ライフサイエンスコーパス: coiled-coil domain

1 ization and increased binding to the Bcr-Abl coiled coil domain.

2 verging alpha-helices of the dimeric Atg16L1 coiled-coil domain.

3 h TRIM27 through its N-terminal RING-B boxes-Coiled-Coil domain.

4 turation upon phosphorylation of S471 in its coiled-coil domain.

5 nected by a disordered region to a predicted coiled-coil domain.

6 Dimerization is controlled by a cytoplasmic coiled-coil domain.

7 horylates Mud in vitro within its C-terminal coiled-coil domain.

8 ot expressed, suggesting interference by the coiled-coil domain.

9 n LeEix2, an effect that requires and intact coiled-coil domain.

10 phosphorylation of serine 142 located in the coiled-coil domain.

11 es both in vitro and in living cells via the coiled-coil domain.

12 de insertion within the uncharacterized Gle1 coiled-coil domain.

13 thylated but not methylated DNAs through its coiled-coil domain.

14 C-terminus of the protein near the predicted coiled-coil domain.

15 inc Finger Ubiquitin Binding protein), and a coiled-coil domain.

16 two LRR domains and an extensive C-terminal coiled-coil domain.

17 n in tobacco leaves, which also requires the coiled-coil domain.

18 ce activity and that are mostly found in the coiled-coil domain.

19 n the Talpid3 protein, including a predicted coiled-coil domain.

20 H1/H5-like domain and a C-terminally located coiled-coil domain.

21 s with another Augmin subunit, Dgt2, via its coiled-coil domain.

22 the long C-terminal region downstream of the coiled-coil domain.

23 OX protein BREVIPEDICELLUS through an acidic coiled-coil domain.

24 en its caspase recruitment domain (CARD) and coiled-coil domain.

25 clusters of the anchor protein Mcp5 via its coiled-coil domain.

26 dation and interacted with STAT2 NTD and the coiled-coil domain.

27 comprises the C-terminal part of the Atg16L1 coiled-coil domain.

28 pendent of the E3 ligase activity, B-box, or coiled-coil domain.

29 omain (LD), DNA-binding domain (DBD) and the coiled-coil domain.

30 contain intrinsically disordered regions and coiled coil domains.

31 n the ATPase that are transmitted to the Smc coiled-coil domains.

32 eria, such as the presence of eukaryote-like coiled-coil domains.

33 roteins associate with the PKD2 proteins via coiled-coil domains.

34 e interactions and helical propensity of the coiled-coil domains.

35 ith nanomolar affinity to the N-terminal and coiled-coil domains.

36 via apolar bonding between their respective coiled-coil domains.

37 protein H contains four predicted C-terminal coiled-coil domains.

38 ed from engineered proteins bearing terminal coiled-coil domains.

39 ng domain and the Mis18alpha-beta C-terminal coiled-coil domains.

40 rm a heterotetramer through their C-terminal coiled-coil domains.

41 d by mechanistic studies that determined the coiled-coil domain 1 of EspD as a key compound-binding s

42 erminal region of Hec1 directly binds to the coiled-coil domain 1 of Hice1.

43 on, c.139_140delAG, in the transmembrane and coiled-coil domains 1 (TMCO1) gene, as the pathogenic ch

44 articipants stratified for transmembrane and coiled-coil domains 1 (TMCO1) risk alleles using Kaplan-

45 flexible linker (798-827), and an oligomeric coiled coil domain (828-895).

46 Deletion of its coiled-coil domain abrogates oligomerization but does no

47 The coiled-coil domain, absent from the smaller variants, is

48 on of INCENP has been proposed to comprise a coiled coil domain acting as a spacer between the N- and

49 These results suggest that the coiled-coiled domain adopts at least two conformations t

50 ctional domains including the N terminus and coiled-coil domain affect the localization and increase

51 protein characterized by a highly conserved coiled-coil domain also found in the human orthologue, K

52 More specifically, a coiled coil domain and a C-terminal helix within CagF co

53 of Srv2 depends on its N-terminal predicted coiled coil domain and that oligomerization optimizes Sr

54 T2 are two Arabidopsis proteins containing a coiled-coil domain and a C-terminal predicted transmembr

55 domains in the N-terminal half of drebrin-a coiled-coil domain and a helical domain-that independent

56 bind to HP1alpha, and two domains of Orc3, a coiled-coil domain and a mod-interacting region domain,

57 ciation is driven by two distinct regions: a coiled-coil domain and a novel 10-amino acid aggregation

58 ocalization of the kinase via the C-terminal coiled-coil domain and activation via activation segment

59 Whereas the coiled-coil domain and aggregation-prone region additive

60 Rtt103 forms homodimers via its long coiled-coil domain and associates densely on the repetit

61 of the C-terminal region with the N-terminal coiled-coil domain and is in agreement with previous res

62 the linker region connecting the N-terminal coiled-coil domain and NPcore are essential for hantavir

63 l SUN-domain proteins including a functional coiled-coil domain and nuclear localization signal.

64 CKT2 is a 30.2 kDa protein with one coiled-coil domain and six putative phosphorylation site

65 C-3 self-association through the cytoplasmic coiled-coil domain and suggest a model by which this may

66 ation of TRIM5alpharh, which depended on the coiled-coil domain and the ensuing linker 2 region, was

67 the C terminus of RFWD3, which encompass the coiled-coil domain and the WD40 domain, is necessary for

68 11 inhibitory domain and involves the CARD11 coiled-coil domain and two independent regions of HOIP.

69 was dependent on the presence of the distal coiled-coil domain and was disrupted by pathogenic misse

70 minal microtubule-binding domain followed by coiled-coil domains and a C-terminal cargo-binding domai

71 A is predicted to be a membrane protein with coiled-coil domains and a peptidoglycan-binding SPOR dom

72 These variants reside outside of SPECC1L coiled-coil domains and result in milder functional defe

73 that block spanin function are found within coiled-coil domains and the proline-rich region, motifs

74 overs the Diaphanous inhibitory-dimerization-coiled coil domains, and the third is the Spa2p-binding

75 o the SNARE core domain of STX17 through its coiled-coil domain, and stabilizes the STX17-SNAP29 bina

76 with heme, one without), two PAS domains, a coiled-coil domain, and two cyclase domains.

77 RDM12 encodes a protein with XS and coiled-coil domains, and is similar to SGS3, which is a

78 ract directly through central and C-terminal coiled-coil domains, and recently it was shown that the

79 coating as well as early infection contained coiled-coil domains, and that these activities were gene

80 A coiled-coil domain appended to one face of the pentameri

81 omomers and heteromers in vivo, and that the coiled-coil domains are required for this.

82 The conserved XS and coiled-coil domains are responsible for RNA-binding acti

83 Using putative sulfonylurea receptor (SUR) coiled-coil domains as baits in a 2-hybrid screen agains

84 -rich repeat region at residues 16-164 and a coiled-coil domain at residues 171-191.

85 10 forms oligomers in vitro, mediated by the coiled-coil domain at the N-terminal region of the prote

86 for NBS-LRR disease resistance proteins with coiled-coil domains at their N terminus.

87 d to encode a protein of 488 residues with a coiled-coil domain between residues 345 and 382.

88 teins, we discovered a recurrent presence of coiled-coil domains both in the partners and in segments

89 ubunit oligomerization through the conserved coiled-coil domain, but can be partially replaced by fus

90 e signal peptide, the lumenal segment or the coiled-coil domain, but not in mutants lacking the long

91 cytoplasmic proteins; MldB has two predicted coiled-coil domains, but MldC lacks obvious conserved do

92 be related to the underlying dynamics of the coiled-coil domains by application of a three-state "hop

93 Destabilization of the coiled-coil domains by site-directed mutagenesis increas

94 This effect requires the N-terminus and coiled-coil domain (C-C) as mutations within the ORF1p C

95 Here we demonstrate that the GCN4 coiled-coil domain can populate either a dimer or trimer

96 Coiled-coil domains can direct the assembly of protein b

97 modulating the interaction of the C-terminal coiled-coil domain (CC) and/or the leucine zipper (LZ) d

98 ed, but they all contain a predicted Central Coiled-Coil Domain (CCCD).

99 ane protein 8 (VAMP8) through its C-terminal coiled coil domain (CCD) to promote autophagic fusion.

100 ity is intrinsically inhibited by a putative coiled-coil domain (CCD) and the autoinhibition is overc

101 ity-driven modification identifies the STAT3 coiled-coil domain (CCD) as a novel ligand-binding site,

102 Structurally, Angptl4 contains an N-terminal coiled-coil domain (CCD) connected to a C-terminal fibri

103 showed that it requires sequences within its coiled-coil domain (CCD) dispensable for homodimerisatio

104 Previous crystallography studies of the coiled-coil domain (CCD) of NSP4 from two different rota

105 is unclear, crystallographic studies of the coiled-coil domain (CCD) of NSP4 from two different stra

106 ECN1 forms an antiparallel homodimer via its coiled-coil domain (CCD).

107 oprotein lipase (LPL) through its N-terminal coiled-coil domain (ccd-Angptl4) inducing dissociation o

108 SK1, SK2, and SK3 subunits contain coiled-coil domains (CCDs) in the C termini.

109 The coiled-coil domains (clathrin light chain-binding) of Hi

110 , where present, there is generally only one coiled-coil domain close to the triple helix, and it is

111 466 in the second short helix of the alpha1 coiled-coil domain closer to the catalytic domain.

112 Recently, a paralogous protein, geminin coiled-coil domain containing (GMNC), was also shown to

113 Mutations in the gene encoding FYVE and coiled-coil domain containing 1 (FYCO1), a PI(3)P-bindin

114 In this study, we report that FYVE and coiled-coil domain containing 1 (FYCO1), a protein previ

115 s mutant schmalhans (smh(tn222)) encodes the coiled-coil domain containing 103 protein (Ccdc103), a f

116 missense mutation, c.92T>C (p.Leu31Ser), in coiled-coil domain containing 115 (CCDC115), the functio

117 We generated a loss-of-function mutant of a coiled-coil domain containing 39 (ccdc39) gene that is p

118 ted proteins CEP104 and CSPP1, we identified coiled-coil domain containing 66 (CCDC66) and TOG array

119 Here, we identified p90 (also called Coiled-Coil Domain Containing 8) as a unique regulator f

120 ible signaling pathway protein 2 (Wisp2) and coiled-coil domain containing 80 (Ccdc80) as direct targ

121 ing transcriptional profiling, we identified coiled-coil domain containing 80 (Ccdc80; also known as

122 We identified an ECM-protective mutation in coiled-coil domain containing protein 88b (Ccdc88b), a p

123 -annotated short open reading frame 2 (Lso2; coiled-coil domain containing short open reading frame 1

124 appeared to be specific, as similar secreted coiled-coiled domain containing proteins from L. pneumop

125 Here, we report coiled coil domain-containing 3 (CCDC3) as a new TAp63 t

126 te that CG42630 encodes a novel protein, the coiled coil domain-containing protein 56 (CCDC56), conse

127 ontaining proteins, such as ATG4B, FYVE, and coiled-coil domain-containing 1 (FYCO1), and autophagy c

128 rovide evidence that EURL interacts with the coiled-coil domain-containing protein CCDC85B so as to m

129 5.3, which spans fatty acid synthase (FASN), coiled-coil-domain-containing 57 (CCDC57), and solute-ca

130 inhibition of ligase oligomerization via its coiled-coil domain could be of therapeutic benefit to br

131 Functional analyses demonstrate that the coiled-coil domain couples inactivation with channel ope

132 rate that distinct regions of its C-terminal coiled-coil domain crosslink to the alveolins IMC3 and I

133 This Mud coiled-coil domain directly binds the adjacent Pins-bind

134 ly, we find that the C-terminal EF-hands and coiled-coil domains do not contribute to PKD2-L1 Ca(2+)-

135 es coupling between binding sites, while the coiled-coil domain does not directly participate in the

136 ARNO lacking the coiled-coil domain does not promote migration and does n

137 We show that the coiled-coil domains encircling the disaggregase constitu

138 hape appears to reside within the N-terminal coiled-coil domain encoded by exons 1-4.

139 ic mutant R4227X, which lacks the C-terminal coiled-coil domain, failed to down-regulate PC2 expressi

140 and two liprin-betas which all contain long coiled-coil domains followed by three tandem SAM domains

141 in Bcr-Abl relies on oligomerization via its coiled coil domain for its kinase activity, suggesting t

142 this region could substitute for the Steppke coiled-coil domain for junction localization and regulat

143 mains form an umbrella-like structure with a coiled-coil domain for the 'pole' and four helical 'ribs

144 This coiled-coil domain forms a homotrimer, in both solution

145 A TRPP3 C-terminal coiled-coil domain forms a trimer in solution and in cry

146 ding peptide (SBP) and (ii) motor, neck, and coiled-coil domains from a plus-end-directed or minus-en

147 , C-terminal ankyrin-repeat, and intervening coiled-coil domains, has multiple actions in cells and a

148 ions together with N REQUIRED GENE1 (AtNRG1) coiled-coil domain helper NLRs as a coevolved TNL cell d

149 teins act on a region of WIT1 containing the coiled-coil domain, HSC70-1 additionally acts on the C-t

150 d to the gain of function of this N-terminal coiled-coil domain in alphabaculovirus FP25K to aid in n

151 reveal a pivotal role of a highly asymmetric coiled-coil domain in coordinating the assembly of cargo

152 Mutation of the coiled-coil domain in COP1, which prevents dimer formati

153 gest that the acquisition of this N-terminal coiled-coil domain in FP25K is important for the evoluti

154 helix of the F-BAR domain of Pacsin 2 via a coiled-coil domain in its C-tail.

155 to form antiparallel dimers, DdMyo7 lacks a coiled-coil domain in its proximal tail region, raising

156 s, RFP-p24delta5, which was dependent on the coiled-coil domain in p24delta5.

157 and crystal structure, and binds to a single coiled-coil domain in the C terminus of PKD1.

158 A newly identified coiled-coil domain in the C terminus of TRPP2 is critica

159 inus resides in the lumen of the ER with the coiled-coil domain in the cytoplasm.

160 elopment and highlight the importance of the coiled-coil domain in this process.

161 Mutating the two coiled-coil domains in Cavin1 revealed that they mediate

162 t correlation between helical content of the coiled-coil domains in isolation and binding affinity fo

163 clarify the roles of both the hinge and the coiled-coil domains in MukB function.

164 m that of the individual components, such as coiled-coil domains in proteins and the eukaryotic axone

165 Requirements for the CARD, linker 1, and coiled-coil domains in signaling are consistent with the

166 mains, which place their critical GTPase and coiled-coil domains in the cytosol.

167 by direct binding of the AP-4 mu4 subunit to coiled-coil domains in the Hook1 and Hook2 subunits of F

168 model also contains approximately 20% of the coiled-coil domain, including an unusual coiled-coil dev

169 physiological functions, and deletion of the coiled-coil domains interferes with correct subcellular

170 We found that the novel WRN coiled coil domain is necessary for multimerization of t

171 at flexibility between the transmembrane and coiled coil domains is functionally important.

172 sociated with zippering of the water-soluble coiled-coil domain is expected to lead to tilting of the

173 ion, suggesting the main role of the Steppke coiled-coil domain is linkage to the junctional targetin

174 An N-terminal pentameric coiled-coil domain is linked to a C-terminal coiled-coil

175 ligomers rather than homo-oligomers, and the coiled-coil domain is necessary and sufficient for this

176 On the other hand, the presence of the coiled-coil domain is necessary for efficient Nrdp1 auto

177 uences revealed that the N-terminal putative coiled-coil domain is present in all alphabaculoviruses

178 The PDZD8 coiled-coil domain is sufficient for HIV-1 capsid bindin

179 tional and, in combination with a portion of coiled-coil domain, is sufficient for nuclear envelope l

180 and show that novel variants outside of the coiled-coil domain lead to constitutively activated NF-k

181 Linker2 region dock to alpha-helices of the coiled-coil domain, likely establishing proper orientati

182 Two antiparallel alpha-helices form a coiled-coil domain linked by a large extended connector

183 ovirus FP25K protein lacking this N-terminal coiled-coil domain localized predominantly to the nucleu

184 ion into plant cells, whereas the C-terminal coiled-coil domain mediates interaction with M.

185 structure-guided mutagenesis, we found that coiled-coil domains modulate in vivo properties of two Q

186 Intriguingly, TRIM5alpharh coiled-coil domain mutants (M133T and/or T146A) showed i

187 ng the head, all 5IQ motifs and the putative coiled coil domain (myosin VIIa-5IQ).

188 entifies the KRAB domain binding site in the coiled-coil domain near the dyad.

189 Its N-terminal coiled-coil domain (Num1CC) is proximal to mitochondria,

190 Key mutations in the coiled coil domain of Bcr-Abl were identified that reduc

191 binding sites located within an antiparallel coiled coil domain of EnvC.

192 The hydrophobic pocket within the coiled coil domain of HIV-1 gp41 is considered to be a h

193 WTX interacted with the coiled coil domain of TRIM28 required for its binding to

194 We observed that although the N-terminal coiled-coil domain of ANGPTL4 by itself and full-length

195 protein-protein interactions mediated by the coiled-coil domain of ARNO are required for ARNO induced

196 We show that the coiled-coil domain of AtZAR1 oligomerizes, and this doma

197 f A33 is sufficient for interaction with the coiled-coil domain of B5 and capable of directing B5-gre

198 t through their lumenal domains and that the coiled-coil domain of B5 is sufficient for an interactio

199 38Ala); these three mutations lie within the coiled-coil domain of CARD14.

200 The coiled-coil domain of cartilage oligomeric matrix protei

201 tion of Ret51, whereas the carboxyl-terminal coiled-coil domain of CD2AP was dispensable.

202 using truncation mutations, we show that the coiled-coil domain of drTRPM7 is involved in the channel

203 re, we describe tsf mutations that alter the coiled-coil domain of elongation factor Ts (EF-Ts) and c

204 n superficial hydrophobicity patterns of the coiled-coil domain of EVI5, which, in turns, affects the

205 a conserved interdomain cleft harboring the coiled-coil domain of hSTAT2, thus preventing associatio

206 We show that the coiled-coil domain of mRIC-3 is not required for the int

207 n between the N terminus of BK-beta1 and the coiled-coil domain of MuRF1 was demonstrated by pulldown

208 ed by the addition of recombinant N-terminal coiled-coil domain of Ndel1.

209 Here, we show that overexpression of the coiled-coil domain of Num1 specifically depletes dynein-

210 long microtubules upon overexpression of the coiled-coil domain of Num1, an event that is not observe

211 during cytokinesis depends on the N-terminal coiled-coil domain of p120 isoform 1A.

212 pathway at two levels: CARM1 methylates the coiled-coil domain of p54(nrb), resulting in reduced bin

213 Three VUS in the coiled-coil domain of PALB2 abrogate the interaction wit

214 lar loop of FtsX(Spn) and the amino terminal coiled-coil domain of PcsB.

215 This transition requires the coiled-coil domain of Pyd-P and implies formation of non

216 xist between the C terminus of Mre11 and the coiled-coil domain of Rad50.

217 In this study, we showed that the coiled-coil domain of rapsyn is required for its targeti

218 t second-site suppressors clustered within a coiled-coil domain of Rz near the outer leaflet of the c

219 A conserved SPSP motif in a coiled-coil domain of SF1 is highly phosphorylated in pr

220 atase complex can bind simultaneously to the coiled-coil domain of Sgo1, suggesting that Sgo1 can int

221 ver, loss of the C-terminus or the predicted coiled-coil domain of Shs1p generates expanded zones of

222 We find that the conserved C-terminal coiled-coil domain of Slik, which is necessary and suffi

223 Remodeling of the coiled-coil domain of Smc3 abrogates the binding surface

224 with a heterozygous missense mutation in the coiled-coil domain of STAT5B that presented with autoimm

225 Finally, the coiled-coil domain of Steppke was required for Sstn bind

226 The second coiled-coil domain of STIM1 is required for coupling to

227 ALK kinase via dimerization mediated by the coiled-coil domain of STRN and to a kinase-dependent, th

228 Specifically, the coiled-coil domain of SYP-1 is required both for its hom

229 n (c.1454C>T [ p.Pro485Leu]) proximal to the coiled-coil domain of TAK1 and three missense mutations

230 embly is the formation of a parallel 3-helix coiled-coil domain of the carboxy-terminal leucine zippe

231 CNK1 that interacts constitutively with the coiled-coil domain of the cytohesins, and found that CNK

232 in the dystonin gene (DST) that encodes the coiled-coil domain of the epithelial isoform of bullous

233 he Ska complex in cells to a region near the coiled-coil domain of the NDC80 complex and demonstrate

234 y crystal structures of the parallel 3-helix coiled-coil domains of CNGA1 and CNGA3 subunits were sim

235 t, the N-terminal pleckstrin homology and/or coiled-coil domains of GRF1 are key to the induction of

236 he cytosol is mainly formed by the predicted coiled-coil domains of Pex14p and Pex17p, possibly provi

237 The coiled-coil domains of Rad50 are important for the DNA b

238 Purified coiled-coil domains of Steppke and Stepping stone hetero

239 esult in amino acid changes within all three coiled-coil domains of the BICD2 protein, and include a

240 ity and were largely confined to the CARD or coiled-coil domains of the CARD11 protein.

241 uired for releasing the inhibitory effect of coiled-coil domain on the NB-ARC-LRR region.

242 oteins containing point mutations in the HA2 coiled-coil domain or in an HA1 histidine or basic patch

243 in-of-function (GOF) mutations affecting the coiled-coil domain or the DNA-binding domain of signal t

244 se observations point to a model whereby the coiled-coil domain plays a key role in regulating Nrdp1

245 tains two transmembrane helices (TMHs) and a coiled-coil domain predicted to mediate protein-protein

246 We found that an N-terminal coiled-coil domain present in all alphabaculovirus FP25K

247 The coiled-coil domain present on only some orthologues rend

248 The coiled coil domain probably terminates near the critical

249 We find that the coiled-coil domain promotes the assembly of a multiprote

250 ENTR1 regulates, via binding to the coiled coil domain protein Dysbindin, the delivery of Fa

251 (FAP)57/WDR65, a highly conserved WD repeat, coiled coil domain protein.

252 Galpha, we found that the transmembrane and coiled-coil domain protein 1 (TCC-1) contributes to prop

253 ding motif (UIM)-containing protein RAP80, a coiled-coil domain protein CCDC98/Abraxas, and a deubiqu

254 CHIBBY (CBY) is a coiled-coil domain protein first described as interactin

255 PC1 that interacts with PC2 via a C-terminal coiled-coil domain regulates PC2 expression in vivo and

256 enforced expression of the isolated p66alpha coiled-coil domain relieves MBD2-mediated globin gene si

257 ain is again fused to an extended C-terminal coiled-coil domain reminiscent of eukaryotic DMPK (Myoto

258 eric disruption resulting from this modified coiled coil domain represents a viable alternative to sm

259 Full rescue by the coiled-coil domain requires LIS1 binding, and increasing

260 with and without a C-terminal, alpha-helical coiled-coil domain respond similarly to the osmolality.

261 rotein (ORF1p), which contains an N-terminal coiled-coil domain responsible for cytoplasmic retention

262 The mutation deletes the coiled-coil domain responsible for polymerization into t

263 x with monobody MS3-6 reveals bending of the coiled-coil domain, resulting in diminished DNA binding

264 iEst) to a small pentameric de novo-designed coiled coil domain, separated by a flexible oligo-glycin

265 HA2 subunit, and a K58I mutation in the HA2 coiled-coil domain significantly altered the pH of activ

266 Novel variants affecting the conserved coiled-coil domain, so far exclusively found in fALS exo

267 Finally, a GFP fusion of the coiled-coil domain stabilizes Nrdp1 and potentiates ErbB

268 an autosomal dominant mutation in the STAT1 coiled-coil domain (STAT1 R274W).

269 mical shift perturbation in SH2, DBD and the coiled-coil domain, suggesting conformational changes in

270 ese interactions are mediated by a conserved coiled-coil domain, termed SARAH, in each of these prote

271 ionally, we identified a polymorphism in the coiled-coil domain that appears to affect TRIMCyp expres

272 g domains of antibodies with a heterodimeric coiled-coil domain that sterically occludes the compleme

273 I IFN, STAT2 is serine phosphorylated in the coiled-coil domain that when phosphorylated can negative

274 Instead, the N-terminal ELKS coiled-coil domains that bind to Liprin-alpha and Bassoo

275 cooperativity is due to association between coiled-coil domains that extend intracellularly from the

276 Cp110 in ciliation are generated in part by coiled-coil domains that mediate preferential binding to

277 However, when the coiled-coil domain (the AChR-binding domain of rapsyn) i

278 TRIOBP-1, finding it to possess two distinct coiled-coil domains: the central and C-terminal domains.

279 xpanding the hydrophobic surface area of the coiled-coil domains through introduction of the bulky le

280 Addition of the BD or dimerization/coiled coil domains to G-DID rescued plasma membrane tar

281 in growth cones, mediated by binding of the coiled-coil domain to myosin-VI.

282 the sGC activation mechanism by coupling the coiled-coil domain to the active site via a series of ho

283 ral protein cage by appending a C4-symmetric coiled-coil domain to the protein through a short, flexi

284 shown that both Hec1 and Nuf2 utilize their coiled-coil domains to form a functional dimer; however,

285 structures that uses short de novo designed coiled-coil domains to mediate assembly.

286 Leu-324 to Leu-352, but not the entire first coiled-coil domain, to ensure overall stability of the N

287 roughout the entire sGC heterodimer, via its coiled-coil domain, to reorient the catalytic domain int

288 Mutations that disrupt the TRPP2 coiled-coil domain trimer abolish the assembly of both t

289 Importantly, the mutant coiled coil domain was more efficacious than the wild ty

290 The coiled-coil domain was also important for a direct inter

291 During Drosophila dorsal closure, Steppke's coiled-coil domain was necessary and sufficient for junc

292 Positive residues around the C-terminal coiled-coil domain were required for membrane binding.

293 Reductions in the size of the BST-2 coiled-coil domain were tolerated as well.

294 attached at positions on the motor and neck coiled-coil domains were used to reconstruct the positio

295 ap revealed that CD2AP consists of a central coiled-coil domain, which forms the tetramer interface,

296 er models between the linker domain HAMP and coiled-coil domains, which is supported by experimental

297 H-NOX domain leads to a straightening of the coiled-coil domains, which, in turn, use the motion to m

298 kinase activity, suggesting that a designed coiled coil domain with enhanced binding to Bcr-Abl and

299 coiled-coil motif or substituting the BST-2 coiled-coil domain with a heterologous coiled-coil motif

300 ized middle domain that is predicted to be a coiled-coil domain with multiple helices.