ライフサイエンスコーパス: cone photoreceptor

1 sociated with the visual pigments of rod and cone photoreceptors.

2 egulating the dark adaptation of rod but not cone photoreceptors.

3 also act locally at the level of individual cone photoreceptors.

4 lpha-tubulin (tdEOS-tubulin) specifically in cone photoreceptors.

5 ation and efficient synaptic transmission in cone photoreceptors.

6 gh-resolution daylight vision is mediated by cone photoreceptors.

7 developed retinal abnormalities and loss of cone photoreceptors.

8 d is critical for the health of both rod and cone photoreceptors.

9 rest the progressive degeneration of rod and cone photoreceptors.

10 or no effect on the survival and function of cone photoreceptors.

11 are extremely long-lived proteins in rod and cone photoreceptors.

12 biochemical and functional role of CNGB3 in cone photoreceptors.

13 ion/amacrine cells at the expense of rod and cone photoreceptors.

14 n the visual transduction cascade in rod and cone photoreceptors.

15 NGA3 ACHM for clinical trials for therapy of cone photoreceptors.

16 zyme in visual excitation pathway in rod and cone photoreceptors.

17 cells, and horizontal cells rather than into cone photoreceptors.

18 put from short wavelength-sensitive ("blue") cone photoreceptors.

19 ) channels regulate Ca(2+) influx in rod and cone photoreceptors.

20 rized by the degeneration of retinal rod and cone photoreceptors.

21 nctional differences between retinal rod and cone photoreceptors.

22 oth alpha-subunit genes expressed in rod and cone photoreceptors.

23 leads to the premature death of both rod and cone photoreceptors.

24 y, by phototransduction signaling in rod and cone photoreceptors.

25 glion cells that also receive input from rod-cone photoreceptors.

26 tric measure of light intensity relevant for cone photoreceptors.

27 (2)(+) dynamics and their (dys)regulation in cone photoreceptors.

28 tional view that mammalian HBCs only contact cone photoreceptors.

29 sociated with the visual pigments of rod and cone photoreceptors.

30 feration and selective failure to regenerate cone photoreceptors.

31 nt light levels by switching between rod and cone photoreceptors.

32 e between horizontal cells (HCs) and rod and cone photoreceptors.

33 in the visual excitation pathway in rod and cone photoreceptors.

34 ating opsin-based visual pigments in rod and cone photoreceptors.

35 d decline of visual function in both rod and cone photoreceptors.

36 ute to the different morphologies of rod and cone photoreceptors.

37 cover accurate input pathways from surviving cone photoreceptors.

38 ondarily to the non-cell autonomous death of cone photoreceptors.

39 ds and their most closely related cell type, cone photoreceptors.

40 r middle- (M-) and long- (L-) wave sensitive cone photoreceptors [2].

41 Cone photoreceptor abnormalities were apparent by 3 week

42 the retinal circuit is provided primarily by cone photoreceptors acting as band-pass filters, but the

43 sitive, but also receive inputs from rod and cone photoreceptors, acting as the primary sensory condu

44 s to benchmark pluripotent stem cell-derived cone photoreceptors and an adult Muller glia cell line.

45 ar localization of zebrafish Crb1 in retinal cone photoreceptors and evidence for its new functions i

46 The retina contains cone photoreceptors and ganglion cells that contain the

47 and functionally distinct from classical rod/cone photoreceptors and have unique properties, includin

48 ded that these cells preferentially generate cone photoreceptors and horizontal cells, however develo

49 unofluorescence assays showed degradation of cone photoreceptors and increased retinal oxidative stre

50 to be present only in the outer segments of cone photoreceptors and may correspond to a homotrimer o

51 dings demonstrate nonredundant roles for rod-cone photoreceptors and melanopsin in mediating pupillar

52 e photoreceptor cell progeny are exclusively cone photoreceptors and not rod photoreceptors, confirmi

53 ut of Gnb3 in mice results in dysfunction of cone photoreceptors and ON-bipolar cells and a naturally

54 Expressed in cone photoreceptors and ON-bipolar cells, Gbeta3 is esse

55 synaptic contact with both L/M as well as S-cone photoreceptors and only minimal contact with rod ph

56 We show that cone photoreceptors and P-type pathway bipolar cells are

57 uronal pathways process signals from rod and cone photoreceptors and support vision over a wide range

58 of complete functional connectivity between cone photoreceptors and the four major types of ganglion

59 nal synapse by signaling between the rod and cone photoreceptors and two general classes of bipolar c

60 e, visual stimulation targeted at individual cone photoreceptors, and a hierarchical computational mo

61 e cell types, including Muller glia, rod and cone photoreceptors, and bipolar cells.

62 e rd1 mutation also prolongs the survival of cone photoreceptors, and partially restores visual funct

63 he visual excitation pathway in both rod and cone photoreceptors, and PDE6 mutations that alter PDE6

64 ral architecture of the visual system inputs-cone photoreceptors-and visual perception and have impli

65 icanthis niloticus) has a high proportion of cone photoreceptors ( approximately 30-40%) compared wit

66 nowing how signals from the three classes of cone photoreceptor are combined in the cortex.

67 Cone photoreceptors are assembled by unknown mechanisms

68 In old world primates including humans, cone photoreceptors are classified according to their ma

69 Rod and cone photoreceptors are coupled by gap junctions (GJs),

70 Cone photoreceptors are essential for vision under moder

71 he elephantnose fish (Gnathonemus petersii), cone photoreceptors are grouped together within reflecti

72 Rod and cone photoreceptors are highly similar in many respects

73 Rod and cone photoreceptors are light-sensing cells in the human

74 The nuclei of cone photoreceptors are located on the apical side of th

75 ng cone, cone-rod, and macular dystrophies), cone photoreceptors are more severely affected than rods

76 electroretinogram responses of both rod and cone photoreceptors are normal in knockout mice at 1 mon

77 Cone photoreceptors are the primary initiator of visual

78 In bright light, cone-photoreceptors are active and colour vision derives

79 Retinal rod and cone photoreceptors arguably represent the best-understo

80 maintain continuous rod function and support cone photoreceptors as well although its throughput has

81 sult of testing-induced damage to the rod or cone photoreceptors, as ERG amplitudes and ONL thickness

82 sents evidence regarding the role of rod and cone photoreceptors, as well as the role of recently dis

83 e immunostained with antibodies specific for cones photoreceptors, bipolar cells, mitochondria, Mulle

84 Vertebrate rod and cone photoreceptors both release vesicles at synaptic ri

85 sis with its accumulation and aggregation in cone photoreceptors but without proteostatic impairment

86 lase isozymes (RetGC1 and RetGC2) in rod and cone photoreceptors by calcium-sensitive guanylyl cyclas

87 a unique and stereotypic wiring pattern with cone photoreceptors by gaining synapses with specific ph

88 In vertebrate cone photoreceptors, Ca(2+) controls photoresponse sensi

89 as performed in combination with markers for cone photoreceptors (calbindin, XAP-1) and ON bipolar ce

90 fish retinae contains a crystalline array of cone photoreceptors, called the cone mosaic.

91 Cone photoreceptors carry out phototransduction in dayli

92 Stat3 and Ascl1a proteins following rod and cone photoreceptor cell apoptosis.

93 roid and retinal pigmented epithelium, early cone photoreceptor cell death, and reduced lengths of ro

94 +) dysregulation is thought to cause rod and cone photoreceptor cell death.

95 ranscription factor that dictates rod versus cone photoreceptor cell fate in the mammalian retina.

96 te-induced cell death in 661W cells, a mouse cone photoreceptor cell line, shown to express both estr

97 In addition, there was a reduction in cone photoreceptor cell number and cone b-wave amplitude

98 PE65 and raised in constant dark have higher cone photoreceptor cell number, improved cone opsin loca

99 phodiesterase gene Pde6beta and lose rod and cone photoreceptor cells (PRC) within the first 6 wk of

100 nterneurons that receive synaptic input from cone photoreceptor cells and provide the output of the f

101 The outer segments (OS) of rod and cone photoreceptor cells are specialized sensory cilia t

102 delete Dicer1 from cone cells, we show that cone photoreceptor cells degenerate and die in the Dicer

103 inal tumor that expresses several markers of cone photoreceptor cells has been described earlier.

104 structures of outer segments between rod and cone photoreceptor cells in the vertebrate retina.

105 hotoactivation of visual pigments in rod and cone photoreceptor cells of the retina.

106 vide additional visible light to the rod and cone photoreceptor cells, and thereby improve the visual

107 rdigitate with the outer segments of rod and cone photoreceptor cells.

108 middle to long wavelength-sensitive (M/LWS) cone photoreceptor cells.

109 e regeneration of visual pigments in rod and cone photoreceptor cells.

110 itive to loss of insm1a expression than were cone photoreceptor cells.

111 e under conditions that fully bleach rod and cone photoreceptor cells.

112 Cone photoreceptors cells can use 11-cis-retinal from th

113 S) and medium/long-wavelength-sensitive (ML) cone photoreceptor classes.

114 counting indicated relatively long surviving cone photoreceptors compared to rods.

115 investigated how the glutamatergic output of cone photoreceptors (cones) in the mouse retina is shape

116 s in expanded dendritic fields and increased cone photoreceptor contacts, demonstrating that DSCAM ac

117 topigment molecule in ipRGCs, as well as rod/cone photoreceptors, contains 11-cis-retinal (a vitamin

118 om several mammalian species with varied rod/cone photoreceptor content identified 18 lincRNAs that w

119 Rod and cone photoreceptors convert light into electrochemical s

120 applied ncRNA profiling to identify rod and cone photoreceptor CREs from wild-type and mutant mouse

121 Vegfa in maintaining choroid vasculature and cone photoreceptors, critical for central and color visi

122 Cone photoreceptor cyclic nucleotide-gated (CNG) channel

123 Precursor mRNA encoding CNGA3 subunits of cone photoreceptor cyclic nucleotide-gated (CNG) channel

124 rly rod death, followed by a slower phase of cone photoreceptor death.

125 ortunity to preserve daylight vision, as the cone photoreceptors degenerate more slowly than do the r

126 e mechanism for the foveal M/long-wavelength cone photoreceptor degeneration in LCA is unknown.

127 Neither ligand altered cone photoreceptor densities.

128 bility in macular retinal layer thicknesses, cone photoreceptor density, and mosaic regularity in ani

129 However, there is limited data examining cone photoreceptor density, foveal pit shape, and foveal

130 The function of cone photoreceptors depends upon the formation and maint

131 rophthalmic and displayed defects in rod and cone photoreceptor differentiation.

132 (HIP) that expresses the p53 gene in rod and cone photoreceptors driven by the human interphotorecept

133 from the cytoskeletal scaffold of zebrafish cone photoreceptors during development.

134 fy pathologic processes leading to secondary cone photoreceptor dysfunction triggering central vision

135 utosomal recessive disorder characterized by cone photoreceptor dysfunction.

136 in humans have recently been associated with cone photoreceptor dystrophy, while mouse models carryin

137 At the first stage, rod and cone photoreceptors encode light and communicate with a

138 scription factor Tbx2b, but might also block cone photoreceptor fate.

139 In the retina, rod and cone photoreceptors form distinct connections with diffe

140 In mammalian retinas, rod and cone photoreceptors form selective synaptic connections

141 Subsequently, we generate cone photoreceptors from human induced pluripotent stem

142 o unravelling the role of specific miRNAs in cone photoreceptor function and survival.

143 l, we identify a critical role of miR-211 in cone photoreceptor function and survival.

144 a demonstrate that Cacna1fa is essential for cone photoreceptor function and synaptic ribbon formatio

145 egenerations (IRDs) preferentially affecting cone photoreceptor function are being considered for tre

146 efficient pigment regeneration required for cone photoreceptor function in bright light.

147 l of these explanations imply that decreased cone photoreceptor function is possible, suggesting that

148 1)), retinal degeneration 8 (Crb1(rd8)), and cone photoreceptor function loss 3 (Gnat2(cpfl3)).

149 al amaurosis (LCA) with rapid cone loss] and cone photoreceptor function loss type 1 mice (severe rec

150 ity in retinol isomerase RPE65-deficient and cone photoreceptor function loss type 1 mice increased a

151 In patients with RP, preserved cone photoreceptor function measured by mfERG amplitude

152 Both rod and cone photoreceptor function were greater in treated (thr

153 he critical role of Elovl4 for proper rod or cone photoreceptor function.

154 going apoptosis and compromised both rod and cone photoreceptor function.

155 al degeneration characterized by the loss of cone photoreceptor function.

156 Cone photoreceptors function under daylight conditions a

157 time- and dose-dependent declines in rod and cone photoreceptor functions as early as 120 days of age

158 In mutant dogs, rod and cone photoreceptors have a sensory cilium, but develop a

159 The light responses of rod and cone photoreceptors have been studied electrophysiologic

160 um (RPE) supplies 11-cis-RAL to both rod and cone photoreceptors; however, stringent demands imposed

161 rrelated with epigenetic profiles of rod and cone photoreceptors, identified thousands of candidate r

162 can be probed at the level of the individual cone photoreceptor in living eyes.

163 Cone photoreceptors in 40 eyes of 20 subjects aged 19-29

164 ological and anatomic rescue of both rod and cone photoreceptors in a preclinical model of RP.

165 rs are able to efficiently transduce rod and cone photoreceptors in addition to retinal pigment epith

166 olarized distribution of Crumbs2a protein in cone photoreceptors in both unperturbed and regenerated

167 regeneration is critical for the function of cone photoreceptors in bright and rapidly-changing light

168 cal for the continuous function of mammalian cone photoreceptors in daylight vision.

169 In this study, selective ablation of cone photoreceptors in live mouse retina and tracking of

170 Relatively retained rod and cone photoreceptors in mid- and far-peripheral temporal-

171 periodic, almost crystalline distribution of cone photoreceptors in the adult teleost fish retina.

172 function and visual behavior and preserving cone photoreceptors in the GC1 knockout (GC1KO) mouse fo

173 Loss of cone photoreceptors in the human macula has the greatest

174 us and specific expression of p53 in rod and cone photoreceptors in the mature retinas of HIP mice le

175 ation: early dysfunction and loss of rod and cone photoreceptors in the outer retina and, progressive

176 tina that convey visual signals from rod and cone photoreceptors in the outer retina to higher-order

177 Cone photoreceptors in the retina are exposed to intense

178 Cone photoreceptors in the retina enable vision over a w

179 Daylight vision begins when light activates cone photoreceptors in the retina, creating spatial patt

180 e related to the maturation and migration of cone photoreceptors, in vivo data describing cone packin

181 on of the visual pigment by light in rod and cone photoreceptors initiates our visual perception.

182 These findings suggest that cone photoreceptor inputs shape bandpass filtering in bi

183 d cone-rod dystrophy, which primarily affect cone photoreceptors instead of rods.

184 retina, depend on signals from both rod and cone photoreceptors, interactions occurring in retinal c

185 first decomposes the outputs of the rod and cone photoreceptors into approximately 12 parallel infor

186 layers away from the fovea, migration of the cone photoreceptors into the fovea, and elongation of th

187 c disorder of color vision where one type of cone photoreceptor is missing.

188 sitivity of cGMP-gated (CNG) ion channels in cone photoreceptors is modulated by CNG-modulin, a Ca(2+

189 the resolution afforded by a dense array of cone photoreceptors is preserved in the retinal output b

190 In the human, cone photoreceptors (L, M, and S) and the melanopsin-con

191 nted the long- and mid- wavelength sensitive cone photoreceptors (L- and M-cones) from adapting.

192 *-HA) expression rescues the degeneration of cone photoreceptors lacking Ranbp2.

193 -noise ratios were compared across simulated cone photoreceptors, lateral geniculate nucleus (LGN) ne

194 e of foveal hypoplasia and disruption of the cone photoreceptor layer.

195 e diseases cause progressive loss of rod and cone photoreceptors, leading to blindness, but spare dow

196 In retinitis pigmentosa, loss of cone photoreceptors leads to blindness, and preservation

197 at physiological differences between rod and cone photoreceptor light responsiveness can be partially

198 l bodies of red-, green-, and blue-sensitive cone photoreceptors localized asymmetrically on the cell

199 including that of amyloid beta, and rod and cone photoreceptor loss occur, but cones are not lost in

200 intrinsic to vertebrate vision where rod and cone photoreceptors mediate dim- and bright-light vision

201 Retinal rod and cone photoreceptors mediate vision in dim and bright lig

202 CRALBP, encoded by RLBP1) can lead to severe cone photoreceptor-mediated vision loss in patients.

203 etermined if treatment with HDACi can rescue cone photoreceptor-mediated visual function.

204 has sought to evaluate the integrity of the cone photoreceptor mosaic in four patients previously de

205 (AOSLO) enables direct visualization of the cone photoreceptor mosaic in the living human retina.

206 bute substantially to the reflectance of the cone photoreceptor mosaic.

207 The retinas of nonmammalian vertebrates have cone photoreceptor mosaics that are often organized as h

208 blems.Digital micrographs were obtained from cone photoreceptor mosaics visualized by anti-opsin immu

209 We created mice lacking RDH10 either in cone photoreceptors, Muller cells, or the entire retina.

210 wn neural retinal cells: rod photoreceptors, cone photoreceptors, Muller glia, bipolar cells, amacrin

211 riking example is the apical localization of cone photoreceptors nuclei at the outer edge of the oute

212 ates the cGMP sensitivity of the channels in cone photoreceptors of striped bass (Morone saxatilis).

213 Expression of opsin photopigments in the cone photoreceptors of the mouse retina provides an exce

214 Rod and cone photoreceptors of the retina are responsible for th

215 ssion of visual pigment proteins (opsins) in cone photoreceptors of the retina.

216 We report here a mechanism whereby zebrafish cone photoreceptors of the same type are produced by sym

217 Cone photoreceptors, OFF-midget bipolar cells (P pathway

218 The classical rod and cone photoreceptors, on the other hand, mediate image vi

219 odel recapitulates many observed features of cone photoreceptor organization during retinal growth an

220 Rod and cone photoreceptor outer segment (OS) structural integri

221 s down the cause of acute vision loss to the cone photoreceptor outer segment and will refocus the se

222 development with lack of a foveal pit and no cone photoreceptor outer segment lengthening.

223 otein essential for the formation of rod and cone photoreceptor outer segments (OS).

224 zebrafish consisting of disorganized rod and cone photoreceptor outer segments resulting in abnormal

225 We evaluated the relationship between cone photoreceptor packing density and outer nuclear lay

226 eceptors within the strips were counted, and cone photoreceptor packing density was calculated.

227 inal rod pathways that ultimately connect to cone photoreceptor pathways via Cx36 gap junctions or vi

228 a childhood retinal tumor that develops from cone photoreceptor precursors in response to inactivatin

229 Retinoblastomas can arise from cone photoreceptor precursors in response to the loss of

230 s, amacrine and horizontal cells, as well as cone photoreceptor precursors, are reduced in low cholin

231 ntal cells and an increase in the numbers of cone photoreceptor precursors.

232 The ability to directly assess cone photoreceptor preservation with SD-OCT and/or adapt

233 opment of HC dendrites and triad synapses of cone photoreceptors proceeds normally in the absence of

234 precise chronological order, but how exactly cone photoreceptor production is restricted to early sta

235 complex consists of four cell types (rod and cone photoreceptors, projection neurons and parapineal n

236 Rod and cone photoreceptor (R(ROD), S(ROD), R(CONE), S(CONE)) an

237 erior pineal complex anlage differentiate as cone photoreceptors rather than parapineal neurons.

238 es in light-evoked responses between rod and cone photoreceptors remains unclear.

239 ures by using intermittent light to activate cone photoreceptors repeatedly in humans.

240 Hz) for 30 min, which was given to activate cone photoreceptors repeatedly, elicited sustained pupil

241 on are initiated in rod and several types of cone photoreceptors, respectively; these photoreceptors

242 Electroretinograms revealed abnormal cone photoreceptor responses from wud mutants, indicatin

243 specifically investigate the development of cone photoreceptor ribbon synapses.

244 illing of a depleted vesicle release pool at cone photoreceptor ribbons is 0.7-1.1 s.

245 stent with this, short- wavelength sensitive cone photoreceptors (S-cones) did not show the adaptive

246 on is achieved by mixing neural signals from cone photoreceptors sensitive to different wavelengths o

247 sion starts with signals in three classes of cone photoreceptors sensitive to short (S), middle (M),

248 Noise in the responses of cone photoreceptors sets a fundamental limit on visual s

249 enes expressed in mutant rod or both rod and cone photoreceptors show significant downregulation, whi

250 In cone photoreceptors, similar to bipolar cells, fusion of

251 ffects of RetGC1 deficiency on human rod and cone photoreceptor structure and function are currently

252 Investigate in vivo cone photoreceptor structure in familial aniridia caused

253 d an unaltered distribution of the different cone photoreceptor subtypes upon Pde6h ablation.

254 Rod and cone photoreceptors support vision across large light in

255 ion and suggest that Dicer1 is essential for cone photoreceptor survival and homeostasis.

256 ed retinal degeneration, and their effect on cone photoreceptor survival, we generated an Rpe65/P25L

257 neurons, impairs synaptogenesis, and reduces cone photoreceptor survival.

258 The mammalian cone photoreceptor synapse provides advantages for compa

259 tropic glutamate receptors (mGluRs) regulate cone photoreceptor synaptic transmission, although the m

260 to two visual arrestins that bind to rod and cone photoreceptors (termed arrestin1 and arrestin4), th

261 l evidence for synaptic transmission between cone photoreceptor terminals and ORDs suggests a novel p

262 onses using two-photon imaging in individual cone photoreceptor terminals and to probe phototransduct

263 n photons of the light interact with rod and cone photoreceptors that are present in the neural retin

264 highly expressed protein secreted by rod and cone photoreceptors that has major roles in photorecepto

265 nd relative retention of the central retinal cone photoreceptors that lack function.

266 consequently results in the death of rod and cone photoreceptors that they support, structurally and

267 and has evolved over time to produce rod and cone photoreceptors that vary in a species-specific mann

268 s then die, causing dysfunction and death of cone photoreceptors, the cell type that mediates high ac

269 is deletion also caused rapid dysfunction of cone photoreceptors, the cells responsible for fine visu

270 Before the maturation of rod and cone photoreceptors, the developing retina relies on lig

271 In cone photoreceptors, the molecular identity of the modul

272 ugh "duplex" retinae containing both rod and cone photoreceptors, the signals from which are processe

273 Instead, foveal cone photoreceptors themselves exhibited slower light re

274 ropagation of visual signals from individual cone photoreceptors through parallel neural circuits was

275 that is mediated by activity of both rod and cone photoreceptors through the ON and OFF pathways.

276 toactivation is critical for the function of cone photoreceptors throughout the day.

277 nalysis identifies glia, vascular cells, and cone photoreceptors to be associated with the risk of AM

278 photoreceptors may be more susceptible than cone photoreceptors to the effects of ocriplasmin.

279 relative contribution of melanopsin and rod-cone photoreceptors to the pupillary light reflex in hum

280 the phototransduction cascade of vertebrate cone photoreceptors to tune gain, inactivation, and ligh

281 Cone photoreceptors transmit signals at high temporal fr

282 identified synapse in the mouse retina, the cone photoreceptor type 4 bipolar cell (BC4) synapse, an

283 Most birds use four cone photoreceptor types for color vision, a fifth cone

284 ion of color relies on signals from multiple cone photoreceptor types.

285 Rod and cone photoreceptors use a specialized structure called t

286 ndent changes in membrane potential, rod and cone photoreceptors utilize synaptic ribbons to sustain

287 ntravenous injection of IAA on swine rod and cone photoreceptor viability and morphology was followed

288 implicated thyroid hormone (TH) signaling in cone photoreceptor viability.

289 cent studies have implicated TH signaling in cone photoreceptor viability.

290 ope (AOSLO) images of foveal capillaries and cone photoreceptors were acquired in a subset of childre

291 synaptic terminals of short and long/middle cone photoreceptors, whereas Pde6h(-/-) retinae remained

292 Most vertebrates have rod and cone photoreceptors, which differ in their sensitivity a

293 (+) signaling is well exemplified by retinal cone photoreceptors, which, with their distinct compartm

294 long-wavelength-sensitive opsin (lws) in red cone photoreceptors, while in retinal pigment epithelium

295 vision in birds is mediated by four types of cone photoreceptors whose maximal sensitivities (lambdam

296 reduced in numbers, reconnected to undamaged cone photoreceptors with correct wiring patterns.

297 They showed substantially retained cone photoreceptors with disproportionate cone function

298 GABAergic interneuron that samples from all cone photoreceptors within reach and modulates their glu

299 Cone photoreceptors within the strips were counted, and

300 Preventing the secondary loss of cone photoreceptors would preserve central visual acuity