ライフサイエンスコーパス: co-repressor

1 own promoter while the toxin often acts as a co-repressor.

2 transcription factor by displacement of SMRT co-repressor.

3 TRIM28, a well-characterized transcriptional co-repressor.

4 to act as a transcriptional co-activator or co-repressor.

5 ty interaction with the RBCC domain of KAP-1 co-repressor.

6 forms a well-defined structure covering the co-repressor.

7 romatin environment and functioned as a GLI3 co-repressor.

8 tion with the Groucho family transcriptional co-repressors.

9 ein-protein interaction between BCL6 and its co-repressors.

10 th proteins that function as transcriptional co-repressors.

11 s transcription, whereas the toxins serve as co-repressors.

12 questering TLE proteins that function as PRH co-repressors.

13 an atypical member of the Gro-TLE family of co-repressors.

14 at mediates interaction with transcriptional co-repressors.

15 ere identified that require tetracyclines as co-repressors.

16 kely explained by their interaction with Tle co-repressors.

17 t with GATA4 and function as transcriptional co-repressors.

18 factors (TCF) and kept silent by Groucho/TLE co-repressors.

19 tide that still binds chromatin and recruits co-repressors.

20 anced RARA interactions with transcriptional co-repressors.

21 pathway initiated by degradation of Aux/IAA co-repressors.

22 at the specific deletion of nuclear receptor co-repressor 1 (NCoR1) in T cells causes excessive negat

23 that suppression of NCoR1 (nuclear receptor co-repressor 1), a co-repressor of PPARalpha, reactivate

24 in which the Ski/Sno family transcriptional co-repressor 2 (Skor2) gene is deleted.

25 SMRT (also known as NCoR2, nuclear receptor co-repressor 2) and NCoR in a variety of developmental s

26 Mtg8) or CBFA2/RUNX1 partner transcriptional co-repressor 3 (Cbfa2t3, also called Mtg16), and derived

27 CBFA2/RUNX1 partner transcriptional co-repressor 3 (CBFA2T3, also known as MTG16 or ETO2) is

28 sor whose activity is modulated by a TOPLESS co-repressor 4 (TPL4)-binding EAR repression motif.

29 CtBP is known as a co-repressor abundantly expressed in many types of cance

30 ether with SIM synergistically regulates the co-repressor activity of MTA1 on PS2 transcription, prob

31 this interaction is essential for human SIX3 co-repressor activity; we infer, in turn, that this func

32 etic modifiers, histones, or transcriptional co-repressors, along with immune escape via T-cell-media

33 activation domain (DAD) from the human SMRT co-repressor (also known as NCOR2).

34 Knockdown of Atrophin, a Tll co-repressor, also increases aggression, and both protei

35 rystal structure of BirA in complex with the co-repressor analog biotinol-5'-AMP.

36 ervations show that TPL is a transcriptional co-repressor and further our understanding of how auxin

37 n is elevated, BsFur may now use Mn(II) as a co-repressor and inappropriately repress iron uptake.

38 nding protein 1 (CtBP1) is a transcriptional co-repressor and metabolic sensory protein, which often

39 at the Hippo component TAZ can function as a co-repressor and regulate biological functions by negati

40 by lncRNA-dependent displacement of the Cyc8 co-repressor and subsequent gene looping, suggesting tha

41 the antagonistic activities of the Tup1-Cyc8 co-repressor and Swi-Snf co-activator complexes.

42 We identify the NuRD complex as a ZEB1 co-repressor and the Rab22 GTPase-activating protein TBC

43 ction mutations in BCORL1, a transcriptional co-repressor and tumour suppressor.

44 of the MeCP2 'bridge' between the NCoR/SMRT co-repressors and chromatin.

45 Binding of hormone dissociates co-repressors and facilitates recruitment of co-activato

46 Conversely, co-repressors and HDAC become co-activators of unligande

47 ncodes a member of the Groucho/TLE family of co-repressors and its function in various cell contexts

48 ene expression by recruiting transcriptional co-repressors and/or by preventing DNA binding of activa

49 This C-terminus binds to the Groucho/TLE co-repressor, and also to the Chip/LDB1-SSDP enhanceosom

50 A polymerase II (RNA pol II), co-activators, co-repressors, and more.

51 e surprising discovery that, in the nucleus, co-repressors are dramatically more abundant than co-act

52 Although transcriptional co-repressors are known to contact other repression doma

53 Atx3 is a transcriptional co-repressor, as well as a deubiquitinating enzyme that

54 involves: 1) an interaction with the Groucho co-repressor at the Eh-1 motif in the C-terminus; and 2)

55 Intriguingly, KorA and KorB can act as co-repressors at varying distances between their operato

56 iption factor as co-activator (ATF3-JunB) or co-repressor (ATF3-NFkappaB).

57 yglutamine expansions in the transcriptional co-repressor Atrophin-1, encoded by ATN1, cause the neur

58 the TNFalpha promoter, while recruiting the co-repressor BCL6.

59 ant PRC1 complex that also contains the BCL6 co-repressor BCOR and the histone demethylase KDM2B.

60 The X-linked BCL-6 co-repressor (BCOR) gene encodes a key constituent of a

61 h is known to be caused by mutations in BCL6 co-repressor (BCOR) gene.

62 e entire MeCP2 protein sequence, the DNA and co-repressor binding domains alone are sufficient to avo

63 tional scanning of the CRISPRi KRAB maps the co-repressor binding surface and identifies substitution

64 ther TA systems, MqsR is not a transcription co-repressor but instead functions to destabilize the Mq

65 toxin does not function as a transcriptional co-repressor, but instead functions to destabilize the a

66 ent (Eya) co-activator and the Groucho (Gro) co-repressor, but the relative contribution that each co

67 The co-repressor buttresses the dimer interface, resulting i

68 functions as an unconventional transcription co-repressor by modulating RNA polymerase II at the elon

69 cer of split (TLE) proteins that function as co-repressors by interacting with histone deacetylases w

70 The transcriptional co-repressor C-terminal binding protein (CtBP) interacts

71 t mechanism that probably uses the canonical co-repressor C-terminal Binding Protein (CtBP).

72 aled that TGF-beta signaling Smads and their co-repressor C-terminal binding protein 1 (CtBP1) transc

73 We also show that E2F7 recruits the co-repressor C-terminal-binding protein (CtBP) and that

74 egulating degradation of the transcriptional co-repressor C-terminal-binding protein-1 (CtBP1) throug

75 educed by overexpressing a dominant-negative co-repressor (c-SMRT), a constitutively active RAR (VP16

76 d modestly increased expression of the ATXN1 co-repressor Capicua (Cic) in anterior cerebellar Purkin

77 Genetic knock out of the transcriptional co-repressor carboxyl-terminal-binding protein (CtBP) in

78 ast to the traditional 'passenger' role of a co-repressor, CBFA2T2 functions synergistically with tra

79 main and a conserved N-terminal co-activator/co-repressor (COAR) domain consisting of A1, B1, B2 sub-

80 lysine-specific histone demethylase 1 (LSD1) co-repressor complex associates with the hTERT promoter

81 ression mediated by the unliganded RARgamma2-co-repressor complex constitutes a novel mechanism to re

82 y ESET (also known as SETDB1 or KMT1E) and a co-repressor complex containing KRAB-associated protein

83 LF14 represses the TGFbetaRII promoter via a co-repressor complex containing mSin3A and HDAC2.

84 ssociation of ER with the core promoter in a co-repressor complex containing SMRT and/or NCoR; this r

85 echanistic studies demonstrate that the NuRD co-repressor complex interacts with EWS/FLI, and that it

86 The Sin3a/HDAC co-repressor complex is a critical regulator of transcri

87 The structure of the co-repressor complex is also a dimer, clearly related to

88 /enhancer-binding protein alpha (c/EBPalpha) co-repressor complex onto human RNF144A promoter.

89 and AtCZS represent two main components of a co-repressor complex that fine tunes flowering and is un

90 matopoietic factor GATA-1, binds to the NuRD co-repressor complex through a conserved N-terminal moti

91 critical for recruitment of the HDAC1/Sin3a co-repressor complex to either the Ncx1 or Bnp promoter.

92 t its primary role is to recruit the NCoR1/2 co-repressor complex to methylated sites in the genome,

93 S (SEU) that function together in a putative co-repressor complex to prevent ectopic AGAMOUS (AG) tra

94 an active transcription mark and recruits a co-repressor complex to regulate gluconeogenic gene expr

95 ranscription factor ARNT2 recruits the NCoR2 co-repressor complex to suppress neuronal activity-depen

96 eosome Remodeling and Histone Deacetylation) co-repressor complex, and NuRD-mediated silencing has be

97 cruitment of the LSD1-containing CoREST-CtBP co-repressor complex, causing repression of an additiona

98 e methyltransferase activity but scaffolds a co-repressor complex, including HDAC3 and G9a.

99 RF2BP2 axis, interacting with the NCOR1/SMRT co-repressor complex, suppresses the expression of the v

100 hylase, LSD1--a component of the CoREST-CtBP co-repressor complex--is required for late cell-lineage

101 cluding activated Smad proteins and the NuRD co-repressor complex.

102 ulate genes by passively dissociating the ER co-repressor complex.

103 brain through its interaction with the NCoR co-repressor complex.

104 nteractions between human ZFP57 and the KAP1 co-repressor complex.

105 also exist in a latent state, maintained by co-repressor complexes containing class I histone deacet

106 me remodeling and deacetylase complex (NuRD) co-repressor complexes in mice.

107 s, information about the composition of such co-repressor complexes is just beginning to emerge.

108 of expression levels by chromatin-modifying, co-repressor complexes provides transcriptional fine-tun

109 ccurs via the recruitment of co-activator or co-repressor complexes that epigenetically regulate gene

110 HDAC5 may function as a scaffold to recruit co-repressor complexes to promoters.

111 ion often depends on the action of recruited co-repressor complexes with intrinsic enzymatic activiti

112 red for the interaction of the HDAC1/2/Sin3a co-repressor complexes with the Nkx2.5 and YY1 transcrip

113 DACs requires recruitment into multi-subunit co-repressor complexes, which are in turn recruited to c

114 lators of gene expression in transcriptional co-repressor complexes.

115 interaction between MeCP2 and the NCoR/SMRT co-repressor complexes.

116 catalytic core of the Sin3A, NuRD and CoREST co-repressor complexes.

117 proteins which in turn recruit multiprotein co-repressor complexes.

118 permiogenesis to regulation of transcription co-repressor complexes.

119 through aberrant recruitment of multiprotein co-repressor complexes.

120 of distinct LSD1-containing co-activator or co-repressor complexes.

121 factor NRSF, which recruits the NADH-binding co-repressor CtBP to generate a repressive chromatin env

122 tio and the NAD(H) sensitive transcriptional co-repressor CtBP.

123 ratio and the NAD(H)-sensitive transcription co-repressor CtBP.

124 with Drosophila Brinker (Brk) recruiting the co-repressors CtBP and Groucho (Gro), in addition to pos

125 at lysine 670 is required for recruiting the co-repressor CtBP1 and transcriptional repression.

126 1(-/-) cells binding of Mll1/2, Bmi1 and the co-repressor Ctbp1 at Hox loci are all abrogated and Hox

127 n is dependent on GI, which interacts with a CO repressor, CYCLING DOF FACTOR 1 (CDF1), and controls

128 This regulation is also dependent on the co-repressor, Dichaete.

129 Dissociation of the CAPERalpha/TBX3 co-repressor during oncogenic stress activates UCA1, rev

130 tive interactions with the co-activators and co-repressors during erythroid development, the activato

131 n was abrogated by expression of SHP and its co-repressor EID1 in hepatoma cells Huh7, Hepa1, and ste

132 The underlying mechanism of transcriptional co-repressor ETO2 during early erythropoiesis and hemogl

133 The TOPLESS/TOPLESS-RELATED (TPL/TPR) co-repressor family proteins are known to interact with

134 the nucleus and functions as a transcription co-repressor for E2F-1.

135 Overexpression of NAB2, a co-repressor for EGRs, attenuated the EGF-induced increa

136 uggest that Ajuba selectively functions as a co-repressor for Gfi1 autoregulation.

137 d the Polycomb-like protein hPCL3 as a novel co-repressor for HIC1.

138 , small heterodimer partner (SHP), acts as a co-repressor for many transcriptional factors and has be

139 Ajuba functions as a co-repressor for synthetic Gfi1 SNAG-repressor domain-co

140 al attributes with Drosophila Insensitive, a co-repressor for the Drosophila CSL factor.

141 ed co-repressor KAP1 is an essential nuclear co-repressor for the KRAB zinc finger protein superfamil

142 entral components of SWI/SNF, act instead as co-repressors for E2F-mediated transcriptional repressio

143 binding partners, including transcriptional co-repressors (for example, the NCoR/SMRT complex), tran

144 ) are the best characterized transcriptional co-repressors from a molecular point of view.

145 molecular mechanism for the displacement of co-repressors from DNA-bound CSL by NICD.

146 roviding important mechanistic insights into co-repressor function in plants.

147 ZBTB family members and broaden the scope of co-repressor functions for the MTG family, suggesting co

148 tion acts as a signal for recruitment of the co-repressor G9a.

149 We show that PRDM1 co-repressors, G9a and HDAC2, are recruited to CIITApI,

150 sed the pancreatic expression of the Groucho co-repressors, Grg1, Grg2, Grg3 and Grg4 (Tle1-Tle4), wh

151 e show that Cux1 directly interacts with the co-repressor Grg4 (Groucho 4), a known effector of Notch

152 ver, we found that the Groucho family member co-repressor Grg6 contributes to Pax6-mediated suppressi

153 ave identified a sea urchin homologue of the co-repressor Groucho (LvGroucho) that has been shown to

154 f the X signal element sisA and the maternal co-repressor groucho.

155 al represses transcription by recruiting the co-repressor Groucho.

156 which vertebrate NKx6-type proteins bind the co-repressor, Groucho.

157 utilizes the Hairless protein to recruit two co-repressors, Groucho (Gro) and C-terminal Binding Prot

158 was no difference in the recruitment of the co-repressor HDAC1 (histone deacetylase 1).

159 oter and are required for association of the co-repressor HDAC1.

160 r nfkb1 operating via p50:p50 dimers and the co-repressor HDAC1.

161 Transcriptional co-repressors HDAC1 and HDAC2 compete with beta-catenin

162 cetylases (HDACs) are normally considered as co-repressors, HDAC1 has been identified as a coactivato

163 and MLL1, as well as enhanced recruitment of co-repressors HDAC2 and LSD1 to the WNT/beta-CATENIN tar

164 e have demonstrated that the transcriptional co-repressor HDAC5 can interact with GEF in the absence

165 The interaction of the co-repressors histone deacetylases 1 and 2 as well as ly

166 modeling ATPases in addition to recruiting a co-repressor/histone deacetylase complex.

167 ere we provide evidence that transcriptional co repressor homeodomain interacting protein kinase 2 (H

168 ike 4 (Vgll4) functions as a transcriptional co-repressor in the Hippo-Yes-associated protein (YAP) p

169 These data reveal a novel mammalian CSL co-repressor in the nervous system, and show that the No

170 e mutants utilize Mn(II) but not Fe(II) as a co-repressor in vivo.

171 d that Shn proteins recruit coactivators and co-repressors in a context-dependent manner, rather than

172 ene regulation is mediated by recruitment of co-repressors in the absence of T3 and coactivators in i

173 of Runx2 is determined by associations with co-repressors including histone deacetylase 7 (HDAC7).

174 g aberrant transcription factor/co-activator/co-repressor interactions and histone-modifying activiti

175 ind Groucho and that binding of Nkx6 to this co-repressor is modulated intra-molecularly.

176 This helps explain why the binding of the co-repressor is necessary to optimize the binding of Bir

177 set, Tcf7l2 interacts with a transcriptional co-repressor Kaiso/Zbtb33 to block beta-catenin signalli

178 The Kruppel-associated box (KRAB)-associated co-repressor KAP1 is an essential nuclear co-repressor f

179 eover, D53 can interact with transcriptional co-repressors known as TOPLESS-RELATED PROTEINS.

180 is dependent upon the phosphorylation of the co-repressor, Kruppel-associated box (KRAB) domain-assoc

181 Upon binding of the co-repressor L-arginine there is a approximately 15 degr

182 d and isolated two Arabidopsis transcription co-repressors LEUNIG (LUG) and SEUSS (SEU) that function

183 r could function by recruiting just a single co-repressor, many can recruit more than one, with Droso

184 a negative regulator of EAAT1 with HDACs as co-repressors, mediating the inhibitory effects of manga

185 elium and revealing how this transcriptional co-repressor modulates this crucial step of beta-cell de

186 ween its proline/serine/threonine domain and co-repressor molecules such as histone deacetylase (HDAC

187 es presented here identifies known and novel co-repressors, most notably the ETO2 and IRF2BP2 protein

188 The transcription co-repressors MTG8 and MTG16 were highly expressed by +4

189 e function is mediated through an ETO-family co-repressor Mtgr1, which tightly binds to the pre-SET/S

190 nt with CTNNB1 mutations, and in the nuclear co-repressor (N-CoR) complex genes GPS2, BCOR and LDB1.

191 s by intercepting the degradation of nuclear co-repressor (N-CoR) protein which has a key role in the

192 structure of a complex between an HDAC and a co-repressor, namely, human HDAC3 with the deacetylase a

193 ene repression is mediated by recruitment of co-repressors NCoR and HDAC3.

194 hown to be modulated by interaction with the co-repressors NCoR and SMRT.

195 or domain of MeCP2 with the nuclear receptor co-repressor (NCoR) complex and suppresses the ability o

196 HDAC3, the catalytic subunit of the nuclear co-repressor (NCoR) complex, and recruits HDAC3 to the n

197 de-repression step in which nuclear receptor co-repressor (NCoR) complexes are actively removed from

198 rotein (CBP) and release of nuclear receptor co-repressor (NCoR) on a TRE but had no significant effe

199 al repressors by recruiting nuclear receptor co-repressor (NCoR)-HDAC3 complexes to Rev-Erb response

200 es its interaction with the nuclear receptor co-repressor (NCoR1), resulting in repression of Rev-erb

201 The ZIM protein domain recruits the co-repressors NINJA and TOPLESS to JAZ-bound transcripti

202 via Rad53-dependent inactivation of the MBF co-repressor Nrm1.

203 CDK whereas MBF targets are repressed by the co-repressor, Nrm1.

204 egulates its translation, and also serves as co-repressor of erp transcription.

205 PA28gamma acts as a co-repressor of HTLV-1 p30 to suppress virus replication

206 KEY POINTS: PA28gamma acts as a co-repressor of HTLV-1 p30 to suppress virus replication

207 ific demethylase 1 (LSD1), a transcriptional co-repressor of nuclear receptor TLX, is a downstream ta

208 f NCoR1 (nuclear receptor co-repressor 1), a co-repressor of PPARalpha, reactivates ketogenesis in ce

209 PBX1 interacting protein (PBXIP1/HPIP) is a co-repressor of pre-B-cell leukemia homeobox 1 (PBX1) an

210 found that this protein is a transcriptional co-repressor of STAT1.

211 ded by Rorc, by acting as a co-activator and co-repressor of STAT3, respectively.

212 w that in breast cancer MCF-7 cells, TLE3, a co-repressor of the Groucho/Grg/TLE family, interacts wi

213 ion of FoxG1 with TLE2, a Xenopus tropicalis co-repressor of the Groucho/TLE family, is crucial for r

214 sociated protein 6 (Daxx) is a transcription co-repressor of the RelB-responsive gene promoters.

215 ospero-related homeobox 1 (Prox1) as a novel co-repressor of the retinoic acid-related orphan recepto

216 rginine methyltransferase (CARM-1) acting as co-repressors of glucocorticoid receptor monomers.

217 However, co-repressors of OPN have not been identified.

218 Transcriptional co-repressors of the Groucho/TLE family are important re

219 fiers histone deacetylases (HDACs) served as co-repressors of YY1 to further decrease EAAT1 promoter

220 X1 and RFX5, associate with distinct sets of co-repressors on the collagen transcription start site i

221 llows it to differentially serve as either a co-repressor or a co-activator of transcription at the s

222 The network is linked to multiple co-repressor pathways and is composed of numerous protei

223 this report, we show that recruitment of the co-repressor protein Grg4 to a Pax DNA-binding site disp

224 Here, we demonstrate that the co-repressor protein Sin3a is crucial for lung endoderm

225 tructures in the presence and absence of the co-repressor protein Tup1.

226 Here we identify a novel co-repressor protein, CBFA2T2, that regulates pluripoten

227 uired for interaction with the TOPLESS (TPL) co-repressor protein.

228 ivator binding and promoted interaction with co-repressor protein.

229 ple mechanisms, including the recruitment of co-repressor proteins belonging to the TLE family of chr

230 r, the molecular mechanism of recruitment to co-repressor proteins has yet to be established.

231 By contrast, numerous CSL co-repressor proteins have been identified, and these ar

232 ly binds auxin, leading to dissociation from co-repressor proteins of the TOPLESS/TOPLESS-RELATED fam

233 by the loss of either one of the downstream co-repressor proteins Rgt1p or Mth1p.

234 eins, or other transcription co-activator or co-repressor proteins.

235 in a pocket sandwiched between the HDAC and co-repressor proteins.

236 tivator interacting with the transcriptional co-repressor pyrimidine tract-binding protein-associated

237 hat directly bind Gro and CtBP; thus, direct co-repressor recruitment is ancestral in the protostomes

238 Repression by GR involves co-repressor recruitment, because treatment of transfect

239 (methyl CpG binding protein 2) and HP-1alpha co-repressor recruitments to Ppargamma promoter and enha

240 These transcriptional co-repressors regulate diverse cell phenotypes depending

241 that direct interaction between Otx2 and Grg co-repressors regulates GnRH gene expression in hypothal

242 ated Sp1 phosphorylation, and HDAC1/2/mSin3A co-repressor release indicating its role as linker coact

243 e show that the LEUNIG (LUG) and SEUSS (SEU) co-repressors repress miR172 expression in the outer who

244 for co-activators and increased affinity for co-repressors, resulting in suppression of the receptors

245 ong the affected transcriptional targets are co-repressor SHP (small heterodimer partner) as well as

246 REL2 encodes a transcriptional co-repressor similar to the TOPLESS protein of Arabidops

247 and YY1 co-sediment with the transcriptional co-repressor Sin3a and its functional partner histone de

248 he pathway, Smad6 and Smad7, and the nuclear co-repressors Ski and Skil (SnoN).

249 constitutively interacted with another Smad co-repressor, Ski, and they formed ternary complex with

250 HGF is shown to induce Smad co-repressor Sloan-Kettering Institute proto-oncogene-re

251 show that knock-in mutations of the nuclear co-repressor SMRT (silencing mediator of retinoid and th

252 Smad transcriptional co-repressor SnoN acts as an antagonist that tightly con

253 ors such as p300 and CREB-binding protein or co-repressors such as HDAC3.

254 Co-repressors, such as KAP-1, function to regulate the r

255 e data show the HigB toxin does not act as a co-repressor suggesting potential novel regulation in th

256 ow that SHARP, which interacts with the SMRT co-repressor that activates HDAC3, is not only essential

257 absence of apo-BCCP, biotin-5'-AMP acts as a co-repressor that induces BirA dimerization and binding

258 ucleus and cytoplasm and serves as a nuclear co-repressor that regulates bone and muscle development.

259 Groucho (Gro) is a Drosophila co-repressor that regulates the expression of a large nu

260 tBP) is a well-characterized transcriptional co-repressor that requires homo-dimerization for its act

261 ylation in vitro, suggesting that DMAP1 is a co-repressor that supports the maintenance and de novo a

262 n as over-induction is prevented by a second co-repressor that the model yeast Saccharomyces cerevisi

263 Hdac9 are activity-regulated transcriptional co-repressors that are highly expressed in innervated mu

264 Tgif1 and Tgif2 are transcriptional co-repressors that limit the response to TGFbeta signali

265 ber of the Groucho family of transcriptional co-repressors that we identified as a Hex target in embr

266 he methionine repressor protein MetJ and its co-repressor, the methionine derivative S-adenosylmethio

267 cetylase activity and their interaction with co-repressors, these enzymes are also found in the cytop

268 estrogen receptor-alpha (ER) transcriptional co-repressor through leucine/isoleucine-rich motifs that

269 hat REL2 also functions as a transcriptional co-repressor throughout development.

270 CRMs during cleavage stages and recruits the co-repressor Tle/Groucho in the early blastula.

271 n using LNCaP prostate cancer cells, loss of co-repressor TLE3 conferred resistance to AR antagonists

272 t G9a functions both as a co-activator and a co-repressor to enhance cellular proliferation and inhib

273 of CtBP1 direct the assembly of a functional co-repressor to influence gene expression is not well un

274 (TFs) that mediate association of Tup1-Cyc8 co-repressor to its promoter.

275 olic genes primarily by recruiting the HDAC3 co-repressor to sites to which it is tethered by cell ty

276 r that acts in concert with co-activators or co-repressors to control the activity of associated targ

277 omb complexes, methyltransferases, and other co-repressors to gene promoters.

278 romatin-bound complexes with transcriptional co-repressors to repress transcription.

279 itment on the viral genome of KAP1, a master co-repressor, together with HP1 and the SETDB1 histone m

280 es are direct targets of the transcriptional co-repressor TOPLESS (TPL) and that PLT1/2 are necessary

281 ts target genes by physically recruiting the co-repressor TOPLESS and the histone deacetylase HDA19.

282 h the bHLH transcription factor MYC2 and the co-repressor TOPLESS but, consistent with the absence of

283 as suggested that the AFPs interact with the co-repressor TOPLESS to inhibit ABA-regulated gene expre

284 teractions with histone deacetylases and the co-repressor TOPLESS.

285 teractions with histone deacetylases and the co-repressor TOPLESS.

286 etween the transcription factor TEAD and its co-repressor VGL4, both playing a central role in the Hi

287 interaction partner CtBP2, a transcriptional co-repressor, was in a complex with beta-catenin.

288 understand how NICD displaces CSL-associated co-repressors, we have quantified the binding of differe

289 recruitment of co-activators and release of co-repressors when ERRalpha and AP1 bind and ERalpha is

290 t should need to recruit CtBP, a short-range co-repressor, when Gro is known to be able to function o

291 -box, essential for interaction with TPL/TPR co-repressors, whereas the repressive EAR domain is disp

292 repressors function primarily by recruiting co-repressors, which are accessory proteins that antagon

293 deacetylase (HDAC) family of transcriptional co-repressors, which induce apoptosis of neoplastic cell

294 PPARgamma requires various co-activators or co-repressors, which may dynamically associate with and

295 (novel INHAT repressor) is a transcriptional co-repressor with inhibitor of histone acetyltransferase

296 k1 translocates to the nucleus and acts as a co-repressor with p53 to down-regulate PKD1 transcriptio

297 h recruitment of co-activators or release of co-repressors with unique roles in elongation.

298 conditions; production is further boosted by co-repressor Zac1 or pharmacologic agents that enhance R

299 terminus and a specific interaction with the co-repressor ZMYND11 (BS69).

300 cells' metal sensors of other types: Zn(II) co-repressor Zur, Co(II) activator CoaR, and Zn(II) dere