ライフサイエンスコーパス: closely mimic

1 on in the crystal structure 1TW7 is found to closely mimic a key intermediate in the flap-opening pat

2 ures of TM oligomers by NMR in bicelles that closely mimic a lipid bilayer.

3 ucture of the S protein TMD in bicelles that closely mimic a lipid bilayer.

4 Abl2Delta688-790, which closely mimics a naturally occurring splice isoform, ret

5 amino acid R820X, to produce an allele that closely mimics a point mutation (E827X) in human SPINK5.

6 is a progressive, lethal disease which very closely mimics active human disease.

7 al structures and found that these compounds closely mimic all key interactions of MLL with menin.

8 Asp-128 --> Ala (D128A) streptavidin mutant closely mimics an intermediate on a well-defined dissoci

9 ibodies (mAbs), which, in vitro and in vivo, closely mimic antibodies that cause thrombocytopenia in

10 ed a clinically relevant cardiomyopathy that closely mimics ARVC in humans.

11 have developed a transgenic mouse model that closely mimics atherosclerosis in humans with type 1 dia

12 This construct closely mimics blimp1/krox1b expression during early sta

13 nsport gene can produce an animal model that closely mimics both the biochemical and histopathologica

14 are capable of inducing a skin disease that closely mimics bullous pemphigoid, supporting the hypoth

15 mmatory subepidermal blistering disease that closely mimics bullous pemphigoid.

16 e genetic circuits in environments that more closely mimic cells' natural 3D settings, to better expl

17 In an attempt to more closely mimic challenge with HIV, we administered repeat

18 a template for photoresponsive sterols that closely mimic cholesterol and may be applied broadly to

19 It is concluded that FCH closely mimics choline uptake by normal tissues and pros

20 of "adequate relief," allows researchers to closely mimic clinical situations and use a cutoff point

21 th skeletal myopathy and cardiomyopathy that closely mimics clinical DMD were studied.

22 Our second-generation test more closely mimics clinical scenarios by applying force to a

23 g an approach to target validation that more closely mimics clinical trials.

24 phologies with Li-ion anode performance that closely mimic commercial shaped graphite is demonstrated

25 hored three-dimensional collagen lattices to closely mimic conditions in vivo.

26 n that are missed on larger pillars and more closely mimic continuous surfaces.

27 nt preclinical models of addiction that more closely mimic diagnostic criteria of addiction.

28 Although CHF-BP most closely mimics diphosphate with respect to its acid/base

29 s following p21 overexpression in PC12 cells closely mimic distinctive events previously shown to occ

30 rough directional non-covalent interactions, closely mimic dynamic behaviors of biological nanofibers

31 We conclude that hESC-derived erythropoiesis closely mimics early human development because the first

32 Hirudo verbana a sequence of behaviors that closely mimic elements of spontaneous reproductive behav

33 ogic changes using radiopharmaceuticals that closely mimic endogenous molecules.

34 erial artificial chromosome (BAC) constructs closely mimics endogenous LRRK2 distribution in the mous

35 We find that organic thin-film growth closely mimics epitaxial growth of inorganic materials,

36 we have developed cell culture conditions to closely mimic events occurring during pancreatic islet o

37 ss forming liquid using a methodology, which closely mimics experiment.

38 duced a stable, proliferative cell type that closely mimics first-trimester placental cytotrophoblast

39 Disease progression closely mimics hallmarks of human CCHF disease, making I

40 n in androgen-independent LNCaP cells, which closely mimic hormone-refractory prostate cancer cells i

41 ical changes related to the treatment, which closely mimic HPV-associated lesions, are a frequent fin

42 is study aimed to establish a mouse model to closely mimic human B-cell PIOL and to test the therapeu

43 capable of triggering blisters in mice that closely mimic human BP.

44 They are adept at generating responses that closely mimic human conversational patterns.

45 ynamic and neurohumoral characteristics that closely mimic human dilated cardiomyopathy.

46 tegies to combat invasive aspergillosis that closely mimic human disease are desirable.

47 onclusion that animal models of disease must closely mimic human disease to produce clinically releva

48 ve elevated levels of IL-1beta and IL-18 and closely mimic human disease.

49 mainly for lack of experimental models that closely mimic human disease.

50 nd with (2) spontaneous canine NSCLCs, which closely mimic human disease.

51 logically representative animal models which closely mimic human diseases.

52 emia) or EL4 (B6 acute T cell leukemia) that closely mimic human GVL.

53 he lack of easily studied animal models that closely mimic human infection.

54 lar development, induces tumors in mice that closely mimic human medulloblastomas.

55 These features closely mimic human MSA-C pathology.

56 anics allows for the creation of models that closely mimic human muscle function so they can be used

57 ale fluid channels to create constructs that closely mimic human organs.

58 ee-dimensional organoid culture systems that closely mimic human retinal development in vitro.

59 provide the community with models that more closely mimic human retinitis pigmentosa.

60 thologic information, few animal models that closely mimic human sepsis, and a relative shortage of s

61 iation block at the promyelocytic stage that closely mimics human APL even in its response to retinoi

62 s is the first report of a murine model that closely mimics human B-cell PIOL.

63 t activation and neutrophil infiltration and closely mimics human BP.

64 of triggering a blistering skin disease that closely mimics human BP.

65 53-null mouse mammary gland tumor model that closely mimics human breast cancer, we have identified,

66 ary cancer (RMC), an animal tumor model that closely mimics human breast carcinoma.

67 odel of chemotherapy-induced alopecia, which closely mimics human chemotherapy-induced alopecia, stro

68 However intravenous administration more closely mimics human cocaine abuse during pregnancy.

69 inistration of cocaine in a manner that most closely mimics human cocaine use has long-term effects o

70 In an animal model that closely mimics human development; chronic treatment with

71 cation of the aortic valve, a phenotype that closely mimics human disease caused by NOTCH1 haploinsuf

72 While this animal model closely mimics human disease, rhesus macaques can harbor

73 tly described as a bubonic plague model that closely mimics human disease.

74 MPO) induces a mouse model of ANCA NCGN that closely mimics human disease.

75 Given that the DMD(mdx) rat model closely mimics human DMD pathology compared to other ani

76 This novel pig model of infection closely mimics human gastric pathology and presents a su

77 t of a mouse model of G6Pase deficiency that closely mimics human GSD-Ia.

78 hamsters with ANDV results in a disease that closely mimics human HPS in incubation time, symptoms of

79 , we used a neonatal mouse model, which more closely mimics human infants, to study the role of the i

80 le for studying ZIKV disease because it more closely mimics human infection by mosquito bite than nee

81 es were used to develop an animal model that closely mimics human Mycobacterium tuberculosis infectio

82 d polymer, termed ZT(Fn) , is presented that closely mimics human plasma fibronectin and serves as an

83 developing a murine model for infection that closely mimics human skin infection, we show that the va

84 data describe a novel transgenic mouse that closely mimics human tauopathy and may represent an impo

85 adult tissues except the gonads and thymus, closely mimics human TERT regulation.

86 To produce a mouse model that closely mimics human VHL disease and avoids embryonic le

87 An LAL null (lal-/-) mouse model closely mimics human WD/CESD, with hepatocellular, Kupff

88 lligence (AI) models can produce output that closely mimics human-generated content.

89 Since the conditions defined here more closely mimic in vivo ionic concentrations, they may per

90 ured IECs, producing an in vitro system that closely mimics in vivo conditions in the human intestine

91 Thus, the nonhuman primate model closely mimics influenza in humans.

92 neonates using an infection route that more closely mimics inhalation or ingestion of bacteria durin

93 the probability of lung involvement and more closely mimics intranasal immunization of humans.

94 triacylglycerol/water interfaces, which more closely mimic lipoprotein surfaces.

95 nucleotide precursors under conditions that closely mimic M13 replication in vivo.

96 f an engineered cytochrome c peroxidase that closely mimics manganese peroxidase (MnP) has been chara

97 ently established a murine model for LF that closely mimics many features of human disease.

98 BL/6 J:129S1/SvImJ mice) model of NAFLD that closely mimics most aspects of human disease.

99 ds and the development of animal models that closely mimic multiple aspects of cerebral microinfarcts

100 from ischemia/reperfusion injury, which more closely mimics myocardial infarction in patients, becaus

101 These membranes closely mimic native cellular architecture by maintainin

102 ug screening process as 3D tissue models can closely mimic native tissues and, in some cases, the phy

103 INKs) rapidly produce tissue constructs that closely mimic native tissues, characterized by strong st

104 .c.), and intranasal exposure routes to more closely mimic natural exposure.

105 gnals for these behaviours, others that more closely mimic natural lighting conditions, and, finally,

106 the factors responsible, animal models that closely mimic natural modes of allergen exposure should

107 The double-stranded stems of these aptamers closely mimic natural substrates near the RNase H domain

108 l wing membrane (thickness < 500 nanometers) closely mimics natural dragonfly wings and can be seamle

109 torial use of different approaches that more closely mimic nature's diverse cues, which may result in

110 volution of neural activities in the network closely mimics neural responses recorded in frontal cort

111 e is associated with clinical syndromes that closely mimic other primary rheumatic diseases.

112 ue 6-base self-complementary sequence, which closely mimics palindromic sequences that mediate functi

113 creatic edema, and acinar cell injury, which closely mimic pancreatitis in humans.

114 lergic disease and a mouse model designed to closely mimic peptide therapy in humans.

115 These rafts closely mimic persistent HPV16 infection, long before ca

116 f these IgGs (i.e., in a situation that more closely mimics physiologic conditions), GE Abs display s

117 We aimed to closely mimic physiological conditions by perforated-pat

118 ng their function under conditions that more closely mimic physiological conditions.

119 This more closely mimics physiological stimuli and circumvents the

120 iation upon TCR engagement in a process that closely mimics positive selection.

121 re several in vitro TBI models, none of them closely mimic post-TBI microglial activation.

122 cells missing chromosome II in a manner that closely mimics postsegregational killing mediated by pla

123 stablished a novel in vitro TBI model, which closely mimics primary neuronal injury-triggered microgl

124 We conclude that these mice very closely mimic severe human von Willebrand disease and wi

125 ps progressive lethal pulmonary disease that closely mimics severe coronavirus disease 2019 (COVID-19

126 or growth and metastatic spread of 4T1 cells closely mimics stage IV breast cancer.

127 And indeed, Yponomeuta sounds closely mimic such arctiine signals, revealing convergen

128 e data indicate that growth in 5 mM KCl more closely mimics survival and maturation of granule neuron

129 Although these side effects closely mimic symptoms of mitochondrial dysfunction, the

130 avis T2DM rats, a well validated model which closely mimics T2DM in humans.

131 axons and myelin with tissue contrasts that closely mimic target histology and enhanced sensitivity

132 uce second-generation Ab molecules that more closely mimic TCR fine specificity.

133 osition using modified growth medium to more closely mimic that of BL-04 yielded cells that showed in

134 of spatial orienting and exploration, which closely mimic that of stroke patients with spatial negle

135 ant allele manifest a retinal phenotype that closely mimics that in humans with RHO mutations.

136 as prostate cancer progression in this model closely mimics that observed in the human disease, and t

137 on of FRP-alphabeta without any FMN addition closely mimics that of a single-component bifunctional m

138 c, ceramic-based scaffold whose architecture closely mimics that of cuttlebone -a structural biomater

139 4-SCF Tg mice, whose melanocyte distribution closely mimics that of human skin, enabling comprehensiv

140 of the associated metabolic disease that so closely mimics that of obesity.

141 the shallow F' pocket in a conformation that closely mimics that of the alkyl chain in the CD1a-sulfa

142 d illustrate that, unexpectedly, its 3D fold closely mimics that of the DEDDh family of exonucleases.

143 ther direct expression in other tissues that closely mimics that of the endogenous gene.

144 eling supports a dual C/D RNP structure that closely mimics that recently visualized by electron micr

145 ies revealed that these diiron(II) complexes closely mimic the active site structures of the hydroxyl

146 e, we generated murine and human models that closely mimic the advanced-stage tumors where Parkin def

147 Appropriate model systems that closely mimic the architecture and function of the endom

148 ated colonic polyps with use of methods that closely mimic the attenuation, noise, and polyp-colon wa

149 mic diphosphorus molecule (P(2)) should more closely mimic the attributes of acetylene (HC=CH) rather

150 o-dimensional culture, tumour spheroids more closely mimic the avascular tumour microenvironment wher

151 it (GPIIb) only when the drug is present and closely mimic the behavior of antibodies found in human

152 Both monoclonals closely mimic the behavior of antibodies from patients w

153 often essential for their study because they closely mimic the biological complexities of cellular en

154 To closely mimic the Cambridge Neuropsychological Test Auto

155 shown by high resolution NMR spectroscopy to closely mimic the CD4 domain 1 CC' surface loop.

156 m cells, have now been generated, which more closely mimic the cellular architecture found within the

157 proving to be powerful in vitro models that closely mimic the cellular constituents of their native

158 istologic changes in the kidney of T2DN rats closely mimic the changes seen in the kidney of patients

159 Simulant reference materials, which closely mimic the characteristic chemical structures of

160 physiologic testing methodologies that more closely mimic the chronic intracellular infection usuall

161 for designing animal model studies that more closely mimic the clinical administration of gonadotoxic

162 when designing large animal studies to most closely mimic the clinical course of MI and enable trans

163 lity and yields dose distributions that more closely mimic the clinical setting relative to current C

164 a canine model that has been demonstrated to closely mimic the clinical situation.

165 structural and surface characteristics that closely mimic the DNA phosphate backbone, enabling it to

166 -receptor interactions under conditions that closely mimic the environment in which these encounters

167 It includes low-level functions that closely mimic the existing C/C++ API and higher-level fu

168 rated theoretical VVC inhibition curves that closely mimic the experimental data for the resistant vi

169 selection for the eye-like color pattern to closely mimic the eye or face of any particular predator

170 d NADP+ or with NAD+ and H2NADPH should more closely mimic the ground states for forward and reverse

171 ave been developed and/or characterized that closely mimic the human disease state.

172 media, wherein experimental conditions more closely mimic the in vivo environment than those in prev

173 an be studied in microenvironments that more closely mimic the in vivo environment.

174 nteractions between GO-APP(3/28) and T cells closely mimic the in vivo immunological synapses between

175 l protocols and 3D cultures will allow us to closely mimic the in vivo microenvironment of the choroi

176 ues and comparing these to simulations which closely mimic the inhibitor actions, careful application

177 es of Cu(II) and Cu(III) aryl complexes that closely mimic the intermediates in Cu-catalyzed C-N coup

178 del of intestinal cells was utilized to more closely mimic the intestinal epithelium.

179 s of miniature all-polymer flow sensors that closely mimic the intricate morphology of the mechanosen

180 ion, allowing formation of biomaterials that closely mimic the material properties of native elastin.

181 ts in diagnosing these cases as these tumors closely mimic the mesenchymal submucosal tumors such as

182 s such as the prototype BG505 SOSIP.664 that closely mimic the native Env spike can induce autologous

183 c or trimeric (gp140) forms of Env that more closely mimic the native proteins on the virion are ofte

184 the number of ticks in the challenge to more closely mimic the natural dose and found a profound defe

185 mall helical spirocyclic molecules that most closely mimic the natural product.

186 SS may more closely mimic the natural route of malaria infection ini

187 smoothing operator produces predictions that closely mimic the number and sizes of the native MemMoRF

188 To more closely mimic the pattern of NKX3.1 loss that occurs in

189 These features closely mimic the periventricular and cortical pathology

190 rstand how PF 06882961, but not CHU-128, can closely mimic the pharmacological properties of GLP-1.

191 pression of PML-RARA in this mouse model may closely mimic the physiologic expression pattern of PML-

192 ents are studied to determine which may most closely mimic the physiological form by comparing stress

193 fied into subspecies, of which the nestlings closely mimic the respective host nestlings in each regi

194 ers down to two, narrow, curved tunnels that closely mimic the shape of the preferred substrate.

195 ates that differentiate and self-organize to closely mimic the spatial and temporal patterning of the

196 ys with a synthetic Zn (2+) complex, to more closely mimic the structure of the active site in proMMP

197 the CaSR, which would be anticipated to more closely mimic the structure of the native CaSR ECD.

198 The UL144 structure was predicted to closely mimic the surface of HVEM, and we also found tha

199 eptide containing a noncanonical residue can closely mimic the tertiary structure of the native seque

200 sophageal mucosa with a cytokine cocktail to closely mimic the Th2 and inflammatory milieu of eosinop

201 rget antigenic sites on a tumor antigen must closely mimic the three-dimensional structure of the cor

202 pigs and rabbits, the canine model may more closely mimic the vascular response of humans.

203 ogically relevant ex vivo tissue model which closely mimics the actual microneedling procedure to elu

204 ults indicate that growth on vertical plates closely mimics the Adh/GUS expression observed for soil-

205 ion state analogue, ADP.AlFx, bound, that it closely mimics the ATP-bound state.

206 introduce intercrystal light sharing, which closely mimics the behavior of dual-ended readout, with

207 to develop an equivalent circuit model that closely mimics the behavior of each of the main componen

208 Our model closely mimics the behavior of Metapolybia wasps, demons

209 In model systems, DHE closely mimics the behavior of native cholesterol.

210 rmed that the fusion chimera (Fusion-F(D12)) closely mimics the binary AMA1-RON2L complex.

211 ium coatneyi, a simian malaria parasite that closely mimics the biological characteristics of P. falc

212 This model closely mimics the clinical and pathological features of

213 ed on the same set of samples that also more closely mimics the clinical environment.

214 ating a drug with standard therapeutics more closely mimics the clinical setting than evaluating the

215 ion of specific mutations, in a context that closely mimics the complexity of cancer.

216 This experimental approach more closely mimics the conditions found in vivo.

217 pho-epitope within the C terminus of LT that closely mimics the consensus Cdc4 phospho-degron found w

218 odel of transgenic MMTV-PyMT tumor that more closely mimics the development of human breast cancer in

219 model is a model of multiple sclerosis that closely mimics the disease characteristics in humans.

220 d an in vitro organotypic culture model that closely mimics the disease.

221 We show here that, unlike IL-2, IL-15 closely mimics the effects of IFN I in causing strong an

222 rentiation and arrested growth in vitro that closely mimics the effects of siRNA-mediated attenuation

223 (TSCs) proliferating in the presence of FGF4 closely mimics the events triggered by FGF4 deprivation:

224 f virus-associated pulmonary B-cell lymphoma closely mimics the full spectrum of human lymphomatoid g

225 ck of an appropriate small animal model that closely mimics the generation of BOOP lesions has been a

226 , which renders cells temperature sensitive, closely mimics the global defects of the Fe-S cluster mu

227 images with results showing performance that closely mimics the gold standard manual process.

228 --> HisPhe-43 --> His, called Cu(B)Mb) that closely mimics the heme-copper center in HCO.

229 arance of the cell cycle events in the mouse closely mimics the human disease progression.

230 immunocompetent model of NUT carcinoma that closely mimics the human disease provides a valuable glo

231 A canine model that closely mimics the human disease was used to determine i

232 ies specific for mouse MPO induces NCGN that closely mimics the human disease.

233 A mouse model of total saposin deficiency closely mimics the human disease.

234 imens, we have developed a murine model that closely mimics the human lung disease process.

235 n orthotopic murine mammary tumor model that closely mimics the human pathology, including pDC and re

236 the authors characterized a mouse model that closely mimics the human phenotype and tested the feasib

237 This biological model closely mimics the human setting and permits transient s

238 ouse model of vascular graft infections that closely mimics the human situation.

239 tep in developing an in vivo model that more closely mimics the IgE-mediated responses in man, we use

240 chlamydial-specific Th1-biased response that closely mimics the immune response produced after chlamy

241 mall molecules tested in a setting that more closely mimics the in vivo cancer microenvironment so as

242 Therefore, using a pulse model that closely mimics the in vivo pharmacokinetics of platinum

243 hat, when placed in a recording chamber that closely mimics the in vivo physiological environment, a

244 Whole blood perfusion more closely mimics the in vivo situation, but extracorporeal

245 The cardiac work-loop technique closely mimics the intrinsic in vivo movement and charac

246 t overexpression of the HU-induced SAR1 gene closely mimics the known effects of HU on K562 and CD34(

247 arning in smooth eye movements in a way that closely mimics the learning instructed by real visual mo

248 tures an alkyne as a key design element that closely mimics the linear, 180 degrees transition state

249 +) for its effects: removal of this tyrosine closely mimics the loss of sli-1 but not of another nega

250 of a bottle-brush polymer whose architecture closely mimics the lubricating protein lubricin.

251 ary, we have identified a novel peptide that closely mimics the MAb 2D7 epitope on CCR5.

252 iabetic Fatty Rat (ZDF/Drt-fa), a model that closely mimics the metabolic abnormalities of NIDDM.

253 portantly, 1(+) in these catalytic reactions closely mimics the mode of action of the transition meta

254 d a biomimetic modular polymer that not only closely mimics the modular multidomain structure of titi

255 ished an ex vivo 3D Ewing sarcoma model that closely mimics the morphology, growth kinetics, and prot

256 he structure of a model membrane system that closely mimics the myelin sheath.

257 he structure of the partially unfolded forms closely mimics the native organization, four residues in

258 he design and fabrication of a scaffold that closely mimics the native skeletal-muscle extracellular

259 ct HR1 redesigns confirm that redesigned Env closely mimics the native, prefusion trimer with a more

260 d by the ACP, indicating that the crypto-ACP closely mimics the natural DH substrate.

261 eadily available protein substrate that more closely mimics the natural substrates of endoproteinases

262 l (3D) air-liquid interface (ALI) model that closely mimics the natural tissue physiology of SARS-CoV

263 ) may result in optic nerve damage that very closely mimics the pathologic course of primary open ang

264 model lacking both dystrophin and telomerase closely mimics the pathological progression of human DMD

265 The mdx diaphragm muscle closely mimics the pathophysiological changes in DMD mus

266 using an intravenous (IV) rodent model that closely mimics the pharmacokinetics seen in humans after

267 This effect closely mimics the phenotype of APP A673T, a recently di

268 yl is a weak allosteric activator, the ester closely mimics the physiological corepressor in activati

269 establish a hormone replacement regimen that closely mimics the physiological diurnal cortisol secret

270 e that the structure of the covalent complex closely mimics the physiological electron transfer compl

271 ess fertilin beta in vitro in a fashion that closely mimics the processing pattern observed in vivo d

272 ures an aspartyl-BeF3 covalent adduct, which closely mimics the proposed aspartyl-phosphate intermedi

273 se and eosinophilia after RSV challenge that closely mimics the RSV vaccine-enhanced disease observed

274 oth late-stage chondrocytes and osteoblasts, closely mimics the skeletal phenotype in fro/fro mice.

275 Remarkably, 2 closely mimics the structure of Mn(V)(O)(mu-O)Ca(II)(OH(

276 d in cellular prosurvival Bcl-2 proteins and closely mimics the structure of the prosurvival Bcl-2 fa

277 a tert-butyldiarylsilyl (TBDAS) linker that closely mimics the tert-butyldiphenysilyl protecting gro

278 This time course more closely mimics the timing of disease onset in affected p

279 substrate with stochastic surface order that closely mimics the topographic features of native baseme

280 DATMe-ImmH more closely mimics the transition of human PNP than does Imm

281 Our structure closely mimics the wild-type fold of TrkAIg2 in complex

282 ts is necessary to induce, and sufficient to closely mimic, the original mutant phenotypes of Trp(P36

283 gent, lipid, or detergent/lipid mixture that closely mimic their native environment.

284 veloped a fluid dynamic novel platform which closely mimics these parameters.

285 traints on the PQS folding process that more closely mimic those found in genomic DNA.

286 ionally-relevant research in conditions that closely mimic those found in the clinic.

287 s on spontaneous and Ca(2+)-triggered fusion closely mimic those observed in neuronal cultures.

288 lts in molecular and morphogenic events that closely mimic those observed in wild-type embryos.

289 kek5 phenotypic effects closely mimic those observed with Short gastrulation (So

290 n chromatin architecture and gene expression closely mimic those of deleting the fetal globin repress

291 nal features of these mouse medulloblastomas closely mimic those of human MYC-subgroup tumors and sig

292 EPR spectra of one-electron oxidized dimers closely mimic those of native special pairs, and strong

293 xposed to low-frequency soil vibrations that closely mimic those of rainfall.

294 board, with stimulus parameters designed to closely mimic those of the commercial FDT test.

295 eference of the bacterially expressed enzyme closely mimic those of the enzyme expressed in mammalian

296 oid tissue and other pathologic sequela that closely mimics those observed in HIV infected humans.

297 , the TLS structure is 'two faced': one face closely mimics tRNA and drives aminoacylation, the other

298 el of spontaneous breast carcinogenesis that closely mimics tumor-host interactions seen in humans.

299 imuli by designing novel paradigms that more closely mimic visual behavior in the wild.

300 tings with lower bacterial inocula that more closely mimic what initially occurs in humans.