ライフサイエンスコーパス: collectin

1 L (SP-D/MBLneck+CRD) to create a novel human collectin.

2 se structures on gp120 are the target of the collectin.

3 t contain collagen-like domains are known as collectins.

4 zing Abs but did not increase sensitivity to collectins.

5 ), which consistently does not interact with collectins.

6 e lectin pathway capable of interacting with collectin-10 (CL-10) and the MASPs to activate the compl

7 annose-binding lectin, ficolin-2, ficolin-3, collectin-10, collectin-11, mannose-binding lectin-assoc

8 Here we report that the lectin collectin 11 (CL-11), particularly kidney produced, has

9 epithelial cells, which after recognition by collectin-11 (CL-11 or collectin kidney 1 (CL-K1)), init

10 Collectin-11 (CL-11) is a pattern recognition molecule o

11 We focused on collectin-11 (CL-11), a pattern recognition molecule tha

12 We investigated the role of collectin-11 (CL-11), an epithelial-secreted carbohydrat

13 ed how the recently discovered C-type lectin collectin-11 (CL-11, also known as CL-K1 and encoded by

14 The interface between collectin-11 and L-fucose, in both the recipient and the

15 r, we could show the specific recruitment of collectin-11 and subsequent initiation of the complement

16 cognized by the pattern recognition molecule collectin-11 and this proceeded in a C4-independent, byp

17 In particular, collectin-11 has been shown to engage L-fucose at sites

18 tubulointerstitial fibrosis in IgAN and that collectin-11 is a key mediator of this association.

19 in hypoxic renal tubules, primarily through collectin-11's interaction with glycan ligands on hypoxi

20 Collectin-11, a soluble C-type lectin expressed in renal

21 lectin, ficolin-2, ficolin-3, collectin-10, collectin-11, mannose-binding lectin-associated serine p

22 Mannose-binding lectin (MBL)/ficolin/collectin-11-associated protein-1 (MAP-1) is a recently

23 that MAP-1 can compete with the MBL/ficolin/collectin-11-associated serine proteases (MASPs) in bind

24 , a new member of the collectin family named collectin-12 (CL-12 or CL-P1) has been identified.

25 tion and proliferation factor-1 (NPDC1), and collectin-12 (COLEC12).

26 C1q and the collectins alone were adequate to trigger amebic phagocy

27 The collectins also bind to bacteria, the usual source of nu

28 uggesting a specific interaction between the collectin and beta(1-->6)-glucan.

29 Because members of the collectin and pentraxin families of serum proteins bind

30 ily with structural similarities to the lung collectins and functional similarities to C1q.

31 , and suggest important interactions between collectins and HNPs in the host response to viruses and

32 ant and/or natural forms of SP-D and related collectins and HNPs were tested for antiviral activity a

33 the receptor-mediated cellular regulation of collectins and offers critical clues for future investig

34 vels that were comparable with the authentic collectins and that the N-terminal interchange converted

35 a1 integrin is a novel receptor for multiple collectins and the C1q complement protein.

36 The collectins and the ficolins are soluble pattern recognit

37 glycosylation sites on HA for sensitivity to collectins and to neutralizing Abs.

38 el of complexity in the interactions between collectins and uPARAP.

39 olved in host defense, including complement, collectins, and other antimicrobial proteins.

40 structure analysis for engineering effective collectin antivirals as in vivo therapeutics.

41 Collectins are a family of innate immune proteins that c

42 In conclusion, we show that collectins are a new class of proteins that bind free DN

43 Collectins are composed of four major structural domains

44 uctures previously thought to be targets for collectins are important in shielding the more vulnerabl

45 enhance removal of apoptotic cells, and that collectins are integral, organ-specific components of th

46 To test the possibility that the collectins are ligands that stimulate E. histolytica pha

47 Collectins are pattern recognition molecules of the inna

48 The collectins are proteins with collagen tails and globular

49 Collectins are secreted collagen-like lectins that bind,

50 To quantify relationships among collectins, bacteria, and inflammation in early cystic f

51 efense mechanisms include components such as collectins, beta-defensins, lactoferrin, and complement,

52 Here we show that collectins bind DNA from a variety of origins, including

53 binding and competition studies suggest that collectins bind nucleic acid via their CRDs as well as b

54 ty, suggesting that requirements for optimal collectin binding to influenza virus and bacteria differ

55 ritical clues for future investigations into collectin biology and pathology.

56 n injured tissues undertake the clearance of collectins by using the endocytic collagen receptor uPAR

57 Distinctive functional properties of collectin collagenous domains and CRDs can be exploited

58 Recently, three novel collectins, collectin liver 1 (CL-L1), collectin kidney

59 nt proteins A and D (SP-A and SP-D) are lung collectins composed of two regions, a globular head doma

60 aggregating activity, activities of chimeric collectins containing the N-terminal and collagen domain

61 Thus collectins could play particularly important roles in se

62 N-acetyl-d-glucosamine (GlcNAc) binds in the collectin CRD calcium site by interacting with the O3' a

63 We conclude that relative collectin deficiency occurs early in CF airways and is i

64 s decrement was attributed to killing of the collectin-exposed yeast since it failed to grow on agar

65 factant proteins A and D (SP-A and SP-D) are collectins expressed in the airway and alveolar epitheli

66 1q because mannose-binding lectin, a related collectin, failed to upregulate Mer expression and funct

67 s an innate immune mediator belonging to the collectin family known to bind to the surfaces of many v

68 Surfactant protein D (SP-D) is a collectin family member with demonstrated immunomodulato

69 In mammals, collectin family members (e.g., mannose-binding lectin [

70 Recently, a new member of the collectin family named collectin-12 (CL-12 or CL-P1) has

71 rfactant protein-D (SP-D) is a member of the collectin family of C-type lectins that is synthesized i

72 ins A (SP-A) and D (SP-D) are members of the collectin family of calcium-dependent lectins and are im

73 t protein D (SP-D) is a 43-kDa member of the collectin family of collagenous lectin domain-containing

74 nglutinin are closely related members of the collectin family of host defense lectins.

75 rfactant protein D (SP-D) is a member of the collectin family of innate defense proteins.

76 rfactant protein A (SP-A) is a member of the collectin family of innate host defense molecules expres

77 Surfactant protein (SP) D is a member of the collectin family of innate immune molecules that plays a

78 These results suggest that the entire collectin family of innate immune proteins (including C1

79 annose binding lectin (MBL), a member of the collectin family of proteins, bind to apoptotic cells an

80 protein A (SP-A), a pulmonary member of the collectin family of proteins, facilitates the rapid clea

81 similarities between C1q and members of the collectin family of proteins, including pulmonary surfac

82 MBL is a member of the collectin family of proteins, which binds to oligomannos

83 MBL is a member of the collectin family with structural similarities to the lun

84 (SP-A) is a hydrophilic glycoprotein of the collectin family, and its main function is related to ho

85 arbohydrate binding, a characteristic of the collectin family, and specific interactions with lipid m

86 surfactant protein D (SP-D), a member of the collectin family, is an innate immune molecule critical

87 Mannan-binding lectin (MBL), a member of the collectin family, is known to have opsonic function, alt

88 humoral pattern recognition molecules in the collectin family, namely surfactant proteins D and A (Sp

89 surfactant protein A (SP-A), a member of the collectin family, plays an important role in innate immu

90 Surfactant protein A (SP-A), a member of the collectin family, selectively binds to Pneumocystis cari

91 urfactant protein-D (SP-D), a member of the "collectin" family, has been shown to play a role in inna

92 Surfactant protein D (SP-D) is one of two collectins found in the pulmonary alveolus.

93 This serum collectin has been shown to activate complement when bou

94 The collectins have been shown to have a role in host defens

95 factant protein D, the other known pulmonary collectin, in response to GBS instillation.

96 Exposure of yeast to either collectin induced a dose-dependent decrease in [3H]leuci

97 novel collectins, collectin liver 1 (CL-L1), collectin kidney 1 (CL-K1 and CL-11), and collectin plac

98 e proteins in the lectin complement pathway (collectin kidney 1 (CL-K1) and MASP-1 and MASP-3, respec

99 after recognition by collectin-11 (CL-11 or collectin kidney 1 (CL-K1)), initiates complement activa

100 nding of mannan-binding lectin, ficolins, or collectin kidney 1 (CL-K1, alias CL-11) to suitable micr

101 lex, MBL-associated serine protease (MASP)-3/collectin-L1/K1 hetero-oligomer, which impacts cardiac n

102 l epithelium clone) family proteins, elafin, collectins, lactoferrin, lysozymes, mucins, secretory le

103 tins, such as mannose-binding lectin and the collectin-like C1q, have been shown to bind to apoptotic

104 f native CL-K1 from plasma, we observed that collectin liver 1 (CL-L1) was copurified.

105 Recently, three novel collectins, collectin liver 1 (CL-L1), collectin kidney 1 (CL-K1 and

106 In contrast, the collectin mannose binding lectin C (MBL-C) but not MBL-A

107 We now demonstrate that the serum collectins mannose-binding lectin (MBL) and conglutinin

108 The collectins mannose-binding lectin (MBL) and surfactant p

109 The role that collectin (mannose-binding protein) may play in the host

110 Because these collectins may bind and opsonize bacteria and viruses, d

111 Collectins may therefore play an important role in decre

112 of AMos from inhibition of AC uptake by lung collectins may, in part, explain the beneficial role of

113 rn recognition molecules, i.e., those of the collectin MBL-C, are involved in the Aspergillus-lectin

114 e role of CR1 as a cellular receptor for the collectin MBL.

115 o dermis or bleomycin-injured lungs of mice, collectins MBL and SP-D were endocytosed and routed for

116 re more susceptible than smooth strains, and collectin-mediated growth inhibition was partially block

117 f the organism and that Hc gains asylum from collectin-mediated killing by rapid entry into pulmonary

118 These results indicate that collectin-mediated viral aggregation per se may be an im

119 Ac-binding pocket in conglutinin and a novel collectin mode of carbohydrate recognition.

120 The model may also be relevant to collectin multimers.

121 To further assess the importance of lung collectin N-terminal domains in surfactant structure and

122 quired for the permeabilizing effects of the collectins on model bacterial membranes.

123 ), collectin kidney 1 (CL-K1 and CL-11), and collectin placenta 1 (CL-P1), were discovered.

124 Collectins play important roles in host defense against

125 Soluble defense collagens including the collectins play important roles in innate immunity.

126 the 16-fold excess in tissue, but the total collectin pool in lavage is still significantly reduced.

127 On the basis of homology with other collectins, potential functions for SP-D include roles i

128 hat the group of collagenous lectins (termed collectins) present in blood and pulmonary surfactant pl

129 Surfactant protein-D (SP-D) is a collectin produced in the distal lung airspaces that is

130 anism through which opsonization of IAV with collectins protects neutrophils against the deactivating

131 rotein D (SP-D) are high abundance pulmonary collectins recently implicated in apoptotic cell clearan

132 The roles of these three collectins remain largely unknown.

133 Deletion of the E. coli OmpA gene from a collectin-resistant smooth E. coli strain enhanced SP-A

134 an increased capacity to inhibit a partially collectin-resistant strain of IAV.

135 sequence and in location from those in other collectins, result in specific, high-affinity binding fo

136 toneal Mos that had not been exposed to lung collectins showed delayed, but not rapid, increase in AC

137 take by alveolar macrophages (AMos) via lung collectin signaling through signal regulatory protein al

138 e also had substantial increases in the lung collectin SP-D, including significant amounts of an S-ni

139 These data suggest that the pulmonary collectins SP-A and SP-D facilitate the resolution of in

140 We have recently shown that collectins SP-A, SP-D, and mannose binding lectin recogn

141 targeted mice that two surfactant-associated collectins (SP-A and SP-D) may serve in these roles and

142 The lung collectins, SP-A and SP-D, are important components of t

143 The collectins, SP-A and SP-D, play distinct roles during ba

144 Surfactant protein A (SPA), a lung-specific collectin, stimulates macrophage chemotaxis.

145 Collectins such as mannose-binding lectin (MBL) and surf

146 Thus, we conclude that collectins such as SP-A and SP-D reduce the generation o

147 Other collectins, such as mannose-binding lectin and the colle

148 We hypothesized that collectins, such as pulmonary surfactant proteins (SPs)

149 We hypothesize a central role for the collectin surfactant protein A (SP-A) in regulating the

150 da and opsonization of F. novicida with lung collectin surfactant protein A (SP-A) increased bacteria

151 bohydrate recognition domains (CRDs) of lung collectin surfactant protein D (SP-D) recognize sugar pa

152 pretreatment of peritoneal Mos with the lung collectin surfactant protein D inhibited AC uptake, and

153 cytokine production, and proteolysis of the collectin surfactant protein-D (SP-D).

154 The pulmonary collectins surfactant protein (SP)-A and SP-D play impor

155 ns of IAV are generally not inhibited by the collectins surfactant protein D or mannose binding lecti

156 The collectins surfactant-associated protein A (SP-A) and SP

157 The lung collectin, surfactant protein A (SP-A), has emerged as a

158 The two lung surfactant collectins, surfactant protein (SP)-A and SP-D, are invo

159 ficantly less in SP-A than in the homologous collectins, surfactant protein D, and mannose-binding pr

160 y, we investigated the role of the pulmonary collectins, surfactant proteins (SP) A and D, in the cle

161 The N-terminal domains of the lung collectins, surfactant proteins A (SP-A) and D (SP-D), a

162 The pulmonary collectins, surfactant proteins A (SP-A) and D (SP-D), h

163 irect antimicrobial actions of the pulmonary collectins, surfactant proteins A (SP-A) and D (SP-D).

164 The pulmonary collectins--surfactant proteins A (SP-A) and D (SP-D)--p

165 mediated at least in part by the collagenous collectin tail domain.

166 particles coated with C1q, MBL, or purified collectin tails were phagocytosed more efficiently than

167 and purified human C1q, MBL, and collagenous collectin tails.

168 and D are innate immune pattern recognition collectins that contain fibrillar collagen-like regions

169 domain residues having an exclusive role in collectin uptake.

170 fic because no, or minimal, binding to other collectins was found.

171 ral and functional similarities with soluble collectins, we hypothesized the existence of a fluid-pha

172 In cellular assays, several types of collectins were endocytosed in a highly specific uPARAP-

173 Mice in which endogenous pulmonary collectins were replaced with D/A were developed by huma

174 s of ligand recognition, the interactions of collectins with complement cascades, and the association

175 RDs can be exploited to generate novel human collectins with potential for therapy of influenza.

176 acquired alterations in the levels of active collectins within the airspaces and distal airways may i