ライフサイエンスコーパス: cobalamin

1 ethyl-amino-acetato] cobalamin, (99m)Tc-PAMA-cobalamin).

2 taining cofactors that includes vitamin B12 (cobalamin).

3 ta and select heterotrophic bacteria produce cobalamin.

4 takes, whereas only the Bolus dose increased cobalamin.

5 reduces Co(II) to Co(I) of the enzyme-bound cobalamin.

6 steine and 5'-deoxyadenosine, and to require cobalamin.

7 ich it removes cyano versus alkyl ligands in cobalamin.

8 risons suggested that the protein may bind a cobalamin.

9 achieved with a predose of 20-100 ug of cold cobalamin.

10 ionine and that methylation does not require cobalamin.

11 eudocobalamin produced by cyanobacteria into cobalamin.

12 travenously before injection of (99m)Tc-PAMA-cobalamin.

13 lved in the lysosome in aiding the export of cobalamin.

14 ur-coordinate cobalamin, and five-coordinate cobalamin.

15 lamin and salvaging of cobinamide to produce cobalamin.

16 nrelated hydrophilic compounds bleomycin and cobalamin.

17 trate surrogate, but only in the presence of cobalamin.

18 at are linked to a decreased availability of cobalamin.

19 aquo-cobalamin (H2OCbl(+)) but not to other cobalamins.

20 oxic, environmentally benign cobalt complex, cobalamin (1) has been successfully utilised in organic

21 819c was found to be essential for uptake of cobalamin(1).

22 Vitamin B12 (cobalamin, 1) is one of a few naturally occurring organo

23 imolar levels with a substantial increase in cobalamin (~20-fold).

24 0.2 per thousand with the enzymatic cofactor cobalamin; -21.3 per thousand +/- 0.5 per thousand and -

25 between biotransformations (3.4 to 3.8) and cobalamin (3.9), but differed markedly for cobaloxime (6

26 do-butyl)-pyridin-2-yl-methyl-amino-acetato] cobalamin, (99m)Tc-PAMA-cobalamin).

27 tent superoxide scavenger, we tested whether cobalamin, a vitamin B12 vitamer, would be neuroprotecti

28 that the methyl group derives from SAM, with cobalamin acting as an intermediate carrier, and that Ma

29 %) obtained from spiked sage sample and from cobalamin also validated the accuracy of the method.

30 Recovery results for cobalt in cobalamin and cobalt detected by the HPLC-ICP-OES system

31 LOD values of cobalt in cobalamin and cobalt for HPLC-ICP-OES system were calcul

32 thod for the separation and determination of cobalamin and cobalt in kefir samples by high performanc

33 Cobalamin and folate status showed a statistically signi

34 ied nitroreductase scaffold tailored to bind cobalamin and glutathione, CblC exhibits versatility in

35 ectives were to explore the concentration of cobalamin and haptocorrin in foremilk and hindmilk durin

36 and hindmilk contained comparable amounts of cobalamin and haptocorrin, but marked changes were obser

37 , and 9 mo postpartum for the measurement of cobalamin and haptocorrin.

38 stal McMurdo Sound, we observed simultaneous cobalamin and iron limitation of surface water phytoplan

39 from SAM; however, the enzyme also requires cobalamin and iron-sulfur cluster cofactors for turnover

40 Cobalamin and other corrinoids are essential cofactors f

41 nine synthase MetH was robustly supported by cobalamin and p-cresolylcobamide, but not pseudocobalami

42 evidence for a dynamic interface between the cobalamin and PLP-binding domains.

43 Here we show that cobalamin and pseudocobalamin coexist in the surface oce

44 st was significantly reduced by intravitreal cobalamin and resulted in increased RGC survival.

45 ents an unprecedented metabolic link between cobalamin and steroid metabolism and suggests that retro

46 hylases catalyze methyl transfer from SAM to cobalamin and then to a substrate-centered carbon or pho

47 ), as well as several commercially available cobalamins and cobinamide.

48 of CobA in complex with ATP, four-coordinate cobalamin, and five-coordinate cobalamin.

49 s article, diagnosis and management of iron, cobalamin, and folate deficiencies, the most frequent ca

50 ajor cobamide groups: commercially available cobalamin, and isolated pseudocobalamin and p-cresolylco

51 thylbenzimidazole (DMB), the lower ligand of cobalamin, and Sporomusa are dominant acetogens.

52 ter injection of 300-500 MBq of (99m)Tc-PAMA-cobalamin, and whole-body scintigrams were obtained at 1

53 ial maternal-fetal transfer of iron, folate, cobalamin, and zinc; limited transfer of fat-soluble vit

54 rocessing, transport, and medical aspects of cobalamins; and the growing roles of heme sensor protein

55 Cobalamins are important biological cofactors involved i

56 Cobalamins are of widespread importance in biology.

57 Derivatives of vitamin B12 (cobalamin) are essential cofactors for enzymes required

58 (the lower ligand of cobalamin), to produce cobalamin as a cofactor for dechlorination.

59 mmonly used benzimidazolyl cobamides such as cobalamin, as the lower axial ligand is a phenolic group

60 A decrease in milk cobalamin at 4 mo was associated with decreases in plasm

61 tetrapyrroles haem, bacteriochlorophyll and cobalamin (B12 ) exhibit a complex interrelationship reg

62 e dehalogenases form a distinct subfamily of cobalamin (B12)-dependent enzymes that are usually membr

63 licates Thaumarchaeota as major producers of cobalamin based on genomic potential, cobalamin cell quo

64 tive roles played by abundant prokaryotes in cobalamin-based microbial interdependencies that sustain

65 ropose that during nutrient-rich conditions, cobalamin-based mutualism intensifies upper water column

66 cks the Asp-X-His-X-X-Gly motif seen in some cobalamin binding enzymes.

67 tuberculosis ATR, which organizes a dynamic cobalamin binding site and exerts exquisite control over

68 esigned to perturb the interface between the cobalamin-binding domain and the PLP-binding TIM barrel

69 at a large scale domain reorientation of the cobalamin-binding domain is linked to radical catalysis.

70 29)-PLP covalent bond, dynamic motion of the cobalamin-binding domain leads to conformational samplin

71 rier, and that MaMmp10 contains a C-terminal cobalamin-binding domain.

72 uncovered key architectural features in the cobalamin-binding pocket that support unusual cob(II)ala

73 op module and a subset of nucleotides in the cobalamin-binding pocket.

74 lamin is hampered by the high content of the cobalamin-binding protein haptocorrin, and limited data

75 The trout cobalamin-binding protein was glycosylated and displayed

76 Given that Mmp10 has not been annotated as a cobalamin-binding protein, these findings suggest that c

77 Approximately 20-25% of circulating cobalamin binds to transcobalamin 2 (TCN2), which is ref

78 resents a new model in both organohalide and cobalamin (bio)chemistry that will guide future exploita

79 athway enzymes, we complete the tool set for cobalamin biosynthesis and pave the way for not only enh

80 lso contributed significantly to metagenomic cobalamin biosynthesis gene abundance throughout Souther

81 The major contributor to cobalamin biosynthesis gene expression was a gammaproteo

82 ing the connection between the occurrence of cobalamin biosynthesis genes and production of the compo

83 On the basis of genomic analyses, cobalamin biosynthesis in marine systems has been inferr

84 es for host glycan metabolism as well as for cobalamin biosynthesis.

85 c pathways including amino acid, purine, and cobalamin biosynthesis.

86 st feed-forward gene regulatory topology for cobalamin biosynthesis.

87 deoxyribonucleases, nickel/cobalt uptake and cobalamin biosynthesis.

88 However, by studying the anaerobic cobalamin biosynthetic pathway in Bacillus megaterium an

89 ntial reduction of the precorrin ring in the cobalamin biosynthetic pathway.

90 es that many Cyanobacteria do not synthesize cobalamin but rather produce pseudocobalamin, challengin

91 Deglutathionylation of glutathionyl-cobalamin by a second molecule of GSH yields GSSG.

92 CZS and compare these changes with those of cobalamin C (cblC) deficiency, a disease with potential

93 Cobalamin C (cblC) deficiency, the most common inborn er

94 Cobalamin C deficiency can be accompanied by a wide spec

95 ycerol kinase epsilon (DGKepsilon) activity, cobalamin C deficiency, or plasminogen deficiency.

96 CblC converts the cobalamin cargo arriving from the lysosome to a common c

97 This tutorial review concisely describes cobalamin-catalysed organic reactions that hold promise

98 and zerovalent iron (Fe(0), ZVI), and (iii) cobalamin-catalyzed biomimetic transformation.

99 The (formal) replacement of Co in cobalamin (Cbl) by Ni(II) generates nibalamin (Nibl), a

100 ceptor-knockout mouse ( Cd320(-/-)) develops cobalamin (Cbl) deficiency in the nervous system, with m

101 (TCblR/CD320) for transcobalamin (TC)-bound cobalamin (Cbl) facilitates the cellular uptake of Cbl.

102 mbrane impermeable by covalent attachment to cobalamin (Cbl) through a photocleavable linker.

103 yle choices may affect placental transfer of cobalamin (Cbl) to the fetus.

104 Vitamin B12 (cobalamin (Cbl)), in the cofactor forms methyl-Cbl and a

105 s the high-affinity binding and transport of cobalamin (CBL), or vitamin B12, across the asymmetric o

106 The existence of cobalamin (Cbl)-dependent enzymes that are members of th

107 Many cobalamin (Cbl)-dependent radical S-adenosyl-l-methionin

108 Cobalamin (Cbl)-dependent radical S-adenosylmethionine (

109 chemical analysis of the encoded proteins, a cobalamin (Cbl)-dependent S-adenosylmethionine (AdoMet)

110 QueG is a cobalamin (Cbl)-dependent, [4Fe-4S] cluster-containing p

111 nscobalamin (TC) saturated with vitamin B12 [cobalamin (Cbl)] and mediates cellular uptake of the vit

112 The system of cobalamin (Cbl, vitamin B12) transport was used as a mod

113 Cobalamin (Cbl; vitamin B12) is an essential micronutrie

114 Conversion of vitamin B12 (cobalamin, Cbl) into the cofactor forms methyl-Cbl (MeCb

115 ers of cobalamin based on genomic potential, cobalamin cell quotas, and abundance.

116 ere recently designed as metabolically inert cobalamins, classified as "antivitamins B12".

117 , show that a direct interaction between the cobalamin cobalt and the substrate halogen underpins cat

118 the dimethylbenzimidazole tail in moving the cobalamin cofactor between active sites.

119 The enzyme contains 1 equiv of its cobalamin cofactor in its as-isolated state and can be r

120 proper intracellular targeting of ABCD4 and cobalamin cofactor synthesis.

121 ition to a [4Fe-4S] cluster, TsrM contains a cobalamin cofactor that serves as an intermediate methyl

122 Class B methylases require a cobalamin cofactor to methylate both sp(2)-hybridized an

123 Each 2-fold increment in plasma cobalamin concentration was associated with a significan

124 n status were excluded, ie, in those who had cobalamin concentrations below the 25th percentile.

125 itive associations in paired maternal-infant cobalamin concentrations were found at all time points.

126 ncentrations, macrocytosis, and normal serum cobalamin concentrations; only one subject was anemic.

127 compete with phytoplankton and are important cobalamin consumers.

128 echanism for how the essential tetrapyrrole, cobalamin controls the synthesis of bacteriochlorophyll,

129 Our study provides insights into how cobalamin coordination chemistry could be utilized for c

130 Even in the presence of cobalamin, Cyanobacteria synthesize pseudocobalamin-like

131 Although Mtb can synthesize vitamin B(12) (cobalamin) de novo, uptake of cobalamin has been linked

132 nborn errors of metabolism and indicators of cobalamin deficiency in older persons.

133 The importance of treating cobalamin deficiency in pregnancy is considered.

134 y and bariatric surgery rates, prevalence of cobalamin deficiency in pregnancy is rising.

135 re of this knockout and the lack of systemic cobalamin deficiency point to other mechanisms for cellu

136 plasma MMA values have been used to diagnose cobalamin deficiency.

137 y years before the establishment of clinical cobalamin deficiency.

138 Vitamin B-12 (cobalamin) deficiency may produce severe neurologic and

139 that the biosynthetic reaction mechanism is cobalamin dependent.

140 nic acid metabolism through the vitamin B12 (cobalamin)-dependent enzyme methylmalonyl CoA mutase.

141 eguminosarum to invoke the activities of two cobalamin-dependent C-methyltransferases.

142 Cobalamin-dependent enzymes enhance the rate of C-Co bon

143 case of the pyridoxal 5'-phosphate (PLP) and cobalamin-dependent enzymes lysine 5,6-aminomutase and o

144 establishes the common features of Class III cobalamin-dependent enzymes, and reveals an unexpected d

145 ates, quantitative proteomic measurements of cobalamin-dependent enzymes, and theoretical calculation

146 ed by propyl iodide, a specific inhibitor of cobalamin-dependent enzymes.

147 The identification of the cobalamin-dependent estrogen methylation thus represents

148 DHT3 cultures, suggested the occurrence of a cobalamin-dependent estrogen methylation to form androge

149 ection, and reactivation of 5'-deoxyadenosyl cobalamin-dependent methylmalonyl-CoA mutase (MCM).

150 gen-fed conditions and predicted to encode a cobalamin-dependent methyltransferase system conserved a

151 Existing evidence points to three putative cobalamin-dependent radical S-adenosylmethionine (RS) en

152 yl group proposed to be formed using CysS, a cobalamin-dependent radical S-adenosylmethionine (SAM) m

153 In countless RiPP biosynthetic pathways, cobalamin-dependent radical SAM (B12/rSAM) enzymes play

154 is is the first in vitro reconstitution of a cobalamin-dependent radical SAM enzyme catalyzing the co

155 binding protein, these findings suggest that cobalamin-dependent radical SAM proteins are more preval

156 ible, QueG, shares distant homology with the cobalamin-dependent reductive dehalogenase (RdhA), howev

157 We show that ThnK of the three apparent cobalamin-dependent RS enzymes performs sequential methy

158 cobalt bond chemistry catalysed by the other cobalamin-dependent subfamilies, we propose that reducti

159 However, severe cobalamin depletion in the central nervous system (CNS)

160 expression patterns consistent with iron and cobalamin deprivation.

161 patterns indicative of co-occurring iron and cobalamin deprivation.

162 ng practice, we have developed a new (99m)Tc-cobalamin derivative ((99m)Tc(CO)3-[(4-amido-butyl)-pyri

163 trate that this riboswitch binds to multiple cobalamin derivatives and correlate its promiscuous beha

164 logies for the synthesis and analysis of new cobalamin derivatives as well as creative purification t

165 Cobalamin derivatives entering the cytoplasm are convert

166 ing cobalamin production, but also design of cobalamin derivatives through their combinatorial use an

167 CblC removes the upper axial ligand of cobalamin derivatives, forming an intermediate in the pa

168 product radical and Co(II) does not restrict cobalamin domain motion.

169 luoride occurred in incubations with reduced cobalamins (e.g., vitamin B12) indicating that biomolecu

170 ignificant difference was observed regarding cobalamin, folate, and red blood cell folate.

171 requires an external supply of vitamin B12 (cobalamin) for growth, which it can obtain in stable lab

172 ae can remodel pseudocobalamin to the active cobalamin form, adding complexity to our assessment of a

173 Fasting plasma folate, cobalamin, free choline, betaine, dimethylglycine, and t

174 milk may not be sufficient for the supply of cobalamin from this age.

175 the cap domain, which protects vitamin B12 (cobalamin) from oxidation.

176 n infants with biochemical signs of impaired cobalamin function and developmental delay or feeding di

177 n infants with biochemical signs of impaired cobalamin function, 1 intramuscular injection of cobalam

178 Infants with biochemical signs of impaired cobalamin function, defined as a plasma tHcy concentrati

179 increase in the AIMS score was higher in the cobalamin group than in the placebo group [7.0 (5.0, 9.0

180 copy confirmed binding (Kd = 34 mum) to aquo-cobalamin (H2OCbl(+)) but not to other cobalamins.

181 vitamin B(12) (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosi

182 the same time points for the measurement of cobalamin, holotranscobalamin, total transcobalamin, tot

183 0 gene was generated to study the effects on cobalamin homeostasis.

184 we report for the first time on (99m)Tc-PAMA-cobalamin imaging in patients with metastatic cancer dis

185 gated cancer-specific uptake of (99m)Tc-PAMA-cobalamin in 10 patients with various metastatic tumors.

186 pectroscopic studies suggest that TsrM binds cobalamin in an uncharacteristic five-coordinate base-of

187 Median (range) concentrations of cobalamin in hindmilk were 760 (210-1880), 290 (140-690)

188 PLC-ICP-OES) in addition to determination of cobalamin in HPLC system.

189 Only the Bolus dose increased cobalamin in milk [Bolus: 0.054 (0.047, 0.061) mug . min

190 alogenase (RdhA), however the role played by cobalamin in QueG catalysis has remained elusive.

191 into the organization of GSH and a base-off cobalamin in the active site of this enzyme.

192 This indicates that cobalamin in the surface ocean is a result of de novo sy

193 f preference for the two biological forms of cobalamin in vitro using isothermal titration calorimetr

194 nthesis and use of cobalt-bearing cofactors (cobalamins) in their genomes.

195 Predosing with cobalamin increased the tumor uptake and improved blood-

196 The cobalamin-independent methionine synthase enzyme catalyz

197 The cobalamin-independent methionine synthase from Candida a

198 8) mug . min-1 . mL-1, P = 0.039] and infant cobalamin intake [Bolus: 0.023 (0.020, 0.027) mug; Contr

199 ts thiol oxidase activity via a glutathionyl-cobalamin intermediate.

200 is characterized by a failure to metabolize cobalamin into adenosyl- and methylcobalamin, which resu

201 of sodium cyanide, to transform all forms of cobalamin into cyanocobalamin.

202 ellular pathway supports the assimilation of cobalamin into its active cofactor forms and delivery to

203 step is critical for assimilation of dietary cobalamin into the active cofactor forms that support th

204 ts 3-10 received between 20 and 1,000 mug of cobalamin intravenously before injection of (99m)Tc-PAMA

205 Cobalamin is a complex organometallic cofactor that is p

206 CBA1 in environmental samples suggests that cobalamin is an important nutritional factor for phytopl

207 Measurement of milk cobalamin is hampered by the high content of the cobalam

208 Cobalamin is produced only by bacteria and archaea, sugg

209 The reactivity of the cobalt-carbon bond in cobalamins is the key to their chemical versatility, sup

210 In mammals, B12 (or cobalamin) is an essential cofactor required by methioni

211 Targeting cancer cells with vitamin B12 (cobalamin) is hampered by unwanted physiologic tissue up

212 Vitamin B12 (cobalamin) is required by humans and other organisms for

213 HbpS.Cobalamin lacks the Asp-X-His-X-X-Gly motif seen in some

214 Low maternal cobalamin may be associated with fetal growth retardatio

215 These data demonstrate that cobalamin may function as an endogenous neuroprotectant

216 folate (mean: +26.8%; 95% CI: 19.6, 34.5%), cobalamin (mean: +31.3%; 95% CI: 24.6, 38.3%), 25(OH)D (

217 ecause zebrafish harbor a full complement of cobalamin metabolic enzymes, we used genome editing to s

218 11 play important roles in the regulation of cobalamin metabolism as well as other pathways involved

219 in the genes LMBRD1 and ABCD4 result in the cobalamin metabolism disorders cblF and cblJ.

220 Defects in cobalamin metabolism lead to disorders characterized by

221 HCFC1 regulates cobalamin metabolism via the regulation of MMACHC expres

222 The most common inborn error of cobalamin metabolism, combined methylmalonic acidemia an

223 he most common inborn error of intracellular cobalamin metabolism, is caused by mutations in MMACHC,

224 At 4 mo, low concentrations of milk cobalamin mirrored biochemical changes in infants, which

225 The cobalamin or B12 cofactor supports sulfur and one-carbon

226 the elimination of the upper axial ligand in cobalamin or B12 derivatives entering the cell from circ

227 To our knowledge, MtcB methylation of cobalamin or Co(I)-MtqC represents the first described m

228 actions of inorganic Hg (Hg(II)) with methyl cobalamin or of dissolved monomethylmercury (CH3Hg) with

229 In humans, cobalamin or vitamin B(12) is delivered to two target en

230 4 mo was associated with decreases in plasma cobalamin (P , 0.0001) and holotranscobalamin (P , 0.000

231 obalamin status [by the measurement of serum cobalamin, plasma total homocysteine (tHcy), and plasma

232 is involved in an early step in cytoplasmic cobalamin processing following entry of the cofactor int

233 esis and pave the way for not only enhancing cobalamin production, but also design of cobalamin deriv

234 re dependent on phytoplankton growth to fuel cobalamin production.

235 differences at the alpha- and beta-faces of cobalamin promote the thiol oxidase activity of ceCblC b

236 roceeded through nucleophilic reactions with cobalamin rather than by an electron transfer mechanism.

237 of the potential energy surfaces controlling cobalamin reactivity and deactivation.

238 obalamin resulted in biochemical evidence of cobalamin repletion and improvement in motor function an

239 ) indicate that transformation with isolated cobalamin resembles in vivo transformation and (iii) sug

240 lamin function, 1 intramuscular injection of cobalamin resulted in biochemical evidence of cobalamin

241 cture of the aptamer domain of this atypical cobalamin riboswitch and a model for the complete ribosw

242 l cobalamin riboswitches and the B. subtilis cobalamin riboswitch reveal that the likely basis for th

243 An unusual variant of the cobalamin riboswitch with predicted structural features

244 ive structural analyses between conventional cobalamin riboswitches and the B. subtilis cobalamin rib

245 by which tertiary structural interactions in cobalamin riboswitches dictate ligand selectivity.

246 Cobalamin riboswitches encompass a structurally diverse

247 based mutagenic approach to demonstrate that cobalamin riboswitches have a broad spectrum of preferen

248 We found that cobalamin scavenged superoxide in neuronal cells in vitr

249 In addition, uptake of cobalamin seems inconsistent with the amino acid sequenc

250 ade ago, but its structure and mechanisms of cobalamin selectivity and translational control have rem

251 It suggests that cobalamin selectivity might ultimately be viewed as exis

252 e presence of NO(2)Cbl, which can serve as a cobalamin source.

253 plementation changed all markers of impaired cobalamin status (ie, plasma tHcy decreased by 54%, and

254 ed psychomotor development were assessed for cobalamin status [by the measurement of serum cobalamin,

255 anges in infants, which suggests an impaired cobalamin status and indicates that nutrition from only

256 ssociation between biomarkers for folate and cobalamin status and psychomotor or mental development s

257 ng trustworthy measures of milk cobalamin to cobalamin status in healthy mothers and their children.

258 gurgitations, which suggest that an adequate cobalamin status is important for a rapidly developing n

259 e these results to biomarkers of an impaired cobalamin status of mother and child.

260 nt index scores only when children with poor cobalamin status were excluded, ie, in those who had cob

261 a biochemical profile indicative of impaired cobalamin status.

262 Poor vitamin B-12 (cobalamin) status is widespread in South Asia.

263 ies frequently have inadequate vitamin B-12 (cobalamin) status.

264 We investigated whether cobalamin supplementation can improve development or sym

265 During follow-up, cobalamin supplementation changed all markers of impaire

266 deficiencies in these nutrients, folate and cobalamin supplementation trials are required to measure

267 ination chemistry accessible to ceCblC-bound cobalamin supports its thiol oxidase activity via a glut

268 Cobalamin, the form bioavailable to humans, has as its l

269 ilable relating trustworthy measures of milk cobalamin to cobalamin status in healthy mothers and the

270 l orders of magnitude less bioavailable than cobalamin to several B12-dependent microalgae representi

271 thylbenzimidazole (DMB) (the lower ligand of cobalamin), to produce cobalamin as a cofactor for dechl

272 s assessed in infancy with the use of plasma cobalamin, total homocysteine (tHcy), and methylmalonic

273 ociation of plasma concentrations of folate, cobalamin, total homocysteine, and methylmalonic acid wi

274 lD to CblC, believed to be contiguous in the cobalamin trafficking pathway, suggests the co-option of

275 or CblC, and for supporting the cytoplasmic cobalamin trafficking pathway.

276 haperones are involved in early steps in the cobalamin trafficking pathway.

277 is a key chaperone involved in intracellular cobalamin trafficking, and mutations in CblD cause methy

278 CblC, a multifunctional enzyme important for cobalamin trafficking, and the activation domain of meth

279 Herein, we review the biochemistry of cobalamin trafficking.

280 reduced to achieve specific labeling of the cobalamin transporter BtuB in Escherichia coli.

281 The cobalamin transporter BtuB was overexpressed and spin-la

282 Mtb does not encode any characterized cobalamin transporter(4-6); however, the gene rv1819c wa

283 utes the first in vivo proof of principle of cobalamin treatment in mut-type MMAuria.

284 in distances were measured to a spin-labeled cobalamin using pulse EPR spectroscopy.

285 he anaerobic pathway for the biosynthesis of cobalamin (vitamin B(12)) has remained poorly characteri

286 Supplementation of cultures with cobalamin (vitamin B(12)) increased nitrite oxidation ra

287 CE-respiring Dehalococcoides whose growth is cobalamin (vitamin B(12))-dependent.

288 and middle-income countries have inadequate cobalamin (vitamin B-12) status.

289 cessive disorder characterized by defects in cobalamin (vitamin B12) metabolism and other development

290 hin all domains of life require the cofactor cobalamin (vitamin B12), which is produced only by a sub

291 of the cobF genome region - involved in the cobalamin/vitamin B12 synthesis - and gene interruptions

292 In addition, cobalamin was simultaneously determined by high performa

293 Vitamin B12 (cobalamin) was recently shown to be a superoxide scaveng

294 Because Nitrobacter spp. cannot synthesize cobalamin, we postulate that they acquire it from organi

295 e]Cba and the increase of biomass-associated cobalamin were correlated with the growth of D. mccartyi

296 .0%, respectively while recovery results for cobalamin were found to be between 89.2 and 98.3% for HP

297 min B-12 status with the exception of plasma cobalamin were significantly associated with the total A

298 und that p-cresolylcobamide ([p-Cre]Cba) and cobalamin were the most abundant corrinoids in the commu

299 showed positive tumor uptake on (99m)Tc-PAMA-cobalamin whole-body scintigraphy.

300 s A, D, B6, thiamine, riboflavin, niacin and cobalamin with insignificant amounts of pesticide residu

301 Ferritin, folate, cobalamin, zinc, and thyroglobulin averaged 1.57-6.75 ti