ライフサイエンスコーパス: commensal bacteria

1 nted filamentous bacteria, but also by other commensal bacteria.

2 systemic dysbiosis of aerobic and anaerobic commensal bacteria.

3 also partially eliminate naturally existing commensal bacteria.

4 which recognizes the products of intestinal commensal bacteria.

5 t likely by enabling pathogens to outcompete commensal bacteria.

6 s disease susceptibility in mice depleted of commensal bacteria.

7 se from mouse liver, including reactivity to commensal bacteria.

8 exposed continuously to dietary antigens and commensal bacteria.

9 eyer's patches and produced IgAs reactive to commensal bacteria.

10 ith broad-spectrum antibiotics which disrupt commensal bacteria.

11 ns pallens) also impairs the survival of gut commensal bacteria.

12 onstant dialog between the immune system and commensal bacteria.

13 uired for control of CD4 T-cell responses to commensal bacteria.

14 als to the host that have been attributed to commensal bacteria.

15 intestine is densely populated by anaerobic commensal bacteria.

16 sis and shape mucosal immunity, similarly to commensal bacteria.

17 ber of microorganisms, generally regarded as commensal bacteria.

18 to the HIV Env gp41 and cross-reactive with commensal bacteria.

19 pathogen colonization by suppressing related commensal bacteria.

20 technology and probed their relationship to commensal bacteria.

21 tion were largely restored in the absence of commensal bacteria.

22 thological adaptive immune cell responses to commensal bacteria.

23 ntal factors, including signals derived from commensal bacteria.

24 alterations in the composition of intestinal commensal bacteria.

25 s under conditions allowed for the growth of commensal bacteria.

26 the continuous dialogue between the host and commensal bacteria.

27 ide (LPS) shed from Gram-negative intestinal commensal bacteria.

28 otic has reduced activity against intestinal commensal bacteria.

29 tous natural process of host colonization by commensal bacteria.

30 and the functional impact of IgA on mucosal commensal bacteria.

31 evolution and promotes genetic diversity of commensal bacteria.

32 heir accumulation and promoting dominance of commensal bacteria.

33 es a synergy between host immune defense and commensal bacteria.

34 gnize both erythrocyte I/i self-antigens and commensal bacteria.

35 vage pathways present in many pathogenic and commensal bacteria.

36 immune response and regulation of cutaneous commensal bacteria.

37 Relish response to both enteropathogenic and commensal bacteria.

38 ch has the unwanted side effect of depleting commensal bacteria.

39 ltaneously or individually in live anaerobic commensal bacteria.

40 epletes multiple immunologically significant commensal bacteria.

41 Importantly, depletion of commensal bacteria abrogates TLR5-dependent differences

42 ucociliary clearance and overgrowth of nasal commensal bacteria accompanied by neutrophil exudation.

43 How commensal bacteria acquire iron during gut inflammation

44 lic stress evokes significant penetration of commensal bacteria across the epithelium, which is media

45 To preserve this niche, commensal bacteria act with the host to prevent coloniza

46 Our results clarify how commensal bacteria affect hepcidin expression and reveal

47 nt of cancer, but it remains unclear whether commensal bacteria affect inflammation in the sterile tu

48 , underpins competition among pathogenic and commensal bacteria alike.

49 ntributing factors, including alterations in commensal bacteria, altered mucosal permeability, epithe

50 t11 expression were observed in mice lacking commensal bacteria, an effect that was reversed by conve

51 ectrum, leading to indiscriminate killing of commensal bacteria and accelerated evolution of drug res

52 ion, these mechanisms preserve the niche for commensal bacteria and assist the host in preventing inf

53 igh amounts in the gastrointestinal tract by commensal bacteria and can be absorbed into the bloodstr

54 that discriminates pathogenic bacteria from commensal bacteria and contributes to host defense in th

55 Interactions between potentially pathogenic commensal bacteria and cutaneous immunity are poorly und

56 zed IgG(+) B-cell clones that recognize both commensal bacteria and hematopoietic I/i self-antigens.

57 crobiome driven by low relative abundance of commensal bacteria and high relative abundance of potent

58 Co-evolution of gut commensal bacteria and humans has ensured that the micro

59 s reciprocal interactions between intestinal commensal bacteria and ILCs in the context of health and

60 Outside of the cancer field, alterations in commensal bacteria and immune function have been implica

61 enerically responsive to the presence of any commensal bacteria and innate in nature, as for IL-22-re

62 a pathogen and yet maintain tolerance toward commensal bacteria and innocuous dietary antigens.

63 ship that exists between the mammalian host, commensal bacteria and invasive pathogens can provide in

64 mmalian intestine is colonized by beneficial commensal bacteria and is a site of infection by pathoge

65 lated adaptive immune cell responses against commensal bacteria and low-grade systemic inflammation.

66 ely shape the symbiotic relationship between commensal bacteria and mammalian hosts.

67 en epithelial cells and prevents invasion by commensal bacteria and mucosal inflammation.

68 These IgAs react with commensal bacteria and oral antigens.

69 ent of the microbiome, and interactions with commensal bacteria and other microbial agents influence

70 Collectively known as the microbiota, the commensal bacteria and other microorganisms that coloniz

71 e may promote ecological competition between commensal bacteria and pathogenic species.

72 malian cells, as well as mechanisms by which commensal bacteria and pathogens maintain immune privile

73 , Muc2(-/-) mice showed increased killing of commensal bacteria and prevented intestinal bacterial ov

74 ognized role for T cells in controlling skin commensal bacteria and provide a mechanism to account fo

75 terize other organisms in the FGT, including commensal bacteria and sexually transmitted infections,

76 c mice were colonized with defined human gut commensal bacteria and subjected to predation by cognate

77 ILCs resulted in peripheral dissemination of commensal bacteria and systemic inflammation, which was

78 tic signalling molecules may be common among commensal bacteria and that manipulation of microbiota g

79 that, after conditioning therapy, intestinal commensal bacteria and the damage-associated molecular p

80 Regular interactions between commensal bacteria and the enteric mucosal immune enviro

81 Tgammadelta17 cells respond to skin commensal bacteria and the fulminant disease in their ab

82 se driven by dysbiosis, an imbalance between commensal bacteria and the host organism.

83 se mechanism to maintain homeostasis between commensal bacteria and the jejunal immune system.

84 s that govern the interactions between these commensal bacteria and their host remain poorly understo

85 Commensal bacteria and their products provide beneficial

86 tem constitutively senses vast quantities of commensal bacteria and their products through pattern re

87 deficiency, demonstrating the importance of commensal bacteria and TNF in the IEC Ripk1 knockout phe

88 inhibit colonization by specific subsets of commensal bacteria, and cooperatively maintain intestina

89 atory protein responses are dependent on the commensal bacteria, and more specifically, lipopolysacch

90 leum anti-gp41 antibodies cross-reacted with commensal bacteria, and of those, 43% showed non-HIV-1 a

91 with these VH4-34-encoded IgG clones binding commensal bacteria antigens.

92 ther than promote, inflammatory responses to commensal bacteria appears to be a central component of

93 Whether mutation and selection among commensal bacteria are associated with infection is unkn

94 Commensal bacteria are believed to have important roles

95 Thus, although commensal bacteria are capable of driving chronic inflam

96 hat control proper anatomical containment of commensal bacteria are essential to maintain tissue home

97 While the majority of commensal bacteria are found in the intestinal lumen, ma

98 glycolipid antigens derived from intestinal commensal bacteria are important hepatic NKT cell agonis

99 Commensal bacteria are known to provide colonization res

100 the numerous gut microbial species, certain commensal bacteria are known to provide health benefits

101 een gastrointestinal parasitic helminths and commensal bacteria are likely to play a pivotal role in

102 Commensal bacteria are necessary for the development and

103 investigate whether targeted pathogenic and commensal bacteria are related to risk of preterm birth

104 A major metabolic product of commensal bacteria are short-chain fatty acids (SCFAs) t

105 interest, such as lipid structures found in commensal bacteria, are emphasized.

106 xample of pathogen T6SS-dependent killing of commensal bacteria as a mechanism to successfully coloni

107 In this review, we propose that commensal bacteria associated with the mammalian GI trac

108 ial products (lipoteichoic acid) produced by commensal bacteria at the epithelial surface.

109 We have assembled a consortium of commensal bacteria belonging to the Clostridiales order,

110 Here we investigate how two commensal bacteria, Bifidobacterium longum and Bacteroid

111 However, the commensal bacteria bound by IgA are poorly characterized

112 umulating that IBD is influenced by not only commensal bacteria but also commensal fungi.

113 , maintaining homeostasis in the presence of commensal bacteria, but activating immune defenses in re

114 ction with Prevotella copri, an abundant gut-commensal bacteria, but not with the other commensals te

115 demonstrate exquisite targeting of distinct commensal bacteria by multiple layers of humoral immunit

116 ised and specific effector responses against commensal bacteria can develop.

117 conclude that serine proteases derived from commensal bacteria can directly impact the excitability

118 Therefore, bacteriocin expression by commensal bacteria can influence niche competition in th

119 Intestinal commensal bacteria can inhibit dense colonization of the

120 Commensal bacteria can interfere with colonization of th

121 Conversely, dysregulated localization of commensal bacteria can lead to inappropriate activation

122 rom host and environmental factors, and many commensal bacteria can produce multiple capsule types.

123 Thus, commensal bacteria can regulate viral regionalization al

124 However, selective species of commensal bacteria can reside within intestinal lymphoid

125 w B. thetaiotaomicron, and other major human commensal bacteria, can metabolize and potentially tailo

126 tyrate, which is secreted in high amounts by commensal bacteria, can modulate the function of intesti

127 Commensal bacteria co-exist on the mucosal surfaces of a

128 ting that, as is widely found in amphibians, commensal bacteria confer protection against this pathog

129 compared with their unmutated precursors, to commensal bacteria, consistent with antigen-driven selec

130 trate that a precisely defined consortium of commensal bacteria containing the Clostridium cluster XI

131 These findings indicate that commensal bacteria contribute to acute stress-induced in

132 Commensal bacteria contribute to immune homeostasis in t

133 imately 5%) escape into the colon, where gut commensal bacteria convert them into various intestinal

134 genesis is proposed, integrating the role of commensal bacteria, cutaneous immune responses, and comp

135 ytokines interleukin-22 and lymphotoxin in a commensal bacteria-dependent and -independent manner, re

136 e RORgammat(+) ILCs resulted in dysregulated commensal bacteria-dependent CD4(+) T-cell responses tha

137 interactions and highlight the influence of commensal bacteria-derived H(2)O(2) on host physiology.

138 rients and metabolites and discuss how these commensal bacteria-derived products may regulate the dev

139 ular and molecular mechanisms that recognize commensal bacteria-derived signals and regulate mammalia

140 In the context of infection, commensal bacteria-derived signals can influence the hos

141 t HDAC3 is a critical factor that integrates commensal-bacteria-derived signals to calibrate epitheli

142 Collectively, our data reveal a unique host-commensal-bacteria dialog whereby selective subsets of c

143 tabolites, presumably from pathogenic and/or commensal bacteria, distinguishes MAIT cells from peptid

144 However, the extent to which commensal bacteria diversify and adapt within the human

145 We report that TLR5-dependent commensal bacteria drive malignant progression at extram

146 disease in their absence was driven by skin commensal bacteria dysbiosis.

147 creen led to the identification of 26 unique commensal bacteria effector genes (Cbegs) that are predi

148 for the systematic identification of diverse commensal bacteria effectors that impact host cellular f

149 tigated whether oral administration of human commensal bacteria engineered to secrete GLP-1(1-37) cou

150 iza et al. (2016) uncover a new link between commensal bacteria, enteric glial cells, and ILC3s that

151 Recently, enteric commensal bacteria Enterobacter cloacae has been recogni

152 d influenza A virus infection occurring upon commensal bacteria eradication is efficiently overturned

153 Commensal bacteria, especially segmented filamentous bac

154 Our results indicate that coinfecting commensal bacteria exacerbate C. albicans infection thro

155 . albicans and nonfermentative gram-negative commensal bacteria exhibited increased fungal burden and

156 Commensal bacteria express factors that support coloniza

157 block HIV-1 infection and transmission with commensal bacteria expressing antiviral proteins are bei

158 dole, which is produced from l-tryptophan by commensal bacteria expressing tryptophanase, not only is

159 S and increased survival of oxygen-sensitive commensal bacteria (Faecalibacterium prausnitzii and Ros

160 gical conditions, IECs acquire antigens from commensal bacteria for generation of T cell responses to

161 for identifying potential mechanisms used by commensal bacteria for host interactions and outlines a

162 Commensal bacteria-free animals have thymocyte maturatio

163 B cells that bound both apoptotic cells and commensal bacteria from healthy adults.

164 Commensal bacteria from the Bacteroidetes phylum also pr

165 the inner mucus layer separates the numerous commensal bacteria from the epithelial cells.

166 Commensal bacteria from the skin and mucosal surfaces ar

167 uctures are abundant on epithelial cells and commensal bacteria, further emphasizing the relevance of

168 The ubiquitous commensal bacteria harbour genes of antimicrobial resist

169 The prevalence of such genes in commensal bacteria has been increased in recent years by

170 Although obligate anaerobic commensal bacteria have been associated with colonizatio

171 Commensal bacteria have been identified as critical driv

172 these nutrients and metabolites derived from commensal bacteria have been implicated in the developme

173 Commensal bacteria have begun to receive much attention

174 It is known that commensal bacteria have evolved a number of mechanisms t

175 g pathway and subsequent maintenance of host-commensal bacteria homeostasis in a demethylase-dependen

176 Overall, TNFR2 blockade appears to disrupt commensal bacteria-host immune symbiosis to reveal autoi

177 These data support the role of H(2)O(2) in commensal bacteria-host interactions and highlight the i

178 Commensal bacteria impact host health and immunity throu

179 GH164 genes are present in several commensal bacteria, implicating these genes in the degra

180 Reintroduction of commensal bacteria in a murine model of enterococcal col

181 terial activity and that S Typhimurium kills commensal bacteria in a T6SS-dependent manner.

182 nal beta diversity and relative abundance of commensal bacteria in antibiotic treated mice.

183 22 tipped the balance between pathogenic and commensal bacteria in favor of a pathogen.

184 n mesenteric lymph nodes and more IgA-coated commensal bacteria in feces of DeltaDC mice.

185 Enterococcus faecalis strains are commensal bacteria in humans and other animals, and they

186 ibution of eosinophils to a response against commensal bacteria in IBD.

187 tained MYD88-dependent signalling induced by commensal bacteria in liver sinusoidal endothelial cells

188 tly labeled bacteria, we found that entry of commensal bacteria in Peyer's patches (PP) via the M cel

189 Is inhibited proliferation of specific human commensal bacteria in radial diffusion assays.

190 uggest a critical role for Cxcr2, Cxcl5, and commensal bacteria in regulation of the IL-17/G-CSF axis

191 e prenatal environment and early exposure to commensal bacteria in shaping the host immune system and

192 The selectivity of the commensal bacteria in stress-evoked IL-1beta and IL-18 r

193 these results demonstrate the importance of commensal bacteria in supporting anticancer immune surve

194 erji et al. now report a surprising role for commensal bacteria in the circadian regulation of glucoc

195 Commensal bacteria in the gastrointestinal tract are cru

196 lso affects the composition and diversity of commensal bacteria in the gut.

197 ow HIV infection might change the balance of commensal bacteria in the gut.

198 elative to the fast-paced research examining commensal bacteria in the intestine.

199 virus can replace the beneficial function of commensal bacteria in the intestine.

200 tary nitrate, serially reduced to nitrite by commensal bacteria in the oral cavity and subsequently t

201 ensor appears to be conserved among numerous commensal bacteria, in contrast with numerous Gram-posit

202 Commensal bacteria, in particular, are key participants

203 ivergence was reconciled by the finding that commensal bacteria, including Escherichia coli, stimulat

204 ivo model to reveal protective mechanisms of commensal bacteria, including those relevant to mammalia

205 Commensal bacteria induce epithelial fucosylation, and e

206 remains unclear whether specific subsets of commensal bacteria induce inflammatory bowel diseases in

207 Commensal bacteria influence host physiology, without in

208 The majority of commensal bacteria inhabit the gastrointestinal tract an

209 e, revealing a more complex picture in which commensal bacteria inhibit viral infection of the proxim

210 bacteria dialog whereby selective subsets of commensal bacteria interact with dendritic cells to faci

211 We propose that binding of free SC to commensal bacteria is a key and conserved mechanism for

212 ommunication between pathogenic bacteria and commensal bacteria is a subject of growing interest.

213 lthy tissue, the neutrophil response to oral commensal bacteria is associated with the select express

214 and colleagues demonstrate that tolerance to commensal bacteria is established during the neonatal pe

215 tion between the mammalian immune system and commensal bacteria is necessary to limit chronic inflamm

216 pathways are fine-tuned by diverse cues from commensal bacteria is not well understood.

217 Whereas the symbiotic contribution of commensal bacteria is well established, the role of euka

218 we demonstrate that lymphoid-tissue-resident commensal bacteria (LRC) colonized murine dendritic cell

219 nction of the immune system, suggesting that commensal bacteria may influence host immunity via nutri

220 results also indicate that interactions with commensal bacteria may inhibit HSV infection, underscori

221 Once ingested, oral commensal bacteria may reduce nitrate to nitrite, which

222 Immunomodulatory commensal bacteria modify host immunity through delivery

223 by antibiotic treatment since secretions by commensal bacteria modulate primary to secondary bile sa

224 ere found using the device developed between commensal bacteria (no infection) and bacteria inoculate

225 nflammation and disrupt the intestinal niche commensal bacteria occupy.

226 Commensal bacteria of low virulence are capable of produ

227 vars and other common respiratory pathogenic/commensal bacteria of pigs.

228 It is suggested that the commensal bacteria of the digestive tract may play a rol

229 eliminary study examined the contribution of commensal bacteria on neutrophil location across the too

230 The impact of commensal bacteria on the host arises from complex micro

231 Recolonization of GF mice with commensal bacteria or administration of lipopolysacchari

232 knockout mice with antibiotics, implicating commensal bacteria or bacterial products in the etiology

233 oteins are highly enriched in pathogenic and commensal bacteria, our work indicates that CRISPR/Cas-m

234 Here, we report that commensal bacteria, particularly members of the genus La

235 udy investigates the interaction of tSC with commensal bacteria, pathogenic bacteria and a fungal pat

236 that MVs isolated from the human lactic acid commensal bacteria Pediococcus pentosaceus suppressed Ag

237 Commensal bacteria protect against invading pathogens us

238 Site-specific commensal bacteria provide key signals ensuring host def

239 inal selection whereby MHCII(+) ILC3 deletes commensal bacteria-reactive CD4 T cells.

240 To better understand how commensal bacteria regulate food allergy in humans, we c

241 Here we review the current knowledge of how commensal bacteria regulate the production and bioavaila

242 ity and the mucosal immune system by sensing commensal bacteria, regulating microbial ecology, establ

243 ulation that orchestrates some of these host-commensal bacteria relationships that can impact immunit

244 al bacteria that result in dysregulated host-commensal bacteria relationships.

245 The identification of antibiotics sparing commensal bacteria remains an ongoing challenge.

246 The survival of commensal bacteria requires them to evade host peptidase

247 mucosal B cells dictates the composition of commensal bacteria residing within the intestine.

248 HuNoV replicates in human B cells, and that commensal bacteria serve as a cofactor for this infectio

249 of Th17 cells differentiating in response to commensal bacteria (SFB) to those differentiating in res

250 It has been shown in the mouse that oral commensal bacteria significantly contribute to clinicall

251 these results define a selection pathway for commensal bacteria-specific CD4(+) T cells in the intest

252 ng T-cell proliferation, ILCs acted to limit commensal bacteria-specific CD4(+) T-cell responses.

253 ns, the mechanisms that control selection of commensal bacteria-specific T cells remain poorly unders

254 LC3s directly induce cell death of activated commensal bacteria-specific T cells.

255 mple, we and others previously reported that commensal bacteria stimulate acute and persistent murine

256 Further, commensal bacteria stimulate the host's immune defenses

257 Mechanistically, commensal bacteria stimulated Myd88-dependent IL-1beta a

258 ng an inflammatory response in the gut, some commensal bacteria such as E. coli can thrive and contri

259 the concept that SIgA-mediated monitoring of commensal bacteria targeting dendritic cells in the sube

260 art by the relationship of the organism with commensal bacteria that affect inflammation with both lo

261 nzae (NTHi) are closely related upper airway commensal bacteria that are difficult to distinguish phe

262 ract is colonized by trillions of beneficial commensal bacteria that are essential for promoting norm

263 Neisseria meningitidis is one of the few commensal bacteria that can even cause large epidemics o

264 Staphylococci are commensal bacteria that colonize the epithelial surfaces

265 ost glycosylation thus fosters the growth of commensal bacteria that compete with C. difficile for th

266 A four-strained consortium of commensal bacteria that contains Blautia producta BP(SCS

267 preinfection memory B cell pool triggered by commensal bacteria that cross-react with Env.

268 th our abilities to culture and sequence the commensal bacteria that dwell on and within a host, we c

269 We conclude that commensal bacteria that have acquired ARGs can mediate s

270 nsal segmented filamentous bacteria or human commensal bacteria that induce intestinal TH17 cells wer

271 Commensal bacteria that interact with a eukaryotic host

272 However, the specific commensal bacteria that promote host resistance and immu

273 017) define a precise, limited consortium of commensal bacteria that restores resistance to colonizat

274 ations in the composition or localization of commensal bacteria that result in dysregulated host-comm

275 orption of the alveolar bone and mediated by commensal bacteria that trigger host immune responses an

276 lamina propria macrophages hyporesponsive to commensal bacteria through the down-regulation of proinf

277 ens have evolved mechanisms that can utilize commensal bacteria to establish a replicative advantage

278 with impaired epithelial integrity, enables commensal bacteria to function as highly pathogenic orga

279 s, it is mutually beneficial to the host and commensal bacteria to inhibit a pathogen's ability to es

280 Attine ants use antimicrobials produced by commensal bacteria to inhibit parasites on their fungal

281 ng VRE, administration of obligate anaerobic commensal bacteria to mice results in a billionfold redu

282 macromolecules are critical for adherence of commensal bacteria to mucus but structural information i

283 The ratio of commensal bacteria to opportunistic pathogens was higher

284 cellular and molecular pathways activated by commensal bacteria to protect against allergic sensitiza

285 lecule and illustrates the lifelong value of commensal bacteria to their host.

286 studies revealed that IL17A synergized with commensal bacteria to trigger Ikkepsilon phosphorylation

287 Given the antagonistic behavior of commensal bacteria toward their pathogenic relatives, we

288 lammatory CD4(+) T cell responses to self or commensal bacteria underlie the pathogenesis of autoimmu

289 e is known about the specific effectors that commensal bacteria use to interact with the human host.

290 s infectivity without affecting host cell or commensal bacteria viability.

291 n gut microbiota composed of fully sequenced commensal bacteria, we elucidated the functional interac

292 Commensal bacteria were characterized in uninfected GC-C

293 memory B cells are repeatedly stimulated by commensal bacteria, were similar between Zbtb32(-/-) mic

294 population specialized in the containment of commensal bacteria when gut barriers are breached.

295 the cytokine production of PBMCs induced by commensal bacteria when these cells were primed by C. al

296 in the number and composition of intestinal commensal bacteria, which leads to susceptibility to opp

297 Future application of MGEfinder to commensal bacteria will further illuminate bacterial ada

298 Overall, our data suggest that defined gut commensal bacteria with a propensity to induce TH17 cell

299 are now a handful of examples of intestinal commensal bacteria with defined immunomodulatory propert

300 urrent study is to compare the prevalence of commensal bacteria, with beneficial properties, for heal