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1 for disassembly of the SRC-3 transcriptional coactivator complex.
2 ionally depends on the multiprotein Mediator coactivator complex.
3 th the human STAGA (SPT3-TAF-GCN5 acetylase) coactivator complex.
4 transcription factor and its cognate, OCA-S coactivator complex.
5 RIP150, a subunit of the multimeric Mediator coactivator complex.
6 nguishable from our previously isolated CRSP coactivator complex.
7 y linked to selective recruitment of a Tip60 coactivator complex.
8 as part of the SAGA (SPT-ADA-GCN5 acetylase) coactivator complex.
9 a human thyroid hormone receptor-associated coactivator complex.
10 , GRIP-1, and DRIP205, a subunit of the DRIP coactivator complex.
11 ctivators and autoregulation by the receptor-coactivator complex.
12 cn5 Acetyltransferase (SAGA) transcriptional coactivator complex.
13 ys a central role in creating a multisubunit coactivator complex.
14 t also with the H3K4 methyltransferase KMT2D coactivator complex.
15 in SCA7 is a subunit of SAGA transcriptional coactivator complex.
16 RNA polymerase II (RNAPII) via the Mediator coactivator complex.
17 an H3K27me3 demethylase Jmjd3/Kdm6b-centred coactivator complex.
18 colon cancer cells by recruiting EZH2 to the coactivator complex.
19 n structures of the yeast SAGA transcription coactivator complex.
20 n the assembly of the active ligand.receptor.coactivator complex.
21 ates hormone signaling by disassembly of the coactivator complex.
22 iates transcriptional activation by the p160 coactivator complex.
23 ximal promoter, and (d) assembles a distinct coactivator complex.
24 ion promotes dissociation of the SRC-3/CARM1 coactivator complex.
25 ix1/Eya bipartite transcription (DNA binding/coactivator) complex.
26 into the interaction of diverse proteins in coactivator complexes.
27 nduce transcription through association with coactivator complexes.
28 stimulating the exchange of corepressor for coactivator complexes.
29 pecific role in substrate recognition by APC-coactivator complexes.
30 the relative affinities for corepressor and coactivator complexes.
31 tion is not driven by a random mixture of ER-coactivator complexes.
32 cruitment of one or more recently identified coactivator complexes.
33 tial recruitment of SRC-1 and PBP-containing coactivator complexes.
34 hanisms, and link the complex to other human coactivator complexes.
35 a robust source of inhibitors for activator-coactivator complexes.
36 uence features that are necessary to recruit coactivator complexes.
37 ed disruption of activator interactions with coactivator complexes.
38 e component of COMPASS-like nuclear receptor coactivator complexes.
39 tress-specific regulation of transcriptional coactivator complexes.
40 mediate assembly of these two very different coactivator complexes.
41 one in deciphering the mechanism of multiple coactivator complexes.
42 vated Stat3-mediated recruitment of distinct coactivator complexes.
43 ch was reported to be a component of the SRC.coactivator complexes.
44 t-interactive protein, 60 kilodalton (TIP60) coactivator complex, a fusion of the yeast switch/sucros
47 )-associated transcriptional corepressor and coactivator complexes allow for the precise regulation o
48 receptor-associated proteins) transcription coactivator complex (also known as Mediator) was first i
49 inctive interface for a transcription factor-coactivator complex and demonstrates a functional role f
50 a basis for understanding assembly of the AR:coactivator complex and its domain contributions for coa
51 o alter the conformation and activity of the coactivator complex and regulate estrogen receptor-media
52 ssion and may be components of both a common coactivator complex and separate complexes with distinct
53 recruitment of the Mediator transcriptional coactivator complex and transcriptional activation, but
54 tes with components of the Mediator and p160 coactivator complexes and is recruited to endogenous NR
55 sociate the repressing complexes and recruit coactivator complexes and RNA polymerase II, thereby ind
56 steroid receptors elicit precise assembly of coactivator complexes and the way the steroid activation
58 r-specific and ligand-specific assembly of a coactivator complex, and that these recognition motifs u
59 tion through action on the MTA1/STAT3/Pol II coactivator complex, and, in turn, on the expression and
60 s a component of two different transcription coactivator complexes, and recent work indicates that di
62 r phosphorylation has been shown to regulate coactivator complex assembly, but the mechanisms by whic
63 s represent unique mechanisms for regulating coactivator complex assembly, conformation, and function
64 irm that a nuclear receptor employs distinct coactivator complexes at different target genes, and pro
67 ed coactivator complex with the PBP-anchored coactivator complex but differentially modulates coactiv
68 or is a conserved, essential transcriptional coactivator complex, but its in vivo functions have rema
69 cn5-acetyltransferase (SAGA) transcriptional coactivator complex, but SAGA's histone acetyltransferas
71 we find that the stability of multi-subunit coactivator complexes can be compromised by loss of a si
73 of a set of representative dynamic activator*coactivator complexes, comprised of the ETV/PEA3 family
75 ent of histone acetyl transferase containing coactivator complexes conserved from yeast to human.
76 two activators differentially recruited the coactivator complexes, consistent with specific activato
77 ne-occupied PR forms a multisubunit receptor-coactivator complex containing two previously described
78 activator complex with other coactivators or coactivator complexes containing actin or actin-like pro
81 ferences in configuration and content of the coactivator complex dictate requirements for specific ac
82 histone H3 and also dictates the subsequent coactivator complex disassembly by methylation of the st
83 e previously identified a novel multisubunit coactivator complex, DRIP (VDR-interacting proteins), re
84 ecently observed that VDR binds to two major coactivator complexes, DRIP (VDR-interacting protein) an
85 insights into how the multisubunit Mediator coactivator complex dynamically links enhancer-bound act
86 al, ligand-dependent recruitment of multiple coactivator complexes (e.g., SRC complexes and Mediator)
88 ator is a large and evolutionarily conserved coactivator complex essential for RNA polymerase II (Pol
90 l as well as participating in formation of a coactivator complex essential for transactivation of MT-
95 ontain activation domains (ADs) that recruit coactivator complexes; however, for nearly all Arabidops
96 The Spt-Ada-Gcn5 acetyltransferase (SAGA) coactivator complex hyperacetylates histone tails in viv
99 tact with DRIP150 and implicate the Mediator coactivator complex in IFN-activated gene regulation.
100 00/CBP and SRC proteins are part of the same coactivator complex in vivo during post-embryonic develo
103 omponent of the SAGA and ADA transcriptional coactivator complexes in budding yeast, suggests an imme
104 d "molecular adaptor" actions of corepressor/coactivator complexes in integrating signal-dependent pr
106 ion protein to components of three different coactivator complexes in Saccharomyces cerevisiae cell e
107 e evolutionarily conserved hADA3 in multiple coactivator complexes, inactivation of its function may
110 the cell uses several classes of regulatory coactivator complexes including two central players, TFI
111 hree components of the p160 nuclear receptor coactivator complex, including CARM1, p300/CBP, and GRIP
112 ctionally require distinct components of the coactivator complex, including CREB-binding protein (CBP
113 ion to Hog1, specific components of the SAGA coactivator complex, including Spt20 and Sgf73, are also
114 sociated with enhanced promoter occupancy of coactivator complexes, including SAGA, Mediator, chromat
115 F9-ADA-GCN5 acetyltransferase) transcription coactivator complex, interacts directly with the GCN5 hi
116 ADA2 or GCN5, encoding components of the ADA coactivator complex involved in histone acetylation, sev
117 and PBP (PPARgamma-binding protein)-anchored coactivator complexes involved in the transcriptional ac
118 nd PBP (PPAR gamma-binding protein)-anchored coactivator complexes involved in the transcriptional ac
121 shows that the MED1 subunit of the Mediator coactivator complex is acetylated in its intrinsically d
124 by the Spt-Ada-Gcn5 acetyltransferase (SAGA) coactivator complex is regulated by a recently discovere
125 Thus, we propose that a CBP/p300-containing coactivator complex is the E1A-sensitive factor importan
128 rginine methyltransferase activity to the ER-coactivator complex, it also alters the structural organ
129 es have implicated the multisubunit Mediator coactivator complex (Med) as a critical component of the
130 lase PCAF has been suggested to be part of a coactivator complex mediating transcriptional activation
132 tion of a number of critical subunits of the coactivator complex Mediator alters only a few MAPK-resp
133 as a surrogate of the general transcription coactivator complex Mediator for identifying active enha
134 se module (CKM) is a dissociable part of the coactivator complex mediator, which regulates gene trans
135 d Tra1, which are subunits of four conserved coactivator complexes, Mediator, SAGA, TFIID, and NuA4.
136 D), belong to two homologous transcriptional coactivator complexes, named MLL3 and MLL4 complexes, re
137 recruited a limited set of chromatin-related coactivator complexes, namely the chromatin remodeler Sw
140 nuclear receptors determines the assembly of coactivator complexes on target promoters to mediate spe
141 irects the recruitment of mutually exclusive coactivator complexes on the p53 response elements in th
142 recruiting transcriptional corepressors and coactivator complexes onto neuroectoderm, mesoderm, and
143 ucers, which act in vivo either as part of a coactivator complex or downstream of a coactivator compl
144 n and stability of transcriptional activator-coactivator complexes, perhaps in part due to the often
148 d by human mediator, another transcriptional coactivator complex potentially implicated in activator
149 ial helix 4 bonding persists across other NR-coactivator complexes, providing a general structural me
150 ubunit of the plant Mediator transcriptional coactivator complex regulates cold-responsive gene expre
151 tor (ARC), a family of large transcriptional coactivator complexes related to the yeast Mediator, was
152 tigate the mechanisms by which transcription coactivator complexes relieve chromatin repression in vi
153 cognition motifs underlie the recruitment of coactivator complexes required for nuclear receptor func
154 venting the assembly of CBP-nuclear receptor coactivator complexes, revealing differences in required
156 lated by activator proteins that recruit the coactivator complexes SAGA (Spt-Ada-Gcn5-acetyltransfera
158 enzyme is found in two functionally distinct coactivator complexes, SAGA (Spt Ada Gcn5 acetyltransfer
160 n assay to discover a multisubunit stem cell coactivator complex (SCC) that is selectively required f
163 itamin D receptor interacting protein (DRIP) coactivator complex shares components with the RNA polym
164 hich encodes a polypeptide unique to the ADA coactivator complex, stimulates Gal4-final sigma(54)-med
165 cription factors make weak interactions with coactivator complexes, such as Mediator, to stimulate tr
166 (54) is TATA-dependent and requires the SAGA coactivator complex, suggesting that Gal4-final sigma(54
167 nd the role of core promoter recognition and coactivator complex switching in cellular differentiatio
170 ediator complex is a central transcriptional coactivator complex that acts as a bridge between transc
173 nd mediates the assembly of a Cti6-Cyc8-Tup1 coactivator complex that functions to recruit the SAGA c
174 accharomyces cerevisiae is a multifunctional coactivator complex that has been shown to regulate tran
175 ort we demonstrate that NF-kappaB recruits a coactivator complex that has striking similarities to th
176 elease the corepressor complex and recruit a coactivator complex that includes multiple histone acety
177 ity chromatography, we have isolated a human coactivator complex that interacts directly with the C-t
179 of posttranscriptional modification of a NR-coactivator complex that is important for NR signaling.
180 r activators (p53 and VP16) through a common coactivator complex that is likely to target RNA polymer
181 y of Gcn4p to interact with several distinct coactivator complexes that are physically and geneticall
182 our results establish hAda3, a component of coactivator complexes that include histone acetyltransfe
183 ependent recruitment of a series of specific coactivator complexes that prove necessary for Cyclin D2
184 other component of the p160 nuclear receptor coactivator complex, the coiled-coil coactivator (CoCoA)
186 nscription is driven by dynamic multiprotein coactivator complexes, the composition of which is thoug
187 scription activators contact the same set of coactivator complexes, the mechanism and specificity of
188 physically interact to stabilize the ERalpha-coactivator complex, thereby permitting other signal tra
191 mediation of transcription factor binding to coactivator complexes through multiple interactions.
192 f a receptor kinase recruits a transcription coactivator complex to a specific chromosomal locus to m
193 oid response, by recruiting the p300/CBP/SRC coactivator complex to an FKH factor site in the IGFBP-1
194 t-Ada-Gcn5-acetyltransferase transcriptional coactivator complex to catalyze histone acetylation at t
195 ural information on the full-length receptor-coactivator complex to complement preexisting and someti
196 of a coactivator complex or downstream of a coactivator complex to modulate transcriptional activity
197 ate ligand-dependent binding of the Mediator coactivator complex to multiple nuclear receptors, inclu
198 the ligand-dependent recruitment of the DRIP coactivator complex to VDR and to the ability of the rec
199 regulates the assembly and activity of bHLH-coactivator complexes to promote neuronal differentiatio
202 Ada3p, suggesting that recruitment of these coactivator complexes to the promoter is a cardinal func
203 cription through the recruitment of multiple coactivator complexes to the promoter regions of target
204 ctivate transcription by recruiting multiple coactivator complexes to the promoters of target genes.
206 merase II transcription machinery, conserved coactivator complexes, transcription activation domains,
209 n depleted extracts showed that the Mediator coactivator complex, which controls PIC assembly, is als
211 receptor-associated protein (TRAP)/Mediator coactivator complex, which interacts with ERalpha and ER
212 an important component of the plant mediator coactivator complex, which links promoter-bound transcri
213 ind general transcription factors and larger coactivator complexes, which position RNA polymerase II
214 -dependent interactions of this multisubunit coactivator complex with nuclear receptors through their
215 Fli-I may facilitate interaction of the p160 coactivator complex with other coactivators or coactivat
216 eraction of the MTA1.RNA polymerase II.c-Jun coactivator complex with the HMMR promoter to stimulates
217 gest that PIMT bridges the CBP/p300-anchored coactivator complex with the PBP-anchored coactivator co
218 g stimulates association of the beta-catenin coactivator complex with two Wnt responsive enhancers (W
219 icoid receptor-interacting protein 1 (GRIP1) coactivator complexed with the ligands OBCP-3M, OBCP-2M,
221 copy to determine atomic structures of APC/C-coactivator complexes with either Emi1 or a UbcH10-ubiqu
223 stic formation of transient nuclear receptor-coactivator complexes with its molecular dynamics and ce
224 LL motif and disrupts the association of HAT coactivator complexes with promoter-bound estrogen recep