ライフサイエンスコーパス: complex assembly

1 ndent protein interfaces and dynamic protein complex assembly.

2 es by impeding the LT-biosynthetic 5-LO/FLAP complex assembly.

3 , together with Munc18-1, orchestrates SNARE complex assembly.

4 hat HerA-NurA is activated by substrates and complex assembly.

5 PS is required in this assay for rapid SNARE complex assembly.

6 terminase subunit plays the dominant role in complex assembly.

7 ons into the regulation of human presynaptic complex assembly.

8 cal to those needed for de novo nuclear pore complex assembly.

9 may be related to regulation of proper SNARE complex assembly.

10 This region is needed for normal SNARE complex assembly.

11 tes with synaptobrevin-2/VAMP2 for the SNARE-complex assembly.

12 --targeted lamellipodin mutants disrupts tip complex assembly.

13 Pch2 and is directly coupled to synaptonemal complex assembly.

14 paxillin Ser273 phosphorylation and paxillin complex assembly.

15 However, Syt-7-KD did not disrupt SNARE complex assembly.

16 op controls syntaxin-1A and subsequent SNARE complex assembly.

17 rhomolog adhesion by regulating synaptonemal complex assembly.

18 ion competence, probably by initiating SNARE complex assembly.

19 DNA missegregation but not the lack of ATOM complex assembly.

20 aximises substrate access while facilitating complex assembly.

21 cal multimeric species that chaperones SNARE-complex assembly.

22 s15/Vps34 heterodimer, suggesting a path for complex assembly.

23 erved that competitive interactions restrict complex assembly.

24 These motifs were further used to guide complex assembly.

25 e nucleotide binding in the D1 ring promotes complex assembly.

26 racts with IKK subunits, and facilitates IKK complex assembly.

27 uction of all AP-4 subunits and loss of AP-4 complex assembly.

28 involves the inhibition of BRCA1-PALB2-BRCA2 complex assembly.

29 rect orientation and register for subsequent complex assembly.

30 e factor attachment protein receptor (SNARE)-complex assembly.

31 ling adopt different mechanisms for receptor complex assembly.

32 t the MTA proteins act as scaffolds for NuRD complex assembly.

33 hesion-independent functions in synaptonemal complex assembly.

34 on-synonymous mutations could disrupt NADPHO complex assembly.

35 e model that is uniquely deficient for DREAM complex assembly.

36 blocking MLL1-WDR5 interaction and thus the complex assembly.

37 l presynaptic plasticity by regulating SNARE-complex assembly.

38 f the viral terminase, but not for terminase complex assembly.

39 enomic occupancy of GR as well transcription complex assembly.

40 mission, can either promote or inhibit SNARE complex assembly.

41 the stabilization of the gamma-tubulin ring complex assembly.

42 have consequences in the overall multienzyme complex assembly.

43 pc110 facilitates higher-order gamma-tubulin complex assembly.

44 ctivation, glucose uptake and beclin 1-UVRAG complex assembly.

45 omains and function as scaffolds for protein complex assembly.

46 are suggestive of prematurely terminated LH1 complex assembly.

47 the Mis18 complex, and CDK inhibiting Mis18 complex assembly.

48 can function as templates to catalyze SNARE complex assembly.

49 transition of closed-to-open Syx1a in SNARE complex assembly.

50 regions of cpTatC were defective in receptor complex assembly.

51 ibutable to a dramatic rearrangement in mTOR complex assembly.

52 either during or after RNA-induced silencing complex assembly.

53 romoter elements and directing preinitiation complex assembly.

54 defective in substrate binding and receptor complex assembly.

55 MCM2-7 double hexamer formation, we analysed complex assembly.

56 me and highlight inherent mechanisms of PP2A complex assembly.

57 either the R- or Qa-SNARE to stimulate SNARE complex assembly.

58 NA duplexes to prevent RNA-induced silencing complex assembly.

59 ion of SNAP25 plays important roles in SNARE-complex assembly.

60 ecular mechanisms that underlie RNA-directed complex assembly.

61 n be mediated through the inhibition of Cas9 complex assembly.

62 rily conserved role of Cpx upstream of SNARE complex assembly.

63 t-SNARE interactions and accelerate ternary complex assembly.

64 olecular interactions essential for effector complex assembly.

65 d shows that CyRPA is a critical mediator of complex assembly.

66 nse downstream events including synaptonemal complex assembly.

67 cal roles in substrate binding and catalytic complex assembly.

68 elix/groove interface essential for RED-SMU1 complex assembly.

69 es its interaction with syntaxin-1 and SNARE-complex assembly.

70 ated scaffold that modulates receptor kinase complex assembly.

71 (+) channels are nucleation points for SNARE complex assembly.

72 complete membrane merging by promoting SNARE complex assembly.

73 remodel chromatin and regulate transcription complex assembly.

74 Y to promote rapid and stable cpSRP54.cpFtsY complex assembly.

75 PX domains function as scaffolds in protein complex assembly.

76 nd syntaxin, probably preparing it for SNARE complex assembly.

77 that NLRC3 might inhibit NALP3 inflammasome complex assembly.

78 biquitination at the initiation of ESCRT-III complex assembly.

79 e first glimpse of the requirements for AT1R complex assembly.

80 rylation-dependent processes of multiprotein complex assemblies.

81 Each motif was mutated, and the impact on complex assembly, activity, and substrate docking was mo

82 hat CCN6 regulates mitochondrial respiratory complex assembly/activity as part of the mitochondrial r

83 bution of CCN6 and mitochondrial respiratory complex assembly/activity in CCN6 depleted cells.

84 mutations disrupt mitochondrial respiratory complex assembly/activity resulting in mitochondrial def

85 utant CCN6 protein and inhibited respiratory complex assembly/activity.

86 of carbohydrates could lead to tantalizingly complex assembly algorithms, but these attributes simult

87 are an invaluable resource for carrying out complex assemblies and other downstream bioinformatics a

88 ormulate a model of Rad1/Rad10/Saw1 nuclease complex assembly and 3' tail removal in recombination.

89 g depends on an internal process of adhesion complex assembly and activation; the operational complex

90 h and function by increasing gamma-secretase complex assembly and activity and, consequently, enhanci

91 he common theme and functional plasticity in complex assembly and activity regulation of MLL family m

92 ALKBH5 also modulates telomerase complex assembly and activity.

93 hydrophobic residues of CD1 mediate the HMW complex assembly and affect the catalytic activity, incl

94 hogenesis by conferring apical identity, Par-complex assembly and apical accumulation of Crb.

95 Beclin 1, and thus plays a key role in ATG14 complex assembly and autophagy initiation.

96 nts, as they are indispensable for gamma-TuC complex assembly and cell division, whereas the other th

97 ex proteins, thereby promoting DNA synthesis complex assembly and cell proliferation.

98 unique and shared functions in transcription complex assembly and chromatin structure regulation.

99 cific regions that are thought to facilitate complex assembly and CSC trafficking.

100 ontrolled by a competition between decapping complex assembly and Dcp2 degradation.

101 a useful tool for studying rates of protein complex assembly and degradation.

102 s illustrate the dynamic nature of the INO80 complex assembly and demonstrate for the first time that

103 suggesting multiple rounds of pre-initiation complex assembly and disassembly before productive elong

104 e spatiotemporal pattern of endogenous ESCRT complex assembly and disassembly in mammalian cells rema

105 e overcome, directionality is established by complex assembly and disassembly.

106 PA (hRPA) and human RAD51 during presynaptic complex assembly and disassembly.

107 d dynamics of human RAD52 during presynaptic complex assembly and disassembly.

108 ty, we now report rapid rates of protein/RNA complex assembly and dissociation for two IRE-RNAs with

109 nteractions with XRCC4 or DNA also disrupted complex assembly and end joining.

110 et, which can favor the productive catalytic complex assembly and enhance the dGTP misincorporation e

111 with WRAD, but the roles of the Win motif in complex assembly and enzymatic activity remain unexplore

112 balanced ATFS-1 accumulation promoted OXPHOS complex assembly and function, our data suggest that ATF

113 ssary to trigger downstream events like HOPS complex assembly and fusion of late compartments with th

114 ntly it is unclear what mechanisms restricts complex assembly and how DDK can overcome this inhibitio

115 lusters involved in protein quality control, complex assembly and intracellular trafficking.

116 uble NSF attachment protein receptor (SNARE) complex assembly and may also perform other functions; p

117 embrane as a critical prerequisite for SNARE complex assembly and membrane fusion.

118 hanced to examine the relation between SNARE-complex assembly and neurotransmitter release.

119 Thus, complex assembly and passive retention, rather than cont

120 asmic reticulum that may function in protein complex assembly and protein folding.

121 proteins that are known to regulate protein complex assembly and protein folding.

122 hich spatial segregation of membrane protein complex assembly and quality control improves assembly e

123 T, to address the relationship between SNARE complex assembly and rapid (micro-millisecond) fusion po

124 STAT2 is critical for the receptor proximal complex assembly and reciprocal transphosphorylation of

125 th HS chains that is critical for junctional complex assembly and regulating the flow response.

126 dings provide fundamental insights into PP2A complex assembly and regulation, identify a unique inter

127 g inhibitor blebbistatin suppressed adhesome complex assembly and SM contraction without inhibiting N

128 sights into LMO2/LDB1 macromolecular protein complex assembly and stability, which has implications f

129 IF4F) complex and promotes 48S preinitiation complex assembly and start-site scanning of 5' untransla

130 has critical functions in telomeric protein complex assembly and telomerase recruitment and regulati

131 -register binding in the multivalent LC8-IDP complex assembly and the degree of compositional and con

132 ntaxin complex, followed by productive SNARE complex assembly and vesicle priming.

133 undancy in using host factors in replication complex assembly and virus replication.

134 for priming because they mediate trans-SNARE complex assembly and/or because they prevent trans-SNARE

135 hromatography demonstrated a defect in TRAPP complex assembly and/or stability.

136 ory proteins are believed to assist with Clp complex assembly and/or to promote complex stability.

137 A14 in the regulation of differential Pol I complexes assembly and subsequent promoter association.

138 hereby Munc18-1 acts as a template for SNARE complex assembly, and autoinhibition of synaptobrevin bi

139 lents, in part by attenuating focal adhesion complex assembly, and prevented and reversed experimenta

140 ded for transcription activation, initiation complex assembly, and productive elongation.

141 e factor attachment protein receptor (SNARE) complex assembly, and second, it boosts spike-evoked pre

142 difications mark the completion of a protein complex assembly, and sensitize the local chromatin for

143 and its implications for protein targeting, complex assembly, and septin biology.

144 mplex, the early rate-limiting step in SNARE complex assembly, and stimulates membrane fusion.

145 dy reveals an activation mechanism for SNARE complex assembly, and uncovers a role of the exocyst in

146 T- or HOPS-specific subunits requires proper complex assembly, and Vps8/miniCORVET is dispensable for

147 the N-terminal 168 residues involved in TSPs complex assembly are disordered in the absence of partne

148 itope mutability and accessibility to immune complex assembly are important attributes to consider wh

149 s involved in Sec1p/Munc18 control and SNARE complex assembly are not well understood.

150 Autophagy and inflammasome complex assembly are physiological processes that contro

151 ic vesicle docking, priming, and trans-SNARE complex assembly are the respective morphological, funct

152 Ternary complex (TC) and eIF4F complex assembly are the two major rate-limiting steps i

153 con offers a unique way to study replication complex assembly, as it enables improved composite polyp

154 into early events of translation initiation complex assembly, as well as how eIF4F interacts with su

155 t only myosin VIIa is indispensable for USH2 complex assembly at ankle links, indicating the potentia

156 ate ZNF281-dependent regulatory step of NHEJ complex assembly at DNA lesions and suggest additional p

157 HOPS was essential to mediate SNARE complex assembly at physiological SNARE concentrations.

158 A motifs (cis-elements) underlies regulatory complex assembly at specific chromatin sites, and theref

159 ied interactions are critical for CENP-H/I/K complex assembly at the centromere and kinetochore funct

160 onstrate that alpha-synuclein promotes SNARE complex assembly at the presynaptic plasma membrane in i

161 e loop and the membrane environment in SNARE-complex assembly at the residue level, which helps to un

162 a-Synuclein physiologically chaperones SNARE-complex assembly at the synapse but pathologically misfo

163 atients' fibroblasts displayed impaired GINS complex assembly, basal replication stress, impaired che

164 define ATP6AP1 as a structural hub for V(o) complex assembly because it connects to multiple V(o) su

165 n of cpSRP54 both accelerates and stabilizes complex assembly between cpSRP54 and cpFtsY.

166 localization, is not only essential for ATOM complex assembly but also for segregation of the replica

167 rototypical T4SSs) were capable of T4SS core complex assembly but defective in CagA translocation int

168 e alpha-synuclein promotes presynaptic SNARE-complex assembly, but its molecular mechanism of action

169 Cas9-gRNA interactions are crucial for complex assembly, but several distinct regions of the gR

170 for the vacuolar SNAREs and catalyzes SNARE complex assembly, but the order of their assembly into a

171 monomeric, and whether chaperoning of SNARE complex assembly by alpha-synuclein involves its cytosol

172 e transduction complex and the regulation of complex assembly by alternative splicing is likely criti

173 er for ORC assembly and then pre-replication complex assembly by binding to mitotic chromosomes, foll

174 Current models suggest that SNARE-complex assembly catalyzes membrane fusion by pulling th

175 re of an elongation complex in which the tip complex assembly composed of FimC, FimF, FimG and FimH p

176 Global analyses of protein complex assembly, composition, and location are needed t

177 SNARE complex assembly constitutes a key step in exocytosis th

178 ss different DNA specificities, control over complex assembly directly discourages recombination at u

179 main approaches used to study multi-protein complex assembly/disassembly dynamics.

180 We show that enhancing SNARE-complex assembly dramatically increases the speed of evo

181 is essential for intraflagellar transport A complex assembly during ciliogenesis.

182 oteins, we also quantified adherens junction complex assembly dynamics during epithelial monolayer fo

183 We further proved that SNARE-complex assembly efficiency decreased when we disrupted

184 UFAF6 encodes NADH:ubiquinone oxidoreductase complex assembly factor 6, also known as C8ORF38.

185 o regulating mitochondrial chaperone, OXPHOS complex assembly factor, and glycolysis genes, ATFS-1 bo

186 2+)-CaM regulation of V100 may control SNARE complex assembly for a subset of synaptic vesicles that

187 its interweaving within the events of SNARE complex assembly for exocytosis remains unclear.

188 ins and is proposed to promote SNARE protein complex assembly for vesicle docking and priming.

189 erization may be coupled to oligomeric SNARE complex assembly for vesicle docking and priming.

190 ediates protein quality control, respiratory-complex assembly, gene expression, and stress responses

191 tes nucleosome positioning and transcription complex assembly >300 bp away and how coregulation coevo

192 eir extracellular domain, the TLR4-TLR6-CD36 complex assembly has been suggested to be induced by int

193 protein unbinding associated with the SNARE complex assembly immediately after vesicle priming.

194 o learn how different modes of preinitiation complex assembly impact transcriptional activity.

195 ites on VAMP721, one also required for SNARE complex assembly, implies a well-defined sequence of eve

196 Munc13s open Syntaxin-1, orchestrating SNARE complex assembly in an NSF-SNAP-resistant manner togethe

197 nd whirlin, function synergistically in USH2 complex assembly in cochlear hair cells.

198 nd whether USH1 proteins play a role in USH2 complex assembly in hair cells.

199 curs via distinctive mechanisms for receptor complex assembly in mice.

200 lear- and mitochondrial-encoded subunits for complex assembly in mitochondria await discovery.

201 owever, myosin VIIa is not required for USH2 complex assembly in photoreceptors.

202 and quantify multi-protein adherens junction complex assembly in situ using light microscopy and Fluo

203 Quantifying multi-molecular complex assembly in specific cytoplasmic compartments is

204 IV, consistent with a defect in mitochondria complex assembly in the aged CPCs.

205 olding factor in the nucleus, aiding protein complex assembly in the dense intracellular milieu.

206 defined the kinetics of neuron-specific BAF complex assembly in the formation of induced neurons fro

207 We demonstrate: minimal cadherin-catenin complex assembly in the perinuclear cytoplasm and subseq

208 n INM proteome identity and membrane protein complex assembly in the remaining ER.

209 ction to catalyze R-, Qa-, Qb-, and Qc-SNARE complex assembly in trans, as well as SNARE engagement b

210 ex, we mapped the binding sites that mediate complex assembly in vitro and in vivo.

211 e for SEC/MUNC18 proteins in promoting SNARE-complex assembly in vivo and suggest that STXBP2 R65 mut

212 tructures and facilitating RNA-protein (RNP) complex assembly in vivo.

213 SBI-756 impaired the eIF4F complex assembly independently of mTOR and attenuated gr

214 A mutation in Slx9 that impairs Crm1-export complex assembly inhibits 40S pre-ribosome export.

215 ms of nucleic acid recognition and signaling complex assembly involving the AIM2 (absent in myeloma 2

216 a model for the cooperativity of CRM1 export complex assembly involving the long-range allosteric com

217 mation on the variable arrangements of these complex assemblies is a challenge.

218 In this manner, a strict order of protein complex assemblies is attained.

219 -1 is rendered constitutively open and SNARE-complex assembly is enhanced to examine the relation bet

220 However, in the absence of S-phase kinases complex assembly is inhibited, which is unexpected, as t

221 bound to PACAP27 and Gs heterotrimer, whose complex assembly is stabilized by a NanoBiT tethering st

222 Spontaneous quaternary SNARE complex assembly is very slow.

223 lear and mitochondrial genomes occurs at the complex assembly level.

224 Complex assembly likely occurs at the stereociliary bund

225 novel lipid-interacting protein in the SNARE complex assembly machinery.

226 and equilibrium aspects of DNA-intercalator complex assembly may allow optimization of DNA binding f

227 After Cdc45-Mcm2-7 complex assembly, Mcm10 promotes origin melting by stimu

228 r contacts, provide insights into Csm(crRNA) complex assembly, mechanisms underlying RNA targeting an

229 SNARE-complex assembly mediates synaptic vesicle fusion during

230 ew structure provided a basis to test switch complex assembly models.

231 We also found that during presynaptic complex assembly, most of the RPA and RAD52 was displace

232 ation products, as well as defects in OXPHOS complex assembly observed in MTO1 deficient mice further

233 microscopy data support the conclusion that complex assembly occurs at specific areas of the ER befo

234 Borromean rings or links are topologically complex assemblies of three entangled rings where no two

235 The extracellular matrix (ECM) is a complex assembly of structural proteins that provides ph

236 Complex assembly of the mRNA cap protein, eukaryotic tra

237 In the absence of the Fld1/Ldb16 complex, assembly of LDs results in phospholipid packing

238 ons appear to play a guiding role in protein-complex assembly on chromatin.

239 ISGs, acting at the point of transcriptional complex assembly on target gene promoters.

240 derstanding the mechanism of the FVIIIa-FIXa complex assembly on the activated platelet surface in th

241 abrogates RNA binding without affecting MLL complex assembly or catalytic activity.

242 on chromatin, absent significant changes in complex assembly or integrity.

243 mTOR or Pim kinases, translation initiation complex assembly, or eIF4A function.

244 A complex assembly pathway conducts their initial synthesi

245 ch eIF4G is at the core of a multi-component-complex assembly pathway.

246 ed from fully sequenced genomes onto protein complex assembly pathways, we demonstrate evolutionary s

247 ap shows that this entire 14-MDa Nup82-Nup84 complex assembly positions the cytoplasmic mRNA export f

248 action in vitro inhibits splicing and blocks complex assembly prior to formation of the prespliceosom

249 ovides a powerful platform for studying this complex assembly process and the effects of other factor

250 similar as carbonyl or methylene groups in a complex assembly process.

251 relying on the others, suggesting four-SNARE complex assembly rather than direct binding of each to H

252 n domain and was necessary for NADPH oxidase complex assembly, reactive oxygen species production, an

253 ch membrane regions could facilitate protein complex assembly remains largely unclear.

254 hy and how the flexible loop facilitates the complex assembly remains poorly understood because it is

255 e of the N-peptide in Munc18a-mediated SNARE complex assembly remains unclear, our results demonstrat

256 r2 in regulating the dynamicity of the TIM23 complex assembly required for preprotein import and coup

257 Core complex assembly requires interaction of WDR5 with the M

258 ough the individual domains bind DNA poorly, complex assembly requires oligomerization and cooperatio

259 actome; we furthermore showed that the motor complex assembly requires two Myo4pShe3p heterotrimers,

260 conjugates that drive protein degradation or complex assembly, respectively.

261 e formation of 2:1 host-guest stoichiometric complex assemblies, resulting in an encapsulated anion s

262 ites, interacts with menin, and inhibits MLL complex assembly, resulting in decreased H3K4me3 and tra

263 solutions, but it is rarely applied to more complex assembly shapes.

264 translation, mitochondrial respiratory chain complex assembly, signal recognition particle-dependent

265 est a new model in which Sec6 promotes SNARE complex assembly, similar to the role proposed for other

266 ones induced subtle alterations in RDS/ROM-1 complex assembly, specifically resulting in the formatio

267 -performance mass transport nanosystems, and complex assembly structures.

268 ically in Cajal bodies, where telomerase RNP complex assembly takes place.

269 mall number of tile types to assemble large, complex assemblies that can retain nanoscale resolution.

270 We report an assay of SNARE complex assembly that does not rely on fusion and for wh

271 s the initiator of sequential ESCRT III-Vps4 complex assembly that facilitates scission and repair of

272 work reveals a specificity in AMPA receptor complex assembly that is dynamic in both space and time.

273 distinguished two pathways of 80S:CrPV IRES complex assembly that produce elongation-competent compl

274 ite (ABS3) in talin is required for adhesion complex assembly, the central ABS2 is essential for foca

275 We detail the mechanisms of receptor complex assembly, the interrelated nature of these recep

276 antified various stages of adherens junction complex assembly, the multiprotein complex regulating ep

277 e factor activating protein receptor (SNARE) complex assembly, thereby clamping fusion in the absence

278 , in turn, promotes mitochondrial DNA repair complex assembly, thereby enhancing mitochondrial DNA re

279 hat the SNAP25 loop region facilitates SNARE-complex assembly through promoting prefusion SNARE binar

280 HOPS can 'template' SNARE complex assembly through SM recognition of R- and Qa-SNA

281 Thus, Vps33 appears to catalyze SNARE complex assembly through specific SNARE motif recognitio

282 n trap, and can now probe the intact protein complex assembly, through its constituent subunits, to t

283 ereby mTORC1 and CK2 coordinate TC and eIF4F complex assembly to stimulate cell proliferation.

284 Munc18-1 orchestrates SNARE complex assembly together with Munc13-1 to mediate neuro

285 oned four USH1 proteins in the cochlear USH2 complex assembly using USH1 mutant mice.

286 DNA damage can initiate complex assembly via ATM phosphorylation of the PIDD dea

287 f eIF2beta and simultaneously bolsters eIF4F complex assembly via the mTORC1/4E-BP pathway.

288 le in substrate ubiquitination from the core complex assembly, we analyzed a series of mutations with

289 foundation for a theory of reliable protein complex assembly, we study here an equilibrium thermodyn

290 transduction pathways regulating mRNA export complex assembly, we used fluorescence recovery after ph

291 ound Ypt7 activates HOPS to catalyze 4-SNARE complex assembly when it is on the same membrane as the

292 trong and weak cooperative coupling of SNARE complex assembly where each mode implicates different in

293 Thus, we propose a model of MET complex assembly where Tomt and the Tmcs interact within

294 Hop2 and Mnd1 co-operate to mediate synaptic complex assembly, whereas ssDNA binding by the Hop2 C-te

295 tion of TA proteins to the OMM is ensured by complex assembly, while orphan subunits are extracted by

296 s to produce density maps of larger and more complex assemblies with multiple protein components of m

297 y involve a new regulatory mechanism linking complex assembly with forward trafficking and provide ne

298 E SNAP33 in the Qa-SNARE transition to SNARE complex assembly with the R-SNARE VAMP721.

299 Putative partial SNARE complex assembly with the SNARE motif mutant Stx1A(AV) (

300 es based on time-lapse TALM images (pcTALM), complex assembly within dynamic submicroscopic zones was