ライフサイエンスコーパス: compromised

1 s when C- and D-functions are simultaneously compromised.

2 kely, and as a result the quality of care is compromised.

3 onditions where cap-dependent translation is compromised.

4 ed in the mesenchymal cells, tumor growth is compromised.

5 inobutyric acidergic synaptic inhibition was compromised.

6 hen extracellular amino acid availability is compromised.

7 her sensory inputs are depleted or otherwise compromised.

8 e models the production of 11-cis-retinal is compromised.

9 reas the responses from the fibroblasts were compromised.

10 her proprioception at the elbow was likewise compromised.

11 Chlamydomonas cells when BBSome function is compromised.

12 Nevertheless, energy state is not compromised.

13 nder conditions where proteasome function is compromised.

14 ting that NLS1 function in Delta27bp MSH3 is compromised.

15 C-receptor detachment post-transport is more compromised.

16 e predominant pro-apoptotic caspase CED-3 is compromised.

17 tion respectively, when separase function is compromised.

18 decreased and the function of the tissue is compromised.

19 to cope with every day or acute stressors is compromised.

20 were exposed and cell membrane integrity was compromised.

21 ted AAA patients was stable and persistently compromised [4-year relative survival and 95% confidence

22 e average activity of TRIAD variants is more compromised, a larger proportion has successfully adapte

23 can be activated, but it exhibited a largely compromised ability to suppress hepcidin expression.

24 Inhibition of beta-catenin signaling compromised activation of the emergency granulopoiesis p

25 When compromised, activation of immune/inflammatory responses

26 Furthermore, Prkcz null mice showed compromised AD-like phenotypes in the MC903 AD model.

27 n of an electric field, the cell membrane is compromised, allowing the delivery of exogenous material

28 This led to compromised and differential alpha1 subunit cell surface

29 ences in gastric BAs between physiologically compromised and healthy individuals have not been fully

30 The performance is not compromised and is comparable to deeper neural networks.

31 e weakened OM of DeltayhdP cells was further compromised and ruptured before the IM during mlaA*-medi

32 ent, the ER integrity of SNX14 (KO) cells is compromised, and both SNX14 (KO) cells and SCAR20 diseas

33 ales when genome-wide defense mechanisms are compromised, and suggests a previously unappreciated epi

34 n is correlated with disrupted cell barrier, compromised angiogenesis and enhanced monocyte adhesion.

35 Both BIDEN-AP and CCPM-BIDEN-AP compromised angiogenesis by downregulating epithelial-me

36 Accordingly, depletion of neutrophils compromised angiogenesis during early age, genotoxic inj

37 ondrial superoxide production coupled with a compromised antioxidant response guided by a defective N

38 redirected T-cell function but significantly compromised antitumor function.

39 partment in Neuro-COVID patients and suggest compromised antiviral responses in this setting.

40 while interrupting the TBK1-DRP1 connection compromised antiviral responses.

41 activation of WNT/beta-catenin signaling was compromised as a consequence of LRP6 mutations.

42 roteomics, as the sole protease for rhEPO is compromised, as no natural tryptic cleavage site is loca

43 The compromised astrocyte activation in FBN-ARO-KO mice was

44 This effect of compromised astroglial function was specific to the NTS

45 We observed that CKM integrity appeared compromised at a subset of repressed promoters, suggesti

46 assessed whether proprioception was equally compromised at the elbow joint, and whether it could be

47 at least one wild-type copy of Ppal15kDa was compromised at varying levels.

48 Older adults showed compromised attention and reduced noradrenergic responsi

49 microbial dysbiosis occur, which can lead to compromised barrier function of the gingival epithelia.

50 Compromised barrier is a key event in IBD pathogenesis.

51 te monocyte phagocytic activity, both likely compromised because of the induction of antibodies that

52 ion, substrate-enzyme interactions are often compromised because of the limited access of macromolecu

53 ognate receptor VPAC2, circadian behavior is compromised because SCN cells cannot synchronize.

54 The R666W and R761W substitutions compromised binding of GCAP1 with RetGC1 in HEK293 cells

55 ositional frequency of <1%) that resulted in compromised biophysical properties (Tm = 61 degrees C an

56 new conceptual framework that positions the compromised blood-brain and intestinal barriers as impor

57 induced systemic inflammation and normalized compromised blood-brain barrier permeability and tight j

58 laminin from the basement membrane across a compromised blood-brain barrier.

59 presents a unique opportunity to reconstruct compromised BOLD signal while capturing features of an i

60 TIMP3 transgenic mice showed compromised bone integrity as opposed to [-1A]TIMP3 mice

61 mine among forager-horticulturalists whether compromised bone strength (indicated by fracture and low

62 itude of productivity losses associated with compromised bone strength.

63 The barrier function was shown to be compromised by 24 hours of exposure to high doses (17.9

64 clease activity on ssDNA but not on dsDNA is compromised by a NEIL3 Zf-GRF repeat, whereas one Zf-GRF

65 effectiveness in birth weight of IPTp-SP is compromised by A581G-bearing parasites, but there was no

66 cell lung cancers, but their efficacy can be compromised by acquired drug resistance conferred by EGF

67 tivity of BET protein inhibitors (BETi's) is compromised by adaptive or innate resistance in acute my

68 f the default mode network (DMN) that become compromised by amyloid pathology years before the clinic

69 long-term survival of the allograft might be compromised by chronic antibody-mediated rejection (CAMR

70 g that prevention efficacy is unlikely to be compromised by DMPA use.

71 s of mature GABAergic interneurons which are compromised by early-life injury have yet to be identifi

72 Predicted solutions were compromised by excessively underdetermined systems, disp

73 CFS stability may be compromised by incomplete DNA replication and repair in

74 t death data as a tool to compare OPO is not compromised by its lack of inclusion of ventilation or o

75 the species from extinction, condors remain compromised by lead poisoning and limited genetic divers

76 val of peritoneal Escherichia coli sepsis is compromised by long-chain polyphosphates, and improves w

77 rought, when ecosystem processes are already compromised by low water availability.

78 Their adaptive responses may however be compromised by other constraints, such as predation risk

79 m 1 of many mutations, after which cones are compromised by oxidative stress.

80 Regulation can be compromised by reducing the overall structure by fusing

81 Malaria vector control may be compromised by resistance to insecticides in vector popu

82 otodynamic therapy, but their utilization is compromised by self-aggregation in aqueous media.

83 obiome, ART may promote microbiome diversity compromised by SIV infection, improve the gut microbiota

84 s, however, existing in utero approaches are compromised by spontaneous fetal motion.

85 Resilience of these forests is likely compromised by structural homogenisation from a century

86 lts demonstrate that the BER DNA ligases are compromised by subtle changes in all 12 possible noncano

87 The quantification of auxin can be compromised by the breakdown of labile auxin-related com

88 hat switching of individual molecules is not compromised by the close proximity of neighbors.

89 ed to treat influenza, but their efficacy is compromised by the emergence of drug-resistant variants.

90 eutralizing antibody (bnAb) therapies may be compromised by the preexistence of less susceptible vari

91 when this fundamental protective barrier is compromised by the specific mechanisms of FUS-BBB openin

92 are highly successful, but their utility is compromised by their propensity to aggregate during manu

93 the identity of those interneurons which are compromised by tissue damage during early life remains u

94 al lipopolysaccharide, which may implicate a compromised capacity to manage harmful pathogens.

95 Compromised CCL3 production in turn creates an immune-su

96 ly, overexpression of a CYP24A1 D-box mutant compromised CDH1 binding, allowing CDH1 hyperactivation,

97 The deletion of cdvB1 compromised cell division, causing occasional division f

98 Likewise, depletion of TAZ compromised cell migration, whereas its overexpression e

99 broblasts and KLF6 in keratinocytes not only compromised cell proliferation, but also increased infla

100 tions led us to discover that XRN2 depletion compromised cell survival after additional knockdown of

101 ribosomes but induced proteotoxic stress and compromised cell viability.

102 While shortening expansion compromised cell yield, this method licensed Th17 cells

103 cytokinesis, supernumerary centrosomes, and compromised cell-cycle checkpoints, allowing accumulatio

104 nuates cancer cell growth and sensitizes p53-compromised cells to chemotherapeutic agents.

105 s (CTLs) and natural killer cells (NKs) kill compromised cells to defend against tumor and viral infe

106 r T cells to distinguish between healthy and compromised cells.

107 rough its role in the removal of genetically compromised cells.

108 of PTEN, both in human and mouse, results in compromised central immune tolerance processes that may

109 n suggest that the tRNA deficiencies lead to compromised chloroplast protein synthesis and the observ

110 ome-mediated degradation of HDAC2 and HDAC3, compromised chromatin maturation, as indicated by elevat

111 e investigation of PLGA use in metabolically-compromised clinical and experimental settings.

112 To examine whether compromised clocks play a role in the pathogenesis of T2

113 genomic stress in the purging of genetically compromised CNS cells, we find that defective AIM2 infla

114 pse in nuclear integrity is concomitant with compromised contractile function and may contribute to t

115 he endosomal system in vulnerable neurons is compromised, contributing to the removal of accumulated

116 vascularization (NV) predisposes patients to compromised corneal transparency and visional acuity.

117 in loss of precious time, money and finally compromised data.

118 compromised SCR to unconditioned stimulus or compromised declarative memory for stimulus-outcome cont

119 n of constitutive heterochromatin results in compromised development and epigenetic reprogramming, wh

120 -income and middle-income countries who have compromised development.

121 rate, spontaneous loss of pluripotency, and compromised differentiation potential.

122 inogens and their complex crosstalk with the compromised DNA repair machinery of BRCA1/2-mutant cells

123 gical functioning of riparian zones is often compromised due to degraded conditions (e.g., vegetation

124 ver, the physical stability over storage was compromised due to the presence of hydrolytic enzymes.

125 embly in S. pombe when its integrity becomes compromised during cytoskeletal damage and stress by red

126 othesis that endothelial Ca(2+) signaling is compromised during obesity, but the underlying abnormali

127 at the mechanical integrity of LiF is easily compromised during plating, making it intrinsically unab

128 As clinical data collection was compromised during the lockdowns, standardized surveys o

129 Ai based suppression of BjuGalpha1 displayed compromised effects on most of the tested vegetative and

130 pha-tubulin detyrosination near kinetochores compromised efficient error correction, without affectin

131 ield lesions comparable to those in cases of compromised elastic fiber integrity.

132 Moreover, PD-L1 deficiency leads to compromised expression of multiple immune-response-relat

133 mice, with Trem2-deficient microglia showing compromised expression of proliferation/Wnt-related gene

134 wed attenuated IgG responses, accompanied by compromised Fcy receptor binding and Fc effector activit

135 Here, we reconstructed compromised fMRI signal using deep machine learning.

136 CDK phosphorylation in mitosis is compromised for approximately half of all mitotic CDK su

137 ssrS mutants lacking Bb6S RNA were compromised for infectivity by needle inoculation, but i

138 rast, Mm47-deficient or knockdown cells were compromised for Nlrp3 inflammasome responses.

139 In vivo, the parA (R351A) allele is compromised for partition, but its repressor activity is

140 ation/stability caused, for example, through compromised function of the actin-binding protein Cdc3-p

141 for neuronal HRI that senses and responds to compromised function of the proteasome to restore proteo

142 d in the case of pre-conditions with already compromised functioning of these systems, such as in pat

143 Compromised functions of these five MKKs in the quintupl

144 c disorders observed in mice and humans with compromised GIGYF2 function.

145 KU-dependent defects in 18S rRNA processing, compromised global protein synthesis in haematopoietic c

146 ccumulation of single genomic rNMPs severely compromised growth, but this was reversed in absence of

147 ating the C-terminal domain of TPS1 severely compromised growth.

148 Compromised gut health and dysbiosis in people with hear

149 e been linked to maladaptive development and compromised health and behavior.

150 are a useful aid in detecting early signs of compromised health and welfare.

151 ntry during the physiological hair cycle and compromised HF regeneration upon transplantation.

152 f host nutritional deficiencies leading to a compromised host-symbiont state and (ii) the opening of

153 COMPROMISED HYDROLYSIS OF TRIACYLGLYCEROLS7 (CHT7) in Ch

154 The Chlamydomonas reinhardtii Compromised Hydrolysis of Triacylglycerols7 (CHT7) prote

155 e with underlying conditions, and those with compromised immune systems can develop severe disseminat

156 In line with the compromised immunity to Pst DC3000, ccc1 mutants show re

157 for complicated infections and patients with compromised immunity.

158 eper of tissue homeostasis whose activity is compromised in aging guts.

159 jmj14 mutants were compromised in both local and systemic defences.

160 SHOCK FACTOR A6B [HSFA6B] family member) was compromised in bzip60-2, and the HSFTF13 promoter was sh

161 r long-term protective immunity but is often compromised in cancer, where T cell exhaustion leads to

162 feron production, and antiviral activity are compromised in cell cultures and mice, while autophagic

163 ows that nonhomologous end joining (NHEJ) is compromised in cells with ablated MEK5 protein expressio

164 drial one-carbon metabolism that is severely compromised in CI mutant cells.

165 embrane beta-barrel precursors were severely compromised in CL-lacking cells.

166 rs insight on the neural systems that may be compromised in cognitive aging and age-related condition

167 o2-S1 cell ghosts were unstable and severely compromised in contraction on ATP addition.

168 ediated degradation of autophagy cargoes, is compromised in cystinosis.

169 ed in the apoplast by flg22 or flgII-28 were compromised in Deltawak1 plants, but PTI at the leaf sur

170 olarizing potential oscillatory activity was compromised in early postnatal days as was both feedforw

171 to clear brain LBs are absent or, possibly, compromised in laforin-deficient murine LD.

172 nd swallowing (S/F/S), a key innate behavior compromised in multiple genetic developmental disorders

173 t HY5 gene expression and protein levels are compromised in multiple myc mutants.

174 pendent anti-parasite immune responses being compromised in Notch dimer-deficient animals.

175 s implicated in many cognitive processes, is compromised in numerous brain disorders, and exhibits a

176 tion factor Kruppel-like factor 2 (KLF2) are compromised in PAH.

177 but the development of bone cancer pain was compromised in Pd1-/- mice.

178 ntact in healthy aging, will be particularly compromised in people at the earliest stages of AD.

179 cuole contacts increase when NPC assembly is compromised in several nup mutants, including nup116Delt

180 nown underlying ionic mechanism that becomes compromised in some forms of lymphedema.

181 d that drive-carrying males are particularly compromised in sperm competition, resulting in reduced r

182 lbumin expression and secretion, is severely compromised in telomerase mutant cells with short telome

183 oinflammation but also when BBB integrity is compromised in the resting state.

184 e penumbrium of the inflammatory injury were compromised in their regenerative capacity.

185 C suggests the ER permeability barrier to be compromised in these mutants.

186 and closed genome compartments is profoundly compromised in tumors.

187 whose biological functionality was severely compromised in vivo but remains catalytically active in

188 te that all tested class II IN substitutions compromised IN-RNA binding in virions by one of the thre

189 ation of insulin secretion in humans and, if compromised, in the development of type 2 diabetes (T2D)

190 n cause severe respiratory illness in immune-compromised individuals.

191 defects, and poses serious risks for immuno-compromised individuals.

192 addition, depletion of SUV420H2 resulted in compromised interactions between H4K20me3 and gene-regul

193 for foxc1a upregulation when its function is compromised; interestingly, the expression of another AR

194 ease associated with dysbiosis, resulting in compromised intestinal epithelial barrier and chronic mu

195 effect on CI assembly is principally due to compromised intramitochondrial transport of the MICOS co

196 Independent of compromised ISVP stability, we also found that T3D/T1L L

197 xogenous E2 administration fully rescued the compromised JAK-STAT3 pathway and reactive astrogliosis,

198 rio also observed in other ciliopathies with compromised kidney function).

199 -state localization showed that structurally compromised KOR1 variants were directed to tonoplasts.

200 striatal Kv3.3-expressing PV neuron may link compromised Kv3 channel function and VLS-based orofacial

201 When any of these resources are compromised, LLAs exhibit poor balance control compared

202 t upfront responses, acquired resistance has compromised long-term applicability.

203 Severely compromised LPL activity causes familial chylomicronemia

204 y be especially susceptible to COVID-19, and compromised lung function from COVID-19 could also put a

205 sine prevented weight loss, tachycardia, and compromised lung function in E. coli-exposed mice.

206 DNA replication fork integrity, which, when compromised, may predispose to the development of early-

207 g TRIM72 lead to skeletal muscle fibers with compromised membrane barrier function, providing a conti

208 memory phenotype, which resulted in severely compromised memory CD8 T cell development.

209 well as higher feelings of virtual immersion compromised memory performance in typically developing c

210 rongly reduced metabolism and conferred this compromised metabolic state to CD8(+) T cells, thereby p

211 Compromised microvasculature resulting from disrupted br

212 ate the role of DNA methylation in continued compromised mitochondrial dynamics and genomic stability

213 This energy deficiency, together with compromised mitochondrial membrane potential and elevate

214 fects, neuromuscular junction abnormalities, compromised motor performance, and premature death.

215 in samples where the spectral resolution is compromised, multivariate regression methods are require

216 Enzymatically-compromised mutants of CypD show reduced abilities to di

217 S. japonicus cells lacking Cmp7 have compromised NE sealing after mitosis but are viable.

218 esting that they arise from acute effects of compromised NMDAR-mediated transmission.

219 uption of these ZIKV NS5-hSTAT2 interactions compromised NS5-mediated hSTAT2 degradation and interfer

220 individual mature thymic epithelial cells is compromised only modestly.

221 ce, in settings where tolerance pathways are compromised or have been genetically manipulated to driv

222 situations including where MHC expression is compromised, or where conventional adaptive and/or NK ce

223 State metrics indicative of compromised oral health correlate with AD mortality rate

224 mbalanced tissue maintenance, cell death and compromised organ function.

225 the symptoms are localized according to the compromised organ.

226 This compromised oxidative phosphorylation, causing severe ox

227 roxide and/or p-anisidine value suggesting a compromised oxidative status.

228 se mechanisms linking abnormal structure and compromised oxygen transport are only partially understo

229 f the most susceptible populations are often compromised, passive immunization treatments using broad

230 T) and MRI chest were performed in 35 immuno-compromised patients suspected of pulmonary infection.

231 res that have increased the number of immune compromised patients, antibacterial antibiotics that dis

232 in cannabinoid receptors, CB1 and CB2, show compromised PDZ with dysregulated angiogenic factors, re

233 As such, they have compromised performance.

234 'steer' survivors towards resistant but more compromised phenotypes, we can potentially improve treat

235 cyclic nucleotide signalling, resulting from compromised phosphodiesterase activity, as well as alter

236 ections have previously been associated with compromised placental antibody transfer, but the mechani

237 the Myt TFs in mouse pancreatic progenitors compromised postnatal beta cell function, proliferation,

238 , or TGF-beta signaling independently led to compromised pro-tenogenic effects of tECM and actin fibe

239 inpatients with SCZ-a state associated with compromised probabilistic reasoning due to reduced gluta

240 recipients resulted in reduced frequencies, compromised proliferation, and diminished suppressive ca

241 Clearly, the lack of muscle spindles compromised proprioception at the knee but not at the el

242 n of these interactions led to catalytically compromised proteins that fail to bind NADH.

243 e complementary UTP opposite template RDV is compromised, providing a second opportunity to inhibit r

244 in one dataset and reconstruct artificially compromised regions in an independent dataset, frame by

245 matory responses promoted renal scarring and compromised renal function, as indicated by elevated ser

246 These yield defects correlated with compromised reproductive development predominantly in fe

247 related encoding and retrieval processes are compromised, resulting in a failure in the prioritizatio

248 A compromised sarcolemmal repair process could promote an

249 g threat acquisition, despite no evidence of compromised SCR to unconditioned stimulus or compromised

250 mation and mammosphere formation, indicating compromised self-renewal capacity.

251 Compromised shape control is particularly hindering in g

252 d prevalence of conduction abnormalities and compromised sinoatrial node function which could lead to

253 In conclusion, S1pr2(-/-) mice have compromised skin barrier function and increased bacteria

254 suggest, for the first time, that effects of compromised smooth muscle contractility are more importa

255 ces was lower than expected, possibly due to compromised somatosensory pathways in individuals with t

256 vented the recruitment of downstream ESCRTs, compromised spindle disassembly, and led to defects in n

257 ydrological controls influenced in winter by compromised subglacial flow and low meltwater production

258 the translocase of the inner membrane 23 is compromised such as in temperature-sensitive mutants of

259 mice, formation of striolar/central zones is compromised, such that they resemble extrastriolar/perip

260 le strength of the biofilm infected skin was compromised supporting the notion that healed wounds wit

261 explain why smokers and elderly persons with compromised surfactant function are at increased risk of

262 ced juvenile growth, mass loss in adults and compromised survival between years in both juveniles (86

263 sruption of both type-A ARRs and EXO70D1,2,3 compromised survival in carbon-deficient conditions, sug

264 Particularly alarming is the severely compromised survival of female patients (4-year relative

265 ss-of-function exo70D1,2,3 mutants exhibited compromised targeting of type-A ARRs to autophagic vesic

266 re, decreased mitochondrial respiration, and compromised TCA flux compared with DLBCL cells expressin

267 dendritic inhibition where dynamic chloride compromised the ability of inhibition to offset neuronal

268 RING finger domain, and that these mutations compromised the ability of MKRN3 to repress KISS1 and TA

269 Substitution of either conserved histidine compromised the ability of Sts-1 to suppress signaling p

270 pression enhanced H5N1 virus replication and compromised the antiviral activity of A77 1726.

271 tivation of the ATP-gated P2X7R channel also compromised the effects of MerTK blockade.

272 rs of either miR-147 or miR-148 reciprocally compromised the effects of the mimics of their counterpa

273 aptive immunity-deficient mice significantly compromised the endometrial innate immunity, demonstrati

274 aptive immunity-deficient mice significantly compromised the endometrial innate immunity.

275 report that feeding a high-fat diet to mice compromised the function of the orexin system, leading t

276 Further, Shank3 knockout severely compromised the in vivo ability of visual cortical circu

277 elongation factor G1 (mEF-G1) progressively compromised the integrity of the electron transport chai

278 so, in the beta frequency band significantly compromised the prediction of the limb to be moved.

279 ry gland macrophages by clodronate liposomes compromised the restoration of irradiation-impaired sali

280 ium grow at normal rates when we genetically compromised their ability to perform insertion/deletion

281 hway when the ubiquitin proteasome system is compromised, thus contributing to the mechanisms targeti

282 These defects are likely due to the compromised trans-endothelial migration of HSPCs since t

283 transfer, but the mechanism underlying this compromised transfer is not established.

284 d at high spatial resolution and can lead to compromised traps.

285 Brd9 ablation compromised Treg cell function in inflammatory disease a

286 y disrupted circadian behavioral rhythms and compromised TTFL time-keeping in the corresponding SCN s

287 ic capacity of COX-deficient ECs is severely compromised under energetically demanding conditions, as

288 thrombosis, and their inhibitory effects are compromised under high shear rates when VWF levels are i

289 enever somatosensation in the intact leg was compromised via perturbations of the platform.

290 on following N refeeding is explained by its compromised viability during N deprivation and by the oc

291 These phenotypes include heart development, compromised viability in combination with low gene dose,

292 Mechanisms involving compromised viral sensing in infected cells may thus be

293 AvrPtoB phospho-null mutants exhibited compromised virulence functions and were unable to suppr

294 PE from miR-211(-/-) mice that show severely compromised vision.

295 cation-induced dwarfism is not merely due to compromised water transport brought about by lignin defi

296 Behavioral indicators that pointed toward a compromised welfare state (e.g. stereotypies, hypervigil

297 omerization properties of SecA were strongly compromised while the levels of individual SecYEG transl

298 As impacted and could increase the number of compromised wilderness areas by ~60%.

299 h codes, resources mediated by nAChRs may be compromised with aging.SIGNIFICANCE STATEMENT When atten

300 aired granulation tissue collagen leading to compromised wound tissue biomechanics.