ライフサイエンスコーパス: complement system

1 le (non-hemolytic, and poor activator of the complement system).

2 eceptors TLR-2 and TLR-4, FcgammaRs, and the complement system).

3 h respect to regulators and receptors of the complement system.

4 ities in the alternative pathway (AP) of the complement system.

5 of the three main activation cascades of the complement system.

6 the classical and lectin pathways within the complement system.

7 regulation of the alternative pathway of the complement system.

8 the activation and effector functions of the complement system.

9 o self versus non-self discrimination by the complement system.

10 hology by their capacity to overactivate the complement system.

11 ic circulation through the regulation of the complement system.

12 se, including the bactericidal effect of the complement system.

13 ve evolved multiple strategies to escape the complement system.

14 sist the antimicrobial activity of the human complement system.

15 Activated platelets can activate the complement system.

16 ble to malignancy through proteolysis of the complement system.

17 his was independent on the activation of the complement system.

18 d injury and, possibly, the evolution of the complement system.

19 PPARalpha and TNFalpha in the regulation of complement system.

20 several strategies to evade detection by the complement system.

21 e implicated an interaction of Trx1 with the complement system.

22 f the central regulatory component C3 of the complement system.

23 mers is critical to evade recognition by the complement system.

24 ere they may interact with components of the complement system.

25 . enterocolitica effectively evades the host complement system.

26 y proteins of the alternative pathway of the complement system.

27 Ps are activated, which in turn activate the complement system.

28 and protection was dependent upon an active complement system.

29 isticated array of proteins that inhibit the complement system.

30 ein (VCP), respectively, to subvert the host complement system.

31 ere, we report a novel role for CFHR4 in the complement system.

32 regulator of the alternative pathway of the complement system.

33 antibody-independent activation route of the complement system.

34 nd protects the pathogen from killing by the complement system.

35 well-established activation pathways of the complement system.

36 of therapeutic approaches that modulate the complement system.

37 pattern- recognition receptors (PRRs) of the complement system.

38 activation of the alternative pathway of the complement system.

39 ocally overcome systemic inactivation by the complement system.

40 otect themselves against killing by the host complement system.

41 plex relationship between merozoites and the complement system.

42 ay and triggers the kallikrein-kinin and the complement systems.

43 concurrently activates both coagulation and complement systems.

44 complex (TCC) is formed on activation of the complement system, a crucial arm of innate immunity.

45 However, the role of the complement system, a crucial component of innate immunit

46 Evasion of killing by the complement system, a crucial part of innate immunity, is

47 -3) is a member of the lectin pathway of the complement system, a key component of human innate and a

48 Controlled activation of the complement system, a key component of innate immunity, e

49 dy provides mechanistic insight into how the complement system, a key component of innate immunity, r

50 Previous studies demonstrated that the complement system, a major component of innate immunity

51 The complement system, a part of the innate immune system, i

52 Components of the complement system act directly on T cells to alter conve

53 Complement system activation occurs in hemolytic disorde

54 Recent investigations demonstrated that the complement system activation participates in 2 critical

55 y antiphospholipid antibodies and subsequent complement system activation play a cardinal role in APS

56 tonomous neuroinflammatory response, classic complement system activation, and STAT3 activation throu

57 It has been recently demonstrated that the complement system activation, which is one of the first

58 e outgrowth to human pulp fibroblast through complement system activation.

59 broblasts to the nerve sprouting through the complement system activation.

60 constitutes a powerful fragment generated by complement system activation.

61 In this manner, the complement system acts as a bridge between the innate an

62 ammatory stimulus promoted activation of the complement system after incubation with serum.

63 Uncontrolled activation of the complement system against endothelial and blood cells is

64 In support of the hypothesis that the complement system along with neutrophils and platelets c

65 an serum because they successfully evade the complement system, an important arm of innate immunity.

66 The complement system, an important element of both innate a

67 The complement system, an intricate network of proteins with

68 However, the link between the complement system and adaptive immunity, which is formed

69 ell as the MASP SP inhibit the action of the complement system and also show a significant associatio

70 We recently revealed a link between the complement system and CC-induced inflammasome caspase-1

71 on represents a novel connection between the complement system and cell surface PDI-mediated thiol-di

72 actor H-related protein 2 (CFHR2, related to complement system and coagulant mechanism) were selected

73 nt, complement dominates when both an intact complement system and Dectin-1 are present.

74 immune insults, triggering activation of the complement system and further injury.

75 factor H (CFH) is a central regulator of the complement system and has been implicated in the etiolog

76 e data establish a critical link between the complement system and immunometabolic adaptations drivin

77 appears to be involved in activation of the complement system and in the production of chemotactic a

78 s and promote inflammatory responses via the complement system and inflammasome activation.

79 comprised the first element of the original complement system and initially functioned intracellular

80 mune response to self-antigens activates the complement system and initiates the inflammatory cascade

81 n activation pattern involving the classical complement system and its associated phagosome pathway.

82 ior research has established the role of the complement system and its effector proteins in the progr

83 Other key pathways included the complement system and lysosome/phagosome pathways.

84 ATXN2 ASO also modified innate immunity, the complement system and lysosome/phagosome pathways.

85 The emergence and evolution of the complement system and mast cells (MCs) can be traced bac

86 g another instance of cross-talk between the complement system and other host defense pathways.

87 ms are poorly understood, roles for both the complement system and reactive macrophages have been imp

88 les exhibited particular upregulation of the complement system and respective regulatory pathways, wi

89 Importantly, these mice have an intact complement system and showed no signs of graft-versus-ho

90 oteases, activates the lectin pathway of the complement system and subsequent inflammatory mechanisms

91 additional mechanism used by Nm to evade the complement system and survive in human blood.

92 mplex crosstalk between the endothelium, the complement system and the hemostasis in health and in di

93 ional connections between alterations in the complement system and the pathogenesis of MD remain to b

94 The complement system and TLRs provide important pattern rec

95 m, causing activation of the coagulation and complement systems and clearance of transplanted cells.

96 ry protein in the alternative pathway of the complement system, and CFH polymorphisms increase the ge

97 R signaling cross-talks extensively with the complement system, and combined CD14 and complement inhi

98 CRPs prevent attack on host cells by the complement system, and complement receptor 1-like protei

99 broad link between the kinin-kallikrein and complement systems, and suggest a role of CPN1 in the co

100 scripts sensitive to infection and implicate complement system, antigen processing and presentation,

101 The classical and lectin pathways of the complement system are important for the elimination of p

102 These results implicate the complement system as a source of sexual dimorphism in vu

103 4 and Ptx3, in addition to activation of the complement system, as measured by immune cell infiltrati

104 in certain anti-proteases and in the immune complement system, both of which react with the ligand o

105 tion or development systemically inhibit the complement system, but since complement is important for

106 The activation of the complement system by canonical and non-canonical mechani

107 Modulation of the complement system by locally increasing CRP expression u

108 It evades the host complement system by upregulating expression of immune e

109 ing evidence suggests that components of the complement system, C1q and C3, can mediate elimination o

110 s involved in bacterial killing, such as the complement system, can also exert cytolytic activity aga

111 In contrast, components of the complement system, chemokines, chemokine receptors, and

112 P. ovis infestation, including roles for the complement system, clotting cascade and fibrinolysis.

113 In particular, it is unclear how the complement system communicates with nociceptors and whic

114 Activation and suppression of the complement system compete on every serum-exposed surface

115 The complement system, consisting of soluble and cell membra

116 The complement system consists of a network of plasma and me

117 The vertebrate complement system consists of sequentially interacting p

118 The complement system constitutes an important part of the i

119 In addition to chemokines, the complement system contributes to the attraction and acti

120 The complement system contributes to the protection of the h

121 The complement system contributes to various immune and infl

122 These results suggest that the complement system could be altered to prevent virus infe

123 Thus, the complement system could be used as one of the 'staging p

124 te that blockade of TLR4, P-selectin, or the complement system could prevent liver injury in hemolyti

125 les, such as Toll-like receptors (TLRs), the complement system, cytokines, chemokines, inflammatory r

126 As FH is responsible for regulating the complement system, decreased affinity for heparin result

127 n C3 (C3(-/-)), an upstream component of the complement system, did not affect mouse susceptibility t

128 atients with HIV infection and influence the complement system during acute illness.

129 and compelling insight into the role of the complement system during mammalian embryonic development

130 this study, we have examined the role of the complement system during the priming phase of liver rege

131 une system is a central player, in which the complement system emerges as a pivotal part of liver hom

132 The complement system, especially the alternative pathway, p

133 ically the areas of nutritional immunity and complement system evasion.

134 anized sialome (Cmah(-/-) mice) or humanized complement system (FH/C4b-binding protein transgenic mic

135 As the complement system forms a key immune pathway that may al

136 data was performed to analyze variants in 32 complement system genes for positive association with CA

137 nly associated with rare genetic variants in complement system genes, unique to each patient/family.

138 e were also observed in oxidative stress and complement system genes.

139 In recent years, the complement system has been associated with a growing num

140 The clinical merit of targeting the complement system has been established for rare clinical

141 Abnormal regulation of the complement system has been implicated in its pathogenesi

142 ng identified, the basic architecture of the complement system has been known for decades.

143 The complement system has been shown to facilitate periphera

144 mmunological and inflammatory processes, the complement system has emerged as an attractive target fo

145 The complement system has evolved to annul pathogens, but it

146 n many types of human cells, our view of the complement system has expanded.

147 Activation of the complement system has long been known to be regulated by

148 The impact that viral hijacking of the complement system has on iDC function could be an import

149 Abnormalities in the complement system have been described in patients with s

150 Inhibitors of the complement system have been described in the saliva of h

151 lar degeneration (AMD), rare variants in the complement system have been described, but their functio

152 ons of rare variants other than those in the complement system have not been determined.

153 An intracellular complement system (ICS) has recently been described in i

154 n of redox homeostasis and activation of the complement system, immune cell infiltration, and phagocy

155 Proteins involved in lipid transport, complement system, immunoglobulin superfamily, and hemos

156 les include ADEVs spreading the dysregulated complement system in AD, mediating motoneuron toxicity i

157 regulates the terminal pathway of the human complement system in addition to being a component of th

158 ce supports a link between microglia and the complement system in Alzheimer's disease (AD).

159 The role of the complement system in antibody-mediated rejection has bee

160 Cumulative evidence indicates a role for the complement system in both pathology and recovery after i

161 The involvement of the complement system in brain injury has been scarcely inve

162 ains, indicating the importance of an intact complement system in clearing Pseudomonas infection duri

163 mportance of C5a and other components of the complement system in inflammatory and neuropathic pain,

164 A role for the complement system in MDs was suggested by genetic associ

165 The role of the complement system in mediating human renal disease has l

166 ient mice, confirming the involvement of the complement system in neurodegeneration.

167 etermined the impact of HIV infection on the complement system in patients with asymptomatic HIV infe

168 els of CFD in the secretome, implicating the complement system in prostate carcinogenesis.

169 rated the pathophysiologic importance of the complement system in several rare diseases.

170 dy, we address the involvement of NA and the complement system in the activation of innate immunity t

171 t epithelial cells before they encounter the complement system in the mosquito hemolymph.

172 study we established the involvement of the complement system in the recognition and the phagocytosi

173 s to consider the potential of targeting the complement system in these patients.

174 P plays in modulating the blood clotting and complement systems in health and disease.

175 a potent modulator of the blood clotting and complement systems in hemostasis, thrombosis, and inflam

176 ical matter for this pivotal protease of the complement system: in silico active site mapping for hot

177 lation, has led to the appreciation that the complement system includes membrane inhibitors that are

178 n to possess several mechanisms to evade the complement system, including binding to complement inhib

179 ria employ a variety of tactics to evade the complement system, including recruitment of complement r

180 At a molecular level, MCs and complement system interactions are based on the producti

181 These data suggest that the complement system involving C1q-C3-C4-membrane attack co

182 The complement system is a crucial component of the innate i

183 The complement system is a crucial part of innate immune def

184 Abnormal activation of the complement system is a feature of these blinding disease

185 The serum complement system is a first line of defense against bac

186 The complement system is a front-line defense system that op

187 The complement system is a fundamental component of innate i

188 ing inflammation including activation of the complement system is a hallmark of systemic lupus erythe

189 The complement system is a key component of the host immune

190 The complement system is a key component regulation influenc

191 The alternative pathway (AP) of the complement system is a key contributor to the pathogenes

192 The activation of the complement system is a key initiating step in the protec

193 erreacting innate immune response, where the complement system is a key player.

194 asome caspase-1 activation, showing that the complement system is a key trigger in CC-induced inflamm

195 Activation of the complement system is a major alteration in early atheros

196 The complement system is a potent component of the innate im

197 The complement system is a tightly controlled proteolytic ca

198 The complement system is activated in a wide spectrum of CNS

199 Complement system is activated in patients with trauma.

200 The complement system is activated in response to tissue inj

201 In blood, the complement system is activated via the classical pathway

202 The complement system is an ancient arm of the innate immune

203 The complement system is an ancient innate immune defense pa

204 The complement system is an efficient plasma immune surveill

205 The complement system is an elegantly regulated biochemical

206 The complement system is an essential element of the innate

207 The complement system is an evolutionarily ancient component

208 The complement system is an immediate sensor of a disturbed

209 The complement system is an important antimicrobial and infl

210 The lectin pathway (LP) of the complement system is an important antimicrobial defense

211 The complement system is an important first line of defense

212 The complement system is an important innate defense mechani

213 The complement system is an important part of the innate imm

214 The complement system is an important part of the innate imm

215 The complement system is an intricate cascade of the innate

216 An overactive complement system is associated with AMD pathogenesis, a

217 The membrane attack complex (MAC) of the complement system is detected in the traumatized brain e

218 Excessive activation of the complement system is detrimental in acute inflammatory d

219 The complement system is highly efficient in targeting patho

220 The human complement system is increasingly perceived as an intric

221 Dysregulation of the complement system is increasingly recognized as a contri

222 The complement system is involved in a range of diverse deve

223 There is growing evidence that the complement system is involved in cancer immune surveilla

224 The complement system is involved in mediation of joint dama

225 The complement system is part of our first line of defense a

226 The complement system is part of the innate immune response

227 Activation of the complement system is primarily initiated by pathogen- an

228 The human complement system is the frontline defense mechanism aga

229 Inadequate control of the complement system is the underlying or aggravating facto

230 The activity of the complement system is tightly controlled by many fluid-ph

231 The complement system is tightly regulated to safeguard agai

232 The complement system is vital for anti-microbial defense.

233 regulator of the alternative pathway of the complement system, is only expressed in the eye and on t

234 ng substances and subsequently activates the complement system, it has been proposed that the antipne

235 In this review, we discuss the complement system, its importance in retinal development

236 by genetic and acquired abnormalities of the complement system leading to alternative pathway (AP) ov

237 empt to evade annihilation by the vertebrate complement system, many microbes capture factor H (FH),

238 nt studies have shown that activation of the complement system may be associated with long-term graft

239 regeneration, and suggest that manipulating complement system may produce therapeutic benefit in mus

240 the protection of digestive tissues against complement system-mediated damage.

241 through DNA damage-driven apoptosis and the complement system of immunity.

242 The complement system of innate immunity is important in reg

243 n through opsonization and activation of the complement system on surfaces with an appropriate presen

244 e identified metabolites and activity of the complement system, one of the main AMD-associated diseas

245 of plaque-induced genes (PIGs) involving the complement system, oxidative stress, lysosomes, and infl

246 Natural killer (NK) cells and the complement system play critical roles in the first line

247 The complement system plays a central role in promoting the

248 Because the complement system plays a critical role in orchestrating

249 The complement system plays a key role in pathogen immunosur

250 Emerging evidence suggests that the complement system plays a key role in this inflammatory

251 The coordinated activity between MCs and the complement system plays a key role, for example, in a nu

252 The complement system plays a pivotal role in the pathogenes

253 et al. is one such team who report that the complement system plays a substantial role in creating t

254 The complement system plays an important role in our innate

255 matory autoimmune joint disease in which the complement system plays an important role.

256 HIV activates the complement system, predominantly via the classical pathw

257 The complement system present in circulating blood is an eff

258 Interactions between T helper cells and the complement system promote loss of sensory neurons in the

259 The complement system protects against extracellular pathoge

260 ckout mice with concomitant normalization of complement system protein expression and reduction of bi

261 force microscopy (AFM), here we studied two complement system proteins at the single-molecule level:

262 nalysis revealed the presence of Igs and the complement system proteins C3, factor B, and clusterin.

263 ng genes encoding cytokines, chemokines, and complement system proteins.

264 The complement system rapidly detects and kills Gram-negativ

265 uctural and mechanistic understanding of the complement system rationalizes the genetic defects confe

266 versely, only E coli challenge activated the complement system, reaching a maximum at 2 hours postcha

267 its ligand C3d provides insight into how the complement system regulates access of antigen by B cells

268 The complement system represents an evolutionary old and cri

269 The complement system represents one of the evolutionary old

270 ts show that therapeutic manipulation of the complement system requires rigorous disease-specific tar

271 hare the common theme of overactivity of the complement system's alternative pathway.

272 mplement component C4 upon activation of the complement system's classical and lectin pathways, which

273 The complement system serves a critical role in the modulati

274 activation of the alternative pathway of the complement system strongly contributes to serum MMP-8 co

275 ociated with an inadequate regulation of the complement system, supporting current evidence on the ro

276 C1q, the initiating component of the classic complement system that is the protein-based arm of the i

277 The four cascades are: the complement system, the blood clotting cascade, the fibri

278 , the discovery of an intracellularly active complement system-the complosome-and its key role in the

279 ding antigen-specific IA interferes with the complement system; this effect may be partially responsi

280 ovel mechanism by which NiV evades the human complement system through a unique factor I-like activit

281 subjected to repeated exposures to the host complement system through cyclic infections of mammalian

282 study we hypothesized whether CC employ the complement system to activate inflammasome/caspase-1, le

283 ost cells that mimics that used by the human complement system to eliminate pathogens.

284 We conclude that CC employ the complement system to induce cytokines and activate the i

285 Spontaneous activation enables the complement system to respond very rapidly to diverse thr

286 d brain disorders.SIGNIFICANCE STATEMENT The complement system, traditionally known as a controller o

287 The complement system, typically associated with innate immu

288 ogrammer of cell metabolism suggest that the complement system utilizes C3 to guard not only extracel

289 Activation of the complement system via classical, lectin, or alternative

290 gosaccharides on pathogens and activates the complement system via the lectin pathway.

291 ta-fibrils in Alzheimer disease activate the complement system, we have here investigated specific in

292 respectively) while acute phase response and complement system were affected stronger in Cbs(-/-) mic

293 including acute-phase response signaling and complement system) were overexpressed in the follicular

294 A number of these proteins inhibit the complement system, which labels bacteria for phagocytosi

295 HIV-1 activates the host complement system, which results in opsonization of viru

296 indings provide initial evidence linking the complement system with cortical thinning in humans, a pr

297 During sepsis, excessive activation of the complement system with generation of the anaphylatoxin C

298 ial sepsis triggers robust activation of the complement system with subsequent generation of anaphyla

299 lly, we investigated activation of the local complement system within the dental pulp and its role in

300 these results suggest that IgM activates the complement system within the glomerulus in an animal mod