ライフサイエンスコーパス: coenzyme A

1 commodates nevanimibe and an endogenous acyl-coenzyme A.

2 d to be essential for PvrA to bind palmitoyl coenzyme A.

3 ulation of citrate, the precursor for acetyl coenzyme A.

4 is from lysophosphatidic acid (LPA) and acyl-coenzyme A.

5 Caffeoyl-coenzyme A 3-O-methyltransferase (CCoAOMT) is an S-adeno

6 s conversion of acetyl coenzyme A to malonyl coenzyme A, a carbon donor for long-chain FA synthesis,

7 human Naa60 (hNaa60) in complex with Acetyl-Coenzyme A (Ac-CoA) or Coenzyme A (CoA).

8 DIP2A) is known to be involved in acetylated coenzyme A (Ac-CoA) synthesis and is primarily expressed

9 the transfer of an acetyl group from acetyl-coenzyme A (Ac-CoA) to the amine of a wide range of subs

10 with inositol hexaphosphate (InsP6), acetyl-coenzyme A (AcCoA) and/or substrate Resistance to Ralsto

11 Acetyl-coenzyme A (AcCoA) is a major integrator of the nutritio

12 at catalyzes pyruvate's conversion to acetyl coenzyme A (AcCoA), thereby connecting these two pathway

13 ne residues by employing the cofactor acetyl-coenzyme A (AcCoA), thereby providing a dynamic control

14 gosome biogenesis via its metabolite, acetyl-coenzyme A (AcCoA).

15 ased levels of acetyl phosphate, acetoacetyl coenzyme A (acetoacetyl-CoA), butyryl CoA, acetoacetate,

16 d ferredoxin for glucose oxidation to acetyl coenzyme A (acetyl-CoA) and CO2, NADH for the reduction

17 in conversion of acetyl phosphate to acetyl-coenzyme A (acetyl-CoA) and posttranscriptionally regula

18 Coenzyme A (CoA) and acetyl-coenzyme A (acetyl-CoA) are ubiquitous cellular molecule

19 Acetate and the related metabolism of acetyl-coenzyme A (acetyl-CoA) confer numerous metabolic functi

20 Acetyl coenzyme A (acetyl-CoA) generated from glucose and aceta

21 t can also catalyze the hydrolysis of acetyl-Coenzyme A (acetyl-CoA) in the absence of an arylamine s

22 Acetyl coenzyme A (acetyl-CoA) is a key metabolite at the cross

23 Metabolic production of acetyl coenzyme A (acetyl-CoA) is linked to histone acetylation

24 riglycerides, suggesting an increased acetyl coenzyme A (acetyl-CoA) load.

25 tochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism.

26 rnative carbon source utilization for acetyl coenzyme A (acetyl-CoA) production and gluconeogenesis.

27 ferentiation in a manner dependent on acetyl coenzyme A (acetyl-CoA) production by the enzyme ATP-cit

28 The metabolite acetyl-coenzyme A (acetyl-CoA) serves as an essential element f

29 esis by suppressing the expression of acetyl coenzyme A (acetyl-CoA) synthetase (Acss), leading to de

30 s cycle, glyoxylate is condensed with acetyl coenzyme A (acetyl-CoA) to give malate, which undergoes

31 te lyase (ACLY) synthesizes cytosolic acetyl coenzyme A (acetyl-CoA), a fundamental cellular building

32 d is sensitive to the availability of acetyl coenzyme A (acetyl-CoA), we investigated a role for meta

33 demonstrate that A-485 competes with acetyl coenzyme A (acetyl-CoA).

34 e, enabling biosynthesis of cytosolic acetyl coenzyme A (acetyl-CoA, the two-carbon isoprenoid precur

35 e oxidation to fuel the production of acetyl coenzyme A, acetylation of histones and induction of gen

36 n architecturally distinct subfamily of acyl coenzyme A (acyl-CoA) dehydrogenase (ACAD) enzymes that

37 tion process is the recognition of free acyl coenzyme A (acyl-CoA) from the lipid bilayer.

38 the transport of cytoplasmic long chain acyl-coenzyme A (acyl-CoA) into the mitochondrial matrix, whi

39 tion of enzymes regulating long-chain acetyl-coenzyme A (Acyl-CoA) metabolism.

40 The AMP-forming acyl coenzyme A (acyl-CoA) synthetases are a large class of e

41 activity of the long-chain cytoplasmic acyl coenzyme A (acyl-CoA) thioesterase 7 (ACOT7) to regulate

42 nd di-, poly-, and persulfide derivatives of coenzyme A, although polysulfide itself is also efficien

43 PqsBC catalyzes the condensation of octanoyl-coenzyme A and 2-aminobenzoylacetate (2-ABA) to form the

44 best inhibitors are competitive with acetyl coenzyme A and an X-ray cocrystal structure reveals that

45 -acetyltransferase (gene: Nat8l) from acetyl-coenzyme A and aspartate.

46 amide synthase that uses C16 fatty acid acyl-coenzyme A and dihydroxy LCB substrates but increased ac

47 e enzyme phosphotransacylase (PTAC) recycles Coenzyme A and generates an acyl phosphate that can serv

48 ation of N-acetylglutamate (NAG) from acetyl coenzyme A and glutamate.

49 irement for growth and specifically inhibits coenzyme A and isoleucine biosynthesis.

50 he downstream metabolites, including malonyl-coenzyme A and palmitic acid, completely restored the in

51 ze the hydrolysis of thioester bonds between coenzyme A and phenylacetyl-CoA.

52 Upon incubation of the enzyme with acyl-coenzyme A and reduced nicotinamide adenine dinucleotide

53 to depletion of the energy substrate acetyl coenzyme A and the antioxidant glutathione.

54 ynthases that use very-long-chain fatty acyl-coenzyme A and trihydroxy LCB substrates.

55 in vitro assay requiring only isolated LDs, Coenzyme A, and ATP to drive lipid synthesis.

56 imidine, isoprenoid, methionine, riboflavin, coenzyme A, and folate, as well as other biosynthetic pa

57 th 3,5-dihydroxybenzoic acid, ATP, malonate, coenzyme A, and the malonyl-CoA ligase MatB, venemycin p

58 anine and pantoic acid moieties required for coenzyme A are annotated.

59 s the polymerization of 3-(R)-hydroxybutyryl-coenzyme A as a means of carbon storage in many bacteria

60 cyltransferase that uses preferentially 16:0-coenzyme A as an acyl donor.

61 ounds known to be metabolized by the benzoyl coenzyme A (benzoyl-CoA) pathway.

62 eracting partner, Golgi adaptor protein acyl-coenzyme A binding domain containing protein 3 (ACBD3).

63 uncover that the Golgi resident protein acyl-coenzyme A binding domain-containing 3 (ACBD3) serves as

64 emperature as the different variants of acyl-coenzyme A binding protein have similar m-values when th

65 enzyme kinetics, suggesting decreased acetyl coenzyme A binding.

66 re, we identify the PO membrane protein acyl-coenzyme A-binding domain protein 5 (ACBD5) as a binding

67 Low-molecular mass (10 kD) cytosolic acyl-coenzyme A-binding protein (ACBP) has a substantial infl

68 Here we show that acyl-coenzyme A-binding protein (ACBP) potently facilitates v

69 SAR-related proteins THIOREDOXIN h3, ACYL-COENZYME A-BINDING PROTEIN6, and PATHOGENESIS-RELATED1 w

70 This is the second inborn error of coenzyme A biosynthesis to be implicated in NBIA.

71 it was uncovered that PZA inhibits bacterial Coenzyme A biosynthesis.

72 mulates the conversion of pyruvate to acetyl-coenzyme A by the pyruvate dehydrogenase complex.

73 ctivated protein kinase activation of acetyl-coenzyme A carboxylase (ACC) and increased lipid content

74 s phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC).

75 ar gene (ACC2) that targets homomeric acetyl-coenzyme A carboxylase (ACCase) to plastids.

76 T cell-specific deletion of acetyl coenzyme A carboxylase 1 (ACC1), an enzyme that catalyze

77 ort into mitochondria via deletion of acetyl coenzyme A carboxylase 2 (ACC2) does not cause cardiomyo

78 tural environments, where heteromeric acetyl-coenzyme A carboxylase encoded in part by the chloroplas

79 d nuclear gene that targets homomeric acetyl-coenzyme A carboxylase to plastids, where the multidomai

80 l regulatory element-binding protein, acetyl coenzyme A carboxylase, and fatty acid synthase.

81 in ACC2, encoding a plastid-targeted acetyl-coenzyme A carboxylase, cause hypersensitivity to specti

82 DI-010976, an allosteric inhibitor of acetyl-coenzyme A carboxylases (ACC) ACC1 and ACC2, reduces hep

83 the post-translational biotinylation of acyl coenzyme A carboxylases.

84 3) Direct acetyl transfer between LD and coenzyme A catalyzed by E2pCD was observed with a rate c

85 We have found previously that acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibition

86 physical interaction of the major SOAT, acyl-coenzyme A:cholesterol acyltransferase (ACAT)-related en

87 ress the cholesterol-esterifying enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT1), but not

88 sterol O-acyltransferase 1 (also named acyl-coenzyme A:cholesterol acyltransferase, ACAT1) transfers

89 -acyltransferase (MBOAT) enzyme family, acyl-coenzyme A:cholesterol acyltransferases (ACATs) catalyse

90 Acetate, a precursor of acetyl coenzyme A (CoA) (a product of fatty acid beta-oxidation

91 Coenzyme A (CoA) and acetyl-coenzyme A (acetyl-CoA) are

92 abundance of the low molecular weight thiols coenzyme A (CoA) and glutathione in S47 cells.

93 ched-chain amino acid metabolism, isovaleryl-Coenzyme A (CoA) and isobutyryl-CoA, with three molecule

94 N-acyltransferase reaction using fatty acyl-coenzyme A (CoA) and long-chain base (LCB) substrates to

95 Cofactors such as NAD, AMP, and Coenzyme A (CoA) are essential for a diverse set of reac

96 (PanK) is a regulatory enzyme that controls coenzyme A (CoA) biosynthesis.

97 olution crystal structure of AF-Est2 reveals Coenzyme A (CoA) bound in the vicinity of the active sit

98 discussed in the context of the peroxisomal coenzyme A (CoA) budget.

99 roduce mm flux through the key fluoromalonyl coenzyme A (CoA) building block, thereby offering the po

100 Pharmaceutical inhibition of acetyl-coenzyme A (CoA) carboxylase (ACC), a key fatty acid bio

101 (OG) is a small molecule inhibitor of acetyl coenzyme A (CoA) carboxylase (ACC), the enzyme that cont

102 kinase (AMPK) levels, and diminished acetyl coenzyme A (CoA) carboxylase phosphorylation than in the

103 Two genes, Psyr_2474, encoding an acyl-coenzyme A (CoA) dehydrogenase, and Psyr_4843, encoding

104 Its coenzyme A (CoA) derivative, itaconyl-CoA, inhibits B(12

105 The Arabidopsis (Arabidopsis thaliana) acyl-coenzyme A (CoA) desaturase-like (ADS) gene family conta

106 ly conserved ER protein FIT2 as a fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acy

107 catalyzes the reduction of hydroxycinnamoyl-coenzyme A (CoA) esters using NADPH to produce hydroxyci

108 metabolic machinery for the biosynthesis of Coenzyme A (CoA) from exogenous pantothenic acid (Vitami

109 directed metabolic fluxes to generate acetyl-Coenzyme A (CoA) from glucose resulting in augmented his

110 nome of MLL-rearranged AML by linking acetyl-coenzyme A (CoA) homeostasis to Bromodomain and Extra-Te

111 eport the identification of a putative enoyl-coenzyme A (CoA) hydratase/isomerase that is required fo

112 While homologous to mammalian enoyl-coenzyme A (CoA) hydratases, EchA6 is non-catalytic yet

113 ty of SPT, allowing utilization of myristoyl-coenzyme A (CoA) in addition to its canonical substrate

114 brida) flowers have the precursor 4-coumaryl coenzyme A (CoA) in common.

115 tion of HMP is also compromised in vivo when coenzyme A (CoA) levels are reduced.

116 zyme DmdB, a methylmercaptopropionate (MMPA)-coenzyme A (CoA) ligase, catalyzes the second step in th

117 DmdB, a 3-methylmercaptopropionate (MMPA)-coenzyme A (CoA) ligase, undergoes two sequential confor

118 a BL-04 gene encoding long-chain fatty acid coenzyme A (CoA) ligase.

119 o enzymes, Ptr4CL3 and Ptr4CL5, catalyze the coenzyme A (CoA) ligation of 4-coumaric acid to 4-coumar

120 Coenzyme A (CoA) mediates thiol-based acyl-group transfe

121 ation of the meta-hydroxyl group of caffeoyl-coenzyme A (CoA) on the pathway to monolignols, with the

122 ity were correlated with changes in the acyl-coenzyme A (CoA) pool in developing seeds of transgenic

123 cate that YacG is frequently associated with coenzyme A (CoA) production enzymes, linking the protein

124 levels of intermediate and anaplerotic acyl-coenzyme A (CoA) species incorporated into the Krebs cyc

125 tauri extraplastidial lipids, while the 16:4-coenzyme A (CoA) species was not detected.

126 carbon-carbon bond forming step between acyl coenzyme A (CoA) substrates offer a versatile route for

127 aloferax volcanii 3-hydroxy-3-methylglutaryl coenzyme A (CoA) synthase (EC 2.3.310).

128 essive missense mutations in COASY, encoding coenzyme A (CoA) synthase in one NBIA-affected subject.

129 rase superfamily member 2 (Them2) is an acyl-coenzyme A (CoA) thioesterase that catalyzes the hydroly

130 tochondrion-associated long-chain fatty acyl coenzyme A (CoA) thioesterase that is highly expressed i

131 t transfers 4'-phosphopantetheine (Ppt) from coenzyme A (CoA) to diverse acyl carrier proteins.

132 the ATP-dependent conversion of citrate and coenzyme A (CoA) to oxaloacetate and acetyl-CoA(1-5).

133 The enzymes YfdW, a formyl coenzyme A (CoA) transferase, and YfdU, an oxalyl-CoA de

134 lysophosphatidylethanolamine (LPE) with acyl-coenzyme A (CoA), designated LYSOPHOSPHATIDYLETHANOLAMIN

135 Acetyl coenzyme A (CoA), malonyl-CoA, adenosine triphosphate (A

136 fatty acid (LCFA) uptake and activation with coenzyme A (CoA), mediating the fate of LCFA.

137 ate generated during synthesis of fatty acyl-coenzyme A (CoA), the reaction catalyzed by an enzyme in

138 gand binding on the energy landscape of acyl-coenzyme A (CoA)-binding protein (ACBP).

139 ing the final and committed step in the acyl-coenzyme A (CoA)-dependent biosynthesis of triacylglycer

140 metabolites into 4-methyl-pentanol (4MP) via coenzyme A (CoA)-dependent chemistry were taken from nin

141 n complex with Acetyl-Coenzyme A (Ac-CoA) or Coenzyme A (CoA).

142 ynthesis of the universal essential cofactor Coenzyme A (CoA).

143 s FALDH) prior to activation via coupling to coenzyme A (CoA).

144 anine, spermine, dihydrouracil, and acryloyl-coenzyme A (CoA).

145 ocess that requires the generation of acetyl-coenzyme A (CoA).

146 LMW) thiols, including glutathione (GSH) and coenzyme A (CoA).

147 on via the reductive conversion to propionyl-coenzyme A (CoA).

148 ffusion of the much larger cofactors NAD and coenzyme A (CoA).

149 ative abundance of the gene encoding butyryl-coenzyme A (CoA):acetate-CoA-transferase, a major enzyme

150 eneration (PKAN) and result in low levels of coenzyme-A (CoA) in the CNS due to impaired production o

151 gluconeogenesis due to sequestration of free coenzyme A (CoASH).

152 ecreased the expression of medium-chain acyl coenzyme A dehydrogenase (MCAD) and short-chain acyl coe

153 A dehydrogenase (MCAD) and short-chain acyl coenzyme A dehydrogenase (SCAD), involved in the regulat

154 h (enoyl-coenzyme A, hydratase/3-hydroxyacyl coenzyme A dehydrogenase)], and a marker of proximal tub

155 mical analyses showed lower beta-hydroxyacyl coenzyme-A dehydrogenase activity and higher lactate deh

156 methionine, which MddA detoxifies by acetyl coenzyme A-dependent acetylation.

157 rrier protein) synthase (ACPS) catalyzes the coenzyme A-dependent activation of apo-ACPP to generate

158 wo separable mechanisms: dampening of acetyl-coenzyme A-dependent carbon metabolism through histone h

159 unable to convert free fatty acids to their coenzyme A derivatives, accumulates free fatty acids dur

160 rom palmitic acid (PA) catalyzed by stearoyl-coenzyme A desaturase (SCD) activity.

161 Changes in stearoyl-coenzyme A desaturase (SCD) expression and activity were

162 es, we conducted a mouse trial of a stearoyl-coenzyme A desaturase (SCD) inhibitor ("5b") that preven

163 e cellular lipid reprogramming upon stearoyl-coenzyme A desaturase 1 (SCD1) inhibition.

164 0 (P = 1.6 x 10(-8)) as a marker of stearoyl coenzyme A desaturase 1 activity, and the ratio of 20:3n

165 abolism genes (fatty acid synthase, stearoyl-coenzyme A desaturase 1, and perilipin 2) was drasticall

166 This review provides an overview of stearoyl-coenzyme A desaturase-1 (SCD1) as a novel therapeutic ta

167 Aramchol, an oral stearoyl-coenzyme-A-desaturase-1 inhibitor, has been shown to red

168 ate (P-HPD, an isomer of AI-2-phosphate) and coenzyme A, determine the crystal structure of an LsrF c

169 of increased or decreased expression of ACYL-COENZYME A:DIACYLGLYCEROL ACYLTRANSFERASE1 (DGAT1) or PH

170 one (line CL37) or together with castor acyl:coenzyme A:diacylglycerol acyltransferase2 reduced HFA a

171 ex (PDHc), which converts pyruvate to acetyl coenzyme A, enables E. coli to resist these antimicrobia

172 uided mutational analyses suggests that acyl-coenzyme A enters the active site through the cytosolic

173 level on the non-heme diiron enzyme benzoyl coenzyme A epoxidase, BoxB.

174 es high carbon flux through the ethylmalonyl coenzyme A (ethylmalonyl-CoA) pathway (EMC pathway).

175 ond within acetyl-CoA, producing acetate and coenzyme A for a range of cellular processes.

176 lism; this limits the availability of acetyl coenzyme A for histone acetylation at genes encoding inf

177 group of N(10)-formyl-THF to produce formyl-coenzyme A (formyl-CoA) as a central reaction intermedia

178 The biosynthesis of the major acyl carrier Coenzyme A from pantothenic acid (PA) is critical for su

179 boxylic acid (TCA) cycle by producing acetyl coenzyme A from pyruvate.

180 interestingly, we also identified endogenous coenzyme A glutathione disulfide (CoA-S-S-G) in tissue f

181 tein E (ApoE) and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)) has been linked t

182 ts under regular 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitor (statin) treatm

183 Until recently, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) have

184 e shown that the 3-hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors known as stati

185 Hydroxy-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors or statins are

186 Statins, or 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, have anti-inf

187 ition particle or 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase.

188 The mevalonate [3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase] pathway synthesizes lipi

189 y acid-binding protein 1), and Ehhadh (enoyl-coenzyme A, hydratase/3-hydroxyacyl coenzyme A dehydroge

190 razinamide (PZA), interrupts biosynthesis of coenzyme A in Mycobacterium tuberculosis by binding to a

191 We describe, for example, a putative coenzyme-A-induced-fit substrate binding mechanism media

192 degradation through hydration of the dienoyl-coenzyme A intermediate as observed in Geobacter metalli

193 We further demonstrated that palmitoyl coenzyme A is a ligand for the PvrA, enhancing the bindi

194 Coenzyme A is an essential metabolite known for its cent

195 In cells, Coenzyme A is synthesized de novo in five enzymatic step

196 Downregulation of 4-coumaric acid:coenzyme A ligase (4CL) can reduce lignin content in a n

197 ciated domain and coenriches with fatty acyl-coenzyme A ligase Faa1 at LD bud sites.

198 o and activated the promoters of 4-coumarate:coenzyme A ligase genes (Os4CL3 and Os4CL5) resulting in

199 that the gene encoding a specific cinnamate coenzyme A ligase likely obtained its new function follo

200 n Escherichia coli, synthesis of the malonyl coenzyme A (malonyl-CoA) required for membrane lipid syn

201 nolignols under the catalysis of p-coumaroyl-coenzyme A monolignol transferase (PMT).

202 The rice (Oryza sativa) p-COUMAROYL-Coenzyme A MONOLIGNOL TRANSFERASE gene was introduced in

203 Plants expressing the p-COUMAROYL-Coenzyme A MONOLIGNOL TRANSFERASE transgene can therefor

204 eficiency of the mitochondrial methylmalonyl-coenzyme A mutase (MMUT).

205 tion, we cloned and characterized a caffeoyl-coenzyme A O-methyltransferase (PhCCoAOMT1) from the pet

206 ed protein (Adrp), whereas it augmented acyl-coenzyme A oxidase 1 (Acox-1), proliferator-activated re

207 lytic transport involving sliders (including coenzyme A) picking up, transporting and selectively del

208 s and in vivo rescue potential of the acetyl-Coenzyme A precursor S-acetyl-4'-phosphopantetheine as a

209 One therapeutic strategy is to generate Coenzyme A precursors downstream of the defective step i

210 ctivity, contributed significantly to acetyl-coenzyme A production.

211 spectrometric sequencing: a hydroxycinnamoyl-Coenzyme A:quinate hydroxycinnamoyl transferase (HQT) wa

212 ne expressing castor FA hydroxylase and acyl-Coenzyme A:RcDGAT2 in its seeds.

213 Cinnamoyl-coenzyme A reductase (CCR) catalyzes the reduction of hy

214 olesterol, in the 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) activity, and in the in vit

215 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR) encodes the rate-limiting e

216 ombination with a 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) inhibitor (statin), will re

217 in Npc1a weakens the ability of ectopic HMG Coenzyme A reductase (Hmgcr) to induce germ cell migrati

218 the formation of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), a main regulator of choles

219 thway upstream of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), the target of statins.

220 ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), which catalyzes a rate-lim

221 particle (SRP) or 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR).

222 tic inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR).

223 synthesis called 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMGCR).

224 ncoding PCSK9 and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR; the target of statins) as i

225 interfering with 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMGR) activity, a key player in is

226 tylase (HDAC) and 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) by having a hydroxamate grou

227 The enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) has a key regulatory role in

228 Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (statins) can modulate inflammatory

229 Inhibitors of 3-hydroxy-3-methylglutaryl-Coenzyme A reductase and isoprenylation attenuated, wher

230 Hydroxymethyl glutaryl-coenzyme A reductase degradation protein 1 (Hrd1) is an

231 AHA/ACC) changed 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitor (statin) eligibility crit

232 indications for 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitor (statin) therapy than mid

233 es of the influence of hydroxymethylglutaryl-coenzyme A reductase inhibitors (also known as statins)

234 Purpose The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) have activity

235 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been vari

236 ering properties, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have broad ant

237 Statins, 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors have been shown to impro

238 Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are an important group

239 Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors), commonly prescribed in

240 ted with elevated 3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA levels and anti-Src-Tyr416 imm

241 inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway to protect against infectio

242 osynthetic enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase results from its sterol-induced bin

243 non-initiation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase therapy in patients with cirrhosis

244 roxylase) and ccr1g (deficient for cinnamoyl-coenzyme A reductase) lines, albeit to a lower extent.

245 protein 2, human 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and human low-density lipoprotein

246 e-limiting enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and increased plasma membrane chol

247 by inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, are among the most widely prescrib

248 family B member 1, peroxisomal trans-2-enoyl-coenzyme A reductase, phospholipase A2 receptor, protein

249 emia, inhibit the 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-limiting enzyme of de nov

250 ically inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase, which is a rate-limiting enzyme fo

251 ive inhibitor of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase.

252 rget of pitavastatin, hydroxymethylglutarate coenzyme-A reductase (HMGCR), was found to be over-expre

253 tins, or HMG CoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase inhibitors, are drugs with multipl

254 ECR encoding the mitochondrial trans-2-enoyl-coenzyme A-reductase involved in human mtFAS.

255 Here, we reintroduced CINNAMOYL-COENZYME A REDUCTASE1 (CCR1) expression specifically in

256 he genes encoding 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE1 (HMGR1) and MAKIBISHI1, the rate-l

257 1) and CER3 catalyzes the conversion of acyl-Coenzyme A's to alkanes with strict substrate specificit

258 ctly dependent on metabolites such as acetyl-coenzyme A, S-adenosylmethionine, and NAD+, among others

259 olignol biosynthetic enzyme hydroxycinnamoyl coenzyme A:shikimate hydroxycinnamoyl transferase (HCT)

260 Mitochondrial acyl-coenzyme A species are emerging as important sources of

261 We show that succinyl-coenzyme A (succinyl-CoA) binds to KAT2A.

262 The acetyl coenzyme A synthase (ACS) enzyme plays a central role in

263 Here, we identified a novel biomarker, coenzyme A synthase (COASY), whose mRNA expression was c

264 onfirmed the role of a hydroxymethylglutaryl-coenzyme A synthase cassette, three flavin-dependent tai

265 ein-based model for the NiP center of acetyl coenzyme A synthase using a nickel-substituted azurin pr

266 nic genes such as 3-hydroxy-3-methylglutaryl-coenzyme A synthase, fatty acid synthase, and stearoyl-C

267 6K1 in insulin-stimulated adipocytes-namely, coenzyme A synthase, lipocalin 2, and cortactin.

268 The 3-hydroxy-3-methylglutaryl coenzyme A synthases (HCSs) are responsible for beta-alk

269 this study is to explore parasite fatty acyl-coenzyme A synthetase (ACS) as a novel drug target.

270 lysine acylation in metabolism is the acetyl-coenzyme A synthetase (Acs) enzyme.

271 or the acetylation of the AMP-forming acetyl coenzyme A synthetase (SacAcsA, SACE_2375).

272 Succinyl Coenzyme A synthetase (SCS) is a key mitochondrial enzym

273 Here, we show that loss of the VLCFA-coenzyme A synthetase Fat1, which is essential for VLCFA

274 Although many Archaea have AMP-Acs (acetyl-coenzyme A synthetase) and ADP-Acs, the extant methanoge

275 Acyl coenzyme A synthetase-1 (ACSL1) facilitates long-chain f

276 ctroscopy, the cutin mutants long-chain acyl-coenzyme A synthetase2 (lacs2), permeable cuticle1 (pec1

277 enin polyketide biosynthetic metabolon (ACYL COENZYME A SYNTHETASE5, POLYKETIDE SYNTHASE A [PKSA], PK

278 is activation is mediated by long-chain acyl-coenzyme A synthetases (LACSs), which are encoded by a f

279 knockout plants have a higher level, of acyl-coenzyme A than the wild type.

280 cycle for the generation of cytosolic acetyl-coenzyme A that can be used for fatty acid and cholester

281 need to be converted to their corresponding coenzyme A thioesters to become metabolically available.

282 It catalyzes acyl-coenzyme A thioesters to synthesize naringenin chalcone

283 talyze the sequential esterification of acyl-coenzyme A thioesters to the R4, R3, R3', and R2 positio

284 aine via the activated benzoyl- or cinnamoyl-Coenzyme A thioesters, respectively.

285 Of the two major 3-ketoacyl coenzyme A thiolases, KAT2 plays the primary role in BA

286 lyse the transfer of an acyl group from acyl-coenzyme A to cholesterol to generate cholesteryl ester,

287 LDHA maintains high concentrations of acetyl-coenzyme A to enhance histone acetylation and transcript

288 n enzyme that catalyzes conversion of acetyl coenzyme A to malonyl coenzyme A, a carbon donor for lon

289 the transfer of an acetyl group from acetyl coenzyme A to polyamines such as spermidine and spermine

290 hydrolyzes phosphatidylcholine and also acyl-coenzyme A to release fatty acids.

291 rix where glycine is condensed with succinyl coenzyme A to yield delta-aminolevulinic acid.

292 ons suggested that SvBAHD05 is a p-coumaroyl coenzyme A transferase (PAT) mainly involved in the addi

293 Inspired by acetyl-coenzyme A transporting and delivering acetyl groups in

294 ith the high carbon efficiency drive, acetyl-coenzyme A was entirely produced using the carbon-effici

295 the synthesis of nicotinate, NAD+, NADP+ and coenzyme A were detected among the essential vitamins an

296 for their mission: E1 and E2 generate acetyl-coenzyme A, whereas the FAD/NAD(+)-dependent E3 performs

297 onverted to the central intermediate benzoyl-coenzyme A, which is enzymatically reduced to cyclohexa-

298 used cysteine to synthesize glutathione and coenzyme A, which, together, down-regulated ferroptosis.

299 ich decarboxylates pyruvate and forms acetyl-coenzyme A with concomitant reduction of low-potential f

300 he transfer of an acetyl group from P-HPD to coenzyme A yielding dihydroxyacetone phosphate and acety