ライフサイエンスコーパス: co-deletion

1 de II and III gliomas associated with 1p/19q co-deletion.

2 p53 dependent and markedly attenuated by p53 co-deletion.

3 ng serine/threonine-protein kinase 3 (Ripk3) co-deletion.

4 Pten deficiency on the backdrop of Smad4/Apc co-deletion.

5 t oligodendrogliomas have chromosomes 1p/19q co-deletion and an IDH mutation.

6 diffuse glioma taxonomy (IDH mutation, 1p19q co-deletion and ATRX mutation), achieving a mean molecul

7 ce of MGMT methylation IDH mutations, 1p/19q co-deletion, and ATRX mutations.

8 s of MGMT methylation, IDH mutations, 1p/19q co-deletion, ATRX mutation, and TERT mutations achieve a

9 ular (MGMT methylation, IDH mutation, 1p/19q co-deletion, ATRX mutation, and TERT mutations) predicti

10 Genetic co-deletion experiments revealed that phenotypes resulti

11 oma subgroups (IDHmt, with or without 1p/19q co-deletion [IDHmt/codel], or IDH wild type [IDHwt]; p=0

12 Ctnnb co-deletion increased CGNP proliferation and rescued cer

13 This co-deletion leads to aggressive tumors with poor prognos

14 Tumorigenesis was exacerbated by Trp53 co-deletion (median age of onset 275 days, penetrance 82

15 n-free survival by molecular markers (1p/19q co-deletion, MGMT promoter methylation status, and IDH1/

16 lternations in IDH1/2, ATRX, TERT, TP53, and co-deletion of 1p/19q have the ability to reclassify gli

17 Co-deletion of 1p/19q is a hallmark of oligodendroglioma

18 Co-deletion of Aspm and either of the apoptosis regulato

19 Co-deletion of Cdkn2a and Trp53 in dysplastic gastric or

20 at occur early during tumorigenesis, such as co-deletion of chromosome arms 1p and 19q (1p/19q codele

21 as characterized by IDH mutation but without co-deletion of chromosome arms 1p/19q, and further conve

22 eficient RER (Rnaseh2b(DeltaIEC)), bearing a co-deletion of disrupted autophagy (Atg16l1/Rnaseh2b(Del

23 lasm of cornifying lingual keratinocytes and co-deletion of DNase1L2 and Trex2 causes massive accumul

24 We find that co-deletion of FcRgamma did not exacerbate the skeletal

25 ted by this strain is completely reversed by co-deletion of FET4 gene.

26 ty of the fet3delta strain was suppressed by co-deletion of FRE1, suggesting that the cytotoxic speci

27 Instead, co-deletion of GSDMD and caspase-8-activated GSDME limit

28 Moreover, co-deletion of Hif1a could not rescue the Vhl(-/-)-depen

29 Co-deletion of Interferon Type I genes and CDKN2A was pr

30 by cathepsin-B/L inhibition, and by genetic co-deletion of lysosomal cathepsin B.

31 Co-deletion of MTAP and methionine adenosyltransferase 2

32 ovides a vulnerability for tumors carrying a co-deletion of MTAP and the adjacent CDKN2A tumor suppre

33 cient macrophages(13) was largely rescued by co-deletion of N4BP1.

34 Tumors bearing the co-deletion of p16 and MTAP genes have been shown to be

35 in NSCLC which is associated with detectable co-deletion of p16INK4A in only half of the cases.

36 c therapeutic vulnerabilities resulting from co-deletion of passenger genes neighboring TSG.

37 rve crush in retinal ganglion cells with the co-deletion of Pten and Socs3.

38 Here we show a frequent genomic co-deletion of PTEN and STAT3 in liquid biopsies of pati

39 Postnatal co-deletion of Pten and Trp53 in mouse neural stem cells

40 engineered murine liver models, we show that co-deletion of Rac1 with Nf2 blocks tumor initiation but

41 as accelerated by diabetes and improved with co-deletion of RAGE in vivo.

42 netically engineered mouse model of PSCC, by co-deletion of Smad4 and Apc in the androgen-responsive

43 Importantly, co-deletion of STING signalling components dampened the

44 Co-deletion of the ADAMTS-5 cysteine-rich domain further

45 th p16/p14ARF deletion were also studied for co-deletion of the contiguous methylthioadenosine phosph

46 organoid cultures, we show that conditional co-deletion of the LATS1 and LATS2 kinases, key effector

47 To determine the frequency of co-deletion of these two genes, we investigated 50 sampl

48 helial denudation that cannot be relieved by co-deletion of Trp53.

49 This defect can be rescued by co-deletion of Usp28, a critical component of the mitoti

50 either by treatment with pro-oxidants or by co-deletion of Yap.

51 Co-deletions of either p53 or Bax and Bak prevented apop

52 develop renal cysts and those with inherited co-deletions of the autosomal dominant polycystic kidney

53 Co-deletions of total 1p and 19q are found in the majori

54 ult mice, we show that either PTEN and SOCS3 co-deletion, or co-overexpression of osteopontin (OPN)/i

55 9q34.3/19p13.3 (NOTCH1/STK11/GNA11) showed a co-deletion pattern, which was associated with a signifi

56 Trp53 co-deletion significantly rescued the microcephaly with

57 In analysis of covariance, 1p/19q co-deletion status was the only significant contributor

58 ssification based on IDH mutation and 1p/19q co-deletion status were recapitulated through analysis o

59 confirmed that MTR(asym) could discriminate co-deletion status with an area under the curve of 0.85.

60 on-invasive biomarker for identifying 1p/19q co-deletion status.

61 When 1p19q co-deletion was absent, numbers of methylated CpG sites

62 uires the presence of both IDH-mt and 1p/19q co-deletion, whereas anaplastic astrocytoma is divided i

63 permethylation and unintentional monoallelic co-deletion with phosphatase and tensin homolog (PTEN) i