ライフサイエンスコーパス: combinatorial library

1 alenediimide-based aqueous disulfide dynamic combinatorial library.

2 creen of a 2304-member one-bead-one-compound combinatorial library.

3 the relative permeability of compounds in a combinatorial library.

4 ding interactions of variable fragments in a combinatorial library.

5 e inhibitors of Int from a synthetic peptide combinatorial library.

6 m a single-chain variable fragment (scFv) PD combinatorial library.

7 ly diversified positional scanning synthetic combinatorial library.

8 en on a 10,000-membered natural product-like combinatorial library.

9 ration and screening of a 135-member indexed combinatorial library.

10 r two different guests from a single dynamic combinatorial library.

11 mic selection of ligands from an imine-based combinatorial library.

12 reening a reduced dipeptidomimetic synthetic combinatorial library.

13 d to the single-bead analysis of a split-mix combinatorial library.

14 mposition of the individual catalysts in the combinatorial library.

15 operties of de novo proteins from a designed combinatorial library.

16 arative HPLC fractions from a small molecule combinatorial library.

17 f transcriptional regulatory elements out of combinatorial libraries.

18 ex mixtures, such as interconverting dynamic combinatorial libraries.

19 ing pairs can be rapidly isolated from large combinatorial libraries.

20 efines a new modular approach to isoindolone combinatorial libraries.

21 s chemical scaffolds for the construction of combinatorial libraries.

22 ads (about 100 microm) used for synthesis of combinatorial libraries.

23 ds for biological targets from equilibrating combinatorial libraries.

24 arless but less suitable for construction of combinatorial libraries.

25 oyed in the solid-phase synthesis of peptide combinatorial libraries.

26 oughput screening of compound collections or combinatorial libraries.

27 d for OBOC peptidomimetic and small molecule combinatorial libraries.

28 oach to preparing potentially highly diverse combinatorial libraries.

29 ate their usefulness in constructing dynamic combinatorial libraries.

30 f thiosemicarbazone exchange to form dynamic combinatorial libraries.

31 ompared with those selected from much larger combinatorial libraries.

32 and efficient strategy for the generation of combinatorial libraries.

33 xes for eight de novo heme proteins from two combinatorial libraries.

34 uld allow direct characterization of massive combinatorial libraries.

35 y identified by directed evolution involving combinatorial libraries.

36 ely used to design individual substrates and combinatorial libraries.

37 he diversity of acyl hydrazone based dynamic combinatorial libraries.

38 ganic materials and as components in dynamic combinatorial libraries.

39 oad and cost of screening sufficiently large combinatorial libraries.

40 the lectins were identified by screening of combinatorial libraries.

41 ive, individual compounds from mixture-based combinatorial libraries.

42 in structure information to generate focused combinatorial libraries.

43 High-diversity genetically-encoded combinatorial libraries (10(8)-10(13) members) are a ric

44 and has enabled easy access to a variety of combinatorial libraries, 2-D macrocycles, and 3-D molecu

45 2 that were discovered by AS-MS screening of combinatorial libraries against the basal form of the pr

46 ingle-chain variable fragment) clones from a combinatorial library against total proteins of Strongyl

47 he isolation of ligand-binding proteins from combinatorial libraries anchored on the periplasmic face

48 portable amino acid sequences selected from combinatorial libraries and supporting the assembly, nuc

49 application in the solid-phase synthesis of combinatorial libraries and the in situ screening of the

50 approach enables scaling up the screening of combinatorial libraries and, together with parallel synt

51 appaB consensus sequence or a bead-bound ODN combinatorial library and adsorption was then assessed u

52 macrocycles that emerge from a small dynamic combinatorial library and compete for a common feedstock

53 tandardized assembly strategy to construct a combinatorial library and express for the first time in

54 is for chemical amplification from a dynamic combinatorial library and lactide can be converted to (M

55 nt cycles, of molecular balances, of dynamic combinatorial libraries, and of crystal structures.

56 ns the carbapenem family comprises a natural combinatorial library, and C-2/C-6 oxidation is associat

57 We report a salicylic acid based combinatorial library approach aimed at binding both act

58 ognition using an "inverse alanine scanning" combinatorial library approach.

59 riations in X and Y functionality by using a combinatorial library approach.

60 e by using the positional scanning substrate combinatorial library approach.

61 Large collections of combinatorial libraries are an integral element in today

62 Dynamic combinatorial libraries are mixtures of compounds that e

63 ll lines can select functional peptides from combinatorial libraries based on the expression of tumor

64 Combinatorial libraries based on these pre-BCR proteins

65 cation of a new software tool CoLibri on 358 combinatorial libraries based on validated reaction prot

66 an RNA aptamer (RNA(11F7t)) selected from a combinatorial library based on its ability to bind facto

67 A posttranslational modification-randomized, combinatorial library based on the first 21 residues of

68 ding protein, N9, obtained by screening of a combinatorial library based on the ultra-stable Sso7d sc

69 ed 10 peptides selected from a 16,384-member combinatorial library based on their ability to permeabi

70 ble to high-throughput screening hit triage, combinatorial library-based affinity optimization, and d

71 roughput analysis of solid-phase synthesized combinatorial libraries by acquiring mass spectra from a

72 er 1,000,000 different peptides derived from combinatorial libraries can activate 172.10, yet the TCR

73 consumes <1 nanomole of each compound, large combinatorial libraries can be subjected to numerous sep

74 Such combinatorial libraries can now also be created and eval

75 To begin to address these issues, we used combinatorial library cloning to isolate pneumococcal po

76 A dynamic combinatorial library composed of racemic hydrazone-base

77 Two targeted chromogenic octapeptide combinatorial libraries, comprised of 38 pools each cont

78 the results of the MCSS calculations, small combinatorial libraries consisting of 10s or 100s of thr

79 ble Ab fragments (IgE-ScFvs) isolated from a combinatorial library constructed from PBMCs of a grass

80 a simple tripeptide "one-bead one-compound" combinatorial library containing 14 unnatural and 19 nat

81 y examining isobaric dipeptides as well as a combinatorial library containing 27 tripeptides.

82 cribe the design and synthesis of an encoded combinatorial library containing 39,304 unnatural small

83 A phage Fab display combinatorial library containing Fab genes from bone mar

84 The equilibrated dynamic combinatorial library contains, amongst various macrocyc

85 owth selection dynamics for Escherichia coli combinatorial libraries created by recursive multiplex r

86 of donor-acceptor [2]catenanes from dynamic combinatorial libraries (DCL) in water.

87 f-assembly of a specific member of a dynamic combinatorial library (DCL) may lead to self-replication

88 cally relevant macromolecules from a dynamic combinatorial library (DCL).

89 Dynamic combinatorial libraries (DCLs) are collections of struct

90 Dynamic combinatorial libraries (DCLs) are powerful tools for di

91 Reactive distillation of such dynamic combinatorial libraries (DCLs) isolates the most volatil

92 ow molecular weight acyclic and heterocyclic combinatorial libraries derived from amino acids, peptid

93 We generated a combinatorial library derived from spleen cells of a pat

94 A combinatorial library derived from the 12 best performin

95 of these substructures is common practice in combinatorial library design and has produced leads, the

96 ent, beta-sheet pore-forming peptides from a combinatorial library designed to mimic membrane-spannin

97 scaffold was used as a template in a focused combinatorial library, designed using the NMR SOLVE meth

98 methods for generating aptamers from random combinatorial libraries (e.g., systematic evolution of l

99 ino acids of ABD were randomized to create a combinatorial library enabling selection of high-affinit

100 A small, focused combinatorial library encompassing all possible permutat

101 aniline as a nucleophilic catalyst, dynamic combinatorial libraries equilibrate rapidly at pH 6.2, a

102 isolation of full-length IgG antibodies from combinatorial libraries expressed in E. coli.

103 Using peptide combinatorial libraries expressed in yeast, we have scre

104 he synthesis and permeability screening of a combinatorial library, followed by deconvolution of memb

105 e writing fields are used to prepare ternary combinatorial libraries for an efficient stepwise optimi

106 modeling to address issues such as designing combinatorial libraries for an entire class of targets a

107 tic search techniques, and methods to design combinatorial libraries for screening and selection.

108 Herein we report the use of mixture based combinatorial libraries for the rapid discovery of a ser

109 By the screening of a combinatorial library for inhibitors of nitric oxide (NO

110 ade of maternofetal transport by screening a combinatorial library for peptides that bind nonendothel

111 n effective chemistry for biological dynamic combinatorial library formation.

112 has formed the basis for the development of combinatorial libraries from which potent pore-forming p

113 a pTyr(992)-binding protein (SPY992) from a combinatorial library generated by mutagenesis of the Ss

114 In the first approach, we screened a combinatorial library generated by random mutagenesis of

115 peptides selected from one-bead-one-peptide combinatorial libraries has been developed.

116 y for "one-bead-one-compound" small molecule combinatorial libraries has been developed.

117 High-throughput screening of combinatorial libraries has evolved from studying large

118 al screening in a huge collection of virtual combinatorial libraries has led to the identification of

119 The combinatorial library/high-throughput screen protocols f

120 h throughput screening of our small molecule combinatorial library identified a class of benzoylnapht

121 ces, which when propagated downstream in the combinatorial library, improve the average quality of th

122 y assembled constructs, or into high-quality combinatorial libraries in only 2-3 d.

123 The possibility of filtering combinatorial libraries in order to maximize the probabi

124 er demonstrates the utility of mixture-based combinatorial libraries in the discovery of novel alpha-

125 ifs for CD4+ T cells using peptide synthetic combinatorial libraries in the positional scanning forma

126 npredictable structures, we prepared dynamic combinatorial libraries in which reversibly binding buil

127 ized and characterized from a single dynamic combinatorial library in water.

128 cell clones to positional scanning synthetic combinatorial libraries is analyzed with a mathematical

129 A new methodology for the construction of combinatorial libraries is described.

130 (iv) The combinatorial library is screened to identify the tighte

131 ivileged scaffold for dehydrogenase-targeted combinatorial libraries, it could also be used in a dire

132 notypic cell-based screen of kinase-directed combinatorial libraries led to the discovery of TWS119,

133 Analysis of separate dynamic combinatorial libraries made from one of six peptide-fun

134 ce of a novel self-replicator from a dynamic combinatorial library made from a threonine containing p

135 A general, combinatorial library method for the rapid identificatio

136 The "one-bead one-compound" (OBOC) combinatorial library method is highly efficient, especi

137 The combinatorial library method should be generally applica

138 The combinatorial library method should be readily applicabl

139 A combinatorial library method was developed to systematic

140 In the "one-bead one-compound" (OBOC) combinatorial library method, each compound bead display

141 In this work, we have developed a novel combinatorial library method, termed "enzyme-catalyzed l

142 Using a positional scanning combinatorial library method, we found that the optimal

143 ed the positional scanning synthetic peptide combinatorial library methodology to screen the p773-782

144 and 6 was identified by using a 352-compound combinatorial library microarrayed in quadruplicates on

145 rther tested using unpurified, mixture-based combinatorial libraries of >1000 compounds, yielding res

146 methods were used to design structure-based combinatorial libraries of antipicornaviral capsid-bindi

147 e strategy described here, we prepared large combinatorial libraries of artificial transcription fact

148 for moulding desired recognition sites uses combinatorial libraries of assemblies that are made of a

149 a1-BAR interaction, we functionally screened combinatorial libraries of BAR in which active site resi

150 or chemical synthesis and screening of large combinatorial libraries of bicyclic peptides displayed o

151 DNA shuffling generates combinatorial libraries of chimeric genes by stochastica

152 AutoClickChem can be used to produce large combinatorial libraries of compound models for use in vi

153 Large combinatorial libraries of cyclic peptides can now be ro

154 ersity by synthesizing one-bead-one-compound combinatorial libraries of cyclic tetrapeptide analogues

155 Combinatorial libraries of de novo amino acid sequences

156 Recent experiments with combinatorial libraries of de novo proteins have demonst

157 Through the screening of combinatorial libraries of dimeric iminodiacetic acid di

158 from the Sargasso Sea were determined using combinatorial libraries of dipeptides and N-acyl derivat

159 ction of protein binders from highly diverse combinatorial libraries of DNA-encoded small molecules i

160 tural homology to the immunoglobulin domain, combinatorial libraries of FN3 designed to date have pri

161 coded by genes assembled stochastically from combinatorial libraries of gene segments.

162 h-throughput screening and/or selection from combinatorial libraries of gene switch and circuit varia

163 tion without destroying it altogether, seven combinatorial libraries of green fluorescent protein var

164 ITCHY) is a novel tool for the generation of combinatorial libraries of hybrid proteins independent o

165 method should facilitate the construction of combinatorial libraries of inhibitors of neuraminidase a

166 Here, we study combinatorial libraries of La(2-x)Sr(x)CuO4-La2CuO4 bila

167 r segments are then ligated together to form combinatorial libraries of long uninterrupted open readi

168 s an in silico prescreen to generate focused combinatorial libraries of mCherry mutants.

169 ulation of bacteria can efficiently generate combinatorial libraries of new strains.

170 Combinatorial libraries of non-biological polymers and d

171 represents a powerful strategy for creating combinatorial libraries of open reading frames that dist

172 anization of membrane proteins and to screen combinatorial libraries of peptides for members that int

173 lices of membrane proteins and for screening combinatorial libraries of peptides for members that int

174 Combinatorial libraries of peptides such as those displa

175 l fidelity, it may be possible to synthesize combinatorial libraries of peptides that contain multipl

176 Screening of nonisotopic reagents used combinatorial libraries of peptidyl compounds, and the r

177 haracterization of large, chemically diverse combinatorial libraries of peptoids (N-substituted oligo

178 ve been shown to interact with proteins, and combinatorial libraries of peptoids have been useful in

179 naproxen and ibuprofen were measured for two combinatorial libraries of polymers prepared in the pres

180 evelop AIDS vaccine components, we generated combinatorial libraries of recombinant human rhinoviruse

181 dentification of cyclic peptide ligands from combinatorial libraries of reversible cyclic depsipeptid

182 ection of de novo heme proteins derived from combinatorial libraries of sequences designed to fold in

183 then filtered and prioritized, and finally, combinatorial libraries of target molecules were synthes

184 hesis of individual cyclic depsipeptides and combinatorial libraries of these compounds is proposed,

185 Chemically synthesized combinatorial libraries of unmodified or modified nuclei

186 method involves the comparative screening of combinatorial libraries of unnatural, synthetic molecule

187 ional regulatory domains, we developed large combinatorial libraries of zinc finger transcription fac

188 A small combinatorial library of 10 structurally related phenyle

189 A mixture-based combinatorial library of 14-membered macrocycles was syn

190 The combinatorial library of 20 compounds gave several compo

191 Using a combinatorial library of 24 GMS hosts and 26 guest molec

192 A combinatorial library of 400 serine protease inhibitors

193 1 nonreactive moieties, resulting in a small combinatorial library of 72 fragment-like compounds.

194 acted and used as scaffolds for generating a combinatorial library of 7912 tetrapeptides.

195 t led to changes in substrate specificity, a combinatorial library of approximately 6000 maltose bind

196 e and 2,2'-oxybis(ethylamine) form a dynamic combinatorial library of at least nine members.

197 A combinatorial library of beads bearing cell- and molecul

198 highly efficacious cellular activity, from a combinatorial library of bidentate benzofuran salicylic

199 Herein, we report a newly developed combinatorial library of cholesteryl-based disulfide bon

200 azobenzene building block produced a dynamic combinatorial library of cyclic oligomers, while multibu

201 eported the design and characterization of a combinatorial library of de novo beta-sheet proteins tha

202 ward achieving these goals, we constructed a combinatorial library of de novo proteins designed to fo

203 High-throughput screening of a combinatorial library of diamidophenols yielded lead com

204 A combinatorial library of dipeptide N-acylethylenediamine

205 We screened an existing combinatorial library of engineered ubiquitin variants f

206 A recent screen of a combinatorial library of fluorescent compounds discovere

207 istics of vaccine candidates isolated from a combinatorial library of human rhinoviruses displaying t

208 and experimental binding free energies for a combinatorial library of inhibitors of cathepsin D (CatD

209 Here, we developed a combinatorial library of ionizable lipid-like materials

210 (iii) A combinatorial library of linked binding elements is prep

211 We expressed a combinatorial library of monomeric M-CSF (M-CSFM) single

212 eps of the method are 1) initial design of a combinatorial library of N-methylated analogues of the s

213 roach: implementing and evaluating in vivo a combinatorial library of nanoparticles with distinct phy

214 We built a combinatorial library of NOR gates that directly convert

215 cing the effector domain of rapamycin with a combinatorial library of oligopeptides.

216 e improvements by assessing the effects of a combinatorial library of oncogenes and tumor suppressors

217 in, for example, plasma, is incubated with a combinatorial library of peptide ligands synthesized on

218 ify specific receptor-binding compounds in a combinatorial library of peptoids displayed on beads.

219 Described herein is the synthesis of a combinatorial library of potential proapoptotic agents a

220 A combinatorial library of quinone-polyamine conjugates de

221 profilin's essential properties, we built a combinatorial library of ScPFY variants containing eithe

222 ernate starter unit 3-hydroxybenzoic acid, a combinatorial library of six polyketide products is read

223 solfataricus; Sso7d-hFc was isolated from a combinatorial library of Sso7d mutants using yeast surfa

224 The preparation of a large combinatorial library of such compounds is also discusse

225 urfactants, we designed and screened a large combinatorial library of surfactant formulations, which

226 HyCoSuL is a combinatorial library of tetrapeptides containing amino

227 n-denaturing conditions to analyze a dynamic combinatorial library of thiols/disulfides with the BcII

228 d by our group, allowing the generation of a combinatorial library of tri-substituted purines by the

229 Mixture-based combinatorial libraries offer a cost-effective alternati

230 Mixture based synthetic combinatorial libraries offer a tremendous enhancement f

231 aradigm established for screening an encoded combinatorial library on polymeric support, an ECLiPS li

232 To design diverse combinatorial libraries or to select diverse compounds t

233 =0.85 similar to one already chosen for the combinatorial library or in the screening set.

234 In silico screening of combinatorial libraries prior to synthesis promises to b

235 endent assays: positional-scanning synthetic combinatorial library profiling and multiplex substrate

236 Protein combinatorial libraries provide new ways to probe the de

237 e synthesis of positional-scanning synthetic combinatorial libraries (PS-SCL) that does not depend on

238 HGFA using positional scanning of substrate combinatorial libraries (PS-SCL), which was used to disc

239 is the use of positional scanning synthetic combinatorial libraries (PS-SCLs).

240 T-cells and a positional scanning synthetic combinatorial library (PS-SCL) was used to analyze and r

241 Using the positional scanning-substrate combinatorial library (PS-SCL) we determined that TcAtg4

242 mixture-based positional-scanning synthetic combinatorial library (PS-SCL) with the alpha4/4-conotox

243 d positional scanning synthetic glycopeptide combinatorial library (PS-SGCL) that vary in number and

244 High-throughput assays using mixture-based combinatorial libraries represent a unique, highly effic

245 s suggesting that the Fabs selected from the combinatorial library represented a varied anti-DbpB imm

246 Positional scanning synthetic combinatorial libraries revealed Kaposi's sarcoma-associ

247 pplied to the cleanup of some representative combinatorial library samples with greater than 98% amin

248 tant for numerous applications, ranging from combinatorial library screening and protein engineering

249 Combining computational design, combinatorial library screening and rational mutagenesis

250 acid residues from positional scan synthetic combinatorial library screening data were synthesized.

251 This work presents the first approach on combinatorial library screening for heparin/heparan sulf

252 Previous combinatorial library screening has shown that FHA1 stro

253 st two-hybrid techniques, we first performed combinatorial library screening of "monobodies" (small a

254 Combinatorial library screening of yeast-displayed mutag

255 We deployed combinatorial library screening to isolate a binding-pro

256 After combinatorial library selection on EGFR ligands, a panel

257 cid based peptidic receptors, derived from a combinatorial library, served as the cross-reactive sens

258 ck and DEL reaction design and deployment in combinatorial library settings, providing a framework fo

259 for the chymotrypsin-like active site via a combinatorial library strategy.

260 describe a novel stepwise fluorophore-tagged combinatorial library synthesis and competitive fluoresc

261 access to novel chemical space by empowering combinatorial library synthesis with a "few good reactio

262 Powerful combinatorial library technologies have been developed t

263 Dynamic combinatorial libraries that equilibrate under thermodyn

264 creenings were performed with triazine-based combinatorial libraries that include various linkers as

265 tion of antibody agonists from intracellular combinatorial libraries that transdifferentiate human st

266 This approach has been used to characterize combinatorial libraries that were synthesized for a vari

267 entification of nine-residue peptides from a combinatorial library that inhibit the intracellular dim

268 ted epistasis constraints among them using a combinatorial library that revealed their individual and

269 Abandoning large combinatorial libraries, the focus has shifted to small,

270 ng billions of antibody variants in tailored combinatorial libraries, they are particularly applicabl

271 We have previously used mixture-based combinatorial libraries to identify hexapeptides that tr

272 strates will prove beneficial when designing combinatorial libraries to screen for artificial TOMMs t

273 We have used synthetic peptide combinatorial libraries to screen for hexapeptides that

274 have devised a method of using intracellular combinatorial libraries to select antibodies that contro

275 Two combinatorial libraries totaling 0.7 Mb were constructed

276 Screening 37 different mixture-based combinatorial libraries totaling more than five million

277 designing and filtering potentially massive combinatorial libraries using structural information of

278 ating stable and unstable RNA sequences from combinatorial libraries using temperature gradient gel e

279 isolated in a high throughput screening of a combinatorial library using bacterially made Omi-(134-45

280 rapidly prepared a high-quality beta-peptide combinatorial library via a split-and-mix strategy.

281 tion of the lead compounds, from the dynamic combinatorial library via magnetic decantation.

282 A positional scan synthetic combinatorial library was constructed based on the three

283 galanin and the tripeptidomimetic galnon, a combinatorial library was formulated, synthesized, and s

284 A combinatorial library was prepared and used to identify

285 ptimization process, a divergent and focused combinatorial library was synthesized using a polymer-su

286 Using selection from synthetic combinatorial libraries, we enhanced its affinity by >10

287 Using combinatorial libraries, we generated synthetic binding

288 collections for one-bead-one-compound (OBOC) combinatorial libraries, we have developed hnuSABR (Ligh

289 By screening synthetic peptide combinatorial libraries, we have identified two related

290 ing high throughput inhibitor screens with a combinatorial library, we have identified two novel clas

291 Four "one-bead one-compound" (OBOC) combinatorial libraries were designed, synthesized, and

292 These combinatorial libraries were separated and characterized

293 In this study, combinatorial libraries were used in conjunction with ul

294 ibility of DCC, single compounds and a small combinatorial library were prepared via the Fischer indo

295 We predicted that combinatorial libraries with alternative base compositio

296 on across compositional variations mapped on combinatorial libraries with minimal computational cost.

297 We have interfaced these hydrazone dynamic combinatorial libraries with two isozymes from the gluta

298 d de novo sequencing procedures and prepared combinatorial libraries with up to 100 million biohybrid

299 or the design and development of much larger combinatorial libraries with varied physicochemical prop

300 A combinatorial library with dipeptide linkers emanating s