ライフサイエンスコーパス: coiled-coil

1 mic region of the MotB dimer into a parallel coiled coil.

2 f the membrane-binding portion of the FIP200 coiled coil.

3 main, revealing a 15-nm parallel homodimeric coiled coil.

4 3)Q(X)(3)D motif repeated on each helix of a coiled coil.

5 nd the alpha2 helices form a tight two-helix coiled-coil.

6 quence repeat that is dominant among natural coiled coils.

7 teractions with the flexible linkers between coiled coils.

8 actions between DNA substrates and the Rad50 coiled coils.

9 ch DNA binding domains are connected by long coiled-coils.

10 varian cancer, we identified the lysine rich coiled-coil 1 (KRCC1), as a potential target.

11 p a region of NEMO (residues 112-150) in its coiled-coil 1 domain that impedes the binding of linear

12 nd establishes that H2 binds directly to the coiled-coil 1B (CC1B) domain of p150(Glued), thus explai

13 ng of linear (M1-linked) di-ubiquitin to its coiled-coil 2-leucine zipper ubiquitin binding domain.

14 We show here that the coiled coil 3 (CC3) domain of Atg11 is required for conc

15 of the structural landscape of alpha-helical coiled coils above the dimers and trimers that dominate

16 his volume matches the void space inside the coiled coil according to the cryogenic electron microsco

17 Tropomyosin is a coiled-coil actin binding protein key to the stability o

18 tro and chromosomes in interphase, while its coiled-coil acts as a central regulatory and structural

19 ein adaptors, CRACR2a and Rab45, that have a coiled-coil adaptor domain, a pair of EF-hands, and a Ra

20 Transport is initiated by coiled-coil adaptors that (a) join dynein and its cofact

21 By fusing coiled-coil adaptors to the IKKbeta-binding domain of NE

22 recognition at DNA breaks in which the Rad50 coiled coils aid movement along DNA substrates until a D

23 hobic pocket of the catalytic core, with the coiled-coil aligned near the entrance of the substrate U

24 forms dimers and trimers, potentially via a coiled-coil alpha-helix.

25 dependent interfaces, comprising an extended coiled coil and a dimeric N-terminal globular domain.

26 d in that the targeted domain of CEP250 is a coiled coil and is topologically featureless, embodying

27 Both contain coiled coils and a family-48 carbohydrate binding module

28 al coiled-coils in Spc42: a central trimeric coiled-coil and a C-terminal antiparallel DCC.

29 this complex depends on the most C-terminal coiled-coil and a conserved region between this coiled-c

30 roteasome-dependent degradation of Cactin, a coiled-coil and arginine-serine-rich domain-containing p

31 Coiled-coil and C2 domain containing 1A (CC2D1A) is an e

32 use model for loss of the signaling scaffold coiled-coil and C2 domain-containing protein 1A (CC2D1A)

33 These mutations cluster in the second coiled-coil and calponin homology domains of SPECC1L and

34 ects are found scattered throughout both the coiled-coil and globular domains.

35 The mutant NEMO lacked part of the CC1 coiled-coil and HLX2 helical domain.

36 Coiled-coil and juxtamembrane domains within the matrix

37 FHA and catalytic domains contact the XRCC4 coiled-coil and LigIV BRCT repeats.

38 C-terminal domains (CTDs) associate with the coiled-coil and marked-box domains (CMs) of E2Fs.

39 led-coil and a conserved region between this coiled-coil and the transmembrane domain of Coy1.

40 Contributions of the three Spc42 coiled-coils and adjacent undetermined regions to the fo

41 ation experiments identified the ArfGAP with coiled-coil, Ank repeat, and pleckstrin homology domain-

42 e, in which their signature motifs and their coiled coils are closely juxtaposed (J heads), creating

43 Scc2's association with engaged heads whose coiled coils are folded around their elbow.

44 Three-stranded coiled coils are peptide structures constructed from amp

45 mplex by high-speed AFM shows that the Rad50 coiled-coil arms are consistently bridged by the dimeriz

46 n amino acids 324-348, between its first two coiled coils, as essential for the formation of TRIOBP-1

47 Among natural proteins, coiled-coil assemblies formed between or among alpha-hel

48 heterotetrameric (SYCP2:SYCP3 and ASY3:ASY4) coiled-coil assemblies that further oligomerize into mic

49 crystal structures, we observed heterochiral coiled-coil associations that closely match a hendecad s

50 We also demonstrate that the stalk coiled-coils assume a previously undescribed registry du

51 er, along the surface of which runs the TSC1 coiled-coil backbone, breaking the symmetry of the dimer

52 peptide that self-assembles into a hexameric coiled-coil bundle and an Fc-binding Protein A fragment,

53 e to form pure heterotrimeric three-stranded coiled coils by combining three distinct characteristics

54 nt, single-residue mutations in the putative coiled-coil C-terminal domain (CTD) of the SMARCB1 (BAF4

55 The alpha-helical coiled coil (CC) is a common protein motif that because

56 f-function variants are located at the PALB2 coiled coil (CC) or at the WD40 domain, highlighting the

57 ve NLR protein Rp1-D21 and of its N-terminal coiled-coil (CC(D21) ) signaling domain when transiently

58 Here we generated a Brca1(CC) mouse with a coiled-coil (CC) domain deletion.

59 that higher-order assembly of SNX16 via its coiled-coil (CC) domain drives membrane tubulation in vi

60 -terminal Toll-interleukin receptor (TIR) or coiled-coil (CC) domain, a central nucleotide-binding (N

61 ance (TIR) domain-containing NLRs (TNLs) and coiled-coil (CC) domain-containing NLRs (CNLs).

62 cterized short segment predicted to harbor a coiled-coil (CC) domain.

63 iated phosphorylation and is mediated by the coiled-coil (CC) domain.

64 In a recent model, extended coiled-coil (CC) domains in the integrase subunits are p

65 dule between the EDS1-SAG101 heterodimer and coiled-coil (CC) HET-S and LOP-B (CC(HELO)) domain helpe

66 N-termini of NRC family proteins and ~20% of coiled-coil (CC)-type plant NLRs.

67 The N-terminal coiled-coil CC1 domain is required for microtubule local

68 crotubule localization, while the C-terminal coiled-coil CC2 domain is sufficient to interact with RA

69 th an N-terminal microtubule-binding tail, a coiled-coil central stalk (central stalk), a neck, and t

70 tepwise assembly of purified structures with coiled-coil conjugates.

71 e stemming from GSK180736A, a Rho-associated coiled-coil containing kinase 1 (ROCK1) inhibitor, the o

72 suppressed FGFR2-TACC3 (transforming acidic coiled-coil containing protein 3) signaling in cultured

73 and subsequent activation of Rho-associated, coiled-coil containing protein kinase (ROCK).

74 n of ERK1/2 and expression of Rho-associated coiled-coil containing protein kinase 1 (ROCK1).

75 tagonist CCG1423 or the Rock (Rho-associated coiled-coil containing protein kinase)-2 inhibitor KD025

76 Rho-associated coiled-coil containing serine/threonine protein kinases

77 GTPase Rho and its downstream Rho-associated coiled-coil-containing protein kinase (ROCK) are also es

78 ith or without inhibitors of Rho-associated, coiled-coil-containing protein kinase (ROCK), ERK, or PI

79 pathophysiological impact of Rho-associated coiled-coil-containing protein kinase (ROCK)1 and ROCK2

80 RHO-associated coiled-coil-containing protein kinase 2 (ROCK2), a serin

81 regulated protein with an N-terminal dimeric coiled-coil (DCC), assembles into a hexameric array at t

82 gn that demonstrated efficacy in fusion with coiled-coil dimer forming polypeptides was fused to a si

83 The coiled-coil dimer is a widespread protein structural mot

84 The specificity of coiled-coil dimer pairing is mainly based on hydrophobic

85 Strep A) surface M protein, an alpha-helical coiled-coil dimer, is a vaccine target and a major deter

86 in the populations of the on-pathway helical coiled-coil dimeric and tetrameric species (tau(ex) <= 5

87 ds likely alters interactions that stabilize coiled-coil dimers and thick filaments, causing disrupti

88 res raised the possibility that heterochiral coiled-coil dimers prefer an 11-residue (hendecad) seque

89 Tpm forms coiled-coil dimers, which assemble into a helical strand

90 high-resolution structures for heterochiral coiled-coil dimers, which represent a starting point for

91 We show that both contain a dynamic coiled-coil discontinuity, the elbow, near the middle of

92 rved arginine residues within the C-terminal coiled-coil disrupted oligomerization, binding, and func

93 Mutation of the predicted coiled coils does not alter AAD oligomerization but does

94 ane protein 8 (VAMP8) through its C-terminal coiled coil domain (CCD) to promote autophagic fusion.

95 binding sites located within an antiparallel coiled coil domain of EnvC.

96 The coiled coil domain probably terminates near the critical

97 ENTR1 regulates, via binding to the coiled coil domain protein Dysbindin, the delivery of Fa

98 (FAP)57/WDR65, a highly conserved WD repeat, coiled coil domain protein.

99 iEst) to a small pentameric de novo-designed coiled coil domain, separated by a flexible oligo-glycin

100 Here, we report coiled coil domain-containing 3 (CCDC3) as a new TAp63 t

101 This effect requires the N-terminus and coiled-coil domain (C-C) as mutations within the ORF1p C

102 modulating the interaction of the C-terminal coiled-coil domain (CC) and/or the leucine zipper (LZ) d

103 ity is intrinsically inhibited by a putative coiled-coil domain (CCD) and the autoinhibition is overc

104 showed that it requires sequences within its coiled-coil domain (CCD) dispensable for homodimerisatio

105 ECN1 forms an antiparallel homodimer via its coiled-coil domain (CCD).

106 an autosomal dominant mutation in the STAT1 coiled-coil domain (STAT1 R274W).

107 d by mechanistic studies that determined the coiled-coil domain 1 of EspD as a key compound-binding s

108 ciation is driven by two distinct regions: a coiled-coil domain and a novel 10-amino acid aggregation

109 Whereas the coiled-coil domain and aggregation-prone region additive

110 Rtt103 forms homodimers via its long coiled-coil domain and associates densely on the repetit

111 A coiled-coil domain appended to one face of the pentameri

112 10 forms oligomers in vitro, mediated by the coiled-coil domain at the N-terminal region of the prote

113 Recently, a paralogous protein, geminin coiled-coil domain containing (GMNC), was also shown to

114 We generated a loss-of-function mutant of a coiled-coil domain containing 39 (ccdc39) gene that is p

115 ted proteins CEP104 and CSPP1, we identified coiled-coil domain containing 66 (CCDC66) and TOG array

116 ible signaling pathway protein 2 (Wisp2) and coiled-coil domain containing 80 (Ccdc80) as direct targ

117 -annotated short open reading frame 2 (Lso2; coiled-coil domain containing short open reading frame 1

118 rate that distinct regions of its C-terminal coiled-coil domain crosslink to the alveolins IMC3 and I

119 this region could substitute for the Steppke coiled-coil domain for junction localization and regulat

120 mains form an umbrella-like structure with a coiled-coil domain for the 'pole' and four helical 'ribs

121 ions together with N REQUIRED GENE1 (AtNRG1) coiled-coil domain helper NLRs as a coevolved TNL cell d

122 Mutation of the coiled-coil domain in COP1, which prevents dimer formati

123 to form antiparallel dimers, DdMyo7 lacks a coiled-coil domain in its proximal tail region, raising

124 s, RFP-p24delta5, which was dependent on the coiled-coil domain in p24delta5.

125 ion, suggesting the main role of the Steppke coiled-coil domain is linkage to the junctional targetin

126 Two antiparallel alpha-helices form a coiled-coil domain linked by a large extended connector

127 entifies the KRAB domain binding site in the coiled-coil domain near the dyad.

128 We show that the coiled-coil domain of AtZAR1 oligomerizes, and this doma

129 a conserved interdomain cleft harboring the coiled-coil domain of hSTAT2, thus preventing associatio

130 Three VUS in the coiled-coil domain of PALB2 abrogate the interaction wit

131 This transition requires the coiled-coil domain of Pyd-P and implies formation of non

132 t second-site suppressors clustered within a coiled-coil domain of Rz near the outer leaflet of the c

133 atase complex can bind simultaneously to the coiled-coil domain of Sgo1, suggesting that Sgo1 can int

134 Remodeling of the coiled-coil domain of Smc3 abrogates the binding surface

135 with a heterozygous missense mutation in the coiled-coil domain of STAT5B that presented with autoimm

136 he Ska complex in cells to a region near the coiled-coil domain of the NDC80 complex and demonstrate

137 uired for releasing the inhibitory effect of coiled-coil domain on the NB-ARC-LRR region.

138 in-of-function (GOF) mutations affecting the coiled-coil domain or the DNA-binding domain of signal t

139 g domains of antibodies with a heterodimeric coiled-coil domain that sterically occludes the compleme

140 the sGC activation mechanism by coupling the coiled-coil domain to the active site via a series of ho

141 The coiled-coil domain was also important for a direct inter

142 During Drosophila dorsal closure, Steppke's coiled-coil domain was necessary and sufficient for junc

143 x with monobody MS3-6 reveals bending of the coiled-coil domain, resulting in diminished DNA binding

144 Novel variants affecting the conserved coiled-coil domain, so far exclusively found in fALS exo

145 ese interactions are mediated by a conserved coiled-coil domain, termed SARAH, in each of these prote

146 roughout the entire sGC heterodimer, via its coiled-coil domain, to reorient the catalytic domain int

147 ontaining proteins, such as ATG4B, FYVE, and coiled-coil domain-containing 1 (FYCO1), and autophagy c

148 verging alpha-helices of the dimeric Atg16L1 coiled-coil domain.

149 en its caspase recruitment domain (CARD) and coiled-coil domain.

150 clusters of the anchor protein Mcp5 via its coiled-coil domain.

151 dation and interacted with STAT2 NTD and the coiled-coil domain.

152 comprises the C-terminal part of the Atg16L1 coiled-coil domain.

153 h TRIM27 through its N-terminal RING-B boxes-Coiled-Coil domain.

154 contain intrinsically disordered regions and coiled coil domains.

155 These variants reside outside of SPECC1L coiled-coil domains and result in milder functional defe

156 that block spanin function are found within coiled-coil domains and the proline-rich region, motifs

157 Destabilization of the coiled-coil domains by site-directed mutagenesis increas

158 Coiled-coil domains can direct the assembly of protein b

159 ding peptide (SBP) and (ii) motor, neck, and coiled-coil domains from a plus-end-directed or minus-en

160 by direct binding of the AP-4 mu4 subunit to coiled-coil domains in the Hook1 and Hook2 subunits of F

161 he cytosol is mainly formed by the predicted coiled-coil domains of Pex14p and Pex17p, possibly provi

162 Purified coiled-coil domains of Steppke and Stepping stone hetero

163 ity and were largely confined to the CARD or coiled-coil domains of the CARD11 protein.

164 cooperativity is due to association between coiled-coil domains that extend intracellularly from the

165 coating as well as early infection contained coiled-coil domains, and that these activities were gene

166 H-NOX domain leads to a straightening of the coiled-coil domains, which, in turn, use the motion to m

167 ith nanomolar affinity to the N-terminal and coiled-coil domains.

168 ed from engineered proteins bearing terminal coiled-coil domains.

169 n the ATPase that are transmitted to the Smc coiled-coil domains.

170 TRIOBP-1, finding it to possess two distinct coiled-coil domains: the central and C-terminal domains.

171 ree adaptor subfamilies use different folds (coiled-coil, EF-hand, HOOK domain) and different surface

172 d KIF1A construct, dimerized via a kinesin-1 coiled-coil, exhibits fast velocity and superprocessivit

173 Hence, BST2 with an unstable or a rigid coiled-coil fails to activate ILT7, whereas substitution

174 are the 'locked' ground state where the FliJ coiled coil filament experiences angular fluctuations in

175 keletal determinant CcfM (curvature-inducing coiled-coil filament interacting with the magnetoskeleto

176 145- angstrom long fiber with an N-terminal coiled coil followed by multiple beta-bracelet repeats.

177 that the LZ mediates FOXP2 dimerization via coiled-coil formation but also contributes to DNA bindin

178 In the absence of coiled-coil formation, the C-terminal domain bound lipos

179 We test multiple coiled-coil formats and show that the optimized masking

180 TP binding induces the transition of the SMC coiled coils from a folded-rod conformation into a more

181 und BM2 lack the periodic trend expected for coiled coil helices, which disagree with the presence of

182 complex induces a drastic movement of a DMS3 coiled-coil helix bundle.

183 modification of two peptides that comprise a coiled-coil heterodimer pair with unique DNA handles in

184 It demonstrates a parallel, coiled-coil heterodimer with a predominantly hydrophobic

185 Thus, coiled-coil heterodimerization with Stepping stone norma

186 Coiled-coil heterodimers are an exception, but the restr

187 ening method based on fusion between SEA and coiled-coil heterodimers was developed that enabled dete

188 pathway, leading to the formation of helical coiled-coil htt(ex1) tetramers, is completely abolished,

189 d evidence for a compression mechanism where coiled coils in the lamin A rod can slide onto each othe

190 structures reveal details of two additional coiled-coils in Spc42: a central trimeric coiled-coil an

191 as two long arms: a Gre cleavage factor-like coiled-coil inserts deep into the RNAP secondary channel

192 , BBS2 and BBS7 form a tight dimer through a coiled-coil interaction and that BBS9 associates with th

193 hat EmMBD2/3 and EmGATAD2A/B proteins form a coiled-coil interaction known to be critical for the for

194 We conclude that an intact Mcm10 coiled-coil interaction surface is important for origin

195 ne microparticles, either through reversible coiled-coil interactions or through intermolecular isope

196 ze steric clashes between side chains at the coiled-coil interface.

197 nsertions within the hydrophobic core of the coiled-coil interface.

198 y formation of an antiparallel alpha-helical coiled-coil involving residues 44-84.

199 ate, in which the gp41 heptad repeat 1 (HR1) coiled coil is assembled at the trimer axis.

200 The coiled-coil is a docking site for sigma factors on RNA p

201 tributes to protein dimerization when the LZ coiled-coil is intact, but it is not involved in DNA bin

202 gy Family Member A (RhoA) and Rho-Associated Coiled-Coil Kinase 1 (ROCK1) activity downstream of Dish

203 could be counteracted by the Rho-associated coiled-coil kinase inhibitor Y-27632.

204 We find that the coiled coil linker and the attached histidine kinase dom

205 an unexpected regulatory concept executed by coiled-coil MDs to tightly control AAA+ chaperone activi

206 associate via head-to-head contacts between coiled-coil middle domains (MDs).

207 Sequence analysis revealed a coiled-coil motif and a putative membrane-binding basic-

208 al helical domain that forms an antiparallel coiled-coil motif and mediates the dimerization of the f

209 ring a single amino acid substitution in the coiled-coil motif of BRCA1.

210 at both ETAA1 and TOPBP1 contain a predicted coiled-coil motif that is required for ATR activation in

211 S-box motif folds back onto the dimerization coiled-coil motif, predictably forming a four-helical bu

212 tral oligomerization domain with a predicted coiled-coil motif.

213 ions of inner positive-cell curvature by its coiled-coil motifs, and independent of the magnetoskelet

214 acteria DogTag linked to the self-assembling coiled-coil nanoparticle IMX313.

215 dentified a single gene candidate encoding a coiled-coil nucleotide binding site Leucine-rich repeat

216 e region including two linked genes encoding coiled-coil nucleotide-binding leucine-rich repeat prote

217 tance gene derived from WEW, which encodes a coiled-coil, nucleotide-binding site and leucine-rich re

218 interface involves interactions between the coiled coil of one WipA molecule and the phosphatase dom

219 ion of the transmembrane region and proximal coiled coil of the complex.

220 of the ULK1 complex to unique regions of the coiled coil of the FIP200 subunit.

221 Thus, the coiled-coil of GreA is not just a measuring stick ensuri

222 ication of a single, essential heptad in the coiled-coil of Spc110 and a minimal PACT domain.

223 tional tension is mediated by sliding of the coiled-coils of the stalk, and that coordinated conforma

224 the membrane Env trimer exposes the gp41 HR1 coiled coil only after CD4 binding, the sgp140 SOSIP.664

225 ts that ATM-3507 integrates into the 4-helix coiled coil overlap junction and in doing so, likely cha

226 de a basis for future design of heterochiral coiled-coil pairings.

227 nucleotide-binding domain and the C-terminal coiled-coil participate in the tetrameric assembly of th

228 ngle beta-barrel domain and an extracellular coiled-coil ("passenger") domain.

229 ch as matrix metalloproteinases 2 and 9, the coiled-coil peptides are cleaved and antigen binding is

230 nding events associated with the unique BST2 coiled-coil plasticity are required to trigger receptor

231 The Tpm coiled coil polymerizes head to tail along the long-pitc

232 ll-length ULK1 complex shows that the FIP200 coiled coil projects away from the crescent-shaped FIP20

233 of a fibroblast feeder layer, rho-associated coiled coil protein kinase inhibitor (ROCKi), and low ox

234 orce manipulations in silico on a variety of coiled-coil protein fragments from myosin, chemotaxis re

235 Here, we describe the function of a large coiled-coil protein in Toxoplasma gondii, TgCep250, in c

236 ion of ripasudil, a selective Rho-associated coiled-coil protein kinase inhibitor, on corneal allogra

237 , we describe a new centriole component, the coiled-coil protein SAS-7, as a regulator of centriole d

238 NuMA is an abundant long coiled-coil protein that plays a prominent role in spind

239 The TGN-localized coiled-coil protein TNO1 is a putative tethering factor

240 at ZapA is encoded in an operon with a small coiled-coil protein we named ZauP.

241 ntified a functional requirement for FLL2, a coiled-coil protein, in the formation of FCA nuclear bod

242 ressed the expression of transforming acidic coiled-coil protein-3 (TACC3), which stabilizes EGFR sig

243 n of the Golgi complex depend on a family of coiled-coil proteins called golgins.

244 Our findings show that coiled-coil proteins can promote liquid-liquid phase sep

245 s2 interacts via Bbp1 with Spc29, one of the coiled-coil proteins forming the central plaque of the S

246 The golgin coiled-coil proteins golgin-97 and GCC88, shown previous

247 Extended coiled-coil proteins of the Golgin family play prominent

248 s lack lamin proteins but contain a class of coiled-coil proteins that serve as analogues to form a l

249 These largely alpha-helical, coiled-coil proteins undergo heterotypic interactions, c

250 ate that aggregates formed by association of coiled-coil proteins, in contrast to those linked by iso

251 into three main regions linked by elongated coiled-coil proteins, revealing a conserved modular arch

252 er packing, as determined by the size of the coiled-coil radius.

253 We also found that the RING B-box coiled-coil (RBCC) domain in KAP1 and the proximal coupl

254 2 binds to coronin-1B through its N-terminal coiled-coil region and negates its function to stabilize

255 of the full-length mini-protein and show the coiled-coil region can be truncated while preserving bot

256 We found that although the coiled-coil region contains a newly defined ILT7-binding

257 t a leucine zipper-like motif in the central coiled-coil region of Golgin45 appears to serve as a Syn

258 consists of the Myc DNA-binding domain and a coiled-coil region to facilitate dimerization of the 90

259 esidue 21, which continues unbroken into the coiled-coil region.

260 EH domain, the proline-rich region, and the coiled-coil region.

261 is interrupted between the transmembrane and coiled coil regions by a flexible Gly-rich linker.

262 ulators are known to interact with different coiled coil regions of NEMO, but the topological complex

263 dynamic, displaying flexibility in the long coiled-coil regions of Rad50, a member of the structural

264 ulations suggest a critical role for the SMC coiled-coil regions, where the coils intertwine with var

265 ubiquitous class of bundle-the alpha-helical coiled coils-relationships have been established that di

266 The presence of the coiled-coil replaced those phenomena with CL-dependent b

267 Surveying cyanobacterial genomes for coiled-coil-rich proteins (CCRPs) that are predicted as

268 isation proteins Mms13 and MmsF on stem-loop coiled-coil scaffold proteins (Mms13cc/MmsFcc).

269 aying active loops from membrane proteins on coiled-coil scaffolds removes membrane protein solubilit

270 we established a panel of SpyCatcher-linked coiled coils, so SpyTag-fusions can be dimerized, trimer

271 ear model, which should help improve current coiled-coil stability prediction algorithms.

272 we show that elongation or shortening of the coiled-coil stalk that connects the motor to the microtu

273 tubule-binding domain (MTBD) at the end of a coiled-coil stalk.

274 arated from the AAA ring by a ~ 135 angstrom coiled-coil stalk.

275 -containing subunits that dimerize through a coiled-coil stalk.

276 otide-dependent conformational change in the coiled-coil "stalk" of the motor protein dynein.

277 Dynein binds to tubulin through two coiled coil stalks and a stalk head.

278 lices, which disagree with the presence of a coiled coil structure in micelles.

279 ax=320A) than predicted for a fully extended coiled-coil structure (>500A).

280 s that reducing the flexibility of native Tm coiled-coil structure decreases the optimum interactions

281 eparated from the GT99 chain terminator by a coiled-coil structure that forms a molecular ruler to de

282 e N-terminal domain strongly destabilize the coiled-coil structure.

283 which folds independently into an elongated coiled-coil structure.

284 rical Ub-binding sites on either side of the coiled-coil structure.

285 eps comparable in length to its 50-nanometer coiled-coil subunits, indicative of a translocation mech

286 globular head of Uso1 binds to Ypt1 and its coiled-coil tail binds to the Golgi-associated SNARE, Se

287 ory vesicles by Ypt1-SW1(Sec4), the extended coiled-coil tail blocks docking to the plasma membrane.

288 omains and a barbed "tail" makes up the TSC1 coiled-coil-TBC1D7 junction.

289 tion of two types of tethering factors: long coiled-coil tethers of the golgin family, and the hetero

290 a well-defined and hyperstable antiparallel coiled-coil tetramer (apCC-Tet).

291 Two of the four helices that form the coiled-coil tetramerization domain of P, and long C-term

292 terotrimer from three pairs of heterodimeric coiled coils that mediate specific interactions while av

293 teractions between the three segments of the coiled coil, the motor domains and the light chains stab

294 s ppGpp, and its N-terminal region, like the coiled-coil tip of DksA, engages the active-site region

295 Using de novo designed three-stranded coiled coils (TRI and Grand peptides formed using a hept

296 d increases in Tpm flexibility and prominent coiled-coil twisting in pseudorepeat 4.

297 Non-associating pairs of coiled-coil units were strategically fused to generate t

298 after CD4 binding, the sgp140 SOSIP.664 HR1 coiled coil was accessible to the gp41 HR2 peptide even

299 sequence repeat preferences of heterochiral coiled-coils, we have examined three M2-TM variants cont

300 h protein, revealed a homodimer comprising a coiled coil with two independent and highly flexible His