD8(+) T-cell function, we clo

92 ction, explaining how Gag293-specific public clonotypes could be selected in individuals with diverse

93 type distributions, the number of observable clonotypes decreases significantly.

94 minate between pathogen-derived ligands in a clonotype-dependent manner, providing a basis for adapti

95 yet constrained by epitope specificity in a clonotype-dependent manner.

96 Clonal expansion of lower-avidity T-cell clonotypes depends on availability of MHC II-expressing

97 sensitive than UMI methods in detecting rare clonotypes, despite the better clonotype quantification

98 We were able to clonotype directly from patient urine samples within 1 t

99 ce to germ-free mice restored germ-dependent clonotypes, directly implicating BCR selection.

100 roliferation phase during which low-affinity clonotypes disappeared despite exhibiting no sign of enh

101 quency analysis shows the same two-component clonotype distribution described earlier for these reper

102 toires is insufficient to describe the older clonotype distribution.

103 lthough the repertoires show broadly similar clonotype distributions, the number of observable clonot

104 HLA-C-restricted, CMV-specific TCRbeta clonotypes dominated the ex vivo T cell response and con

105 er, we found that private, hyperexpanded TCR clonotypes dominated the T cell response after anti-PD-L

106 f our method when studying diseases in which clonotype-driven responses are critical to understanding

107 elies on the recruitment of antigen-specific clonotypes, each defined by the expression of a distinct

108 o/8/1934 and Staphylococcus aureus USA300, a clonotype emerging as a leading contributor in postinflu

109 ant targeted reductions in the expression of clonotypes encoded by 14 specific Vkappa genes with the

110 We identify related TRAJ24(+) TCRalphabeta clonotypes encoded by identical alpha/beta gene regions

111 clonotypes; and 2) recruitment of particular clonotypes endowed with superior functional capabilities

112 med in a prospective vaccine trial, in which clonotype engagement was governed by the nature of the a

113 s modulated by diverse T cell receptor (TCR) clonotypes engaging peptide-MHC class I complexes on inf

114 were significantly correlated with specific clonotypes, especially with CH40-30 (also known as H30),

115 One clonotype evolved from a germline precursor recognizing

116 We focus on the case where the two clonotypes exhibit negligible competition with other T c

117 e two patients, whereas a TRAJ24-C allele(+) clonotype expands in a control.

118 Rather, a selective clonotype expansion must be included to achieve the best

119 Moreover, TCRB CDR3 clonotypes expressed by autoantigen-specific CD4(+) T ce

120 These newly recruited clonotypes expressed TCRs that engaged wild-type and mut

121 We found that clonotypes expressing the T cell antigen receptor (TCR)

122 At low peptide concentrations, dominant clonotypes fail to survive in culture.

123 epertoire portraits establish a link between clonotype fate decisions in the complex world of CD4(+)

124 post-vaccination-and select several antibody clonotypes for epitope and structural analysis.

125 ntaining approximately 10,000 distinct viral clonotypes for which all genetic differences were within

126 The first component includes lower frequency clonotypes for which distribution can be described by a

127 The cross-reactive clonotypes form a well-connected network that could prov

128 ee germinal centres are enriched in 'public' clonotypes found in multiple individuals, indicating str

129 Notably, expanded clonotypes found in the tumour and normal adjacent tissu

130 P = 0.02), decreases in the number of T-cell clonotypes found within epitope-specific T cell receptor

131 The expanded clonotype from one T1D subject was detected at repeat vi

132 Although being private, these top clonotypes from anti-PD-L1-treated mice revealed a more

133 closely related CDR3 motif than those of top clonotypes from persistently infected control mice.

134 han 2.9 million natively paired TCRalphabeta clonotypes from six healthy human donors and identified

135 escribe two genetically similar V(H)6-1 bnAb clonotypes from the same individual that exhibit differe

136 ctivity and identified gluten-induced T-cell clonotypes from total blood and gut TCR repertoires in a

137 d subsequent activation of the CD8(+) T-cell clonotype G9C8, which recognizes insulin B15-23 via an a

138 14 T cell receptor (TCR) cDNAs, the dominant clonotype generated in splenocytes after immunization of

139 The most prevalent public clonotypes generated TCRs with affinities at the higher

140 Clonotype-guided antimicrobial selection significantly r

141 eptide demonstrated that Tp2(49-59)-specific clonotypes had a broad range of fine specificities for t

142 Some of the B cell clonotypes had thousands of clones, or somatic variants,

143 o correlated with intrinsic changes in Vbeta clonotype heterogeneity.

144 Clonotype identity was determined by fumC and fimH (CH)

145 ng the usage of a single identical VA12-JA29 clonotype in all eight older donors.

146 onses, we compared the T cell receptor (TCR) clonotype in parent and hybrid strains of respiratory sy

147 Vbeta gene usage and greatly reduced public clonotypes in 3-d-old neonates.

148 We found that T cell clonotypes in a mouse Salmonella infection model span ea

149 strate liver-infiltrating disease-associated clonotypes in all three diseases evaluated, and evidence

150 The unexpectedly high prevalence of shared clonotypes in B cell repertoires, and identification of

151 ed oligoclonal expansion of specific TCRbeta clonotypes in CD8(+)PD-1(+) compared with CD8(+)PD-1- TI

152 expansion, and the repertoire of responding clonotypes in chronic HIV-1 infection.

153 duction, and the emergence of public TCRbeta clonotypes in circulating Tfh cells.

154 the role of individual T-cell receptor (TCR) clonotypes in differential antiviral CD8(+) T-cell funct

155 dance analysis, we identified gluten-induced clonotypes in each patient that were composed of a large

156 mine paired alpha/beta T-cell receptor (TCR) clonotypes in single cells or perform alpha and beta TCR

157 the development and maintenance of neonatal clonotypes in the brain and spleen of mice during chroni

158 urthermore, the most highly expanded TCRbeta clonotypes in the CD8(+) and the CD8(+)PD-1(+) populatio

159 Our data suggest that dominant clonotypes in the exhausted subset are derived from a di

160 The fraction of cross-reactive clonotypes in the M1(58-66) repertoire varied from 45-58

161 eas protein vaccines maintained low-affinity clonotypes in the memory compartment.

162 oportions of unique Gag-specific CD8+ T cell clonotypes in the mesenteric lymph nodes relative to rhe

163 T-cell subsets with diverse T-cell receptor clonotypes in the periphery.

164 LA-A2 adult subjects, we identified the BV19 clonotypes in the recall response to the influenza epito

165 bit negligible competition with other T cell clonotypes in the repertoire, since this case provides a

166 Overall, 97% of detectable clonotypes in the viral stock were identified in the pla

167 ssue was used to quantitate and track T-cell clonotypes in these treated subjects with prostate cance

168 ed repertoires, as we also identified shared clonotypes in umbilical cord blood samples and all adult

169 ortion of the homologous CD8(+) EBV-specific clonotypes, in the "fluctuant" group was substantial hig

170 hree individuals that we studied shared many clonotypes, including between 1 and 6% of B cell heavy-c

171 imumab triggered increases in the numbers of clonotypes, including newly detected clones and a declin

172 rential phenotypes among subsets of expanded clonotypes, including type 2 helper CD4(+) T cell (T(H)2

173 hat were recurrently selected in such public clonotypes, indicating that affinity maturation occurs i

174 und that the predominant conventional T cell clonotypes infiltrating target lesions express antigen r

175 ation of MHC promiscuous autoreactive CD4(+) clonotypes into antidiabetogenic autoregulatory T cells.

176 results in the diversion of Treg cell-biased clonotypes into pathogenic conventional T cells.

177 We prove that the ultimate fate of both clonotypes is extinction and provide a bound on mean ext

178 al number of peptides recognized by a single clonotype, is as high as six.

179 ed initially rare high-avidity CD4(+) T cell clonotypes, known to mediate protection.

180 ne the antibody repertoire at the individual clonotype level in the sera of young adults before and a

181 s of clones, or somatic variants, within the clonotype lineage.

182 stable over time and dominated by persistent clonotypes, many of which also occurred in more than one

183 ) T-LGL leukemia and suggest that many T-LGL clonotypes may be private to the disease and may not be

184 Amplification or transfer of such clonotypes may contribute to immunotherapeutic approache

185 and suggest that cross-reactive, subdominant clonotypes may retain greater capacity to suppress repli

186 be cross-recognized by identical CD8 T cell clonotypes mobilized in vivo, yet even subtle difference

187 ments to sequencing reads and assembling the clonotypes, most of them are not designed to track and e

188 tively transferred clonotypes and endogenous clonotypes not detected in the ACT products.CONCLUSIONTh

189 ly localized expansions of gammadelta T cell clonotypes not previously associated with the immune res

190 sponse and contributed the highest-frequency clonotype of the entire repertoire in two of eight donor

191 Tracking clonotypes of anti-insulin B cells in H chain-only VH125

192 The number, phenotype, and BCR clonotypes of GlcNAc-reactive B-1 B cells were modulated

193 nformation on the distribution of individual clonotypes of T cells in patients with cancer.

194 TRAJ24-G allele(+) clonotypes only expand in the two patients, whereas a TR

195 cines may expand distinct Ag-specific T cell clonotypes or induce disparate degrees of protection are

196 tor beta variable or joining genes, specific clonotypes or obvious "public" T-cell response were not

197 tween HIV-1 and virus-specific CD8(+) T-cell clonotypes orchestrated at the TCR-antigen interface.

198 ming events manifesting in a dominant T-cell clonotype over many years.

199 An average clonotype overlap of 0.85% was detected among PSC sample

200 T cell receptor (TCR) repertoire and higher clonotype overlap relative to myeloma-free BMT recipient

201 Escherichia coli species into clonal groups (clonotypes) predicts antimicrobial susceptibility or cli

202 on in COVID-19 patients of convergent B cell clonotypes previously reported in SARS-CoV infection pre

203 s representing variant epitopes, subdominant clonotypes produce higher relative levels of cytokines a

204 ation of MHC-promiscuous autoreactive T-cell clonotypes, promoting their deviation into autoregulator

205 ble family genes encoded the same amino acid clonotypes, providing additional support for antigen-dri

206 etecting rare clonotypes, despite the better clonotype quantification accuracy of the latter.

207 rms of the self-antigens they recognise, one clonotype quickly becomes extinct in a process resemblin

208 se TCR repertoire comprising several private clonotypes rarely observed in control mice or in the pre

209 The other clonotype recognized group 2 subtypes and developed bind

210 We find that clonotypes recognizing HLA class II-restricted epitopes

211 verall hierarchy of dominant T cell receptor clonotypes remained stable compared to that pre-ART.

212 h-resolution analysis of gene expression and clonotype repertoire of different B cell subtypes.

213 c virus type 1; (ii) T cell antigen receptor clonotype repertoires; and (iii) microbial data from inf

214 Despite this shift in clonotype representation indicative of differential sele

215 equences were extremely diverse, without any clonotype representing more than 2% of the overall TCR p

216 ing within an individual reveals private AST clonotypes resident in the memory population, as would b

217 Analyses of T-cell clonotypes reveal the presence of recurrent priming even

218 High-definition analysis of individual clonotypes revealed that the Ag loss-induced gain of fun

219 ective alleles' is modulated by specific TCR clonotypes selected during natural infection, which prov

220 e NY-ESO-1-specific and TRAG-3-specific Treg clonotypes share a common TCR CDR3 Vbeta usage with Foxp

221 Other AST clonotypes share CDR3beta amino acid sequences through c

222 uding between 1 and 6% of B cell heavy-chain clonotypes shared between two subjects (0.3% of clonotyp

223 notypes shared between two subjects (0.3% of clonotypes shared by all three) and 20 to 34% of lambda

224 Notably, we found no clonotype sharing between subjects, indicating a predomi

225 We found extensive TCR clonotype sharing in Ag-activated cells, especially from

226 ntification of the sequences of these shared clonotypes, should enable better understanding of the ro

227 Multiple clonotypes simultaneously underwent Ag-driven proliferat

228 tained the initial advantage of high-avidity clonotypes, slower completion permitted uninhibited accu

229 gate TCR-pMHC interactions from multiple CTL clonotypes specific for a well-defined HIV-1 epitope.

230 We also observed clonotype-specific differences in antiviral efficacy for

231 f the individual, as evidenced by discordant clonotype-specific transitions directed against differen

232 repeat visits spanning >15 mo, demonstrating clonotype stability.

233 rofiles were recapitulated within individual clonotypes, suggesting parallel differentiation programs

234 proportion of polyreactive and self-reactive clonotypes, suggesting that activation checkpoints exist

235 tructure, immunophenotyping, T-cell receptor clonotypes, T-cell function, immune responses to transge

236 recognized the autologous tumor and included clonotypes targeting mutated antigens.

237 ance hinder the contribution of high-avidity clonotypes targeting residues 206-214 of islet-specific

238 red resistance toward dominant CD8(+) T-cell clonotypes targeting stage III tumor cells.

239 diabetes (T1D), DEs are predominated by one clonotype that encodes a potent CD4 T cell autoantigen i

240 hat pregnancy supports the expansion of Treg clonotypes that are equipped to recognize EAE-associated

241 different mice expand public BCR clonotypes (clonotypes that are shared between many mice) that often

242 competition process between a pair of T cell clonotypes that are similar in terms of the self-antigen

243 ymic development producing individual T cell clonotypes that express TCRs with unique patterns of Ag

244 tead, the expanded clones consisted of novel clonotypes that had not previously been observed in the

245 e skewing and the presence of high-frequency clonotypes that had undergone significant in vivo expans

246 hierarchy of recurrence rates for individual clonotypes that is determined by relative production fre

247 ure of the memory repertoire and whether the clonotypes that make up the repertoire decay at random.

248 erized by highly expanded dermal alphabeta T clonotypes that produce the type three cytokines, IL-17

249 that were composed of four different T-cell clonotypes that specifically targeted KRAS G12D.

250 accination by electroporation primed for TCR clonotypes that were associated with HIV control, highli

251 he exhausted subset was composed of dominant clonotypes that were shared with the stem-like subset.

252 erum repertoire comprised between 40 and 147 clonotypes that were specific to each of the three monov

253 ome, epigenetic profile, and T cell receptor clonotype, the authors provide evidence that a subset of

254 xposure identified subsets of highly similar clonotypes, the most proliferative of which showing sign

255 T cells expresses two T cell receptor (TCR) clonotypes, though the extent and functional significanc

256 phenotype, trafficking of the same expanded clonotype to different regions of the kidney and to the

257 The contribution of TCR clonotype to inhibitory potency was investigated by deli

258 ion profiles of dominant and subdominant TCR clonotypes to evaluate the relationship between the comp

259 persistent gut antigens select recurrent BCR clonotypes to seed chronic PP GC responses.

260 Clonotype tracking within an individual reveals private

261 ther than the context of exposure and public clonotype usage was associated with enhanced recognition

262 patient, but notably all six cross-reactive clonotypes used VH1-46.

263 is of responses to B51-TI8 revealed a public clonotype using TRAV17/TRBV7-3 TCR genes in six out of s

264 A single TCR clonotype was also identified that was largely restricte

265 The frequency of identified, tumor-enriched clonotypes was tracked across serial blood samples.

266 ies repertoires, a high frequency of OmniRat clonotypes were also found in the human repertoire.

267 In PSC and PBC, disease-associated clonotypes were detected among patients with human leuko

268 atients examined, no neoantigen-specific TCR clonotypes were identified despite clonal neoantigen exp

269 Tumour clonotypes were identified in pretreatment specimens fro

270 We found that cross-reactive CD8+ T cell clonotypes were mobilized to counter the rapid emergence

271 In addition, public Gag-specific CD8+ T cell clonotypes were more commonly shared across distinct ana

272 Only 2/839 TCRB clonotypes were shared between patients and none associa

273 cy and the number of Gag CM9-specific public clonotypes were strongly correlated with VIA mediated by

274 From eight to 42 clonotypes were uniquely detected in each of the three d

275 son, antibodies with 18 different CDRH3s (12 clonotypes) were represented in the antigen-specific IgG

276 mory CD4 TCR repertoire toward high-affinity clonotypes whereas protein vaccines maintained low-affin

277 ifferential testing enabled the detection of clonotypes which were significantly changed across time.

278 e early mobilization of public CD8(+) T-cell clonotypes, which can exert profound biological effects

279 are derived from a diverse pool of stem-like clonotypes, which may be contributing to the clonality o

280 tomical sites than the corresponding private clonotypes, which tended to form tissue-specific reperto

281 0 of the most representative public TCR beta clonotypes, whose abundance among the top 100,000 clones

282 Tandem HTS-based clonotyping will facilitate studying AST dynamics, epito

283 The associations of clonotype with antimicrobial susceptibility and clinical

284 types, with 93% of the isolates belonging to clonotypes with >/= 2 isolates.

285 us mice showed selective retention of T cell clonotypes with a greater competitive advantage as evide

286 ntigens for the selection of superior T-cell clonotypes with enhanced antigen recognition properties.

287 Presence of dominant clonotypes with limited TCR gene usage for both TCR alph

288 In addition, clonotypes with low frequencies were found in significan

289 Together, these findings indicate that TCR clonotypes with superior functions are associated with H

290 CH typing divided the isolates into >200 CH clonotypes, with 93% of the isolates belonging to clonot

291 ertoire comprises approximately 100 antibody clonotypes, with three clonotypes accounting for >40% of

292 30 (also known as H30), a recently described clonotype within sequence type 131 (ST131).

293 1 was expressed at higher levels on dominant clonotypes within epitope-specific responses before and

294 ion of PD-1 on T cell populations and T cell clonotypes within epitope-specific responses from these

295 These data indicate that dominant clonotypes within HIV-specific T cell responses display

296 agnitude, the efficacy of constituent T-cell clonotypes within the primed population can be poor.

297 nd increased the frequency of EAE-associated clonotypes within the Treg compartment.

298 bution, and authenticity of individual viral clonotypes within this synthetic swarm using samples fro

299 ) T cells, we hypothesized that neonatal TCR clonotypes would be locked in the brain and persist into

300 12)) does not eliminate germ-free-associated clonotypes, yet does induce a concomitant commensal-spec