ライフサイエンスコーパス: clostridial

1 that is predominantly from within the Order Clostridiales.

2 Bacteroides spp., and a species of the order Clostridiales.

3 Breast-fed infants had lower proportions of Clostridiales.

4 hment of a protective microbiota enriched in Clostridiales.

5 and expansion of Lactobacillales and loss of Clostridiales.

6 ncluding increased Proteobacteria, decreased Clostridiales abundance, and a longer duration of decrea

7 Depletion of Clostridiales also abolished colonization resistance in

8 es showed high in vitro activity against the clostridial and bacillary collagenases.

9 Importantly, Clostridial and butyrate-producer abundance as well as S

10 S] clusters compared with the well described clostridial and chromatium types.

11 Nineteen clostridial and gastrointestinal bacteria strains were u

12 Sequences were aligned to SILVA database and Clostridiales and Erysipelotrichales orders were more ab

13 d that deworming treatment reduced levels of Clostridiales and increased Bacteroidales.

14 associated dysbiosis, including decreases in Clostridiales and increases in Moraxellaceae, Veillonell

15 0.06, and produced communities dominated by Clostridiales and Lactobacillales.

16 -indoxylsulfate levels, reduced abundance of Clostridiales and low inverse Simpson and effective Shan

17 otomaculum and Bacteroidetes, enrichments of Clostridiales and Psychrosinus species, and a temporal s

18 e highest microbial diversity, abundances of Clostridiales and Ruminococcaceae, and lower abundance o

19 eased proportions of two orders of Bacteria: Clostridiales and Syntrophobacterales, with Desulfotomac

20 ially protective taxa (eg, Lactobacillus and Clostridiales) and increased risk of Enterococcus domina

21 erococcaceae and Streptococcaceae, decreased Clostridiales) and taxa associated with gastrointestinal

22 ium genus, a decreased level of unclassified Clostridiales, and a tendency to decrease Oxalobacterace

23 We previously developed nanoCLAMPs (nano Clostridial Antibody Mimetic Proteins), a class of antib

24 ecies, and three novel bacteria in the order Clostridiales are among the bacterial species significan

25 toward AADC, along with previously reported clostridial asRNAs, were examined for structural feature

26 el, Clostridia (44%) at the Class level, and Clostridiales at the Order level (41%).

27 cr found in hypervariable genomic regions of clostridial bacteria and their prophages from human gut

28 f either a Megasphaera species or one of the Clostridiales bacteria yielded a sensitivity of 99% and

29 higher in women with baseline detection of 3 Clostridiales bacteria, designated as BVAB1 (risk ratio,

30 rhamnosus and murinus increase the levels of Clostridiales bacteria, which induces a hostile environm

31 ng with stromal cells, and Bacteroidales and Clostridiales bacterial taxa.

32 converted l-carnitine to gammaBB, and only 1 Clostridiales bacterium, Emergencia timonensis, that con

33 , the role of these putative drug targets in clostridial biological pathways was studied while subcel

34 Clostridial botulinum neurotoxin (BoNT) causes a neuropa

35 The clostridial botulinum neurotoxins (BoNTs) are the most p

36 Clostridial botulinum neurotoxins (BoNTs) cause neuropar

37 Clostridial botulinum neurotoxins (BoNTs) exert their ne

38 Administration of Clostridiales, but not Bacteroidales, protected neonatal

39 n, many members of the orders Bacillales and Clostridiales can sporulate, generating dormant and resi

40 ically deduced structure of the A-Cluster in clostridial carbon monoxide dehydrogenase.

41 whereas anaerobic sporeformers (for example, Clostridiales) cause spoilage in a range of products tha

42 feature might be common to all cellulosomal clostridial CBM4 modules.

43 We propose that clostridial CBM4s have possibly evolved to bind the free

44 sphaera, Ruminococcaceae, Coriobacteriaceae, Clostridiales, Christensenellaceae, YS2 (Cyanobacteria),

45 They are adjacent on the Clostridial chromosome and encode polypeptides of 57.3 a

46 egration of multiple functional genes into a clostridial chromosome--here, the C. acetobutylicum chro

47 ad member of the Firmicutes belonging to the Clostridiales cluster XIVa, can grow on the unusual but

48 m human feces that represent three different clostridial clusters (IV, XIVa, and XVI).

49 icially synthesized NTR gene using optimized clostridial codons (sNTR).

50 A mouse model of antibiotic-associated clostridial colitis was established to examine the role

51 A mouse model of antibiotic-associated clostridial colitis was set up.

52 Western blot analysis showed that Clostridial collagenase degraded various collagens but s

53 However, the instability of clostridial collagenase I (Col G) results in a degraded

54 rystal structures of the peptidases of three clostridial collagenase isoforms (ColG, ColH, and ColT).

55 Clostridial collagenases are among the most efficient en

56 critically affects the enzymatic activity of clostridial collagenases.

57 composition of the gut microbiota found that Clostridiales colonization was increased in NcDase(-/-)

58 ce in Erysipelotrichales, Bacteroidales, and Clostridiales, correlates strongly with disease status.

59 lethal toxins, A and B, members of the large clostridial cytotoxin family.

60 The tpeL gene encoding the large clostridial cytotoxin was localized to the cpb plasmids

61 lap that appear to be unique among the large clostridial cytotoxins.

62 proteins with significant homology to large clostridial cytotoxins.

63 logy with the catalytic domains of the large clostridial cytotoxins.

64 The current clostridial-derived vaccines against BoNT intoxication h

65 lated genomes and show that these subsurface Clostridiales differ, from the surface derived genomes,

66 Bacteria from the orders Bacillales and Clostridiales differentiate into stress-resistant spores

67 ortant implications for human and veterinary clostridial disease epidemiology and provides important

68 e observations lead to the conclusion that a clostridial endopeptidase conjugate that can be used to

69 ngens is recognized as an important cause of clostridial enteric diseases, only limited knowledge exi

70 d phosphonates that takes advantage of (i) a Clostridial enzyme to set the absolute stereochemistry a

71 orted for the analogous radical bound to the clostridial enzyme.

72 eoxyadenosyl radical as in the action of the clostridial enzyme.

73 tate of E. coli LAM, as in the action of the clostridial enzyme.

74 obium, Desulfovibrio and four members of the Clostridiales family.

75 of bacteria from the class Clostridia, order Clostridiales, family Ruminococacceae and related genera

76 eates a methodology to combine solventogenic clostridial fermentation and chemical catalysis via extr

77 SKO1 cells never achieved the swollen clostridial form typical of the parental strain and did

78 rved extended time between the appearance of clostridial forms and endospore formation.

79 A diagnosis of presumed Clostridial gas gangrene was made, and treatment was ini

80 gas embolism, severe decompression sickness, clostridial gas gangrene, necrotizing fasciitis, and acu

81 The clostridial gene encoded a basic 14.5-kDa protein (TcbC)

82 In Clostridial genomes, only the Spo0A protein was found, s

83 ing CPB2 (cpb2) are strongly associated with clostridial GI diseases in domestic animals, including n

84 TpeL is a member of the family of clostridial glucosylating toxins produced by Clostridium

85 hin the RTX toxin that is conserved in large clostridial glucosylating toxins TcdB, TcdA, TcnA, and T

86 phospholipase, neuraminidase, and two large clostridial glucosylating toxins, TcsL and TcsH.

87 lights the profound clinical significance of clostridial glucosylating toxins.

88 a process that is conserved across the large clostridial glucosylating toxins.

89 es of bacterial toxins, including all of the clostridial glucosyltransferase toxins and various MARTX

90 CROP-independent receptor-binding domain in clostridial glycosylating toxins and suggest a two-recep

91 RBD-like regions are conserved in all other clostridial glycosylating toxins preceding their CROP do

92 wo-receptor model for the cellular uptake of clostridial glycosylating toxins.

93 Lineages of Firmicutes, including Clostridiales, have been frequently detected in oil rese

94 Here, we present the crystal structure of a clostridial hemagglutinin (HA) complex of serotype BoNT/

95 rotein in the E. coli host compared with the clostridial host, which we hypothesized could be the res

96 S compared with controls, whereas uncultured Clostridiales I, genus Faecalibacterium (including Faeca

97 Despite their high pathogenicity, clostridial infections and food contaminations present s

98 n the development of therapies for arresting clostridial infections by enabling the isolation of indi

99 dence supporting a role for any QS system in clostridial infections.

100 n interaction between Lactobacillus spp. and Clostridiales involving cooperation between microbiota m

101 sed abundance of Veillonella, Dialister, and Clostridiales) is significantly associated with increase

102 Clostridial isolates were typed and toxin genes detected

103 estinal microbiota, including members of the Clostridiales, Lachnospiraceae and Ruminococcaceae, from

104 Clostridiales, Lachnospiraceae, and Faecalibacterium pra

105 radicals at the active sites of E. coli and clostridial LAM are different.

106 The radical in the reaction of clostridial LAM has the (S)-configuration, whereas that

107 on different from that at the active site of clostridial LAM.

108 . coli is 5.0 min(-1), 0.1% of the value for clostridial LAM.

109 roader host spectrum, by identifying PMP1, a clostridial-like neurotoxin that selectively targets ano

110 he iron-sulfur cluster at the active site of Clostridial lysine 2,3-aminomutase.

111 Here, we identify Clostridiales members of the gut microbiota associated w

112 ociated monosaccharides and identify several Clostridiales members that utilize intestinal mucins.

113 mework advances our understanding of complex clostridial metabolism and physiology and also facilitat

114 r electron transfer (e.g., Bacteroidales and Clostridiales) might indirectly contribute to bioelectro

115 dium perfringens is the most common cause of clostridial myonecrosis (gas gangrene).

116 ase, including food poisoning, gas gangrene (clostridial myonecrosis), enteritis necroticans, and non

117 eral human diseases, including gas gangrene (clostridial myonecrosis), enteritis necroticans, antibio

118 h buprenorphine and morphine do not die from clostridial myonecrosis.

119 vel therapies to reduce tissue damage during clostridial myonecrosis.

120 Cleavage of syb by a clostridial neurotoxin resulted in significant defects i

121 The clostridial neurotoxins (CNTs) are the most toxic protei

122 The potency of the clostridial neurotoxins (CNTs) relies primarily on their

123 n (TeNT) and botulinum neurotoxin (BoNT) are clostridial neurotoxins (CNTs) responsible for the paral

124 The clostridial neurotoxins (CNTs), comprised of tetanus neu

125 Clostridial neurotoxins (CNTs), which include botulinum

126 tant impact on the study of the evolution of clostridial neurotoxins and provides the basis for the u

127 Clostridial neurotoxins are bacterial endopeptidases tha

128 Clostridial neurotoxins are the causative agents of the

129 Clostridial neurotoxins are zinc endopeptidases that blo

130 Clostridial neurotoxins are zinc endopeptidases, and eac

131 First, clostridial neurotoxins block neurotransmission to or fr

132 Clostridial neurotoxins comprising the seven serotypes o

133 t for antiepileptic drugs and a receptor for clostridial neurotoxins including Botox.

134 The catalytic component of the clostridial neurotoxins is their light chain (LC), a Zn2

135 Clostridial neurotoxins potently and specifically inhibi

136 se studies provide new insights into how the clostridial neurotoxins recognize their substrates.

137 Binding of the clostridial neurotoxins to receptors on neuronal cells i

138 Clostridial neurotoxins' metalloprotease domain selectiv

139 urotoxin type A is the most potent among the clostridial neurotoxins, and to date there is no post-ex

140 Clostridial neurotoxins, including tetanus and botulinum

141 other data for inhibitors of the proteolytic clostridial neurotoxins.

142 T/G and BoNT/B subtypes, but varies in other clostridial neurotoxins.

143 es, and were sensitive to Ca2+ depletion and clostridial neurotoxins.

144 ns and the related metalloprotease domain of clostridial neurotoxins.

145 rystal structure of a BoNT in complex with a clostridial nontoxic nonhemagglutinin (NTNHA) protein at

146 f methanogens, and enterotypes enriched with Clostridiales or Prevotella species.

147 We find that microbes in the Clostridiales order and Lachnospiraceae family are assoc

148 were observed in bacterial species from the Clostridiales order during therapy.

149 ersity and abundance of specific taxa in the Clostridiales order may contribute to the association be

150 zed species, including three bacteria in the Clostridiales order that were highly specific for bacter

151 terium prausnitzii and a novel member of the Clostridiales order was kept.

152 s is associated with several bacteria in the Clostridiales order, Megasphaera phylotype 2, and P. lac

153 rtium of commensal bacteria belonging to the Clostridiales order, which exerts in vitro antilisterial

154 ch as several members from Bacteroidales and Clostridiales orders and genera including Moraxella, Sta

155 f germination proteins in the Bacillales and Clostridiales orders are discussed and models for the ge

156 spore-forming members of the Bacillales and Clostridiales orders, although SpoVAEa's amino acid sequ

157 spore forming members of the Bacillales and Clostridiales orders.

158 This was the first report of a clostridial organism containing more than two neurotoxin

159 A clostridial OTU was overabundant in prediagnosis samples

160 elothrix, Atopostipes, Bacteroides, and many Clostridiales OTUs; additional experiments must determin

161 at this enzyme is not the well-characterized clostridial p-hydroxyphenylacetate decarboxylase (CsdBC)

162 To address this and other questions in clostridial phylogeny, we have compared a phylogenetic t

163 me is (R)-beta-lysine, the enantiomer of the clostridial product.

164 e vector with one of two powerful endogenous clostridial promoters: that of the thiolase gene (thlP)

165 The predominance of spore-forming Clostridiales provided evidence for the resilience of th

166 0.06, 0.31; P < 0.01), higher abundances of Clostridiales (Q4-Q1: beta: 449; 95% CI: 96.3, 801; P =

167 n the gut microbiota, with Bacteroidales and Clostridiales responding the most.

168 study lays the foundation for understanding clostridial riboregulation with implications for the inf

169 w that site-1 proteolysis in B. subtilis and Clostridial RsgI family members is mediated by enzyme-in

170 mpared with control mice, with enrichment of Clostridiales (Ruminococcaceae, Lachnospiraceae) and dep

171 fatty acid effects in bacteria belonging to Clostridiales, Rykenellaceae, and in species of the gene

172 n and has several conserved homologues among clostridial saccharolytic, cellulolytic, and pathogenic

173 bers of the Negativicutes revealed typically clostridial sets of sporulation genes.

174 XDXGXTW motifs and catalytic residues of the clostridial sialidase are conserved in the mycoplasmal g

175 timulate the hydrolysis of NeuAc from GM2 by clostridial sialidase, but not the hydrolysis of GalNAc

176 the external NeuAc from this ganglioside by clostridial sialidase.

177 ase the number of noncommensal/nonpathogenic clostridial species and provide a key foundation for fut

178 . difficile spore proteome to those of other clostridial species defined 88 proteins as the clostridi

179 To expand the knowledge base for clostridial species relevant to current biofuel producti

180 were determined to high resolution from the clostridial species Thermoanaerobacterium thermosaccharo

181 Clostridial species were regarded as classic examples.

182 reconstruction of Rex regulons in 11 diverse clostridial species with detailed experimental character

183 f healthy or CMA colonized mice identified a clostridial species, Anaerostipes caccae, that protected

184 Ts) are produced by at least four pathogenic clostridial species, and several LCTs are proven pivotal

185 ts of nGRs from spores of all Bacillales and Clostridiales species and defines two highly conserved s

186 Therapy with Clostridiales species impacted by dysbiosis, either as a

187 st an early onset dysbiosis with the loss of Clostridiales species, which promotes the differentiatio

188 dysregulation was rescued by treatment with Clostridiales species, which upregulated Tgfb1 expressio

189 us, although they are apparently absent from Clostridiales species.

190 ostridial species defined 88 proteins as the clostridial spore "core" and 29 proteins as C. difficile

191 The endogenous compounds that regulate clostridial spore germination are not fully understood.

192 Clostridial spore germination requires degradation of th

193 Clostridial spore-formers lack, among others, spoIIB, sd

194 present a key regulatory protein controlling clostridial sporulation.

195 ously shown that spores of the nonpathogenic clostridial strain C. sporogenes genetically engineered

196 es higher than that produced by the original clostridial strain.

197 Oral application of a mix of four Clostridiales strains (CC4) in mice prevented and even s

198 ass conversion, cellulosome composition, and clostridial systems biology.

199 n response to treatment and sex, composed of Clostridial taxa and several Firmicutes known to be prot

200 idetes, as well as a peculiar arrangement of Clostridiales taxa, may enhance the Hadza's ability to d

201 Our studies revealed that the clostridial TcbC protein activated the transcription of

202 ria to one dominated by Bacteroidales and/or Clostridiales that poorly stimulate TLR4.

203 rst dominated by Firmicutes (Lachnospiraceae/Clostridiales), the second by Proteobacteria (Klebsiella

204 ylum Firmicutes, class Clostridia, and order Clostridiales This ancillary analysis of the iHMP data t

205 bacteria enhanced the ability of protective Clostridiales to colonize the gut.

206 cytotoxin active site shared with the large clostridial toxin (LCT) family and proteins such as ToxA

207 ium sordellii lethal toxin (TcsL) is a large clostridial toxin (LCT) that glucosylates Ras, Rac, and

208 ogy to only the enzymatically active site of clostridial toxin B.

209 are indistinguishable from those mediated by clostridial toxin B.

210 related toxins that are members of the large clostridial toxin family.

211 omain required for enzymatic activity of the clostridial toxin homologs, suggesting a role in urogeni

212 The sensitivity to the action of clostridial toxin indicates the docking-fusion complex i

213 Neutralization of PLC activity in the clostridial toxin preparation completely abrogated human

214 Intramuscular injection of a clostridial toxin preparation containing both phospholip

215 Pretreatment with clostridial toxin resulted in reduced co-immunoprecipita

216 homologous CPD is also present in the large clostridial toxin TcdB and recent studies showed that in

217 eins of the presynaptic active zone, but not clostridial-toxin-sensitive VAMP-family SNARE proteins,

218 Large clostridial toxins (LCTs) are produced by at least four

219 lethal toxin (TcsL) is distinct among large clostridial toxins (LCTs), as it is markedly reduced in

220 nt class of virulence factors known as large clostridial toxins (LCTs).

221 with the glycosyltransferase domain of large clostridial toxins (LCTs).

222 e pathogenicity locus (PaLoc), which encodes clostridial toxins A and B.

223 sion, we have identified six CPPs from large clostridial toxins and have demonstrated the ability of

224 colitis through the elaboration of two large clostridial toxins and other virulence factors.

225 The most powerful clostridial toxins are tetanus and botulinum neurotoxins

226 However, pretreating cells with clostridial toxins blocked the cellular translocation of

227 quence is strictly conserved among all large clostridial toxins is shown to be functionally important

228 g exocytosis and to determine the effects of clostridial toxins on SNARE-mediated trafficking of H(+)

229 Flow cytometry confirmed that these clostridial toxins or recombinant PLC induced formation

230 Research is underway to use clostridial toxins or toxin domains for drug delivery, p

231 on of GR activity also occurs with the large clostridial toxins produced by Clostridium sordellii and

232 ion arise because of the production of large clostridial toxins that disrupt the intestinal barrier a

233 vations represent a unique property of these clostridial toxins whereby they can associate into large

234 ing of peptides derived from two other large clostridial toxins, TcdA and TcsL, uncovered two new Tcd

235 ology with the catalytic domain of the large clostridial toxins, which are retaining glycosyltransfer

236 tivity to KB-R7943, and resistance to native Clostridial toxins.

237 been prepared for use in our studies of the clostridial toxins.

238 nding of the substrates selectivity of large clostridial toxins.

239 of the thiolase gene (thlP) and that for the clostridial transcription factor abrB310 (abrBP).

240 says and Western blots of cell extracts from clostridial transformants harboring plasmid constructs o

241 esults suggest that C. reinhardtii employs a clostridial type H(2) production pathway in the dark, es

242 that the C. tepidum Fds are chimeras of both clostridial-type and chromatium-type Fds, suggesting tha

243 In clostridial-type ferredoxins, each of the two [4Fe-4S]2+

244 Fe azotobacter-type ferredoxins from the 8Fe clostridial-type ferredoxins, one of the two motifs pres

245 The "clostridial-type" ferredoxins have two Cys-Xaa-Xaa-Cys-X

246 an increased abundance of Acetatifactor and Clostridiales vadin BB60 genera in the gut; increased li

247 ack of colonization resistance occurred when Clostridiales were absent in the neonatal microbiota.

248 nd in U(VI)-free incubations, members of the Clostridiales were dominant with sulfate-reducing phylot

249 higher in CLD (OR: 1.89, p = 0.04), whereas Clostridiales were more abundant in controls.

250 Certain bacterial taxa (eg, Clostridiales) were negatively associated with CRPA colo

251 We examined members of the Clostridiales, which included the families Clostridiacea

252 level, pointing towards a positive role for Clostridiales while negative for Enterobacteriales.

253 methanogens: all but two were members of the Clostridiales, with several being, or related to, known

254 Stool Bacteroidaceaeae and Clostridiales XIV predicted 90-day hospitalizations inde

255 Specifically, lower stool Bacteroidaceae, Clostridiales XIV, Lachnospiraceae, Ruminococcacae and h

256 nt prediction using stool Bacteroidaceae and Clostridiales XIV.

257 bligate and facultative anaerobes, including Clostridiales year round, suggests that anaerobic bacter