ライフサイエンスコーパス: complement protein

1 vascular endothelium, both produce C3 and C4 complement protein.

2 nhibited the binding of fH, a downregulatory complement protein.

3 receptor for multiple collectins and the C1q complement protein.

4 l as on the local concentration of available complement proteins.

5 and C5a, potent anaphylatoxins derived from complement proteins.

6 ndependent of complement activation or other complement proteins.

7 are considered as extrahepatic producers of complement proteins.

8 re of receptors that directly bind activated complement proteins.

9 data derived from targeted gene deletions of complement proteins.

10 as animals that were deficient in individual complement proteins.

11 s, phosphatidylcholines, and coagulation and complement proteins.

12 1r and C1s, the serine proteases that cleave complement proteins.

13 myloid (fAbeta) and other components such as complement proteins.

14 with thrombospondin, properdin, and several complement proteins.

15 es to or rare pathogenic genetic variants in complement proteins.

16 mmune systems, and reduces the expression of complement proteins.

17 ling, and surprisingly, increased binding of complement proteins.

18 ro-inflammatory pathways and upregulation of complement proteins.

19 ts structure, function, and interaction with complement proteins.

20 ositive selection maturation are targeted by complement proteins.

21 at coagulation proteases can directly cleave complement proteins.

22 nching fibrils (12-24 nm) composed of Ig and complement proteins.

23 immune cell type capable of synthesizing all complement proteins.

24 ent for binding to the excision repair cross-complementing protein 1 (ERCC1)/xeroderma pigmentosum co

25 se) polymerase 1 (PARP1), X-ray repair cross-complementing protein 1 (XRCC1) and tyrosyl-DNA phosphod

26 forms an important complex with X-ray cross complementing protein 1 (XRCC1) during single strand bre

27 SSBR complex mediated by X-ray repair cross-complementing protein 1 (XRCC1) is assembled sequentiall

28 ging, we demonstrate that X-ray repair cross-complementing protein 1 (XRCC1), a key factor in single-

29 polymerase 1 (PARP1), and X-ray repair cross-complementing protein 1 (XRCC1), all essential component

30 edox factor-1 (Ref-1) and X-ray repair cross-complementing protein 1 (XRCC1), relevant to neurodegene

31 d the scaffolding protein X-ray repair cross-complementing protein 1 (XRCC1), which completes the fou

32 nuclear partner protein, X-ray repair cross-complementing protein 1 (XRCC1).

33 omplexes, in turn recruit X-ray repair cross-complementing protein 1 (XRCC1).

34 In contrast, cells deficient in x-ray cross-complementing protein 1, DNA polymerase beta, or poly (A

35 X-ray repair cross-complementing protein-1 (XRCC1)-deficient cells are sens

36 mologous to SP-A, mannose-binding lectin and complement protein 1q, did not.

37 hrough cross-linking the B-cell receptor via complement protein 3d and antigen to the complement rece

38 dditional factors, XRCC4 (X-ray repair cross-complementing protein 4), XLF (XRCC4-like factor/Cernuno

39 , a humanized monoclonal antibody that binds complement protein 5 (C5).

40 Complement protein 5 fragments or formylmethionyl-leucyl

41 culizumab, a monoclonal antibody against the complement protein 5, stops the intravascular hemolysis

42 mune responses in mice with knockout (KO) of complement protein 6 (C6).

43 After excluding complement proteins, a series of studies identified chon

44 with axons and myelin, it is unknown whether complement proteins affect axon growth or regeneration.

45 nd how polymorphisms in genes encoding human complement proteins affect susceptibility to this import

46 Complement proteins aid in the recognition and clearance

47 More recently, the observation that complement proteins also act in the intracellular space

48 ring Western blots and immunoprecipitated C4 complement protein and alpha-2-macroglobulin.

49 d a novel way to coat themselves with the C3 complement protein and invade macrophages by interaction

50 sation by the cleavage products of the third complement protein and might promote inflammatory reacti

51 Here, we investigated whether a panel of complement proteins and activation products would provid

52 available concerning the interaction between complement proteins and capsule type 5 and 8 Staphylococ

53 ecent papers reporting on the association of complement proteins and complement regulators with high

54 (Fc) region, such as interacting with human complement proteins and Fcgamma-receptors (FcgammaRs) th

55 The liver produces the majority of the complement proteins and is the home of important immune

56 es were able to activate deposition of human complement proteins and passively protect against challe

57 gnificant proteins and oxidative regulators, complement proteins and protease inhibitors were enriche

58 Recent evidence indicates that complement proteins and receptors are synthesized on or

59 germ line variants or acquired antibodies to complement proteins and regulators.

60 everal other proteins including the terminal complement proteins and the neural adhesion molecules F-

61 I discuss immune and nonimmune functions of complement proteins and the tumor-promoting effect of co

62 Using purified classical activation pathway complement proteins and the Western blot assay, we showe

63 extensive examples that implicate classical complement proteins and their receptors in CNS dysfuncti

64 gocytes, NK cells, NKT cells, cytokines, and complement proteins) and later by the adaptive immune sy

65 n convalescent serum was shown to inactivate complement proteins, and the contribution of complement

66 Complement proteins are ancient components of innate imm

67 Sequence variations in complement proteins are associated with age-related macu

68 formation, structures, and interplay between Complement proteins are complex, and this has limited ou

69 Complement proteins are deposited in the muscles of pati

70 Genetic variants in complement proteins are found in ~60% of patients.

71 Complement proteins are involved in early innate immune

72 Complement proteins are localized to developing CNS syna

73 Since complement proteins are produced in virtually any cell i

74 Complement proteins are profoundly upregulated in many C

75 Over 40 "Complement" proteins are produced in blood or on cell su

76 ehydrogenase and TM0449 thymidylate synthase-complementing protein are presented as examples of final

77 onclusion, this study documents functions of complement proteins as prosurvival factors that, through

78 The ways complement proteins assemble on nanoparticles have remai

79 Small molecule photoswitches could complement protein-based switches by mitigating potentia

80 Analysis of C3 complement protein binding demonstrated that NAbs increa

81 e deposits were immunopositive for Abeta and complement proteins but did not stain for conventional a

82 kness or the interaction of the capsule with complement proteins, but the effects of small chemical m

83 n C3 allowed insight into the recognition of complement proteins by invading pathogens.

84 mplement is facilitated by the production of complement proteins by MCs and their activation by the M

85 The complement protein C1q binds to apoptotic cells, facilit

86 treatments also increased deposition of the complement protein C1q in beta-endorphin neuronal cells

87 Complement protein C1q is induced in the brain in respon

88 Complement protein C1q is required to maintain immune to

89 Mice deficient in complement protein C1q or the downstream complement prot

90 rthermore, pharmacological inhibition of the complement protein C1q prevents dorsal horn inhibitory s

91 time, to our knowledge, a unique function of complement protein C1q, as a molecular bridge between pn

92 croglia also express C1qR(P), a receptor for complement protein C1q, ligation of which in vitro enhan

93 The complement protein C1q, mannose-binding lectin (MBL), an

94 interaction, whereby pneumococci use a host complement protein C1q, primarily involved in the host-d

95 ystem to spread apoptotic factors, including complement protein C1q, to induce the membrane attack co

96 ACRP30 is a close homologue of the complement protein C1q, which is involved in the recogni

97 orrelates strongly with synaptic markers and complement protein C1q.

98 he microglial receptor TREM2 and the soluble complement proteins C1q and C3 are recognized as key pla

99 Immune molecules, including complement proteins C1q and C3, have emerged as critical

100 A panel of complement proteins (C1q, C3, C3b/iC3b, C4, factor B and

101 sue, we subjected mice deficient in selected complement proteins (C1q, C3, C5) to transient focal cer

102 ization of fAbeta microaggregates to that of complement protein, C1q-coated fAbeta microaggregates, a

103 was shown to bind to collagen type V and the complement protein, C1q.

104 lyses identified a gene signature, including complement protein C1qB and eukaryotic translation initi

105 scube1 (signal peptide-CUB (complement protein C1r/C1s, Uegf, and Bmp1)-EGF domain-c

106 NT003, a mouse monoclonal antibody targeting complement protein C1s, prevents induction of in vitro h

107 ammalian and insect cell-derived NS1 bind to complement proteins C1s, C4, and C4-binding protein, as

108 Type II complement protein C2 deficiency is characterized by a s

109 We identify complement protein C3 as an astroglial target of NFkappa

110 rprisingly, the functional deficiency of the complement protein C3 did not rescue the abnormal reprod

111 in complement protein C1q or the downstream complement protein C3 exhibit large sustained defects in

112 tor B (FB) and factor D (FD) and the central complement protein C3 in genotyped human postmortem dono

113 sults suggest a novel and prominent role for complement protein C3 in mediating aged-related and regi

114 Complement protein C3 is a 187-kDa (1641-aa) protein tha

115 Complement protein C3 is the converging point for activa

116 Importantly, deletion of the complement protein C3 or the receptor for the anaphylato

117 Binding of the central complement protein C3 to wild-type immature thymocytes r

118 nd that the opsonic fragments of the central complement protein C3, C3b and iC3b, were present on the

119 Plasminogen binds the central complement protein C3, the C3 cleavage products C3b and

120 tein produced by S. aureus that binds to the complement protein C3.

121 activity, as assessed by serum levels of the complement protein C3.

122 1-antitrypsin, ceruloplasmin, hemopexin, and complement protein C3.

123 ens from the body is the covalent binding of complement proteins C3 and C4 to their surfaces.

124 m earlier studies by Prodeus et al. in which complement proteins C3 and C4 were shown to be required

125 is known about other neisserial targets for complement proteins C3 and C4, which covalently attach t

126 Modeling of homologous domains from complement proteins C3 and C4, which do not participate

127 r, as well as the synthesis and secretion of complement proteins C3 and C5.

128 th their identical functions in cleaving the complement proteins C3 and C5.

129 Prominent deposition of complement proteins C3 and C9 in brains of MRL/lpr mice

130 rum complement, and this inhibition required complement proteins C3 and factor B, but not C4 or C5, s

131 ation of the antimicrobial peptide LL-37 and complement proteins C3, C4, and C5.

132 c iron oxide (SPIO) nanoworms with the third complement protein (C3) was dependent on the biomolecule

133 CD27 ligand and 4-1BB ligand, and the third complement protein (C3), which positions LIGHT within th

134 tivation products (C3bc and C4bc) and native complement proteins (C3 and C4).

135 in two flavors: (i) proteolytic fragments of complement proteins (C3, C4, C5) generated during activa

136 , a serine protease that cleaves the central complement protein, C3.

137 Using complement protein C3a as a marker of complement activat

138 asmin(ogen) bound to PGK cleaved the central complement protein C3b thereby further modifying the com

139 minogen activator, generated plasmin cleaved complement protein C3b thus assisting in complement cont

140 asles virus for binding to CD46 but not with complement protein C3b.

141 ound plasmin was able to degrade the central complement proteins C3b and C5 and inhibited the bacteri

142 1b/CD18, Mac-1) mediates the phagocytosis of complement protein (C3bi)-coated particles.

143 Complement protein C3dg, a key linkage between innate an

144 35 or transferred into mice deficient in the complement protein C4 are not anergized by soluble self-

145 The complement protein C4, encoded by two genes (C4A and C4B

146 ease and they also displayed lower levels of complement proteins C4 and C3 in blood.

147 Deposition of the complement protein C4d in renal allograft biopsies obtai

148 complement by blocking the activation of the complement protein C5 and shows remarkable clinical bene

149 The complement protein C5 initiates assembly of the membrane

150 Although proteolytic activation of the complement protein C5 initiates important defensive and

151 e of the innate immune system along with the complement protein C5 on exosomes' rate of clearance.

152 This antibody against terminal complement protein C5 reduces intravascular hemolysis, h

153 mab, a humanized monoclonal antibody against complement protein C5 that inhibits terminal complement

154 ymph tissue of mice immunized with the human complement protein C5, fused with a limited repertoire o

155 rapeutic monoclonal IgG that neutralises the complement protein C5--in neuromyelitis optica spectrum

156 PSA was able to cleave iC3b and the related complement protein C5.

157 , immunoglobulin light chains, Factor X, and complement proteins (C5 and C5b-9 complex) were identifi

158 Using purified distal complement proteins (C5-9) to assemble functional MAC on

159 Complement protein C5a, acting via C5aR, is shown in thi

160 activation of eosinophils with TNF-alpha and complement protein C5a, respectively.

161 scpA, encoding a peptidase that inactivates complement protein C5a.

162 Activated terminal complement proteins C5b to C9 form the membrane attack c

163 is formed by sequential assembly of soluble complement proteins C5b, C6, C7, C8 and C9, but little i

164 bstrate-binding domain, was found to bind to complement proteins C8 and C9 and to inhibit zinc-induce

165 Here we show how the receptor binds complement proteins C8 and C9 at the membrane to prevent

166 ently by blocking the hCD59-binding site for complement proteins C8alpha and C9.

167 As part of the membrane attack complex complement protein C9 is responsible for direct killing

168 ever, a very recent study has indicated that complement proteins can also promote tumor growth.

169 Previous studies have suggested that complement proteins can contribute to the immune surveil

170 dopeptidase inhibitors, coagulation factors, complement proteins, carbonic anhydrases, and redox enzy

171 healthy controls had a greater abundance of complement proteins CFHR1, C1q chains A, B, and C, and p

172 mplement protein, falling at the base of the complement protein clade.

173 t the liver, which produces large amounts of complement proteins, clears activators of complement and

174 mined for immunoreactivity (IR) of classical complement proteins (Clq and C3), markers indicating act

175 Experiments using human serum as a source of complement proteins confirmed Pic proteolytic activity o

176 arious inactive mutant permease proteins can complement proteins containing mutations at position 257

177 Plasma levels of complement proteins correlated with response to immune c

178 A fragment of this protein spanning the two complement protein (CP)-modules (residues 126 to 243) wh

179 external factors including immunoglobulins, complement proteins, cytokines, chemokines, integrins, a

180 es are intravenously injected into the body, complement proteins deposit on the surface of nanopartic

181 The detection of complement proteins deposited within transplanted tissue

182 However, complement proteins did not correlate with the severity

183 t information is available about the role of complement proteins during enteric infections.

184 X3CL1, were marked by profoundly upregulated complement proteins (e.g., C1q and C3), and were surroun

185 Additionally, other complement proteins (e.g., C1s) have been reported to in

186 h complete deficiencies of one of the plasma complement proteins enabled the field to move beyond the

187 We have complemented protein-encoded defects in HCV by construct

188 Several complement proteins exacerbate prion disease, including

189 source of C4 and raise the possibility that complement protein expression by the cells plays a role

190 Complement protein expression or deposition was observed

191 Reestablishment of complement protein expression was found to be mediated b

192 he ability of NK cells to positively mediate complement protein expression.

193 Complement proteins facilitate synaptic elimination duri

194 To investigate the role of complement protein factor B (Bf) and alternative pathway

195 ulin, shows that SpC3 is the first divergent complement protein, falling at the base of the complemen

196 Immunoglobulin G (IgG)- and complement protein fragment 3bi (C3bi)-opsonized zymosan

197 We investigated deposition of the complement protein fragment C3b and its breakdown produc

198 w variants of the streptococcal inhibitor of complement protein has been implicated in the perpetuati

199 C1q signature domain, also found in many non-complement proteins, has a compact jelly-roll beta-sandw

200 The multiple interconnections among complement proteins, immune cells, and mediators provide

201 luding the major histocompatibility complex, complement proteins, immunoglobulin receptors, cytokines

202 In vitro, C1q, in the absence of other complement proteins, improves neuronal viability and neu

203 Although the role for the cytolytic complement proteins in astrocyte destruction in NMO is w

204 plement activation in vitreous, but not with complement proteins in BM/C protein extracts.

205 Furthermore, levels of several complement proteins in circulatory IgA-ICs of IgAN patie

206 ceptor C3aR, revealing an unexpected role of complement proteins in early vertebrate development.

207 severe COVID-19, with abundant deposition of complement proteins in inflamed tissue and on the endoth

208 The distinct expression profile of complement proteins in regenerative tissues of the urode

209 nized liver rats expressed human albumin and complement proteins in serum and showed a normal liver z

210 Resistance to complement proteins in serum is critical for the surviva

211 that rs800292 was associated with levels of complement proteins in serum.

212 ic lupus erythematosus (SLE) but the role of complement proteins in SLE is not yet clear.

213 s, because rodent models indicate a role for complement proteins in synaptic pruning and neurodevelop

214 The function of complement proteins in the brain appears analogous to th

215 To determine possible sources of complement proteins in the brain, we investigated by in

216 mplement pathway that leads to deposition of complement proteins in the renal glomerulus.

217 RI) and cardiomyocytes are a known source of complement proteins including the central component C3,

218 cial stress and observed dysregulation of 11 complement proteins, including three that were altered i

219 l or danger-associated molecular patterns by complement proteins initiates a cascade of events that c

220 the increased activation and localization of complement proteins, innate immune molecules, to these s

221 Several complement proteins interact with hemostatic factors.

222 ectrometry was used to specifically quantify complement proteins interacting with the cartilage expla

223 Our results demonstrate that the complementing protein interacts directly with apobec-1 i

224 ntigen presentation and protein degradation, complement proteins, interferon-regulated proteins, and

225 t 1, r) and C1s (complement component 1, s), complement proteins involved in vascular collagen metabo

226 in this superfamily, a unique feature of the complement proteins is a 150-residue-long C-terminal ext

227 Opsonization of bacteria by complement proteins is an important component of the imm

228 munoglobulins for the interaction with human complement proteins is demonstrated and potential protec

229 e to proteins provided in trans, even if the complementing protein is translated from a different cis

230 ent peripheral T cells were bound by IgM and complement proteins, leading to the elimination of these

231 tion of human C3 protein with multiple mouse complement proteins, leading to unregulated C3 activatio

232 used to assess between-group differences in complement protein levels in serum and CSF.

233 Sex differences in complement protein levels may help to explain the more p

234 Complement protein levels were found elevated in the cer

235 However, the association of complement protein levels with clinical outcome suggests

236 ral definition and biological activity, thus complementing protein ligation and recombinant protein e

237 0) is a member of the Ixodes scapularis anti-complement protein-like family of tick salivary proteins

238 C3 is a key complement protein, located at the nexus of all compleme

239 he alternative pathway and absence of the LP complement protein mannan-binding lectin abrogates elast

240 an improved understanding of locally derived complement proteins, many of which promote host defense.

241 Similarly, synapses tagged with complement proteins may be eliminated by microglial cell

242 Whole-blood transcriptome findings complement protein measurement from the site of disease,

243 Recent studies have indicated that complement proteins might exert novel functions that are

244 r on cell surfaces through activation of the Complement protein network mainly by infection or injury

245 With the availability of new structures for Complement proteins, new knowledge of how they function,

246 , we demonstrate that C1q, but neither other complement proteins nor FcRgamma, is required for early

247 Furthermore, the glomerular complement proteins of CP and AP were positively correla

248 Deposition of complement proteins on the bacteria was monitored by Wes

249 Plasma complement protein or activation product levels were sim

250 Opsonization with either complement proteins or antibody is not required for upta

251 ttack against host cells due to mutations in complement proteins or autoantibodies against complement

252 Six out of the 29 targeted complement proteins or protein subcomponents were signif

253 These include complement proteins, other bactericidal peptides, cytoki

254 findings indicate that dysregulation of the complement protein pathway in blood is associated with i

255 ion, but increasing evidence also implicates complement proteins produced locally within the graft, i

256 C to PMN-synthesized concentrations of these complement proteins promoted astrogliogenesis and cell m

257 first time, to our knowledge, that the human complement protein properdin binds to early apoptotic T

258 The complement protein properdin, traditionally viewed as a

259 Cytoskeletal and complement proteins, proteases, and their inhibitors wer

260 mation about DNA elements and cells that can complement protein-protein and co-expression data.

261 the protein to the plasma membrane, thereby complementing protein-protein interactions, located in f

262 The intricate system of serum complement proteins provides resistance to infection.

263 cell response more strongly than circulating complement protein, raising the possibility that there i

264 ts cDNA-derived amino acid sequence contains complement protein-repeating modules (CP) 1-6, 28, 29, a

265 Complement proteins resulting from activation of the cla

266 Serum depleted of individual complement proteins revealed that C3 and factors B and D

267 eletion strains expressing either one of the complementing proteins revealed that in addition to a cy

268 omplement factor B (Cfb), in detail, because complement proteins secreted by cells other than cardiom

269 the hypervariable streptococcal inhibitor of complement protein (Sic).

270 e TED (thioester-containing domain) and CUB (complement protein subcomponents C1r/C1s, urchin embryon

271 ency anemia-causing mutant (Mt2I286F) in the complement protein subcomponents C1r/C1s, urchin embryon

272 The occurrence of APOBEC-1-complementing proteins suggested a naturally occurring m

273 he liver constitutes the primary circulating complement protein synthesis site, extrahepatic synthesi

274 (W54011) demonstrated that the activation of complement proteins synthesized by pulp fibroblasts and

275 Recent work suggests that genes encoding complement proteins that are active in the innate immune

276 C8 is one of five complement proteins that assemble on bacterial membranes

277 ophism, but also through modulation of local complement proteins that could protect against complemen

278 ack complex generated from the five terminal complement proteins that directly binds to and penetrate

279 role for function-altering mutations in the complement proteins that form or regulate the alternativ

280 AMD is associated with genetic variation in complement proteins that results in enhanced activation

281 We describe the complex network of complement proteins that target muscle, the neuromuscula

282 sess the structures of these segments of the complement proteins, their relationships with other doma

283 e Fabs shows how Biacore T100 can be used to complement protein therapeutic discovery programs from b

284 proteins are a group of partly characterized complement proteins thought to promote complement activa

285 the contribution of individual inflammatory complement proteins to spinal cord injury (SCI) patholog

286 nionic lipids in the binding of the terminal complement proteins to the membrane and the efficiency o

287 mined the contribution of activated terminal complement proteins to the pathogenesis of the lupus-lik

288 e complement system is critical for enabling complement proteins to titrate immune defense while also

289 e lack of CRP and the exposure of activating complement proteins to tubular cells, alternative comple

290 to quantify the attachment of HUVEC-released complement proteins to ULVWF strings secreted by, and an

291 as ascertained by measuring levels of plasma complement proteins using an enzyme-linked immunosorbent

292 The association of terminal complement proteins was investigated by analytical ultra

293 was specific in that synthesis of two other complement proteins was normal.

294 The production of other complement proteins was normal.

295 , 80 kDa), with actively assembling terminal complement proteins were characterized.

296 oassay, and CpG interactions with individual complement proteins were evaluated using magnetic beads

297 The xeroderma pigmentosum group A complementing protein (XPA) and eukaryotic replication p

298 The xeroderma pigmentosum group A complementing protein (XPA) is believed to be involved i

299 interact with Xeroderma pigmentosum group A complementing protein (XPA), a key protein involved in n

300 degradation of xeroderma pigmentosum group B-complementing protein (XPB), a component of human transc