ライフサイエンスコーパス: clonotypic

1 Maternal transfer of TCR clonotypic Ab protected young NOD mice against the adopt

2 TCR-IgG1-immunized AKR/J mothers making D10 clonotypic Ab, the effect was immunologically specific.

3 ptors, are commonly contrasted with diverse, clonotypic adaptive responses of lymphocyte antigen rece

4 ssion difference likely lowers levels of the clonotypic AI4 TCR in NOD, but not B6.H2g7 thymocytes, b

5 an oligomeric protein complex consisting of clonotypic alpha beta polypeptides associated with invar

6 receptor (TCR)-alpha gene locus to generate clonotypic alpha/beta TCR, after which a few cells expre

7 Here we used the clonotypic alphabeta chains of the T cell receptor (TCR)

8 tocompatibility complex (MHC) molecule via a clonotypic alphabeta heterodimeric structure (Ti) non-co

9 t T lymphocytes consists of disulfide-linked clonotypic alphabeta heterodimers noncovalently associat

10 Clonotypic alphabeta T cell responses to cargoes present

11 mechanism through which the interaction of a clonotypic alphabeta T-cell receptor (TCR) with a peptid

12 plasma membrane with a clone-specific (i.e. clonotypic) alphabeta heterodimer that binds its cognate

13 Clonotypic analyses of the reconstituted TRBV4-1(+) TCR

14 Clonotypic analyses revealed expansion of B and CD4 clon

15 More generally, clonotypic analysis and comparison of the variable porti

16 udy provides the first proof-of-concept that clonotypic analysis may be used as a tool to monitor the

17 oire formation, we conducted a comprehensive clonotypic analysis of CD8(+) T cell populations directe

18 Clonotypic analysis of responses to B51-TI8 revealed a p

19 Clonotypic analysis of TCRs in fresh RCCs showed that EM

20 Clonotypic analysis of the two iNK TCR types with a sing

21 Clonotypic analysis revealed that the HIV-specific CD4(+

22 ed potent anti-glioma therapeutic effects in clonotypic and genetically engineered murine models of g

23 yet the persistence of T cell receptor (TCR) clonotypic and transcriptional features of epitope-speci

24 ong the ligands QL9/L(d), SIYR/K(b), and the clonotypic antibody 1B2.

25 recognition and indicated that the pMHC and clonotypic antibody epitopes on the TCR were similar.

26 nal antibody (mAb) 1F7 as a therapeutic anti-clonotypic antibody in HIV-1-infected patients, we used

27 rs, we studied the functional properties and clonotypic architecture of EBV-specific CD4(+) T cells i

28 To test the applicability of clonotypic assays, we developed rational molecular metho

29 al was to assess the behavior of circulating clonotypic B cells clinically.

30 wever, has never been corroborated, and such clonotypic B cells have never been documented in HL pati

31 ugh the clinical significance of circulating clonotypic B cells in HL remains unclear, these data sug

32 ma plasma cells prompted the notion that the clonotypic B cells that exist in the blood and bone marr

33 Rituximab-ABVD and clonotypic B cells warrant additional study in classical

34 Persistence of detectable circulating clonotypic B cells was associated with a greater relapse

35 s consistently show an absence of pre-switch clonotypic B cells, while M-PCs circulate in the periphe

36 Our results suggest that circulating clonotypic B-cell populations represent multiple myeloma

37 is dependent on the surface expression of a clonotypic B-cell receptor complex (BCR) consisting of m

38 uencing and crystallographic analysis of the clonotypic B-cell receptor immunoglobulin.

39 ne whether the immunogenetic features of the clonotypic B-cell receptors (BcR) may identify different

40 reaction-based studies suggested pre-switch "clonotypic" B cells sharing the immunoglobulin (Ig) rear

41 reover, we profiled the Ag reactivity of the clonotypic BCR Ig expressed as rmAbs.

42 Immunogenetic studies of the clonotypic BCR Ig of CLL subset #4 suggested a resemblan

43 ion in the evolution of Ag reactivity of the clonotypic BCR Ig.

44 cytic leukemia (CLL) subgroups with distinct clonotypic BCRs present discrete patterns of TLR express

45 B lymphocyte involvement, the proportion of clonotypic cells among the CD19-expressing cells from my

46 ple myeloma are undefined, and contaminating clonotypic cells could contribute to disease recurrence.

47 was 0.0009% (range, 0%-0.1%) or 0.5 x 10(4) clonotypic cells per kilogram (range, 0-41.2 x 10(4)/kg)

48 h allows specific recognition of unassembled clonotypic chains by the ER chaperone machinery and, the

49 The clonotypic characteristics of CD8 T-cell populations eli

50 Here, the clonotypic composition of CMV-specific CTL was determine

51 itude, specificity, phenotype, function, and clonotypic composition of CMV-specific T-cell responses

52 Previous studies assessed the clonotypic composition of CTL specific for individual im

53 ns was linked to a substantial switch in the clonotypic composition of epitope-specific CD8+ T cells,

54 Ag presentation patterns in determining the clonotypic composition of vaccine-induced T cell respons

55 ype that was not characterized by a distinct clonotypic composition.

56 clonal, highly skewed, and exhibited diverse clonotypic configurations; TCRB CDR3 sequence analysis i

57 Estimated clonotypic contamination per SCC was 0.0009% (range, 0%-

58 Melphalan-mobilized SCCs contain minimal clonotypic contamination.

59 itiated after CD94 ligation and suggest that clonotypic differences in signaling generate fundamental

60 consists of at least seven polypeptides: the clonotypic, disulfide-linked alpha/beta heterodimer that

61 tion in iHEU was preceded by lower TCR Vbeta clonotypic diversity and linked to TCR clonal depletion

62 eficial to the host, yet the determinants of clonotypic diversity are poorly defined.

63 ar T cell response size on immunization, the clonotypic diversity of the CD4 T cell response correlat

64 s is the primary parameter that dictates the clonotypic diversity of the responding CD4 T cell compar

65 Despite the enormous clonotypic diversity that resides within the naive T-cel

66 We measured CD8 T cell clonotypic diversity to three epitopes recognized in C57

67 he genes that regulate their function, their clonotypic diversity, and the thymus where they mature.

68 pensation mitigates this process to maintain clonotypic diversity.

69 entional CD8 alphabetaT cells exhibit modest clonotypic diversity.

70 decline in the fraction of singletons and in clonotypic diversity.

71 homeostatic competition, result in narrowed clonotypic diversity.

72 normal subjects is characterized by striking clonotypic dominance and the potential for epitope focus

73 n 15 pediatric patients by screening for the clonotypic E2A-PBX1 translocation in neonatal blood spot

74 Clonotypic elimination of activated T cells through Fas-

75 tored by human adenovirus serotype 5 induced clonotypic expansion irrespective of avidity, eliciting

76 ed amongst autoimmune follicular T cells and clonotypic expansion is associated with differential gen

77 flammatory effector cells, and post-infusion clonotypic expansion of effector memory T cells.

78 We find clear evidence of clonotypic expansion of effector-like T cells not only w

79 es in lymph nodes and skin revealed a single clonotypic expansion of the encoded complementarity-dete

80 Patients with gene signatures of such clonotypic expansion respond best to anti-PDL1 therapy.

81 Nonselective clonotypic expansion was caused by relatively weak adeno

82 h a distinct T cell signature and pattern of clonotypic expansion within the native T cell compartmen

83 re is progressively diversified by staggered clonotypic expansion, according to functional avidity, w

84 CD8(+) T-cell response magnitude, reflecting clonotypic expansions and contractions related to altera

85 s, and all foetal populations contained more clonotypic expansions than adult.

86 ific T cell responses are often comprised of clonotypic expansions with distinct functional propertie

87 r gene segment usage, less diverse with more clonotypic expansions, and more closely encoded by genom

88 R ligands'; the correct text is "...in a non-clonotypic fashion are striking...".

89 of CD8(+) TILs and TCR beta chain (TCRbeta) clonotypic frequency in melanoma tumors to identify pati

90 We conducted a detailed clonotypic, functional, and phenotypic survey of SIV-spe

91 n has been endorsed by the identification of clonotypic gene fusion sequences in archived neonatal bl

92 Clonotypic genomic AML1-ETO sequences were detected in t

93 l-time PCR assay to measure the frequency of clonotypic HCV-specific CD8(+) T cells in peripheral blo

94 uctural biology of the Fab-like TCRalphabeta clonotypic heterodimer and its unique features in conjun

95 two functional domains: the antigen-binding clonotypic heterodimer and the signal-transducing invari

96 In most vertebrates, there are two different clonotypic heterodimers (TCRalphabeta and TCRgammadelta)

97 T cells differ not only in their respective clonotypic heterodimers but also in the subunit composit

98 (TCR) and pre-TCR complexes are composed of clonotypic heterodimers in association with dimers of si

99 this work we take advantage of the profound clonotypic hierarchies of the large human CD4(+) T cell

100 This analysis revealed a stable clonotypic hierarchy in which 1-3 dominant clonotypes ar

101 morphologic remission and that expansion of clonotypic HSCs precedes clinical relapse.

102 nce of lymphocytosis and irrespective of the clonotypic IGH variable gene somatic hypermutation statu

103 he somatic hypermutation (SHM) status of the clonotypic IGHV gene.

104 To address these issues, we investigated clonotypic IGHV-IGHD-IGHJ gene rearrangements in a serie

105 in chronically infected primates as an anti-clonotypic immunogen to boost antibodies that neutralize

106 ith lack of somatic hypermutation within the clonotypic immunoglobulin heavy variable (IGHV) genes.

107 Clonotypic immunoglobulin rearrangements were detected i

108 ansitions involving partial unfolding of its clonotypic immunoglobulin-like (Ig) domains and coupled

109 udy, we manipulated TCRs in vivo to generate clonotypic iNKT cells using TCR retrogenic chimeras.

110 apped the compositional, transcriptional and clonotypic landscape of mucosal and circulating B cells.

111 In 4 cases, the clonotypic leukemic Vdelta2-Ddelta3 rearrangement was de

112 of fresh (unexpanded) memory T cells at the clonotypic level.

113 o decreased proliferative capacity of BDC2.5 clonotypic-like cells.

114 ne a T cell memory repertoire as the pool of clonotypic lineages participating in a recall response t

115 e emergence of antigen receptor diversity in clonotypic lymphocytes drove the evolution of a novel ge

116 expression within the lung, and an influx of clonotypic lymphocytes.

117 CS analysis or immunohistochemistry with the clonotypic mAb KJ1-26.

118 In classical Hodgkin lymphoma, circulating clonotypic malignant cells express CD20, which potential

119 S mu/c-myc junctions are thus useful clonotypic markers for monitoring the conversion of Igh

120 Clonotypic markers revealed different plaque and adventi

121 n the analysis of recombination sequences as clonotypic markers, migration of c-myc recombination-pos

122 f these cells through the use of congenic or clonotypic markers.

123 says were capable of identifying circulating clonotypic memory B-cell populations within the peripher

124 lloantigen Ld and can be identified with the clonotypic monoclonal antibody 1B2.

125 Using clonotypic oligonucleotide probes to quantify the size o

126 , the maintenance of the initially recruited clonotypic pattern of HIV-1-specific CD8+ T cells was as

127 at nodular PR in CLL represents MRD and that clonotypic PCR detects MRD in CLL more frequently than f

128 vast majority of patients remain positive by clonotypic PCR.

129 tment biopsies were subjected to semi-nested clonotypic PCR.

130 on of the HIV-specific T cell repertoire and clonotypic phenotype and function.

131 e a minimal deleted region of chromosome 13, clonotypic plasma cells from 50 consecutive patients wit

132 T fusion was present in more than 80% of the clonotypic plasma cells in these novel cases, there was

133 ase (MRD) in a highly specific and sensitive clonotypic polymerase chain reaction (cPCR).

134 We determined molecular remission status by clonotypic polymerase chain reaction (PCR).

135 cluded flow cytometry and a highly sensitive clonotypic polymerase chain reaction (PCR).

136 nt study, IL-2 expression and signaling in a clonotypic population of antiviral CD4+ T cells was anal

137 ositional scanning format with two different clonotypic populations of CD4+ T cells to identify pepti

138 tification of peptide ligands that stimulate clonotypic populations of T cells.

139 Nested CDR-III clonotypic primers were used in a semi-nested cPCR with

140 ones in different cell populations using TCR clonotypic probing.

141 oires highlighted an oligoclonal and private clonotypic profile in both resolved ALP-induced SJS/TEN

142 pheral blood after transplantation by use of clonotypic quantitative real-time PCR.

143 ells was done in 13 myeloma patients using a clonotypic, quantitative allele-specific oligonucleotide

144 Using clonotypic real-time RT-PCR, we have detected low freque

145 IgA repertoires of myeloma patients for the clonotypic rearrangement by next-generation sequencing.

146 ost-switch IgG/IgA repertoires, however, the clonotypic rearrangement was detected at high frequency

147 cells were then analyzed for the presence of clonotypic rearrangements of the T-cell receptor (TCR) V

148 oma patients and that this population shares clonotypic rearrangements with the malignant plasma cell

149 creas, actively turning over, expressing the clonotypic receptor, and containing functional regulator

150 CD8+ T cells respond to Ags when their clonotypic receptor, the TCR, recognizes nonself peptide

151 For the clonotypic receptors of B and T cells and for Fc recepto

152 most, if not all, memory T cells expressing clonotypic receptors that bind a tetrameric complex of i

153 nd to foreign antigenic peptides using their clonotypic receptors.

154 V9, both T cell populations displayed biased clonotypic repertoires and reacted similarly against HLA

155 es 1 (IGHV1) and 5 (IGHV5) was higher in IgE clonotypic repertoires compared with other antibody clas

156 ell populations with architecturally diverse clonotypic repertoires that displayed potent lytic activ

157 Conversely, diverse clonotypic repertoires without discernible motifs were n

158 We previously reported a strong public IgHu clonotypic response against the rhabdovirus viral hemorr

159 sponse to rechallenge, the magnitude of each clonotypic response was 10-fold higher in the liver than

160 that are independent of or largely override clonotypic responses.

161 T cell clones identified by their clonotypic sequence as expanded in the valve were also f

162 We identified the clonotypic sequence of T-LGL clones in 60 patients, incl

163 eview we discuss how features of this single clonotypic specificity anticipated insights into adaptiv

164 ion status, functionality, distribution, and clonotypic structure of MAIT cell populations in the per

165 gamma delta T cells are distinguished by the clonotypic subunits contained within their TCRs.

166 mploy two discrete binding modalities: a non-clonotypic, superantigen-like interaction mediating subs

167 The clonotypic surface Ig receptor expressed by malignant B

168 conditions of Ab excess, but also to prevent clonotypic T cell activation by inhibiting the ability o

169 ource of cognate antigens that contribute to clonotypic T cell expansion and the induction of GVHD in

170 rmed double immunohistochemical staining and clonotypic T cell receptor (TCR) beta-chain sequencing i

171 Clonotypic T cell receptor (TCR) genes undergo ordered r

172 D8+ T cells to the self-specificity of their clonotypic T cell receptor (TCR).

173 If a clonotypic T cell receptor expressed on a circulating T

174 ell maturation requires the rearrangement of clonotypic T cell receptors (TCR) capable of interacting

175 T cells express clonotypic T cell receptors (TCRs) that recognize peptid

176 rough the specificity and diversity of their clonotypic T cell receptors (TCRs).

177 The remaining clonotypic T cells are unresponsive to antigenic stimula

178 of Treg, the lack of peripheral expansion of clonotypic T cells is due to the absence of its high-aff

179 In contrast, Vbeta5(high)Valpha2(high) clonotypic T cells were not expanded, displayed the naiv

180 s fail to prevent autoimmunity by LAG-3(-/-) clonotypic T cells, implicating an important role for LA

181 13 inhibited proliferation of islet-reactive clonotypic T cells.

182 olecules (pMHCI or pMHCII, respectively) via clonotypic T-cell receptors (TCRs) remains debated.

183 we performed a comprehensive analysis of the clonotypic T-cell response using complementary murine mo

184 r monitoring corresponding clones, including clonotypic Taqman polymerase chain reaction (PCR) and cl

185 result in high vs low expression of the AI4 clonotypic TCR alpha-chain on developing thymocytes in B

186 gative biopsy samples showed no evidence for clonotypic TCR amplification.

187 Using clonotypic TCR beta-chain length and sequence analysis w

188 Addition of antibody to CD3 or the clonotypic TCR caused rapid CTCL cell apoptosis followed

189 signal CD4 commitment even in the absence of clonotypic TCR chains.

190 R structure, and is blocked by a recombinant clonotypic TCR comprised of TRAV17 and TRBV4-1, proving

191 unity provides a unique example in which the clonotypic TCR conveys the Th2 disease phenotype.

192 s development; notably, Tregs expressing the clonotypic TCR did not.

193 clusion, thymocytes with lower levels of the clonotypic TCR evaded deletion in TS1 x HA12 and TS1 x H

194 roducing T cells and to specifically measure clonotypic TCR frequencies in the T cell pool.

195 r a mimetic epitope recognized by the BDC2.5 clonotypic TCR in NOD mice.

196 ave a minimal loss of T cells expressing the clonotypic TCR in the thymus and spleen.

197 ression of effector CD4(+) T cells using the clonotypic TCR in vivo, but failed to mediate bystander

198 hritis, in which CD4(+) T cells expressing a clonotypic TCR induce disease by an IL-17-dependent mech

199 pheral self-antigen; should the autoreactive clonotypic TCR induce T conv to T reg cell conversion up

200 viously developed a useful method to isolate clonotypic TCR sequences from Ag-specific IFN-gamma-prod

201 (TCR) transgenic (Tg) mice that expressed a clonotypic TCR specific for a class II major histocompat

202 TCR) transgenic (Tg) recipients expressing a clonotypic TCR specific for an allogeneic major histocom

203 anchored RT-PCR, and real-time quantitative clonotypic TCR tracking.

204 HA, thymocytes expressing high levels of the clonotypic TCR were deleted in both HA-transgenic lineag

205 at the majority of the T-cells expressed the clonotypic TCR, and the phenotype and function of the ce

206 n early thymocytes, before the initiation of clonotypic TCR-alpha and TCR-beta gene rearrangement but

207 and are increased in cells that express the clonotypic TCR.

208 ticulin as a molecular chaperone for nascent clonotypic TCRalpha and -beta proteins and demonstrate t

209 that, unlike calnexin, which associated with clonotypic TCRalpha and -beta proteins and invariant CD3

210 s, calreticulin associated specifically with clonotypic TCRalpha and -beta proteins.

211 specificity and function in response to the clonotypic TCRs of pMHCII-specific CD4(+) T cells, and 2

212 on is mediated through direct interaction of clonotypic TCRs with complexes formed between Ag-present

213 presented by MHC molecules (pMHC) via their clonotypic TCRs.

214 solation of specific T-cell clones and their clonotypic TCRs.

215 utiny of the DNA from an archived slide with clonotypic TEL-AML1 primers showed that the presumptive

216 aemia at age 4 years, who shared a single or clonotypic TEL-AML1 sequence that suggested prenatal ori

217 None of 12 cases showed pre-switch clonotypic transcripts.

218 These clonotypic Tregs exerted Ag-specific suppression of effe

219 mechanism of T cell activation showed that a clonotypic Valpha2/Vbeta21 TCR transmitted activating si