ライフサイエンスコーパス: coated vesicle

1 s) or by protein-protein interactions (e.g., coated vesicles).

2 (2)) to form the outer layer of the clathrin-coated vesicle.

3 peared together upon formation of a clathrin-coated vesicle.

4 ore coated-pit pinching and formation of the coated vesicle.

5 paratus via Coat Protein I (COPI)- and COPII-coated vesicles.

6 bind cargo and grow in size to form clathrin-coated vesicles.

7 ternalization of PC7 is mediated by clathrin-coated vesicles.

8 endocytosis and is associated with clathrin-coated vesicles.

9 key roles in transport mediated by clathrin-coated vesicles.

10 pression inhibited the uncoating of clathrin-coated vesicles.

11 ermore, PC7 was present in isolated clathrin-coated vesicles.

12 (+) channel that is internalized by clathrin-coated vesicles.

13 a morphology distinct from that of clathrin-coated vesicles.

14 c70-dependent clathrin uncoating of clathrin-coated vesicles.

15 he ability to inhibit the formation of CopII coated vesicles.

16 jected terminals, without affecting clathrin-coated vesicles.

17 reduction in the internalization of clathrin-coated vesicles.

18 and HCs encoded by chc1-box formed clathrin-coated vesicles.

19 early secretory pathway is mediated by COPII-coated vesicles.

20 and CLCb) are major constituents of clathrin-coated vesicles.

21 icle scission and also in uncoating Clathrin-coated vesicles.

22 e range of cargo accommodated by human COPII-coated vesicles.

23 nd beta-arrestin 1 (beta-Arr1) into clathrin-coated vesicles.

24 range of cargo proteins packaged into COPII-coated vesicles.

25 al of a postfusion SNARE complex in clathrin-coated vesicles.

26 which comprises the coat framework of COPII-coated vesicles.

27 80, also regulates the formation of clathrin-coated vesicles.

28 rted from the endoplasmic reticulum by COPII coated vesicles.

29 ning cargoes for incorporation into clathrin-coated vesicles.

30 pits assemble on a membrane and pinch off as coated vesicles.

31 receptors into distinct cohorts of clathrin-coated vesicles.

32 gh its secretory pathway is dependent on GGA-coated vesicles.

33 uptake occurs in both caveolae- and clathrin-coated vesicles.

34 localization of unsheathed mum with clathrin-coated vesicles.

35 sorting of an ER membrane protein into COPII-coated vesicles.

36 rom the membrane and sequestered in clathrin-coated vesicles.

37 lization of the LDL receptor within clathrin-coated vesicles.

38 cific membrane compartments and pinch off as coated vesicles.

39 ant component of the LC, interacts with COPI-coated vesicles.

40 nt with this, WIPI49 is enriched in clathrin-coated vesicles.

41 ot Galpha(q), internalized with the clathrin-coated vesicles.

42 ct from those of well-characterized clathrin-coated vesicles.

43 teins that promote the formation of clathrin-coated vesicles.

44 membrane vesicles, microsomes, and clathrin-coated vesicles.

45 ocytosis and membrane recycling via clathrin-coated vesicles.

46 at proteins that drive formation of clathrin-coated vesicles.

47 which triggers the formation of new clathrin-coated vesicles.

48 Grb2/Sos1 complexes associated with clathrin-coated vesicles.

49 diators of cargo protein sorting in clathrin-coated vesicles.

50 Scap to bind COPII proteins for transport in coated vesicles.

51 adaptor in mediating SAC1 transport in COPII-coated vesicles.

52 o proteins and promotes assembly of clathrin-coated vesicles.

53 teins' role in the struggle to make clathrin-coated vesicles.

54 ly, in the fission and uncoating of clathrin-coated vesicles.

55 ing its transport in coat protein complex II-coated vesicles.

56 n events, including the scission of clathrin-coated vesicles.

57 tually pinch off and internalize as clathrin-coated vesicles.

58 C7 requires endocytosis into acidic clathrin-coated vesicles.

59 membrane to begin the formation of clathrin-coated vesicles.

60 0, thus initiating uncoating of the clathrin-coated vesicles.

61 membrane, which invaginate to form clathrin-coated vesicles, a process that is well understood.

62 The endosome is resolved into coated vesicles after 3 s, which in turn become small-di

63 tion of Golgi-derived coat protomer I (COPI)-coated vesicles after activating or inhibiting signaling

64 l receptor (TCR) internalization by clathrin-coated vesicles after encounter with antigen has been im

65 se cells exhibit an accumulation of clathrin-coated vesicles and an increase in U-shaped clathrin-coa

66 TRAPPII is enriched on COPI (Coat Protein I)-coated vesicles and buds, but not Golgi cisternae, and i

67 through the removal of membrane via clathrin-coated vesicles and by callose synthesis.

68 hat is required for localization to clathrin-coated vesicles and contains a putative pleckstrin-homol

69 ion, including accumulation of free clathrin-coated vesicles and delayed vesicle reavailability, impl

70 protein preparations extracted from clathrin-coated vesicles and directly binds to both clathrin and

71 An increased number of clathrin-coated vesicles and empty cages were present at knockout

72 e also abundant inside the cells in clathrin-coated vesicles and endosomes.

73 l antibody Hu1A3B-7 delivered in glucosamine-coated vesicles and had improved survival and reduced br

74 at REEP6 is detected in a subset of Clathrin-coated vesicles and interacts with the t-SNARE, Syntaxin

75 ins, we showed that HCVpp enter via clathrin-coated vesicles and require delivery to early but not to

76 related JC virus can enter cells in clathrin-coated vesicles and subsequently traffic to caveolae, th

77 led that TBC1D24 is associated with clathrin-coated vesicles and synapses of hippocampal neurons, sug

78 promoting its internalization into clathrin-coated vesicles and the consequent disassembly of interc

79 lattice organization of individual clathrin-coated vesicles and the disposition of the captured vesi

80 We provide evidence that COPII-coated vesicles and the ER-Golgi fusion machinery are ne

81 s to the trans-Golgi network (TGN), clathrin-coated vesicles and the plasma membrane.

82 Moreover, similarities between structures in coated vesicles and those in the NPC support our prior h

83 -ER transport vesicles, different from COPII-coated vesicles and those involved in traffic of VSVG.

84 ound to be associated with isolated clathrin-coated vesicles and to colocalize with clathrin light ch

85 previously found to be enriched in clathrin-coated vesicles and to promote clathrin assembly in vitr

86 pter complex of the "inner" coat in clathrin-coated vesicles, and a heterotrimeric B-subcomplex, whic

87 s from mammalian macrophages, also uses WASH-coated vesicles, and cells expressing dominant negative

88 ts including the nuclear pore complex, COPII-coated vesicles, and inside the nucleus as a transcripti

89 structures, including mitochondria, clathrin-coated vesicles, and the actin cytoskeleton, in either H

90 o ribosomal assembly, the formation of Golgi-coated vesicles, and the maintenance of PS asymmetry.

91 rmine the functional specificity of clathrin-coated vesicles, and together they control a multitude o

92 extends to less well characterized types of coated vesicles, and we identify and characterize the fi

93 ulted in the binding of mu1A of the clathrin-coated vesicle AP-1 complex.

94 mately 300-nm diameter) and typical clathrin-coated vesicles ( approximately 90 nm) makes it unlikely

95 evidence that, as in animal cells, clathrin-coated vesicles are a major means of internalisation by

96 ER-derived COPII-coated vesicles are conventionally targeted to the Golgi

97 COPII-coated vesicles are delivered to the early Golgi via dis

98 Clathrin-coated vesicles are important vehicles of membrane traff

99 Coated vesicles are key components of the machinery of v

100 Clathrin-coated vesicles are known to play diverse and pivotal ro

101 Endocytic clathrin-coated vesicles are short-lived transport intermediates

102 In vivo, glucosamine-coated vesicles are superior to uncoated or transferrin-

103 COPII-coated vesicles are the primary mediators of ER-to-Golgi

104 Clathrin/AP2-coated vesicles are the principal endocytic carriers ori

105 Clathrin-coated vesicles are vehicles for intracellular trafficki

106 and the transition to highly curved clathrin-coated vesicles - are adaptable and can follow many path

107 Clathrin-coated vesicle assembly and disassembly is regulated by

108 l PtdIns(4,5)P(2) generation during clathrin-coated vesicle assembly at the synapse.

109 recise sequence of events promoting clathrin-coated vesicle assembly is still debated.

110 We have identified CVAK104 (a coated vesicle-associated kinase of 104 kDa) using a mas

111 Here we show that the coated vesicle-associated kinase SCYL2/CVAK104 plays a c

112 2) is required for the formation of clathrin-coated vesicles at the plasma membrane (PM).

113 tors required both for formation of clathrin-coated vesicles at the TGN (the Chc1p clathrin heavy cha

114 participates in cargo sorting into clathrin-coated vesicles at the trans-Golgi network (TGN) and end

115 rotein involved in the formation of clathrin-coated vesicles at the trans-Golgi network.

116 mannose 6-phosphate receptors into clathrin-coated vesicles at the trans-Golgi network.

117 rking Kir2.1 for incorporation into clathrin-coated vesicles at the trans-Golgi.

118 coat recruitment to facilitate AP-1/clathrin-coated vesicle budding from the TGN.

119 ion, and that epsin is required for clathrin-coated vesicle budding in cells.

120 tion that measures coat subunit assembly and coated vesicle budding on chemically defined synthetic l

121 ing Drs2p and how it contributes to clathrin-coated vesicle budding remain unclear.

122 osin VI and Hip1R in actin-mediated clathrin-coated vesicle budding.

123 in for unsaturated lipids, and are sites for coated vesicle budding.

124 er auxilin or GAK, not only uncoats clathrin-coated vesicles but also acts as a chaperone during clat

125 l of receptors from the membrane in clathrin-coated vesicles, but it remains unclear how clathrin rec

126 TPase dynamin promotes formation of clathrin-coated vesicles, but its mode of action is unresolved.

127 lins results in the accumulation of clathrin-coated vesicles, but not of clathrin-coated pits, at syn

128 COPI coated vesicles carry material between Golgi compartment

129 Clathrin-coated vesicles carry traffic from the plasma membrane t

130 equential region required to uncoat clathrin-coated vesicles catalytically.

131 incorporation into AP-1-containing clathrin-coated vesicles, caused loss of TGN localization and som

132 ) were required for plasma membrane clathrin-coated vesicle (CCV) budding and marked sites of CCV for

133 species, actin assembly facilitates clathrin-coated vesicle (CCV) formation during endocytosis.

134 compared the protein composition of clathrin-coated vesicle (CCV) fractions from control and knocksid

135 We then tested whether the clathrin-coated vesicle (CCV)-associated proteins could be phosph

136 cargo to visualize the formation of clathrin-coated vesicles (CCVs) at single CCPs with a time resolu

137 Clathrin-coated vesicles (CCVs) facilitate the transport of cargo

138 te proteomics approach to analyzing clathrin-coated vesicles (CCVs) from HeLa cells.

139 en proposed to involve formation of clathrin-coated vesicles (CCVs) from immature SGs (ISGs).

140 subcellular fractions enriched for clathrin-coated vesicles (CCVs) indicated that pip5k1 and pip5k2

141 The size of endocytic clathrin-coated vesicles (CCVs) is remarkably uniform, suggesting

142 n particular, it is unknown whether clathrin-coated vesicles (CCVs) participate in this transport ste

143 Clathrin-coated vesicles (CCVs) that form at the PM and trans-Gol

144 f J-domain proteins load Hsp70 onto clathrin-coated vesicles (CCVs) to drive uncoating.

145 ng signals for packaging cargo into clathrin-coated vesicles (CCVs), and also facilitate down-regulat

146 ein-2 (AP2), a central component of clathrin-coated vesicles (CCVs), is pivotal in clathrin-mediated

147 entire population of intracellular clathrin-coated vesicles (CCVs), suggesting a more global functio

148 e adaptor protein (AP) complexes of clathrin-coated vesicles (CCVs), together with an FKBP and rapamy

149 eads to presynaptic accumulation of clathrin-coated vesicles (CCVs)-all without decreasing GABAergic

150 it is critical for CFTR uptake into clathrin-coated vesicles (CCVs).

151 uration before pinching off to form clathrin-coated vesicles (CCVs).

152 ion of AP2 uncoating from endocytic clathrin-coated vesicles (CCVs).

153 nvestigate mechanical properties of clathrin-coated vesicles (CCVs).

154 at invaginate and pinch off to form clathrin-coated vesicles (CCVs).

155 During the formation of clathrin-coated vesicles, clathrin and endocytic accessory protei

156 Coated vesicles concentrate and package cargo molecules

157 Endoplasmic Reticulum (ER)-derived COPII coated vesicles constitutively transport secretory cargo

158 endosome sorting process begins at clathrin-coated vesicles, depends on microtubule-dependent motili

159 or proteins, leading to cargo packaging into coated vesicles destined for the endolysosomal system.

160 erone for Hsc70 in the uncoating of clathrin-coated vesicles during endocytosis.

161 on is to remove missorted proteins by small, coated vesicles during maturation of these spherical org

162 exomer leading to the capture of Fus1p into coated vesicles en route to the cell surface.

163 hrin heavy chain and is involved in clathrin-coated vesicle endocytosis.

164 ation protocols were used to obtain modified coated vesicle-enriched fractions, which were compared b

165 COPII-coated vesicles export newly synthesized proteins from t

166 that the binding of TRAPPI to Sec23 marks a coated vesicle for fusion with another COPII vesicle or

167 t the TGN, resulting in p14 sorting into AP1-coated vesicles for anterograde TGN-plasma membrane tran

168 cles are superior to uncoated or transferrin-coated vesicles for delivering cargo to the mouse brain.

169 nd beta'-COP subunits and packaged into COPI-coated vesicles for Golgi-to-ER retrieval.

170 o proteins to incorporate them into clathrin-coated vesicles for trafficking.

171 tic cells packages cargo proteins into COPII-coated vesicles for transport from the endoplasmic retic

172 COPI-coated vesicles form at the Golgi apparatus from two cyt

173 Clathrin-coated vesicles form by rapid assembly of discrete coat

174 Instead, blockade of clathrin-coated vesicle formation and forward trafficking prevent

175 be involved in both the initiation of COPII-coated vesicle formation and scission of the nascent ves

176 rate to increase the probability of clathrin-coated vesicle formation and to control the number, size

177 e 15) is well known for its role in clathrin-coated vesicle formation at the plasma membrane through

178 ptor EPSIN1 (EPS1) is implicated in clathrin-coated vesicle formation at the trans-Golgi network (TGN

179 or protein-1 (AP1), responsible for clathrin-coated vesicle formation at the trans-Golgi, was selecti

180 1 deficiency had no apparent effect on COPII-coated vesicle formation in an in vitro assay.

181 evidence for a role of actin during clathrin-coated vesicle formation is lacking.

182 Clathrin-coated vesicle formation is responsible for membrane tra

183 at Eps15 plays an important role in clathrin-coated vesicle formation not only at the plasma membrane

184 own to depend on dynamin by rapidly blocking coated vesicle formation within seconds of dynasore addi

185 ruit accessory proteins involved in clathrin-coated vesicle formation, but the spectrum of known adap

186 lathrin adaptors are key factors in clathrin-coated vesicle formation, coupling clathrin to cargo and

187 ces of cell-substrate attachment in clathrin-coated vesicle formation.

188 lti-modular proteins that stimulate clathrin-coated vesicle formation.

189 Dynamin is essential for clathrin-dependent coated vesicle formation.

190 with the endocytic machinery during clathrin-coated vesicle formation.

191 proteins involved in early steps of clathrin coated vesicle formation.

192 AP-3 cofractionates with clathrin-coated vesicle fractions isolated from PC12 cells even a

193 s (CME) occurs via the formation of clathrin-coated vesicles from clathrin-coated pits (CCPs).

194 Budding of COPI-coated vesicles from Golgi membranes requires an Arf fam

195 essential for the retrograde traffic of COPI-coated vesicles from the Golgi to the ER.

196 n, a GTPase required for budding of clathrin-coated vesicles from the plasma membrane.

197 The endocytosed NPs remain in clathrin-coated vesicles from which they mediate intracellular de

198 sistent with the formation and detachment of coated vesicles from within large patches.

199 and therefore independent of canonical COPII-coated vesicle function.

200 The clathrin-coated vesicle fuses with an endosome where the pH is lo

201 Clathrin-coated vesicles had no detectable role in virion traffic

202 s in plants, but the involvement of clathrin-coated vesicles has been unclear; a new study provides s

203 We previously showed that clathrin-coated vesicles have a dynamic phosphoinositide landscap

204 ith the trans-Golgi and cytoplasmic clathrin-coated vesicles, implicating huntingtin in vesicle traff

205 In addition, the presence of clathrin-coated vesicles in cells containing elevated levels of c

206 ,K(+)-ATPase alpha(1)-subunits into clathrin-coated vesicles in cells transfected with the S11A mutan

207 ),K(+)-ATPase alpha(1)-subunit into clathrin-coated vesicles in cells transfected with WT and S18A ra

208 mirror the localization of FAM21 to retromer-coated vesicles in cells.

209 ed by ubiquitination, is present in clathrin-coated vesicles in epithelial cells that natively expres

210 The role of clathrin-coated vesicles in receptor-mediated endocytosis is cons

211 Aux1 and GAK appear on coated vesicles in successive transient bursts, immediat

212 sts the involvement of caveolae and clathrin-coated vesicles in the transcytotic process.

213 disassembly of clathrin coats from clathrin-coated vesicles in vitro.

214 oration of TGN cargo molecules into clathrin-coated vesicle intermediates.

215 s well as the transport velocity of clathrin-coated vesicles involved in endocytosis.

216 laboratory indicates that the lifetime of a coated vesicle is extremely short, and assembly of nasce

217 Assembly of a COPI coated vesicle is initiated by the small GTPase Arf1 tha

218 tomer and formation of coat protein I (COPI)-coated vesicles is crucial to homeostasis in the early s

219 The proper formation of clathrin-coated vesicles is dependent on, and highly regulated by

220 mediating endocytic trafficking of clathrin-coated vesicles is well established.

221 n-coated profiles (in this case, of clathrin-coated vesicles) is observed at inhibitory synapses of n

222 chain (CHC), the main component of clathrin-coated vesicles, is well characterized for its role in i

223 sis of heterogeneous populations of clathrin-coated vesicles isolated from cells.

224 dense-core particles, liquid-filled, bilayer-coated vesicles/liposomes, and gas-filled bubbles.

225 ein complex found at the cytoplasmic face of coated vesicles located at the Golgi complex.

226 Clathrin-coated vesicles lose their clathrin lattice within secon

227 Sar1, and dynamin are core components of the coated vesicle machinery.

228 ity monitors that govern cargo packaging and coated vesicle maturation and as components of the fissi

229 lia, suggesting that disassembly of clathrin-coated vesicles may proceed through a partially uncoated

230 Also, our findings suggest that clathrin-coated vesicles may regulate Megatrachea turnover at the

231 Clathrin-coated vesicles mediate a variety of endocytosis pathway

232 Coat protein I (COPI)-coated vesicles mediate retrograde transport from the Go

233 Clathrin-coated vesicles mediate sorting and intracellular transp

234 COPII-coated vesicles mediate the transport of newly synthesiz

235 COPI-coated vesicles mediate trafficking within the Golgi app

236 COPI coated vesicles mediate trafficking within the Golgi app

237 Clathrin-coated vesicles mediate vesicular traffic in cells.

238 In the final coated vesicle, most appendage binding partners are abse

239 e structures larger than the typical protein-coated vesicles must be involved in transport.

240 verning the sorting of a SNARE into clathrin-coated vesicles, namely the direct recognition of the th

241 tures, and is enriched in placental clathrin-coated vesicles, new possibilities for Ced-6/Gulp operat

242 The formation of clathrin-coated vesicles occurs continuously in non-dividing cell

243 roach, we visualized the NEC in situ forming coated vesicles of defined size.

244 We examined the composition of clathrin-coated vesicles on an internal organelle responsible for

245 at AREs and caused aberrant accumulation of coated vesicles on AREs, suggesting a previously unrecog

246 pose that AP180 directs Vamp7B into clathrin-coated vesicles on contractile vacuoles, creating an eff

247 element-binding proteins (SREBPs) into COPII-coated vesicles on endoplasmic reticulum (ER) membranes

248 es offer a valuable system to study clathrin-coated vesicles on internal organelles within eukaryotic

249 Coat protein complex I (COPI)-coated vesicles, one of three major types of vesicular c

250 mics and does not involve clathrin assembly, coated vesicles or membrane cholesterol.

251 of the hydrolase-MPR complexes into clathrin-coated vesicles or transport carriers (TCs) destined for

252 n, associates with a freshly budded clathrin-coated vesicle, or with an in vitro assembled clathrin c

253 tant components for the cleavage of clathrin-coated vesicles, phagosomes, and mitochondria.

254 Clathrin-coated vesicles play an established role in endocytosis

255 rom HeLa cells and identified known clathrin-coated vesicle proteins with >90% accuracy.

256 a universal method for defining the clathrin-coated vesicle proteome and may be adapted for the analy

257 port the first comprehensive insect clathrin-coated vesicle proteome.

258 Protein-coated vesicles provide a major mechanism for intracellu

259 Coated vesicles provide a major mechanism for the transp

260 ociated with neck fission; 26 are enough for coated vesicle release in cells partially depleted of dy

261 Sorting of transmembrane cargo into clathrin-coated vesicles requires endocytic adaptors, yet RNA int

262 We conclude that, similar to coated vesicles, several copies of the same structural b

263 variable cage architecture and adaptation of coated vesicle size and shape during clathrin-mediated v

264 ) are too big to fit into conventional COPII-coated vesicles, so how are these bulky cargoes exported

265 ncreases the number of postsynaptic clathrin-coated vesicles, some of which traffic NMDA receptors, d

266 we demonstrate the existence of mobile COPII-coated vesicles that completely encapsulate the cargo PC

267 CHC17 forms the ubiquitous clathrin-coated vesicles that mediate membrane traffic.

268 lization on the plasma membrane and clathrin-coated vesicles that originated from the plasma membrane

269 COPI proteins oligomerize to form coated vesicles that transport contents between the Golg

270 EC23A is an essential component of the COPII-coated vesicles that transport secretory proteins from t

271 After the internalization of a clathrin-coated vesicle, the vesicle must uncoat to replenish the

272 For clathrin-coated vesicles, the motifs are recognized by clathrin a

273 roteins that influence the lifecycle of COPI-coated vesicles; this conclusion is supported by the obs

274 link ubiquitinated Notch ligands to Clathrin-coated vesicles through other Clathrin adapter proteins.

275 lytically supports the uncoating of clathrin-coated vesicles through recruitment of Hsc70 in an ATP h

276 te the intracellular trafficking of clathrin-coated vesicles through their interaction with several o

277 hat mTRAPPII is a Rab1 GEF that tethers COPI-coated vesicles to early Golgi membranes.

278 ind to the adaptor protein (AP) complexes of coated vesicles to modulate protein traffic, but the mol

279 mulate Gap1 incorporation into AP-1/clathrin-coated vesicles to promote Gap1 trafficking from endosom

280 rafficking of cargo via a subset of Clathrin-coated vesicles to selected membrane sites in retinal ro

281 ily protein driven, such as the formation of coated vesicles, to those that are primarily lipid drive

282 ur results reveal the importance of clathrin-coated vesicle trafficking in C. burnetii infection and

283 vel insight into the TGN-associated clathrin-coated vesicle trafficking machinery that impacts plant

284 nclude effector endocytosis through clathrin-coated vesicle trafficking, defense signaling through me

285 Coat protein II (COPII)-coated vesicles transport proteins and lipids from the e

286 Clathrin-coated vesicle uncoating requires ATP and is mediated by

287 hoinositide phosphatase involved in clathrin-coated vesicle uncoating.

288 ed strong inhibition against bovine clathrin-coated vesicle V-ATPase (10 nM).

289 ATPase (V-ATPase) from bovine brain clathrin coated vesicles was analyzed by electron microscopy and

290 in that plays major role in the formation of coated vesicles, was slower in rsw4 than in the control.

291 Otherwise, normal docking and clathrin-coated vesicles were observed, albeit at much reduced nu

292 k and plasma membrane, and abundant clathrin coated vesicles were recruited to the region of nascent

293 rmore, mum failed to associate with clathrin-coated vesicles when receptor destabilization was inhibi

294 exit the endoplasmic reticulum (ER) in COPII-coated vesicles, whereas resident and misfolded proteins

295 C/HOPS proteins cofractionate with clathrin-coated vesicles, which are devoid of Hrs.

296 a core component of coat protein complex II-coated vesicles, which transport secretory proteins from

297 y components are returned to the ER via COPI-coated vesicles, which undergo similar tethering and fus

298 ate secretory route are mediated by clathrin-coated vesicles, while the COat Protein I and II (COPI a

299 equired for the fusion of endocytic clathrin-coated vesicles with endosomes and also for subsequent p

300 omplexes) link the outer lattice of clathrin-coated vesicles with membrane-anchored cargo molecules.