ライフサイエンスコーパス: colocalization

1 DA neurons (defined by tyrosine hydroxylase colocalization).

2 kely owing to increased fitness by virtue of colocalization.

3 increase after treatment and exhibit strong colocalization.

4 two-sample Mendelian randomization (MR) and colocalization.

5 lidated by electrophoretic and histochemical colocalization.

6 rable loci are identified using trans-ethnic colocalization.

7 creased phosphorylated NMIIA and NMIIA/actin colocalization.

8 ence/confocal microscopy was used for IL-17F colocalization.

9 myosin light chain quantity and actin fiber colocalization.

10 ve and fixed cells with dramatic microtubule colocalization.

11 dmixture on gene expression, eQTLs, and GWAS colocalization.

12 s the impact of population structure on GWAS colocalization.

13 We present the circular colocalization affinity with network structures test (CI

14 obank (European ancestry n ~ 320,000), while colocalization analyses leveraging multi-omic data from

15 Colocalization analyses of associations with eGFR among

16 Transcriptome-wide colocalization analyses showed association of WMH-volume

17 alyses, genetic risk profiling, and Bayesian colocalization analyses were also performed.

18 While colocalization analyses were inconclusive, functional ch

19 he function of NS is virtually restricted to colocalization analyses, since an organizing core, witho

20 130 (31.5%) were not supported by results of colocalization analyses, suggesting that genetic confoun

21 can substantially affect the conclusions of colocalization analyses.

22 We implemented Bayesian multitrait colocalization analysis (moloc) and summary data-based M

23 Superresolution microscopy-based colocalization analysis and inhibition of H129 particle

24 the promise and limitations of the available colocalization analysis approaches.

25 luence on anterograde DCV runs, and detailed colocalization analysis by superresolution microscopy re

26 Colocalization analysis confirmed that the same set of S

27 Mediation testing and colocalization analysis demonstrate that MSMB is a cis-a

28 Colocalization analysis has emerged as a powerful tool t

29 These results, together with colocalization analysis of different TPC subunits, allow

30 Colocalization analysis of several nexus components and

31 roduces composite pictures of the signals or colocalization analysis on brightfield hematoxylin and e

32 Colocalization analysis showed that for 18 out of these

33 ontrollable practical factors on outcomes of colocalization analysis through realistic simulations an

34 Here, we used genetic colocalization analysis to identify loci at which gene e

35 Scientists often use genomic colocalization analysis to interpret such region sets, f

36 lgorithm that combines cluster detection and colocalization analysis to observe the organization of 5

37 The findings from colocalization analysis yield insights into the molecula

38 dosome trapping, as attested by fluorescence colocalization analysis, gene knockdown assay and animal

39 Integration, through the use of Bayesian colocalization analysis, of publicly available GWAS summ

40 By cis- and trans-eQTL colocalization analysis, we identified 34 and 20 genes,

41 ovide recommendations for performing genomic colocalization analysis, while also discussing common me

42 ved data and (2) separating fine-mapping and colocalization analysis.

43 ollowing strategies for the best practice of colocalization analysis: (1) estimating prior enrichment

44 and transmembrane proteins, allowing for the colocalization and concentration of enzymes and substrat

45 Colocalization and fine-scale synteny suggest genetic li

46 gh SMAD signaling, which was confirmed using colocalization and genetic knockdown studies.

47 HIN1 colocalization and interaction with serine-arginine rich

48 n intracellular calcium levels promotes AMPK colocalization and interaction with STIM2.

49 ation spectroscopy analysis revealed partial colocalization and molecular association of IL-2 (and IL

50 icant loci (P < 5 x 10(-8)) with evidence of colocalization and shared directions of effect between p

51 However, this pattern was weak overall, with colocalization and synteny being relatively rare.

52 owever, the nature of the seemingly receptor colocalization and the role it plays in immune regulatio

53 Using endocytic colocalization and ubiquitination assays, we have identi

54 sruption of the MPS prevented such molecular colocalizations and downstream ERK signaling.

55 Focusing on variant-level colocalization approaches, we first establish the connec

56 he appearance of pol IV foci and RecA-pol IV colocalization are all dependent on RecB function.

57 ; without a preexisting prion, however, such colocalizations are rarely seen during Swi1-PrD overprod

58 eby MCL-1 depletion increases 53BP1 and RIF1 colocalization at DSBs, which inhibits BRCA1 recruitment

59 tein complex and display notable subcellular colocalization at presynaptic and postsynaptic regions.

60 Wdb and MEI-S332 show colocalization at the centromere region until release of

61 in genome-wide association studies; and (d) colocalization between 47 islet cis-eQTLs and variants i

62 C-CMs) from Danon patients exhibit decreased colocalization between ATG14 and VAMP8, profound defects

63 We observed interactions and colocalization between Bcl-xL, VPS35, VPS26, and MICAL-L

64 Colocalization between EHRL-4-opsonized ehrlichiae, poly

65 m the published studies and our own study of colocalization between eQTLs and loci associated with CA

66 We observed colocalization between LITAF and LTCC in tsA201 and card

67 The colocalization between SOX9 and COL1 could also be confi

68 We demonstrated colocalization between technetium Tc 99m tilmanocept (99

69 To contextualize the observed pattern of colocalization between TH-ir and EGFP(Vgat) , we first p

70 by CALR+ varicosities, with a high degree of colocalization between the two markers.

71 This interaction, and colocalization between the two proteins in vitro and in

72 metabolomic-QTL (met-QTL), 92% demonstrated colocalization between these signals, but interpretation

73 te that nanoscale proximity, not necessarily colocalization, between Dectin-1 and TLR2 is required fo

74 allenge, we have developed a single-molecule colocalization binding titration assay (smCoBRA) that ca

75 MT1- and MT2-MMP showed a high degree of colocalization but were located on the distinct endosoma

76 ing traditional statistical approaches since colocalization cannot be normalized to the density of bo

77 WAS signals and evaluated the differences in colocalization classification between the two tests.

78 nal GWAS loci can reconcile disagreements in colocalization classification between the two tests.

79 error rates in characterizing intercellular colocalization compared to generic approaches that are c

80 ly characterize the identified associations: colocalization, conditional, and fine-mapping analyses t

81 Colocalization demonstrated Nox5 expression in mesangial

82 on with actin is also dependent on ZO-1, but colocalization demonstrates intermittent rather than con

83 In this study, we design colocalization-dependent protein switches (Co-LOCKR) tha

84 Colocalization, driven by hydrodynamics, ultimately redu

85 Examining colocalization events across conditions is often complic

86 A colocalization experiment with LysoTracker Red DND-99 co

87 Colocalization experiments confirmed that, upon FAC trea

88 In vitro co-immunoprecipitation and in vivo colocalization experiments suggest that PIAS3 acts as th

89 Here we introduce a method based on ion colocalization features that allows the classification o

90 n lead to severe inflation of false-positive colocalization findings.

91 ng expression quantitative trait loci (eQTL) colocalization, fine-mapping, and human rare-disease, an

92 ored GWAS signals for 4083 traits, detecting colocalization for 180 disease loci with eQTLs.

93 pplications like superresolution microscopy, colocalization, Forster resonance energy transfer, near-

94 Among the methods that quantify colocalization from multicolor images, image cross-corre

95 LatB decreased AFL1-Clathrin Light Chain colocalization, further indicating that effects of AFL1

96 We used several approaches (colocalization, glutathione S-transferase pulldown, coim

97 which coincided with a greater vGlut1/PSD95 colocalization, higher dendritic spine density, and enha

98 ypothesis test to probe for enriched network colocalization in 2D z-projected multichannel images by

99 roxylase demonstrate that there is selective colocalization in adult dopamine cells with shh-GFP in t

100 -activated macrophages, and Nhe1-FcepsilonR1 colocalization in atherosclerotic lesion macrophages sup

101 The P2Ns manifest transferrin receptor (TfR) colocalization in ex vivo intestinal tissue sections, de

102 on in the endoplasmic reticulum with partial colocalization in mitochondria and lysosomes of water-so

103 ed analogues of the enantiomers showed their colocalization in racemic fibrils.

104 ion as shown by NLRP3/ASCII and NLRP3/Casp-1 colocalizations in these cells while use of mice lacking

105 ectly probe the role of phagocytic receptor "colocalization" in innate immune regulation.

106 In response to DNA damage, colocalization increases and RecF dimerizes.

107 We have developed a technique to measure colocalization independent of structure density and appl

108 observe 31 loci (0.02%) where a significant colocalization is called only with one eQTL ancestry adj

109 We found that Rab11A and vRNA colocalization is dependent upon dynamic MT filaments.

110 mating cells are in contact (prezygotes) and colocalization is required for cell fusion.

111 This colocalization is reversible in the absence of drug sele

112 by signals may share causal variants, termed colocalization, is affected by the presence of allelic h

113 Mutated pyrin prohibits this colocalization, leading to higher IL-1beta levels on NET

114 stepwise photobleaching and single molecule colocalization may be used to study the subunit stoichio

115 We then applied two Bayesian colocalization methods and identified shared causal SNPs

116 colocalizations within each of two different colocalization methods, COLOC and FINEMAP.

117 scale total internal reflection fluorescence colocalization microscopy, we visualized toxin pore form

118 delian randomization (MR) and multiple-trait colocalization (moloc) analyses to highlight putative ce

119 nd gene expression by using a multiple-trait colocalization ("moloc") framework.

120 Testing colocalization moves it closer to establishing causal re

121 HA-tagged PAI-1 in COS7 cells confirmed the colocalization observations in HUVECs.

122 Colocalization of 3-NT staining with neurofilament prote

123 graphy and immunohistochemistry demonstrated colocalization of [(89)Zr]Zr-DFO-N-suc-muS110 and [(89)Z

124 In vivo, colocalization of actin filaments and divalent ions are

125 is directly regulated by NF-kappaB, and the colocalization of activated NF-kappaB and GDF-15 in epit

126 Colocalization of alphaS pathology with galectin-3 (a ma

127 high-resolution confocal microscopy to show colocalization of Ambn with ameloblast membrane surfaces

128 This technique could be used to analyze colocalization of any annular structure with an arbitrar

129 Colocalization of AQP-1 with EphB guidance receptors in

130 ding 'cage' formed by BAHCC1(BAH), mediating colocalization of BAHCC1 and H3K27me3-marked genes.

131 We observed colocalization of C difficile and F nucleatum in an aggr

132 fs for drug or nanoparticle delivery, or for colocalization of cellular components.

133 eosinophils with INF-gamma induces the rapid colocalization of CLC/Gal-10 with eosinophil-derived neu

134 The strong colocalization of COP1 and SUMO in these NBs might also

135 support, immunofluorescence assays revealed colocalization of D2Rs and Ca(v) 3.2 calcium channels wi

136 Based on homologous properties, the colocalization of Df-PPN and (89) Zr-Df-PPN in the tumor

137 , the binding of other DLC1 ligands, and the colocalization of DLC1 with focal adhesions and attenuat

138 of DNA-PK autophosphorylation as well as by colocalization of DNA-PK with early Ad replication cente

139 Immunohistochemistry demonstrated colocalization of dopamine D(3) receptor and dopamine D(

140 mmunohistochemistry was performed to examine colocalization of dopamine receptors with endocrine horm

141 ed microspectroscopy analyses to demonstrate colocalization of endogenous metals within the hydrophil

142 show that NF-kappaB activation is boosted by colocalization of engaged immune receptors, such as CD40

143 ylation of EWSR1/FLI1 at Thr 79 promotes the colocalization of EWSR1/FLI1 and Aurora B on the chromos

144 can be assigned to ocher, notably due to the colocalization of Fe with aluminum, and the detection of

145 performing in vivo neuronal calcium imaging, colocalization of fluorescent labels, non-invasive pH me

146 The colocalization of FOS and oxytocin in sites that project

147 arker Fos in the NAc, and cell-type-specific colocalization of Fos with Drd1- and Drd2-expressing neu

148 We observed colocalization of G. bethesdensis with an early endosome

149 Intriguingly, YopK limited the colocalization of Galectin-3 with YopD, suggesting that

150 LADL facilitates colocalization of genomic loci without exogenous chemica

151 An increased or decreased colocalization of GFP with KDR/SFRP4 and CD31 in the reg

152 d with diminished Gle1 shuttling, as well as colocalization of Gle1 at R-loops.

153 he presence of IgG in the IgAN biopsies with colocalization of glomerular IgA and IgG.

154 We found extensive colocalization of GRAF1b/2 with Rab8a/b and partial with

155 In telophase, colocalization of growing microtubules ends from the phr

156 Colocalization of H3Cit with extracellular DNA released

157 Finally, 62 unique loci were identified by colocalization of haQTLs with the subthreshold loci of h

158 ed expression, and analyzed the movement and colocalization of Hh, Patched (Ptc) and Smoothened (Smo)

159 ChIP-seq analyses show high colocalization of HMGNs and of REX1, a zinc finger prote

160 pe I IFN induction and its disruption of the colocalization of HSP70 with IKKepsilon.

161 Furthermore, we identify colocalization of inflammatory fibroblasts and cancer ce

162 reduced by loss of UCH-L1, which affects the colocalization of intracellular MHC I with late endosoma

163 ere, by taking advantage of the preferential colocalization of intravenously administered erythrocyte

164 Following the colocalization of ISD with cGAS, the downstream pathway

165 solution microscopy revealed nanometer-scale colocalization of JPH2 clusters with type 2 ryanodine re

166 The colocalization of KCNQ1 with adherens junction proteins

167 Our previous studies showed the colocalization of KIT with DAPI-stained nuclei in GIST c

168 t hairpin RNA (shRNA) gene silencing and the colocalization of LAMP-1, glycoprotein B (gB) of MDV, an

169 Further analysis found the colocalization of LC3 with a small portion of R. austral

170 Colocalization of LC3 with LDs was significantly inhibit

171 is induced under starvation as indicated by colocalization of LDs with the autophagic marker and the

172 ution microscopy revealed distinct nanoscale colocalization of LEL-expressing TRPML1 channels with ry

173 nd to contribute to NIR-AF, indicated by the colocalization of lipofuscin-AF and NIR-AF under the flu

174 In C1q(-/-) TM mice, colocalization of MASP-2 and C3 in both the glomeruli an

175 I was detected on the surface of HUVECs, and colocalization of MBL with beta2-GPI was observed on the

176 This accurate colocalization of MS and IHC signals showed limited pene

177 criptional atlas, we further established the colocalization of mu-opioid and kappa-opioid receptor ge

178 Colocalization of NOS and tyrosine hydroxylase was obser

179 Colocalization of NRL and the retinal TF CRX correlated

180 ssembly, DRM localization of NS2 and E2, and colocalization of NS2 with Core and endoplasmic reticulu

181 Disruption of colocalization of nuclear beta-catenin with TBL1 and TCF

182 Further, immunostaining revealed the colocalization of OSTERIX with OLFM4 and LGR5, two bona

183 f larger plaques or in small plaques without colocalization of other Abeta isoforms.

184 ques, and interestingly, there was extensive colocalization of p27(gag) and CD169, suggesting product

185 -XRF maps reveal a peculiar distribution and colocalization of Pb, phosphorus (P), and sulfur (S), wh

186 We show colocalization of PDGFRalpha in murine carbon tetrachlor

187 This sorting process promotes colocalization of Plexin-D1 with vesicular pools of acti

188 c vesicles, and further the Pearson value of colocalization of pre and postsynaptic elements in each

189 roscopic analysis of a fibroblast ECM showed colocalization of procollagen I with FN fibrils, and pro

190 tion time to disease and is characterized by colocalization of PrPSc with microglia and a very profou

191 Colocalization of RabA2 with ArfA1 and a Golgi marker in

192 chondrial membranes promotes recruitment and colocalization of RhoB to these membrane microdomains.

193 (e) There is no colocalization of shh and islet1 as shown by respective

194 We also examined the colocalization of slit diaphragm proteins with exocyst p

195 Colocalization of structures in biomedical images can le

196 RNA binding proteins, revealing preferential colocalization of subsets of factors.

197 me showed a classical Rabl organization with colocalization of subtelomeric virulence genes, while th

198 mice treated subcutaneously with C2C showed colocalization of subunit C2I with CGRP-positive sensory

199 aSyn inclusions dramatically compromised the colocalization of synaptic markers and altered dynamic c

200 athology, which dramatically compromised the colocalization of synaptic markers and altered the dendr

201 acterial burden, which occurs only after the colocalization of T cells and infected cells.

202 tylation occurred rapidly and coincided with colocalization of TDP-43 and SG markers.

203 gh in different populations judging from the colocalization of TH immunoreactivity and PSST6 expressi

204 No colocalization of the dopamine D(3) receptor or dopamine

205 n enzyme-mediated reaction that follows from colocalization of the enzyme and substrate by a protein-

206 riginal cofactor, FVIII, in that it promotes colocalization of the enzyme-substrate complex.

207 m cells (GSCs) demonstrated a high degree of colocalization of the GSC marker CD133 and CSPGs.

208 Immunostaining on day 3 revealed colocalization of the l-type amino acid transporter, wit

209 wo different anti-M6PR antibodies, extensive colocalization of the major VZV glycoprotein gE (known t

210 Both MTA and TGH are necessary for efficient colocalization of the Microprocessor components Dicer-li

211 and analysis to investigate the presence and colocalization of the peptides vasoactive intestinal pol

212 nase, while confocal microscopy demonstrated colocalization of the proteins.

213 d with the late endosome, but no significant colocalization of the receptor was found with the early

214 However, colocalization of the S. cerevisiae mispair recognition

215 Colocalization of these bodies with COP1 required, in ad

216 ponse to extracellular stimuli, resulting in colocalization of these molecules and RTK transactivatio

217 cancer cells and was supported by a partial colocalization of these two proteins.

218 so use the tomographic approach to study the colocalization of tissue strains to specific chondrocyte

219 rescence labeling, we observed the potential colocalization of TnBVANK1 and Alix proteins in the cyto

220 in-1 reduced this interaction as well as the colocalization of UNC5C and TUBB3 in the GC.

221 The strong colocalization of vanadium and P signal intensities demo

222 Furthermore, extensive colocalization of viral Gag and CD169 was observed in ly

223 The observed colocalization of viral transcriptional factories with r

224 ost Plasmodium species is constrained by the colocalization of virulence genes.

225 Colocalization of zymogen and lysosomal fraction occurs

226 ociated with PID, and found evidence for the colocalization of-and interplay between-novel high-penet

227 c protein (RIBEYE) is found adjacent to some colocalizations of GluR1 and TH in the inner plexiform l

228 eQTL) data from the GTEx (v.8) suggests that colocalizations of molecular QTLs and causal complex tra

229 le simultaneously quantifying their relative colocalization on living cells.

230 E-cadherin regulated ACTN4 and beta-catenin colocalization on trophoblast cell podosomes, and ACTN4

231 high frequencies of homologous chromosome X colocalization (or coalescence), typically associated wi

232 c pleiotropy (few trait correlations and QTL colocalization, particularly between traits of different

233 yses were performed, including fine-mapping, colocalization, phenome-wide association studies, pathwa

234 ntroduce Proximity RNA-seq, which identifies colocalization preferences for pairs or groups of nascen

235 One class of colocalization problems is examining an annular structur

236 Furthermore, genetic colocalization provided evidence that the same causal va

237 Furthermore, this colocalization requires PRC1, PRC2, and TrxG complexes,

238 structures and had fewer nuclei and reduced colocalization signals, compatible with decreased fusion

239 by routine immunofluorescence, were used for colocalization studies by confocal microscopy.

240 ize ASC specks or caspase-1 activity, making colocalization studies of inflammasome components and en

241 Colocalization studies of PSGs with proteins of the yeas

242 Colocalization studies reveal increased TSP1 expression

243 Data were corroborated by colocalization studies via dSTORM microscopy.

244 D1/5/8 was quantified by immunostaining, and colocalization studies were performed.

245 wed that target-indication pairs with MR and colocalization support were more likely to be approved,

246 is of interest to develop and apply various colocalization testing approaches.

247 l variants across phenotypes (verified using colocalization tests).

248 TOA scores can be directly coupled with eQTL colocalization to further resolve effector transcripts a

249 tive analysis of Mendelian randomization and colocalization to uncover causal relationships between g

250 Here, we reevaluated evidence of colocalization using two approaches, conditional analysi

251 h CRISPR guide RNAs and induce their spatial colocalization via light-induced heterodimerization of c

252 olic traits examined for adipose tissue eQTL colocalizations, waist-hip ratio (WHR) and circulating l

253 oss all brain regions, but the most striking colocalization was found in a circumscribed portion of t

254 No colocalization was found with serotonin immunostaining.

255 CXCR-2 and MHC-II colocalization was observed in inflamed lung tissue and

256 etromer-positive endosomes, and DAT/retromer colocalization was observed in male mouse dopaminergic s

257 olocalization with clathrin, the increase in colocalization was present in both mobile and immobile F

258 thods test the null hypothesis that there is colocalization, which is not ideal because often the nul

259 Immunofluorescence showed ERICH3 colocalization with 5-HT in vesicle-like structures, and

260 The rgh3 mutant protein disrupts colocalization with a known ZRSR2-interacting protein, U

261 Phosphorylated myosin light chain colocalization with actin stress fibers increased in end

262 We also found that PPM1F protein levels and colocalization with CAMK2G were altered in amygdala and

263 9/VX661 recover diminished Nrf2 function and colocalization with CFTR in CF human primary bronchial e

264 Genome-wide colocalization with cis-expression quantitative trait lo

265 While postsynaptic Bin1 shows colocalization with clathrin, a major endocytic protein,

266 AMGO exposure corresponded to an increase in colocalization with clathrin, the increase in colocaliza

267 mobility state of the receptor accounted for colocalization with clathrin.

268 nally, immunofluorescence also showed ERICH3 colocalization with dopamine in human iPSC-derived neuro

269 e-derived stem cells (ASCs) exhibit enriched colocalization with endothelial cells forming arborized

270 ession pattern, represses fruit ripening via colocalization with epigenetic mark H3K27me3.

271 TGR5 expression and its colocalization with Galphas were increased approximately

272 s, fine-mapping of urate-associated loci and colocalization with gene expression in 47 tissues implic

273 an islets showed a significant SGLT2 protein colocalization with glucagon but not with insulin or som

274 itoylation cycle of this RAS isoform enables colocalization with HK1 on the outer mitochondrial membr

275 we identified a mechanism that prevents Cdr1 colocalization with its inhibitory target Wee1 during os

276 We observed VacA colocalization with LAMP1- and LC3-positive vesicles in

277 n 1 (EEA1)-positive compartment, followed by colocalization with lysosome-associated membrane protein

278 One FYCO1 variant protein had reduced colocalization with MAP1LC3 when expressed in mouse musc

279 ce shortly after injection, with significant colocalization with marginal zone (MZ) B cells.

280 ow that locally delivered ASCs have enriched colocalization with murine retinal microvasculature in a

281 H domain of Cnk1, preventing plasma membrane colocalization with mut-KRas.

282 OSM staining was observed in NPs, showed colocalization with neutrophil elastase (n = 10), and di

283 these core clusters without altering HCV RNA colocalization with NS5A.

284 adjacent uninfected cells and shows similar colocalization with parasite biomarkers such as UIS4 and

285 VPS33B had reduced coimmunoprecipitation and colocalization with Rab11a and Rab25 and did not rescue

286 -/-) platelets, the 2 cargoes showed limited colocalization with Rab4, Rab11, or VWF.

287 Both proteins also showed some degree of colocalization with the cytoskeleton marker beta-tubulin

288 edes nuclear translocation of GOLPH3 and its colocalization with the DNA-dependent protein kinase cat

289 r SUMO NB formation and for their subsequent colocalization with the E3 ubiquitin ligase CONSTITUTIVE

290 hway with the Ser23 variant having decreased colocalization with the early endosome versus the Cys23

291 similar, NV NS3 displayed a higher level of colocalization with the Golgi apparatus and the endoplas

292 and PRR7) as displaying a high frequency of colocalization with the PIF proteins at their binding si

293 er by MatP in wild-type cells directs MukBEF colocalization with the replication origin.

294 uorescence microscopy to demonstrate dynamic colocalization with TRIM proteins at the axonal peripher

295 IRS-2 colocalization with tubulin is enhanced upon Taxol-media

296 the kidney showed statistically significant colocalization with variants identified in CKD GWASs, in

297 We used the two approaches to test for colocalization with WHRadjBMI GWAS signals and evaluated

298 While colocalization within a bacterial operon enables coexpre

299 m expression at 3 days after impact and main colocalization within resident microglia of the brain.

300 ments produce similar numbers of significant colocalizations within each of two different colocalizat