ライフサイエンスコーパス: collagen fiber

1 precisely match the dimensions of an intact collagen fiber.

2 llagen density and a greater amount of thick collagen fibers.

3 ion between |G( *)| and the concentration of collagen fibers.

4 changing with the density and orientation of collagen fibers.

5 tive subcapsular sinus (SCS) macrophages and collagen fibers.

6 ed stiffening and multidirectionality of the collagen fibers.

7 isible, with a clear SHG signal representing collagen fibers.

8 res, and mimics the banding found in natural collagen fibers.

9 imeric versus normal (heterotrimeric) type I collagen fibers.

10 ing collagen I and III to form the fibrillar collagen fibers.

11 hat is 4-6 times stiffer than the underlying collagen fibers.

12 on formation, properties, and remodeling of collagen fibers.

13 glutaraldehyde for moderate cross-linking of collagen fibers.

14 es of diffusion along primary orientation of collagen fibers.

15 crystals were found stacked along bundles of collagen fibers.

16 eness at early times is limited by available collagen fibers.

17 oven bone-like matrix of highly disorganized collagen fibers.

18 C plays a role in modifying the structure of collagen fibers.

19 zation affecting both elastic structures and collagen fibers.

20 results in greater anisotropy of superficial collagen fibers.

21 within the matrix, in close apposition with collagen fibers.

22 oth muscle cells, the cellular source of the collagen fibers.

23 ctive tissue composed of type I and type III collagen fibers.

24 hich deposit extracellular matrix, including collagen fibers.

25 ial plateaus was assayed against 14C-labeled collagen fibers.

26 olyols affect the formation and stability of collagen fibers.

27 d thereby improves the tensile properties of collagen fibers.

28 ncorporation on the mechanical properties of collagen fibers.

29 tly higher stiffness in the direction of the collagen fibers.

30 ges in the structure and organization of the collagen fibers.

31 to quantify how cells manipulate individual collagen fibers.

32 sprouts and the associated rearrangements of collagen fibers.

33 5) and maintenance of the amount of gingival collagen fibers.

34 kPa), with and without RGD binding sites or collagen fibers.

35 ce-dependent unbinding of weak bonds between collagen fibers.

36 ssion and is associated with a thickening of collagen fibers.

37 OX), an enzyme responsible for cross-linking collagen fibers.

38 r percentage of the cell surface attached to collagen fibers (78 +/- 6 versus 58 +/- 8%; P < 0.01) an

39 e axis perpendicular to the main axis of the collagen fiber, a conformation producing a strong achira

40 ns in fibrillar collagen turnover leading to collagen fiber accumulation, there are also alterations

41 The asymmetric eardrum with collagen fibers achieves optimal transmission at high fr

42 Additionally, peritoneal collagen fibers adopted a more linear anisotropic alignm

43 Collagen fibers affect metastasis in two opposing ways,

44 ammation resolves, and mesenchymal cells and collagen fibers align.

45 nly the simulations in which cells deposited collagen fibers aligned with their own orientation repro

46 ibiting LKB1 or MARK1 in NSCLC increases the collagen fiber alignment and captures outward alignment

47 affecting myosin II activity and promoted 3D collagen fiber alignment and macroscopical gel contracti

48 or analysis method to quantitatively measure collagen fiber alignment as a vector field using Circula

49 Using these tools, we found that collagen fiber alignment was driven strongly by nondegra

50 , activation of this pathway correlates with collagen fiber alignment, a marker of increasing ECM sti

51 eas PLOD2 is required for ECM stiffening and collagen fiber alignment.

52 Furthermore, the range of collagen-fiber alignment for elliptical cells with polar

53 This approach is used to mimic the collagen-fiber alignment in the human meniscus to create

54 Our results show that tension-driven collagen-fiber alignment plays a crucial role in force t

55 We systematically investigate the range of collagen-fiber alignment using both finite-element simul

56 ty and resulted in the formation of oriented collagen fibers, all features characteristic of ligament

57 mice to long-term disease with deposition of collagen fibers, all leading to inflammatory cardiomyopa

58 ments of myosin II, and extracellular matrix collagen fibers-all of which possess filamentous coiled-

59 n excess of collagen, qualitative changes in collagen fibers also contribute to the detrimental impac

60 SG and PDCimG, gingival mucosa exhibited few collagen fibers among numerous inflammatory cells.

61 sults suggest that glycosaminoglycans in the collagen fiber and mineral interface may chelate with a

62 were analyzed histopathologically had coarse collagen fibers and 24 of 26 stained with Miller elastic

63 ecture in WT animals, modifying alignment of collagen fibers and altering synthesis of ECM components

64 nerate sufficient actomyosin force to deform collagen fibers and are able to push through the ECM.

65 one and tooth surfaces by a gel formation of collagen fibers and blood may be stabilized without sutu

66 ts that are found in cartilage and bone, the collagen fibers and bundles are most influential in tran

67 in the cardiac interstitium associated with collagen fibers and co-localized with decorin.

68 enlarged Tem cells were highly motile along collagen fibers and continued to migrate rapidly for 18

69 Focusing on the cerebellar cortex, thinner collagen fibers and disorganized pBM were found.

70 nt remodeling leads to thickened elastin and collagen fibers and during stretching, the newly deposit

71 of collagenase on microscale changes to the collagen fibers and embedded neurons.

72 rolysis of proteoglycans and telopeptides in collagen fibers and fibrils.

73 stroma, being composed of a loose network of collagen fibers and fibroblasts.

74 The junction between collagen fibers and foamlike adhesive plaques in mussel

75 nd hyaluronic acid were detected both in the collagen fibers and ground substances.

76 production of surprisingly stable artificial collagen fibers and hydrogels.

77 nockout mice presented severely disorganized collagen fibers and neovascularization in the tendon mid

78 aque flow niches to GPVI-Fc-free segments of collagen fibers and recruited other platelets onto aggre

79 llagen matrix by deforming and tearing apart collagen fibers and that the fast motility mode describe

80 s process, the architecture of the resulting collagen fibers and the global network, and the macrosco

81 Interstitial collagen fibers and the narrow spacing between cancer ce

82 TM) is a porous matrix made up of the radial collagen fibers and the striated sheet matrix.

83 between the measured mechanical behavior of collagen fibers and their appearance in the micrographs

84 etween the streptavidin-coated beads and the collagen fibers and then manipulated by an external magn

85 The histology of orientation of collagen fibers and vessels in the two zones was consist

86 mentation products in the basement membrane, collagen fibers, and granular osmiophilic material withi

87 arance of nests of nevus cells surrounded by collagen fibers, and the structure of the epidermal-derm

88 The collagen fibers appeared densely packed and disorganized

89 months after transepithelial CXL; similarly, collagen fibers appeared disorganized in keratoconus, wh

90 tes where collagen and Cthrc1 were adjacent, collagen fibers appeared smaller, suggesting involvement

91 e investigations demonstrate disturbances of collagen fiber architecture in tissues rich in fibrillar

92 Collagen fibers are an important component of capillary

93 The collagen fibers are crimped in the undeformed configurat

94 Collagen fibers are deposited by fibroblasts infiltratin

95 astin and glycosoaminoglycans are increased, collagen fibers are more compactly organized, and matrix

96 Irregular thin collagen fibers are present in the wounded cornea during

97 ments are found associated with interstitial collagen fibers, around cells, and in contact with endot

98 the dermis corresponding to the location of collagen fibers, as confirmed with polarized light micro

99 Collagen fiber assembly affects many physiological proce

100 emonstrated swollen and irregularly arranged collagen fibers associated with internal porosity.

101 d light microscopy revealed networks of long collagen fibers at lower concentrations along with short

102 um-like structures when in direct contact to collagen fibers at the bottom of the thrombus.

103 Hpx) domain is essential for cleaving type I collagen fibers at the cell surface.

104 Barring an anchoring zone of interwoven collagen fibers at the Descemet-stroma interface, the fi

105 n tumor CAFs is thus critical for remodeling collagen fibers at the tumor-stromal boundary to generat

106 sican at the atrial side, and densely packed collagen fibers at the ventricular side.

107 It consisted of a uniform layer of parallel collagen fibers attaching proximally to the base of the

108 served to compact the collagen gel and align collagen fibers between neighboring cells within 24 h.

109 The 3-D reconstructions revealed complex collagen fiber branching patterns in the anterior cornea

110 y to obtain quantitative data of elastin and collagen fiber bundles under in situ loading of coronary

111 gnment of intracellular actin filaments with collagen fiber bundles.

112 not require the pericellular degradation of collagen fibers but is modulated by MMPs.

113 ere slightly higher than those obtained from collagen fibers, but display the same increases in slope

114 acellular matrix containing hyaluronic acid, collagen fibers, but few elastic fibers.

115 don was organized along with the reorienting collagen fibers by 1 wk after surgery, in comparison wit

116 molecular basis of elastic energy storage in collagen fibers by analysing the areas under conformatio

117 associated fibroblast (TAF) interaction with collagen fibers by stimulating beta1-integrin activity,

118 rved increase in mineral accumulation within collagen fibers can provide significant stiffening of th

119 ange into ordered arrays (e.g., lipids, DNA, collagen fibers) can be determined from x-ray diffractio

120 Collagen fiber color analysis revealed a progressive tem

121 bovine bone in combination with 10% porcine collagen fibers combined with a resorbable bilayer membr

122 + mouse has less dense and more disorganized collagen fibers compared to controls.

123 podosome lifetime dramatically increased on collagen fibers compared with fibrinogen.

124 owed increased numbers and thickness of each collagen fiber component of the matrix (perimysial coils

125 DL region was maintained with well-organized collagen fibers connecting the adjacent bone to a thin l

126 ted a strong positive correlation with thick collagen fiber content (r = 0.76, p < 0.001) and SMC den

127 pulmonary acute lung injury, a reduction in collagen fiber content was observed associated with a ba

128 Microscopy results demonstrate that collagen fibers deform in an affine manner over physiolo

129 treatment of osteoporosis, the mechanism of collagen fiber degradation by cathepsin K remained elusi

130 he structural and mechanical consequences of collagen fiber degradation by catK.

131 er with biochemical analyses, confirmed that collagen fiber degradation by myroicolsin begins with th

132 Edman degradation analysis of collagen fiber degradation products revealed those initi

133 microscopically by measuring the density of collagen fibers (degree of fibrosis) and concentration o

134 es, including epidermal thickening, elevated collagen fiber density, and increased microvessel diamet

135 ion of interstitial microscars, perivascular collagen fiber deposition, and increased thickness of my

136 14, these mice also displayed an increase of collagen fiber deposition.

137 Abundant type II collagen fibers developed on day 21; while Sox9, type II

138 er number density (P:<0.05), and 42% smaller collagen fiber diameter (P:<0.05).

139 d-type (WT) mice demonstrated an increase in collagen fiber diameter and density in response to physi

140 Collagen fiber disorganization was the earliest and most

141 - and distal portions and a higher degree of collagen fiber disorganization.

142 upper vaginal wall indicated a signature of collagen fiber dissociation with smooth muscle and a cha

143 ere able to observe the delayed alignment of collagen fibers during mechanical loading, thus demonstr

144 osition, cross-linking, and linearization of collagen fibers during tumor development, especially at

145 cally continuous mineral network within each collagen fiber (e.g., the case of mineral connectivity e

146 bers of the reticular network, a meshwork of collagen fibers ensheathed by fibroblastic reticular cel

147 deficient platelets formed stable thrombi on collagen fibers ex vivo and in 2 models of occlusive art

148 exposed to a physiological matrix of type I collagen fibers form elongated collagenolytic invadopodi

149 omycin, and suggest that MCP-1 may influence collagen fiber formation in vivo.

150 8%; P<0.0001) and was accompanied by greater collagen fiber formation, capillary density, smooth musc

151 Collagen fibers formed in the presence of DDR1 had a lar

152 Although collagen fibers formed on the surface of SPARC-null fibr

153 The results help to explain why collagen fibers found in nature consist of TC molecules

154 e-dimensional structure of the intact type I collagen fiber from rat tail tendon has been resolved by

155 ispersion in the orientation distribution of collagen fibers from tendon to bone is a second major de

156 rstitial matrix is comprised of cross-linked collagen fibers, generally arranged in nonisotropic orie

157 platelet collagen receptors onto the intact collagen fiber in three dimensions.

158 Collagen fibers in both layers exhibit significant reali

159 but has not yet been applied to characterize collagen fibers in cases diagnosed as invasive breast ca

160 by promoting formation of blood vessels and collagen fibers in CT.

161 showed that the enthalpy of denaturation of collagen fibers in ethylene glycol was high, varied only

162 The results show that elastin and collagen fibers in inner adventitia form concentric dens

163 In addition, collagen fibers in metastatic lung tumors exhibit greate

164 smooth muscle and a change in the density of collagen fibers in multiparous rats.

165 Dissociation of collagen fibers in native and engineered tissues in the

166 esis and degradation of multiple families of collagen fibers in response to cyclic strains imparted i

167 odel that they termed a "liquid crystal" for collagen fibers in tendons.

168 Electron microscopy revealed that collagen fibers in the capsules produced by SPARC-null m

169 of cartilage is sensitive to organization of collagen fibers in the cartilage, it may be a noninvasiv

170 s move, the tendons are strained causing the collagen fibers in the extracellular matrices to be stra

171 Abnormal architectures of collagen fibers in the extracellular matrix (ECM) are ha

172 ied upon a Cdc42-dependent reorganization of collagen fibers in the extracellular matrix by fibroblas

173 tumors that the structure and orientation of collagen fibers in the extracellular space leads to diff

174 luoxetine group (P <0.05), and the amount of collagen fibers in the gingival tissue was maintained.

175 rved that the Lyve-1+ cells colocalized with collagen fibers in the meninges, and some of Lyve-1+ cel

176 Subsequently, changes in the orientations of collagen fibers in the sheath suggest that Fak-mediated

177 prognostic information from the alignment of collagen fibers in the tumor microenvironment.

178 BAPN treatment changed the ultrastructure of collagen fibers in the vessel basement membrane, and the

179 ranscript, resulting in reduced and aberrant collagen fibers in tibiae of seal homozygous mice.

180 tension (i.e., a ligament with high density collagen fibers), increasing the fundamental frequency r

181 While thermal injury disrupts collagen fibers initially, healing is recovered as infla

182 ; the PRP-BMA group showed NC formation with collagen fibers inserted obliquely or perpendicularly to

183 ed significant NC formation at 30 days, with collagen fibers inserted obliquely or perpendicularly to

184 collagen type III predominance, and lack of collagen fiber insertion in the necrotic bone were assoc

185 astic modulus of the cornea, suggesting that collagen fiber intertwining and formation of bow spring-

186 Collagen fiber intertwining was quantified by determinin

187 y the progressive disassembly of macroscopic collagen fibers into primary structural elements by catK

188 f fibers decrease linearly, but the width of collagen fiber is relatively constant at lambda(theta) =

189 tic endothelial cell (LEC) migration through collagen fibers is affected by physical matrix constrain

190 y showed that the predominant orientation of collagen fibers is in the axial direction, while lymphat

191 eneral, it has a hierarchical structure with collagen fibers joining more rigid units (scales or oste

192 romal structure is remarkably complex in the collagen fiber/lamellar organization, involving branchin

193 and has organized radial and circumferential collagen fiber layers that provide the scaffolding.

194 malian basilar membrane (BM) consists of two collagen-fiber layers responsible for the frequency-to-p

195 air processes modify the distribution of its collagen fiber lengths.

196 linking plays a key role in stiffness at the collagen fiber level following infarction, and highlight

197 Collagen fiber matrix deposition was accelerated with up

198 t that the layer of round lipid particles on collagen fibers mediates the mineral deposition onto the

199 ir bulk rheology; however, variations in the collagen fiber microstructure and cell adhesion forces c

200 We simulated MVAL collagen fiber network as an ensemble of undulated fiber

201 issue-level scale of approximately 1 mm, the collagen fiber network in the MVAL deforms according to

202 had evidence of reduced dermal thickness and collagen fiber network organization akin to non-irradiat

203 pN forces to microparticles embedded in the collagen fiber network.

204 to tendon regeneration with densely aligned collagen fibers, normal level of cellularity, and functi

205 collagen area fraction (P:<0.05), 38% lower collagen fiber number density (P:<0.05), and 42% smaller

206 The fluorescent signal from the collagen fibers of the corneal stroma was evident in the

207 rolled mineralization process: unmineralized collagen fibers of the periodontal ligament anchor direc

208 OVAs were conducted to compare thickness and collagen fiber organization and a chi-square analysis wa

209 nonlinear multiphoton microscopy to quantify collagen fiber organization in mouse carotid arteries an

210 ed light microscopy indicated alterations in collagen fiber organization in the growth plate.

211 reveals disarray of extracellular matrix and collagen fiber organization within the valve leaflet.

212 ng in increased vascularization, more mature collagen fiber organization, and a two fold improvement

213 ements of the depth-dependent shear modulus, collagen fiber organization, and extracellular matrix co

214 thelial phenotypes, in addition to restoring collagen fiber organization, as detected by second-harmo

215 A cells in 3D collagen matrix by influencing collagen fiber organization.

216 laser beam that can simultaneously determine collagen fiber orientation and a parameter related to th

217 No difference was found in the preferred collagen fiber orientation and fiber concentration facto

218 Collagen fiber orientation and matrix damage were assess

219 tween the shear modulus |G( *)| and both the collagen fiber orientation and polarization.

220 IOP elevation; and (4) FE-based estimates of collagen fiber orientation demonstrated no change in the

221 gnificantly improves cartilage repair with a collagen fiber orientation more similar to the normal ca

222 modulus, structural stiffness, and preferred collagen fiber orientation were mapped for each posterio

223 al heterogeneity of biochemical composition, collagen fiber orientation, and geometric deformation.

224 y Raman spectroscopy; and 2), a gradation in collagen fiber orientation, measured by polarized light

225 se properties arise from the depth-dependent collagen fiber orientation.

226 tation is dictated locally by the underlying collagen fiber orientation.

227 of explanted valves showed greater amount of collagen fibers (P=0.01), and Masson trichrome staining

228 Collagen fiber patterns in skin were disordered, and abn

229 lagen-rich extracellular matrix (ECM), where collagen fibers provide topological cues that direct cel

230 hese uniform peptide substrates, rather than collagen fibers, provides independent control of each ax

231 Collagen fiber reassembly is governed by the displacemen

232 ly low local retardation, which increased as collagen fibers remodeled, and a persistently high degre

233 hymal-like migration of LECs associated with collagen fiber remodeling.

234 terestingly, depletion of mmp9 impaired this collagen fiber reorganization.

235 utive law accounting for mechanically driven collagen fiber reorientation is proposed.

236 ll-populated collagen matrices: alignment of collagen fibers, responses to applied force, strain stif

237 xylases promotes cancer cell alignment along collagen fibers, resulting in enhanced invasion and meta

238 Histology of collagen fibers revealed marked reductions in collagen v

239 was evident in the TPAF channel; the scleral collagen fibers showed no organization and appeared rand

240 Transmission electron microscopy of collagen fibers, showed that the native periodic banded

241 esearchers have developed ACL scaffolds with collagen fibers, silk, biodegradable polymers, and compo

242 which correlates with decreased alignment of collagen fibers, similar to published findings of human

243 x with short stress relaxation time enhanced collagen fiber size and tumor density and increased lung

244 AFs controls tumor stiffness by reorganizing collagen fibers specifically at the tumor-stromal bounda

245 uantify the intensity change associated with collagen fibers straightening in the arterial wall durin

246 This study investigates how the collagen fiber structure influences the enzymatic degrad

247 eta-jelly roll domain did not bind insoluble collagen fiber, suggesting that myroicolsin may degrade

248 riodontal bone resorption and destruction of collagen fibers, suggesting that fluoxetine can constitu

249 Aligned collagen fibers support elevated tensions that promote t

250 thesis that scar formation is the product of collagen fiber synthesis and alignment in the presence o

251 reticular cells (FRCs) and their specialized collagen fibers termed 'conduits' form fundamental struc

252 ore strongly in model gels composed of short collagen fibers than in those composed of long fibers, w

253 rized by bundles of straightened and aligned collagen fibers that are oriented perpendicular to the t

254 ing into a dense mat of irregularly arranged collagen fibers that overlaid normal orthogonally arrang

255 sult in excess growth of trabecular bone and collagen fibers that replace hematopoietic cells, result

256 How collagen fibers, the dominant matrix protein in bones, a

257 The assembly of collagen fibers, the major component of the extracellula

258 understanding of the associated formation of collagen fibers, the primary determinant of connective t

259 mes accompanied by the increased presence of collagen fibers, thickened epithelia, and elongated rete

260 its potential to evaluate collagen content, collagen fiber thickness, and SMC density, we anticipate

261 ent of the periodontal ligament and gingival collagen fibers to both the cementum of the root surface

262 feature sizes comparable to those of in vivo collagen fibers to measure and compare actin dynamics fo

263 tion of second harmonic generation images of collagen fibers to overcome difficulties in tracking str

264 tendon model independently predicts rates of collagen fiber turnover that are in general agreement wi

265 stretching, the newly deposited elastin and collagen fibers undergo substantially larger distortions

266 he greatest value in mean area percentage of collagen fibers using Masson trichrome stain.

267 of volumetric densities of fibroblasts (Vf), collagen fibers (Vcf), and blood vessels (Vbv).

268 The Young's moduli of untreated collagen fibers versus catK-treated fibers in dehydrated

269 nt manner, with the ratio of HA deposited on collagen fibers versus that distributed homogeneously be

270 light micrographs, the density of TM radial collagen fibers was lower in Col11a2 -/- mice than wild-

271 ergy stored in unmineralized and mineralized collagen fibers was measured and compared to the amount

272 Unmasking of collagen fibers was most predictive of abnormal signal i

273 Lower percentage of mature collagen fibers was observed in DBG/HV (P <=0.05).

274 that the native periodic banded structure of collagen fibers was weakened and nearly absent in the pr

275 ages and fibroblasts and the accumulation of collagen fibers, was significantly reduced in CysLT(2) r

276 ease of the relative dispersion (SD/mean) of collagen fiber waviness suggests a heterogeneous mechani

277 gen alpha(1) synthesis and the deposition of collagen fibers were both markedly decreased in LmBSN cu

278 On average, scleral collagen fibers were circumferentially oriented around t

279 In adult mice, type I collagen fibers were cleaved rapidly in situ during a hi

280 Alveolar bone resorption and gingival collagen fibers were histologically analyzed using eithe

281 Mouse tail type I collagen fibers were incubated with either catK or non-c

282 taining with picrosirius-red showed that the collagen fibers were less mature in SPARC-null than in w

283 Additionally, collagen fibers were more aligned in adult than fetal va

284 Collagen fibers were noted in the extracellular matrix.

285 In addition, abnormally shaped collagen fibers were observed in capsules from mutant mi

286 SHG transmission images of collagen fibers were spatially resolved due to a coheren

287 Self-assembled collagen fibers were stretched 0-50% before cross-linkin

288 ore, the ability of MT10 to degrade rat tail collagen fibers when it was cultured at 37 degrees C was

289 ties to the densely packed triple helices of collagen fibers whereas solution NMR structures reveal t

290 with an investigation into the properties of collagen fibers which suggested that variations in desmo

291 Type I collagen molecules form collagen fibers, which are viscoelastic and can therefor

292 K at the edge of the fibrillar gap region of collagen fibers, which suggest initial cleavage events a

293 0 mum thick) of randomly arranged, unaligned collagen fibers, which was positive for collagen types I

294 ase (MMP)-1 and interstitial accumulation of collagen fibers with impairment of cardiac function.

295 lagen deformation by concomitantly detecting collagen fibers with reflectance detection during these

296 clonal antibodies fail to spread and envelop collagen fibers with their cellular processes.

297 oid, has been shown to associate with dermal collagen fibers within infected skin lesions.

298 b cross-linking enhanced NK cell adhesion to collagen fibers within the node.

299 evealed thinner and less aligned periluminal collagen fibers within the plaques of Mmp-13(+/+)/apoE(-

300 The fluorescent signal from collagen fibers within the sclera was evident in the TPA