ライフサイエンスコーパス: conceptus

1 ndometrial luminal epithelium but not in the conceptus.

2 kers are scattered throughout the dab2 (-/-) conceptus.

3 om proliferating CTB at the periphery of the conceptus.

4 toward the implantation of a semiallogeneic conceptus.

5 E, as well as in the binucleate cells of the conceptus.

6 ined in cultured cells and in the developing conceptus.

7 sm to provide for the growing demands of the conceptus.

8 the effect of origin on the phenotype of the conceptus.

9 own syndrome conceptus than that of a normal conceptus.

10 for the survival of the genetically foreign conceptus.

11 tocyst anticipates the polarity of the later conceptus.

12 contribution of donor allantoic cells to the conceptus.

13 onic and embryonic angioblasts in the murine conceptus.

14 ype depends on the genetic background of the conceptus.

15 ontaneous abortion of a chromosomally normal conceptus.

16 on of multiple embryos to select one healthy conceptus.

17 sive due to the inaccessibility of the early conceptus.

18 t dialogue between the mother and developing conceptus.

19 arks for HSC migration and maturation in the conceptus.

20 air in assuring the genomic integrity of the conceptus.

21 and plays a pivotal role in programming the conceptus.

22 had begun to move from the main body of the conceptus.

23 a (the decidua) that surrounds the implanted conceptus.

24 nutrient availability for the growth of the conceptus.

25 d maintaining the growth and survival of the conceptus.

26 ately 2%) environment of the first trimester conceptus.

27 ifferentiation in the periimplantation ovine conceptus.

28 global role for T in vascularization of the conceptus.

29 of H19 imprinting persisted in mid-gestation conceptuses.

30 476 individual trophoblast cells from these conceptuses.

31 in horses carrying interspecies hybrid mule conceptuses.

32 visceral yolk sac of organogenesis-stage rat conceptuses.

33 laced into the base of the allantois of host conceptuses.

34 d with a data set from long and short day-15 conceptuses.

35 fferent between in vivo and in vitro-derived conceptuses.

36 ass II expression, which was specific to IVP conceptuses.

37 but did not occur in ILB2-null (IL1B2(-/-)) conceptuses.

38 it interspecies chimeric competency in mouse conceptuses.

39 lfonylated derivatives, were detected in the conceptuses.

40 to BW males produce overgrown but dysmorphic conceptuses.

41 ear trophectoderm cells isolated from day 15 conceptuses.

42 the developing forebrain in humans (1 in 250 conceptuses, 1 in 16,000 live-born infants).

43 vo versus in vitro and in vivo versus cloned conceptuses (1153 and 334DEGs respectively) with limited

44 Control cows yielded more filamentous conceptus ( 25 mm) compared with HS cows (71 vs 45%; P <

45 mited differences between in vitro Vs cloned conceptuses (36 DEGs).

46 ceptuses 8 mm in diameter (comparison 1) and conceptuses 8 mm (comparison 2) versus samples from cycl

47 ormed, samples derived from pregnancies with conceptuses 8 mm in diameter (comparison 1) and conceptu

48 in the trophectoderm of the elongating ovine conceptus after day 12 of pregnancy.

49 last giant cells, which are derived from the conceptus and are directly in contact with maternal tiss

50 een the IVP and in vivo derived (IVD) bovine conceptus and endometrium, a Day 16 conceptus-endometria

51 ers predicted molecular interactions between conceptus and endometrium.

52 L) metabolite previously found in the day 10 conceptus and kidneys of vitamin A-deficient rats mainta

53 traembryonic cells that are derived from the conceptus and play a major role in this process.

54 d maternal T cell recognition of the foreign conceptus and subsequent breakdown in maternal-fetal tol

55 equires coordinated interactions between the conceptus and surrounding decidual cells, but the involv

56 al endoderm remains in the distal tip of the conceptus and the ADE fails to form, whereas the node an

57 s unknown how these interactions between the conceptus and the endometrium are coordinated at the lev

58 r disruption of signaling between the cloned conceptus and the endometrium, particularly the intercar

59 cting as multi-signal messengers between the conceptus and the maternal tract, and contributing to MR

60 etic cells originate from other sites in the conceptus and then colonize the placenta.

61 ene had high expression in porcine and mouse conceptus and throughout placenta development.

62 ession from a competent blastocyst to a long conceptus and vice versa; these were enriched for KEGG p

63 Finally, when removed from conceptuses and cultured in isolation, neural plate and

64 ects on the survival of both male and female conceptuses and fetuses.

65 nd embryonic vasculopathy in cultured murine conceptuses and in the conceptuses of streptozotocin-ind

66 th Gtl2 during mouse embryogenesis in normal conceptuses and in those with uniparental disomy for chr

67 that the first platelet-forming cells of the conceptus are not megakaryocytes (MKs) but diploid plate

68 In humans, ~50% of conceptuses are chromosomally aneuploid as a consequence

69 The mUPD12 conceptuses are invariably growth-retarded while pUPD12

70 However, conceptus aromatase expression and estrogen secretion we

71 orphological analyses of the Ikbkap(-)(/)(-) conceptus at different stages revealed abnormalities in

72 , a small number of allantoises removed from conceptuses at a considerably earlier stage were found t

73 w embryo before birth thereby supporting two conceptuses at different stages of pregnancy.

74 uring early human placental development, the conceptus attaches itself to the uterus through cytotrop

75 involved in epithelial barrier formation and conceptus attachment and implantation reflected the uniq

76 important role in protecting the developing conceptus before it establishes an efficient circulation

77 Hematopoiesis in the mouse conceptus begins in the visceral yolk (VYS), with primit

78 ium drives and responds to divergence of IVP conceptus biochemistry, likely contributing to pregnancy

79 expressed genes; DEG) diverged from the IVD conceptus but only after co-culture with endometrium (37

80 occurred on day 14 in wild-type (IL1B2(+/+)) conceptuses but did not occur in ILB2-null (IL1B2(-/-))

81 MTHFR polymorphism in mothers of trisomy 18 conceptuses but were unable to identify any other signif

82 trophoblast cells promote blood flow to the conceptus by actively remodeling the uterine vasculature

83 stages second polar bodies were attached to conceptuses by a thin, extensible, weakly elastic 'tethe

84 , and that of betaH1-globin, in normal mouse conceptuses by means of in situ hybridization.

85 a single spermatozoon can yield up to three conceptuses carrying an identical paternal haplotype.

86 omplete deletion of Hif1alpha from the mouse conceptus causes extensive placental, vascular and heart

87 t for yeast one-hybrid screening of a day 13 conceptus cDNA library.

88 ellular vesicles (EVs) recovered from Day 16 conceptus-conditioned medium were characterized and thei

89 genetically disparate (allogeneic) mammalian conceptus contradicts the laws of tissue transplantation

90 uced or drug-induced changes in maternal and conceptus copper metabolism, or both.

91 ify maternal cortisol secretion and increase conceptus cortisol exposure.

92 d second cleavage, the second polar body and conceptus could remain coupled ionically up to the blast

93 Use of MAO-SLC7A1 knockdown in conceptuses decreased arginine transport (73%, P<0.01),

94 onic generation microscopy to evaluate early conceptus (defined as the embryo and extra-embryonic tis

95 Further, of the IVP conceptus DEG, 81 genes (21%) were associated with abnor

96 The miRNA cargo contained in conceptus-derived EVs was similar between all three grou

97 heria may be facilitated by highly conserved conceptus-derived proteins such as macrophage capping pr

98 al development and fetal growth, we examined conceptuses developing in the absence of maternally deri

99 mpensation that may result in differences in conceptus development across species.

100 In cattle, conceptus development after elongation relies on well-ch

101 nockdown of SLC7A1 mRNA resulted in retarded conceptus development and abnormal function compared to

102 lase and agmatinase were activated to rescue conceptus development.

103 s critical in supporting the early stages of conceptus development.

104 ses was inhibited, expression of a number of conceptus developmental genes was not altered.

105 gly, mares carrying interspecies hybrid mule conceptuses did not exhibit this transient, pregnancy-as

106 netic background, approximately 50% Tgfb1-/- conceptuses die midgestation from defective yolk sac vas

107 plantation mouse embryo to that of the later conceptus due to the lack of markers that endure long en

108 from the heat-stressed (HS) dam to the IUHS conceptus during early gestation.

109 at an antiviral inflammatory response in the conceptus during early pregnancy impacts TS cell develop

110 polar bodies relative to the surface of the conceptus during either cleavage or blastulation.

111 The first known hormonal signal of the conceptus during implantation is human chorionic gonadot

112 to different EVs miRNA cargo produced by the conceptus during the peri-implantation period of pregnan

113 n the extracellular vesicles secreted by the conceptus during the peri-implantation period of pregnan

114 tory response of endometrium to IL1B2 during conceptus elongation and attachment to the uterine surfa

115 oach retarded trophectoderm outgrowth during conceptus elongation and inhibited trophoblast giant bin

116 onceptus trophectoderm and are essential for conceptus elongation and trophectoderm growth and develo

117 GD-7 transferable embryos, and stunted GD-16 conceptus elongation.

118 nd the secretion of IL1B2 during the time of conceptus elongation.

119 n humans is interstitial, meaning the entire conceptus embeds in the endometrium before the placental

120 les of arginine within the uterine lumen for conceptus (embryo and extraembryonic membranes) developm

121 and differentiation in the periimplantation conceptus (embryo/fetus and associated extraembryonic me

122 he uterus support survival and growth of the conceptus (embryo/fetus and associated membranes) during

123 (FDR < 0.05) associated with the IVD and IVP conceptus-endometrial co-cultures, respectively, compare

124 ) bovine conceptus and endometrium, a Day 16 conceptus-endometrial mono-culture and co-culture system

125 rone and might support a role for enJSRVs in conceptus-endometrium interactions during the peri-impla

126 In day 17 and 19 conceptuses, enJSRV RNAs were also detected in binucleat

127 e involved in the spatiotemporal increase in conceptus estrogen synthesis needed for the establishmen

128 Collectively, compared to the IVD conceptus, evidence suggests the endometrium drives and

129 Even the idea that the conceptus evokes a uniformly tolerogenic immune response

130 yperglycemic and hyperinsulinemic, and their conceptuses exhibit hyperinsulinemia and placentomegalia

131 are invariably growth-retarded while pUPD12 conceptuses exhibit placentomegaly.

132 Conceptus expansion throughout the uterus of mammalian s

133 due to the inaccessibility of the implanted conceptus for biochemical studies.

134 CRP, official gene symbol ABCG2) protect the conceptus from exposure to toxins and xenobiotics presen

135 Analysis of post-implantation conceptuses from embryonic day (E)9.5 to E13.5 revealed

136 By day 90, however, placentae of conceptuses from the high PE group expressed greater (P

137 and VEGF-R2 mRNA expression in day 70 and 90 conceptuses from Yorkshire females selected for high PE,

138 e the genetics of a single sperm cell before conceptus generation.

139 ng that although the signals that coordinate conceptus growth are similar between rodents and pigs, t

140 roperties, fed to a/a dams harboring A(vy)/a conceptuses has been reported to induce a significant sh

141 Mouse conceptuses homozygous for mutations in brachyury (T) ex

142 Conceptuses homozygous for the T(Curtailed) (T(C)) mutat

143 tal conditions during culture, and elongated conceptuses (iii) of different length, or (iv) developed

144 /Cas9 gene editing was used to knock out pig conceptus IL1B2 expression and the secretion of IL1B2 du

145 movement and cellular differentiation after conceptus implantation to generate placenta.

146 In most successful human pregnancies, the conceptus implants 8 to 10 days after ovulation.

147 aternal immune recognition of the developing conceptus in equine pregnancy is characterized by the st

148 pe," are at a competitive advantage over a/a conceptuses in certain uterine environments.

149 A greater (P < 0.05) PE was observed for conceptuses in the high PE selection group when compared

150 epiblast and amniotic ectoderm parts of the conceptus, including lumenogenesis of the epiblast and t

151 and might therefore coordinate growth of the conceptus, including the imprinted Igf2 and Grb10 genes.

152 part, by proteins produced by the developing conceptus (inner cell mass and extraembryonic membranes)

153 receptive endometrium and disrupted maternal-conceptus interactions can cause infertility due to preg

154 nancy loss because of the development of the conceptus into a complete hydatidiform mole in which ext

155 mmetry into the axes of the postimplantation conceptus involves asymmetric visceral endoderm cell mov

156 Implantation of the conceptus is a key step in pregnancy, but little is know

157 w days during the time at which the ruminant conceptus is first establishing intimate contacts with t

158 is uncertain when during pregnancy the human conceptus is most vulnerable to the virus.

159 l number of definitive HSC/RUs in the entire conceptus is only about 3.

160 ands and blood vessels by angioblasts in the conceptus, is a dynamic process modulated, in part, by c

161 Conceptuses lacking an embryo proper are also observed a

162 epiblast or visceral endoderm layers of the conceptus leads to apoptosis and inhibition of embryo gr

163 rganized visceral endoderm in Dab2-deficient conceptus leads to the growth failure of the inner cell

164 he THI negatively were associated with GD-16 conceptus length (P < 0.05).

165 hree major vascular systems in the mammalian conceptus, little is known about the murine allantois, w

166 he proteomic environment surrounding the IVP conceptus may be suboptimal.

167 rnally derived population of free trisomy 21 conceptuses ( n = 67).

168 reduced risk for a recognized Down syndrome conceptus (odds ratio (OR) = 0.54; 95% confidence interv

169 imitive trophoblast, which may put the early conceptus of an infected mother at high risk for destruc

170 hy in cultured murine conceptuses and in the conceptuses of streptozotocin-induced diabetic pregnant

171 astocyst stage in nearly two-thirds of mouse conceptuses of the PO strain.

172 l endoderm, leads to posteriorization of the conceptus or failure to elongate the anteroposterior axi

173 entomes of infected ewes pregnant with 171QR conceptuses or in the non-pregnant uterus of infected ew

174 n's age or parity, the size or volume of the conceptus, or the presence of fluid in the peritoneal ca

175 In this study, we modeled human conceptus peri-implantation development from blastocyst

176 In mutant conceptuses, placental areas were approximately 50% less

177 se health effects of maternal PM exposure on conceptus/postnatal growth and development.

178 d transcriptional changes within the initial conceptus prior to gastrulation.

179 seq) to compare the transcriptomes in cattle conceptuses produced by SCNT and artificial insemination

180 Conceptus production of a unique interleukin 1beta, IL1B

181 ds into blood islands of headfold-stage host conceptuses provided no evidence that the yolk sac contr

182 rors in meiosis, and most of these aneuploid conceptuses result in spontaneous miscarriage.

183 Subsequent whole embryo culture of operated conceptuses resulted in the formation of regenerated all

184 f microdissected trophectoderm of the bovine conceptuses revealed the presence of enJSRV RNA and, in

185 To determine effects of conceptus secretory proteins (CSP) containing IFN-delta

186 Placentas from all conceptuses showed expression of the transgene as detect

187 Analysis of spontaneously aborted conceptuses shows that CMV infects the placenta before t

188 Examination of Dnmt3l(-/+) conceptuses shows that imprinted expression for all gene

189 ome from genetic mapping studies of trisomic conceptuses, so the incidence of this defect and its imp

190 he hyperglycemia-induced vasculopathy in the conceptus support the concept that VEGF levels can be mo

191 s, by catabolizing tryptophan, the mammalian conceptus suppresses T cell activity and defends itself

192 metrial function and receptivity, to enhance conceptus survival and development, and to evaluate and

193 conceptus Tr, and arginine is essential for conceptus survival and development.

194 ults support a "bottleneck" model for cloned conceptus survival during the periimplantation period de

195 ast and placental development, and/or affect conceptus survival in mice.

196 In NIH/Ola, C57BL/6J/Ola and F1 conceptuses, Tgfb1-/- lethality can be categorized into

197 y to reduce the viability of a Down syndrome conceptus than that of a normal conceptus.

198 Among the 102 conceptuses that implanted by the ninth day, 13 percent

199 eration in the vascular regions of the mouse conceptus-the aorta, vitelline and umbilical arteries, y

200 polar body normally remains attached to the conceptus through persistence of the intercellular bridg

201 and an absence of IL-22 expression in other conceptus tissues.

202 This tumor-like process anchors the conceptus to the mother and diverts the flow of uterine

203 This process attaches the conceptus to the uterine wall and starts the flow of mat

204 rial infections likely alter exposure of the conceptus to toxins and drugs during early pregnancy, wh

205 effects of estrogens, which are secreted by conceptuses to prevent corpus luteum regression, nonpreg

206 SLC7A1 is the key transporter of arginine by conceptus Tr, and arginine is essential for conceptus su

207 nclusion bodies in endometrial epithelia and conceptus Tr.

208 The IVP conceptus transcriptome (differentially expressed genes;

209 rmine the maternal response to an implanting conceptus, triggering either menstruation-like disposal

210 screte cytoplasmic crystalline structures of conceptus trophectoderm (Tr).

211 C7A1 mRNA, the arginine transporter in ovine conceptus trophectoderm (Tr).

212 al and glandular epithelia as well as in the conceptus trophectoderm and are essential for conceptus

213 of arginine transporter SLC7A1 mRNA in ovine conceptus trophectoderm.

214 ne lumen and could potentially transduce the conceptus trophectoderm.

215 ed enJSRV envelope protein production in the conceptus trophectoderm.

216 ight be affected by the presence of a cloned conceptus, ultimately leading to mortality before or dur

217 Pig conceptuses undergo a unique rapid morphological transfo

218 arly somite stages (E7.25 to E8.5), when the conceptus undergoes rapid morphologic changes with forma

219 onic and embryonic angioblasts in the murine conceptus using both in vitro and in vivo models.

220 In E5.5 dab2 (-/-) conceptus, visceral endoderm-like cells are present in t

221 e found that development of the experimental conceptus was affected, at least in part, by a lack of g

222 toises grow and differentiate outside of the conceptus was investigated.

223 leptin, demonstrating that the heterozygous conceptus was not the source of the leptin.

224 h the morphological transition of IL1B2(-/-) conceptuses was inhibited, expression of a number of con

225 e tissue for survival and development of the conceptus, we conducted an in vivo morpholino antisense

226 d weight (31.4 4.3 vs. 42.4 6.2 mg) of GD-16 conceptus were greater for CON compared with HS cows (P

227 The first GP1bbeta-positive cells in the conceptus were identified in the yolk sac at E9.5, while

228 After 23 hours in culture, operated conceptuses were examined histologically for contributio

229 tionship was also seen when denuded two-cell conceptuses were prevented from rotating during subseque

230 ic day 19, placental and fetal weights in P0 conceptuses were reduced to 66% and 76%, respectively, o

231 with abundant endometrial DEG induced by IVP conceptuses were related to GTPase activity and the infl

232 es were affected by the presence of a cloned conceptus, whereas at d 34, approximately 36% and <0.7%

233 10alpha in the different compartments of the conceptus, which control fetal resource acquisition and

234 t results in reduced levels of VEGF-A in the conceptus, which in turn, leads to abnormal VEGF recepto

235 Data suggest that A(vy)/a conceptuses, which may possess a so-called "thrifty geno

236 As were different between in vivo and cloned conceptuses, while only 6 miRNAs were different between

237 l to coordinating the metabolic needs of the conceptus with those of the mother and are primary parti

238 f infected ewes are not pregnant or conceive conceptuses with a resistant PrP genotype.

239 iptomic data from blastocysts and elongating conceptuses with different developmental capacities and

240 Using conceptuses with maternal or paternal uniparental disomy

241 sential role of this gene suggests that male conceptuses with these variants may not be viable.

242 We have therefore generated conceptuses with uniparental disomy for chromosome 12, i

243 the differentiated cell types that build the conceptus, yet how to capture this property in vitro rem