ライフサイエンスコーパス: commitment

1 fever-mediated modulation of their cytokine commitment.

2 genomic position and the kinetics of lineage commitment.

3 ulating balance between HSC self-renewal and commitment.

4 ecome primed for recombination during B cell commitment.

5 subsets at the earliest stages of T lineage commitment.

6 expression, genomic stability, and cell fate commitment.

7 ovided deep, consistent long-term regulatory commitment.

8 ereas loss of esr2b impaired biliary lineage commitment.

9 the balance between pluripotency and lineage commitment.

10 and progenitor cell maintenance and lineage commitment.

11 uberculosis (Mtb) directly regulates myeloid commitment.

12 iferation, and biases MEPs toward Mk lineage commitment.

13 in regulating the haemopoietic cell lineage commitment.

14 tworks that influence cell fates and lineage commitment.

15 iciently from the proliferative stage toward commitment.

16 This ultimately induces osteogenic fate commitment.

17 t a direct role for CSF1R in myeloid lineage commitment.

18 on trajectory during early stages of lineage commitment.

19 e position checkpoint in maintaining meiotic commitment.

20 ESCs) must be reconfigured to enable lineage commitment.

21 ion between cells that is also necessary for commitment.

22 toplasmic role for Yap in epithelial lineage commitment.

23 l physiological parameters drives cell cycle commitment.

24 induced MSC differentiation prior to lineage commitment.

25 gulator of sexual conversion, as a marker of commitment.

26 thymocytes leading to the CD4 helper lineage commitment.

27 corresponding to around 20 cm or 1/5 of that commitment.

28 tilineage priming followed by gradual T cell commitment.

29 8 had no effect on cell stability or lineage commitment.

30 NT and FGF signaling to regulate MSC lineage commitment.

31 properties followed by gradual shifts toward commitment.

32 endent support during activation and lineage commitment.

33 we asked if checkpoints could ensure meiotic commitment.

34 step transitions in the early T cell lineage commitment.

35 on model of CD4(+) and CD8(+) T cell lineage commitment.

36 minating a mechanism of age-specific lineage commitment.

37 tive lineage genes is critical for cell fate commitment.

38 ition initiates S phase entry and cell cycle commitment.

39 ammary gland development and luminal lineage commitment.

40 priming of HSCs/MPPs prior to their lineage commitment.

41 independently and can occur prior to lineage commitment.

42 ms precede cell fate stabilization and final commitment.

43 ng of regulatory events leading to cell fate commitment.

44 ving as a potential early marker of ASC fate commitment.

45 macologically induce a shift toward terminal commitment.

46 nducer CDK1, regulates the critical size for commitment.

47 in accessibility may prime cells for lineage commitment.

48 ouseholds (>98%) were willing to accept this commitment.

49 plication of the centrality of collaborative commitment.

50 tives for balancing self-renewal and lineage commitment.

51 r students who have family, work, or housing commitments.

52 nment policy, public discourse, and industry commitments.

53 s emissions in accordance with China's Paris commitments.

54 romised to reduce under their Kyoto Protocol commitments.

55 ) joint intentional collaboration; (2) joint commitment; (3) "self-regulative pressure from 'we'"; an

56 key biological processes including cell fate commitment, 3D chromatin organization and transcription

57 Therefore, Tfap2 is a regulator of germ cell commitment across germ line-sequestering and germ line-n

58 xhibit decreased proliferation and Mk-biased commitment after knockdown of transferrin receptor 2, a

59 One proposed solution is a matching-commitment agreement, through which countries can change

60 Matching-commitment agreements are attractive because they do not

61 Here, we study matching-commitment agreements between two heterogeneous countrie

62 We find that existing commitments alone could reduce emissions 25% below 2005

63 n mediating the splicing networks of lineage commitment, alteration of which may be involved in early

64 e students' show that even with minimal time commitment, an impactful science communication training

65 tance and mindfulness procedures, along with commitment and behavior change strategies, to increase p

66 Expression of miR-34a occurs upon luminal commitment and differentiation and serves to inhibit the

67 ganoid system induced an orderly sequence of commitment and differentiation from PSC-derived embryoni

68 s of progenitor cell proliferation, myogenic commitment and differentiation, myocyte fusion, and myot

69 ed interactions as a consequence of myogenic commitment and differentiation.

70 s appropriate CD8(+) T cell lineage-specific commitment and differentiation.

71 perate to inhibit genes involved in neuronal commitment and differentiation.

72 r our results support views that termination commitment and DNA release are separate steps and that R

73 the functional role of PfAP2-G during sexual commitment and early gametocytogenesis.

74 generated a single cell map of early lineage commitment and found that SDS hematopoiesis was left-shi

75 l disagreements related to tuft cell lineage commitment and function.

76 olecular determinants that reinforce lineage commitment and help resist cell fate changes.

77 Here I outline my understanding of joint commitment and its normative impact.

78 signaling is critical for melanocyte lineage commitment and melanoma development.

79 ssed expression of key regulators of lineage commitment and neurogenesis (REST and ASCL1/hASH1).

80 helial cells (cTECs) regulate T cell lineage commitment and positive selection, while medullary (m) T

81 evidence that TGF-beta disrupts the lineage commitment and promotes the accumulation of tumor-initia

82 hat enhancer potential is reset upon lineage commitment and show how pervasive epigenetic priming ste

83 that Fam3a is required for muscle stem cell commitment and skeletal muscle development.

84 ding of NONO in stem cell functions, lineage commitment and specification.

85 alamic progenitors and contribute to lineage commitment and subtype-specific neuronal identifies, but

86 However, its function in neuronal lineage commitment and the molecular mechanisms of its action in

87 Lineage commitment and tumorigenesis, traits distinguishing stem

88 red pathway that controls liver cell lineage commitment and whose dysregulation may play a role in bi

89 to interrogate HSC self-renewal and lineage commitment and, more broadly, to study and characterize

90 t together direct stem cell renewal, lineage commitment, and differentiation.

91 a-driven decision making, political will and commitment, and international unity.

92 stem cells and is important both for lineage commitment, and reprogramming to naive pluripotency.

93 multaneously with temptations, without prior commitment; and that use of it is limited by its cost, c

94 relationship quality were perceived-partner commitment, appreciation, sexual satisfaction, perceived

95 that the engagement steps prior to substrate commitment are fast relative to subsequent deubiquitinat

96 A new plan and new political commitment are needed if these global health aspirations

97 Organisational and service-wide commitment are needed to create the culture and context

98 timately govern stiffness-dependent NSC fate commitment are not fully understood.

99 poststarvation, but the mechanisms governing commitment are unknown.

100 s towards total asbestos bans and government commitments are needed.

101 However, the time commitment associated with MICT is a potential barrier t

102 e for H3K9me3 heterochromatin during lineage commitment at the onset of organogenesis and for lineage

103 oietic cells, contributes to the MEP lineage commitment bias observed in Tmprss6-/- mice.

104 hereas deletion following eosinophil lineage commitment blunted the decrease in EoPs without increasi

105 ritical not only for HSC differentiation and commitment but also for HSC homeostasis.

106 in a cell-autonomous manner to regulate the commitment but not the maintenance phase of beige adipog

107 Tomasello frequently refers to joint commitment, but does not fully characterize it.

108 hat express Wnt4, an early marker of nephron commitment, but migrate back into the progenitor populat

109 t EPHA2 maintains pluripotency and restrains commitment by antagonising ERK1/2 signalling.

110 Increased commitment by endemic countries, when possible, around t

111 t into action and will require unprecedented commitment by scientists to engage with communities of p

112 multigenerational inheritance, and timing of commitments-can instead be explained by simple stochasti

113 ive theory of ownership includes ontological commitments, causal-explanatory reasoning, and unobserva

114 During lineage commitment, chromatin accessibility at DORCs precedes ge

115 % to 101%) when the sales offer included the commitment, compared to a 23% decrease (95% CI = 14% to

116 % of the population of the 18 initial FP2020 commitment countries in the region.

117 Considering the ambitious commitments currently set by governments, annual emissio

118 e of granulocytic specification but not post-commitment defects in innate immune effector function, a

119 rmancy in brown adipocytes but not for their commitment, differentiation, or cold-induced activation.

120 e effect of BMP2/4 on adipose precursor cell commitment/differentiation.

121 leadership, job performance, organizational commitment, effort and reward style has been identified

122 capacity of PSC cultures and emerge prior to commitment events or phenotypes associated with pluripot

123 ective in somatic differentiation or meiotic commitment expressed transcripts normally present in ear

124 icted to various Vgamma subsets are known, a commitment factor essential to all Tgammadelta17 cells h

125 tudies indicate that SOX3 functions as a pro-commitment factor in spermatogonial stem/progenitor cell

126 ion, and repression of the terminal myogenic commitment factor Myogenin.

127 key paraxial mesoderm and skeletal myogenic commitment factors-mesogenin 1 (Msgn1), T-box 6 (Tbx6),

128 yte production, suggesting higher gametocyte commitment following IBSM.

129 reasingly implemented, with growing national commitments for MPA expansion.

130 hibit plasticity in altering their endocrine commitment; for example, by switching from secretion of

131 It will take continued effort and commitment from key stakeholders such as health care pro

132 distinct stages to guide eosinophil lineage commitment from the GMP and suppress the neutrophil prog

133 wed altered expression of fibroblast lineage commitment genes in fibroblasts undergoing MEndoT.

134 pression of p53 and most endothelial lineage commitment genes were upregulated in MEndoT-derived cell

135 threatened Brazilian Atlantic Forest, where commitments have been made to restore 1 million hectares

136 After commitment, however, inhibiting clamp movements slowed r

137 6 cm (12 cm) of the projected sea-level-rise commitment in 2300 can be attributed to emissions from t

138 c (few minutes) and chondrogenic (3-4 hours) commitment in contrast to osteogenic and basal cultured

139 n markedly increases with eosinophil-lineage commitment in eosinophil progenitors (EoPs), downstream

140 ning alternative lineage gene repression and commitment in lymphocytes are largely unknown.

141 34a, controlling both proliferation and fate commitment in mammary progenitors by modulating several

142 modimer is sufficient to drive robust neural commitment in pluripotent cells, even under non-permissi

143 role for E2A in establishing neural lineage commitment in pluripotent cells.

144 oid differentiation, but its role in lineage commitment in the liver has not been investigated.

145 f either PKS or GCM revealed spatial lineage commitment in the transition from bilaterality of the la

146 g increased suppressive function and lineage commitment in thymic-derived T(REG) cells and potentiati

147 the financial requirements for meeting this commitment in urban settings of low-income countries.

148 marks the earliest stages of B-cell lineage commitment in utero.

149 This suggests that the adult lineage commitments in the five outgrowths of the hydropore in t

150 Cell fate commitment involves the progressive restriction of devel

151 Although T cell commitment is accompanied by large scale epigenetic chan

152 st that the ThPOK-induced CD4 helper lineage commitment is strongly influenced by TCR signal strength

153 ent, organizational commitment, professional commitment, job stress, patient satisfaction, patient-nu

154 Nono deletion impedes neuronal lineage commitment largely due to a failure of up-regulation of

155 are building at faster rates and that higher commitment leads to higher growth rates.

156 Their stronger lineage commitment makes tTreg cells the safest cells to use in

157 Here, we provide lineage commitment maps of HSC clones under homeostasis and afte

158 We propose that early commitment may be a feature of BMP-driven fate choices a

159 ection theory, these changes in the level of commitment might correspond to shifts in the subject's d

160 This Primer considers the various levels of commitment neuroscientists have to the neuronal process

161 The commitment of a cell to differentiate into a particular

162 pression on differentiated myocytes promotes commitment of adjacent myoblasts to terminal differentia

163 BCR with Ags triggers signaling pathways for commitment of B lymphocyte responses that can be regulat

164 sis has been linked to heightened osteogenic commitment of bone marrow stromal cells (BMSCs).

165 Sox9 in Jag1(+/-) livers impairs the biliary commitment of cholangiocytes and enhances the inflammato

166 DPP4+ cell identity and inhibits adipogenic commitment of DPP4+ and CD142+ cells.

167 at contribute to the development and lineage commitment of hematopoietic cells.

168 R inhibits their T cell potential and enacts commitment of HR(+)ETPs to thymic resident CD11c(+)CD8al

169 An early commitment of IRES/ribosome complexes for global pre-tra

170 e show that Hippo signaling promotes lineage commitment of lung epithelial progenitors by curbing Fgf

171 port the hypothesis that low iron biases the commitment of megakaryocytic (Mk)-erythroid progenitors

172 enin signaling regulates the maintenance and commitment of mesenchymal nephron progenitors during kid

173 -mesenchymal transition (EMT) factors in the commitment of metastasis have not been well characterize

174 e completely restored the CD4 helper lineage commitment of MHCII-specific Thpok (-/-) thymocytes.

175 light entrains circadian clocks without any commitment of other Bmal1-dependent clocks, and a memory

176 and WNT pathways collaborate to trigger the commitment of proliferative progeny by fueling LEF1- and

177 This pathway is important for both the commitment of SSCs to osteoprogenitors and their subsequ

178 piration and other newer techniques, and (5) commitment of stakeholders to use of guideline documents

179 monized high-quality studies and by a united commitment of the scientific community to share personal

180 nhanced the suppressive capacity and lineage commitment of these cells in vitro and in vivo.

181 reening in the axolotl requires an extensive commitment of time and space.

182 programming enhanced the endothelial lineage commitment of WJ-MSC and increased the vasculogenic pote

183 Today, the commitment of young scientists to public service is at a

184 the polarized yet updateable group effector commitment often observed in vivo are all explained by t

185 global cause of concern, requiring a greater commitment on the full implementation of the WHO Framewo

186 ion factors play important roles in the fate commitment or differentiation of specific ARC neuronal t

187 ng our ability to monitor the impact of such commitments over time.

188 e and lineage bias and uncovered the lineage commitment pathways that lead HSC clones to different le

189 Leading up to and during the commitment period, dev mRNA increased in wild type, but

190 quiescent cells in G0, revealing a possible commitment point and a cryptic stochasticity in an other

191 trient-rich medium is added before a defined commitment point in mid-prometaphase I, they can return

192 RNA-velocity analysis identifies a commitment point that separates the plastic basal and tr

193 Cells in stages beyond the commitment point will finish meiosis, even with nutrient

194 ovide a new perspective on the concept of a "commitment point" during the growth of Chlamydomonas cel

195 nt-rich medium addition at stages beyond the commitment point, cells that are deficient in both check

196 s inactivate APC/C(CDH1) and cross the final commitment point.

197 stinct sensing periods, giving rise to three Commitment Points for S phase entry (CP1-3).

198 ment, structural empowerment, organizational commitment, professional commitment, job stress, patient

199 s showing that the expression of key lineage commitment regulators, GATA1, GATA2 and PAX5 were dysreg

200 ecular switch acts to drive progressive cell commitment, remodeling the epigenomic landscape to defin

201 to form partnerships with teachers, the time commitment required for the presenting scientist, and th

202 Lymphocyte lineage specification and commitment requires the activation of lineage-specific g

203 fer for a spare LPG cylinder on a reversible commitment requiring initially disabling indoor chulhas.

204 ht on the intricacies underlying ETP lineage commitment, reveal a novel, to our knowledge, function b

205 as an important determinant of chondrogenic commitment, reveal a role for FOXO transcription factors

206 fap2-g transcripts, indicative of gametocyte commitment (rho = 0.62; P = 0.002).

207 pathway regulates division number as well as commitment size.

208 CD2 expression defined T cell commitment stages where loss of B cell potential precede

209 comprised of a spectrum of specification and commitment states characterized by multilineage priming

210 ompanies and governments with sustainability commitments struggle to understand their own sourcing pa

211 programs controlling erythropoietic lineage commitment, suggesting a role for O-GlcNAcylation in reg

212 es are essential for inducing T cell lineage commitment, T cell positive selection and the establishm

213 motivating extraordinary levels of in-group commitment that can promote extreme behaviors and endure

214 e first gene regulatory network of cell fate commitment that integrates temporal protein stoichiometr

215 and telomere integrity in stem cell lineage commitment that may have implications in aging and cance

216 actor PfAP2-G is a key determinant of sexual commitment that orchestrates this crucial cell fate deci

217 proving this list is a long-term, high-value commitment that will require a collaborative approach in

218 incentivize both countries to make matching commitments that in turn incentivize efficient emissions

219 Acceptance and commitment therapy (ACT) is a psychological intervention

220 otiating practices of acting jointly and the commitments they underwrite.

221 ion of gene expression during stem cell fate commitment through the utilization of metabolic intermed

222 liferation of stem cells and prevented their commitment to a hair follicle lineage.

223 is limited by loose terminology, and by its commitment to a view of the child learner as inference-m

224 llective material gain, but because of their commitment to abstract moral and sacred ideas.

225 ents' care experience require organizational commitment to addressing cost concerns, clear roles and

226 Commitment to and adherence with recommended infection p

227 m their identities in the thymus and undergo commitment to become T cells.

228 and histone deacetylase (HDAC) essential for commitment to both the T cell and the innate lymphoid ce

229 e expression in late G1 phase that underlies commitment to cell division, termed Start.

230 asts exhibit a previously unidentified early commitment to cholangiocyte fate.

231 anical stimuli that lowers the threshold for commitment to chondro/osteogenic lineages.

232 Development of robust policies and commitment to collaboration among professional organizat

233 the coordinated RT changes during cell fate commitment to create highly complex RT networks composed

234 Upon commitment to crossover repair, MutLgamma-Exo1 associate

235 re is increased awareness and organisational commitment to dementia-friendly healthcare in general ho

236 impact of ethnic antagonism on Republicans' commitment to democracy underlines the significance of e

237 ll phenotype in vitro, and will also enhance commitment to differentiation in WT cells.

238 accumulation driven by an impaired molecular commitment to differentiation, which was associated with

239 out delays differentiation and prevents fast commitment to differentiation.

240 e GATA3-BMP4 axis induces fast, irreversible commitment to differentiation.

241 beyond, we recommend that SER strengthen its commitment to diversity, inclusion, and equity by: 1) in

242 ntensity should be considered in meeting its commitment to emission reductions.

243 e potential to achieve the UNAIDS Fast Track commitment to end AIDS by 2030.

244 well as science more generally, and show our commitment to ensuring gender diversity within the journ

245 etal liver, impeding a key step required for commitment to erythroid maturation.

246 ple living with HIV-1 burdened by a lifelong commitment to expensive daily medication.

247 ific community will be accelerated through a commitment to findable, accessible, interoperable, and r

248 involved in initiating macropinocytosis, the commitment to forming a macropinosome and the handling o

249 istent with the American Heart Association's commitment to health equity and its focus on social dete

250 In addition, we show that pDC commitment to IFN-I production was marked early on by th

251 er temperature (39 degrees C), they enhanced commitment to IL4/5/13 (Th2) and away from IFNg (Th1).

252 ndritic cell lineage potential and enforcing commitment to ILC fate.

253 sectoral poverty reduction strategies; and a commitment to improving girls' education.

254 al quiescence associated with maturation and commitment to iNKT1 cells by suppressing proliferation a

255 This updated statement affirms ASCO's commitment to moving beyond descriptions of differences

256 myf5 and myod genes, which are required for commitment to myogenesis.

257 , one should also consider people's sense of commitment to non-human entities, such as ideals, values

258 l beta, when bound to a lesion, has a strong commitment to nucleotide incorporation and thus repair.

259 that the basal ganglia control the level of commitment to particular motor or cognitive outcomes bas

260 onment relies on sustained research support, commitment to providing the requisite mentoring, access

261 s' humanitarian stance and positive national commitment to pursuing universal health coverage (UHC).

262 es at reproductive maturity, indicating that commitment to reproduction is detrimental to somatic hea

263 Global commitment to sustainability and demands for a sustainab

264 obust expression of TOX therefore results in commitment to T(ex) cells by translating persistent stim

265 g to increased self-renewal and reduced HSPC commitment to the B cell lineage.

266 Commitment to the CD4 or CD8 lineage is determined by wh

267 ase activity enables Start, the irreversible commitment to the cell division cycle.

268 y orchestrate T cell antitumor responses and commitment to the exhaustion program.

269 Endotoxemia is associated with early commitment to the follicular T-cell lineage in IgA-defic

270 al respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis.

271 cluding nervous system development, prior to commitment to the neural lineage.

272 ng history and memory together, and a strong commitment to the norms and values of liberal democracy,

273 These features were moderated by older age, commitment to the public healthcare sector, and fit to i

274 urveillance study was conducted to fulfill a commitment to the Regulatory Authority of India to exami

275 systems has revealed mechanisms controlling commitment to the sperm fate, but how this fate is subse

276 The path forward requires our commitment to transforming the conditions of historicall

277 mprovement trends, and likely reflects PC4's commitment to transparency and collaboration.

278 results highlight the gap between political commitments to address the consequences of unsafe aborti

279 ce antidiscrimination laws and institutional commitments to diversity, equality, and inclusion.

280 ce organizations have recently pledged their commitments to diversity, equity, and inclusion in exami

281 uate and geographically inequitable, and new commitments to funding have declined since 2011.

282 that the USA is likely to fall short of its commitments to halting biodiversity loss unless more con

283 Scientific disciplines embody commitments to particular questions and approaches, scop

284 s been path dependent with regard to ongoing commitments to privately provided health.

285 While institutional commitments to use VSS to meet sustainable procurement p

286 es Foundation made an unusually long funding commitment toward a surveillance system using pathology

287 CPSC also display a higher commitment toward chondrogenesis as demonstrated by a hi

288 bolism within the niche, promote HBC lineage commitment toward two types of respiratory cells that wi

289 isolated from Anp32b KO mice showed a strong commitment towards Th17 immune responses.

290 , I have offered a detailed account of joint commitment, tying it to a sense that the parties form a

291 Amazon Basin countries are to achieve their commitments under the Paris Climate Agreement.

292 e the role of mTORC1 in haemopoietic lineage commitment using knock out (KO) mouse and cell line mode

293 Raptor (mTORC1) in erythrocyte and B lineage commitment was confirmed in adult Mx1-cre(+)Raptor(fl/fl

294 ture of obligation's force and collaborative commitment were directly linked, possibly through Tomase

295 These commitments were included in China's nationally-determin

296 ors launched the pneumococcal Advance Market Commitment, which helped countries access more affordabl

297 and biasing of the MEPs toward megakaryocyte commitment, which ultimately results in thrombocytosis a

298 ic regulators of differentiation and lineage commitment, while cytokine signaling has been shown to i

299 We aggregated U.S. state, city, and business commitments within an integrated assessment model to ass

300 of inflexible loyalty to their interpersonal commitments within the group.