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1 ed bevacizumab, ranibizumab, and aflibercept conferred 0.141, 0.141, and 0.164 QALY gains, respective
2 e, Watson-Crick A-T base pairs in dsDNA only conferred ~130-fold protection against adenine-N1 methyl
3 cines and live attenuated rotavirus vaccines confer 19.7% (95% confidence interval, 3.4-43.4%) and 11
5 because mobilities of both unsaturated tails confer a cone shape to DOPC, and PGPC separates form DOP
7 ff did not appear to be modulated by time or confer a long-term increase in the total amount of infor
8 rature in healthy young men is not enough to confer a major oxidative and inflammatory burden on the
11 scopic lipid- and protein-based interactions confer a steady-state organization of the plasma membran
13 1 margins but wider resection margins do not confer a survival benefit [57 months (95% confidence int
14 breakdown of a variety of dietary nutrients confer a wide array of host benefits, including ameliora
15 otic group (P = 0.72).Antibiotic prophylaxis conferred a 17.7% (95% confidence interval 7.2%-28.1%),
16 ion in penicillin-binding protein PBP2X that conferred a 2-fold increased penicillin G and ampicillin
19 raction and the hyperactivation of WNT, thus conferring a malignant phenotype to the organoids and th
20 entiviral Vpu.IMPORTANCE Genetic alterations conferring a selective advantage in protecting from life
21 Structural modeling predicts that SY242CS confers a conformational change that mediates stable bin
23 rmine whether humanization of the As3mt gene confers a human-like pattern of iAs metabolism in mice.
27 in structured environments, and thus likely confers a selective advantage in natural habitats of mag
28 bilized cellular NF-kappaB depot potentially confers a survival advantage to CD5(hi) T cells over CD5
29 g tumor suppressor and that KMT2D deficiency confers a therapeutic vulnerability to glycolytic inhibi
33 eural plaques on radiologic imaging does not confer additional increase in the risk of lung cancer.
34 t, heterozygosity for PIEZO1 E756del did not confer additive protection and homozygosity was associat
35 stress conditions, suggesting that they may confer advantages to M. tuberculosis by modulating its i
36 pigenetic regulators such as DNMT3A and TET2 confer an advantage by enhancing self-renewal of stem an
37 the 0.40-mg/kg dose of tenecteplase does not confer an advantage over the 0.25-mg/kg dose in patients
40 of homology-dependent repair (HDR)(5,6) and confer an exquisite sensitivity to inhibitors of poly (A
41 maller (<9.5 mm) corneal diameter at surgery conferred an increased risk for glaucoma or glaucoma sus
42 esign flexibility for dinuclear VT complexes confers an advantage over two-step spin crossover comple
47 ch demonstrate that wild-type AdeT1 does not confer antimicrobial resistance in E. coli, highlighting
48 lective ISG expression during infection that confers antiviral protection but minimizes disruption of
49 ions and propose a model in which genes that confer ASD risk operate in signal transduction networks
50 nsortium of five cultured bacterial invaders conferred augmented CT-IgA responses in mice fed the sup
51 We uncovered a dimeric state of UBE2S that confers autoinhibition by blocking a catalytically criti
52 erichia coli In addition, Q8 was proposed to confer bacterial osmotolerance by accumulating during gr
53 led that while this moiety was sufficient to confer binding to FGF14, altering the C-terminal moiety
54 n of whether a certain signaling pathway can confer bistability involves a substantial amount of hypo
55 are important factors in our lifestyle, and confer both susceptibility to and protection from a vari
57 ncodes a glutathione S-transferase (GST) and confers broad resistance to Fusarium species by detoxify
59 ccelerating protein (GAP) activity, which is conferred by a conserved domain dubbed the "RGS-box." He
61 ing understanding of the detrimental effects conferred by broad-spectrum antibiotic use on the health
62 extent of protection from methylation damage conferred by dsDNA relative to ssDNA has not been quanti
66 ntial interpretation of a common BMP signal, conferred by low affinity pMad/Medea binding motifs, can
67 gnancy, particularly in attenuating the risk conferred by maternal asthma on childhood asthma or recu
68 channel while Ca(2+)-dependent regulation is conferred by MICU1 and MICU2 through an enigmatic proces
70 e to divide, the extent of the disadvantages conferred by other fates is sufficient to account for th
71 ophy, with functional effects on the channel conferred by PKA-dependent phosphorylation at serine-465
74 e examine whether the strength of protection conferred by Spiroplasma to its host, Drosophila melanog
79 breeding line #394-1-27-12 (C. moschata) is conferred by three independent dominant genes (R1R2R3).
83 ggesting that the obese/diabetic environment confers cancer-selective dependencies that can be therap
84 veal a transcriptional program sufficient to confer cardiac potential onto trunk neural crest cells,
87 seeds the endosperm surrounding the radicle confers coat dormancy and controls germination responses
89 urally similar to characterized enzymes that confer colistin resistance in Gram-negative bacteria.
90 -5461 in previously sensitive lymphoma cells confers collateral resistance to the topoisomerase II po
91 dominant epitope, CSP-based vaccines did not confer complete protection, despite the induction of hig
92 ons markedly reduce oxygen affinity and even confer cooperativity, because an ancient linkage between
93 a membrane-bound multivalent immunoreporter, confer Cre-dependent sparse and bright labeling of thous
94 the clinical need is greatest, and does not confer cross-protection against newly emerging phylogrou
95 serves as a base-labile protecting group and confers crystallinity to these cyclopropanone precursors
97 ial cells form an anatomic architecture that confers defense, robustness, and adaptation toward exter
98 etabolic differences among cancer cells thus confer differences in metastatic potential as metastasiz
101 ma (AtLEGgamma) is controlled by the latency-conferring dimer state, the activation of the monomeric
103 mmonly found in various protein complexes to confer distinct cellular functions, but how the multi-su
104 everal distinct conformations (strains) that confer distinct phenotypes when introduced into cells th
106 e PGANT9A and PGANT9B O-glycosyltransferases confers distinct preferences for a variety of endogenous
107 ns, mechanistic understanding of the factors conferring drought tolerance in trees is increasingly im
109 t PLB interacts with multiple binding sites, conferring dynamic responsiveness to changing physiologi
114 ive metabolites of those fruits can possibly confer enhanced tolerance to postharvest abiotic stresse
116 are attached to a de novo-designed protein, conferring entirely novel functions on the peptide scaff
117 ctivated SE upregulates CHPT1 expression and confers Enz resistance in CRPC, suggesting that SE-media
118 al anticoagulants (NOACs) have been shown to confer equivalent benefits for stroke prevention with le
119 significant residual MR after the procedure conferred even worst outcomes (2-year all-cause mortalit
121 is spectral site polymorphism is expected to confer expanded "UV-blue" spectral sensitivity and is es
123 v) channels with modified TTX binding sites, conferring extreme physiological resistance to TTX.
125 agnitude and rate of placental infection and conferred fetal infection, in contrast to ZIKV M1404, wh
129 the epithelial-to-mesenchymal phenotype and confer gemcitabine resistance of PDAC cells induced by C
132 is and other lines, two suppressor mutations confer greater improvement than one alone, suggesting th
133 unosuppressants in people with psoriasis may confer greater risk of adverse outcomes of coronavirus d
134 T regimens with INSTIs or PIs vs. NNRTIs may confer greater risk of DM, likely mediated through weigh
136 cell disposal during negative selection and confers heightened sensitivity to experimental autoimmun
137 11.2 and 22q11.2 Copy Number Variants (CNVs) confer high risk for Autism Spectrum Disorder (ASD), sch
138 t documentation of a major resistance allele conferring high levels of Vip3Aa resistance in a field-d
139 tates induced-fit conformational changes and confers high-affinity RNA hairpin binding, which may be
142 s modified by CD4 cell count with protection conferred if CD4 count was <=350 cells/muL (aHR, 0.51 [9
143 caused hyperactivated MAP kinase signaling, conferred IL-3 hypersensitivity and sensitized the cells
146 and very simple geometry induced by the TPT confers important benefits, including better generalizat
148 o modeling demonstrated that these mutations conferred increased migratory capability, suggesting pat
149 characterized mechanism by which DNMT3A loss confers increased fitness to HSCs by analyzing a rare ex
150 ship to animal viruses, and evaluate factors conferring infection susceptibility and resistance.
153 uter membrane (OM) of gram-negative bacteria confers innate resistance to toxins and antibiotics.
155 the sugar polymerization mechanism and that confer its ability to produce a very-high-molar-mass pol
157 city gains, while quantitative-phase imaging confers label-free recognition of cells and organelles,
159 ological memory of past antigen exposure can confer long-lived protection against infections or tumor
160 nd the role that these modifications play on conferring long-term adverse health effects remains unex
161 nsufficiently powered to address whether MAR confers long-term benefit over SAR in patients with rena
162 ore, the prevalence of amantadine resistance-conferring M2 mutations increased over time, and viral l
165 97 mutations T409M, H411Y or C480F emerge to confer maribavir resistance in patients with recurrent C
166 VEGFR2 that is necessary and sufficient for conferring mechanosensitivity upstream of the junctional
167 sed S1P(1) functional antagonist, siponimod, conferred minimal renal protection and desensitized S1P(
169 hesis, species from drier summers had traits conferring more tolerance to drought such as small scler
170 h these hyperplastic cells to malignancy and confer mutation-specific characteristics associated with
171 identifying established and novel resistance-conferring mutations in genomic data include genome-wide
172 g, 78.6% (95% CI 76.1%-80.9%) had resistance-conferring mutations in the katG gene and 14.6% (95% CI
174 om polarizing a field of epithelial cells to conferring new properties at subcellular levels to regul
175 enetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican patient
176 udies with untargeted 225Ac-DOTA-trastuzumab conferred no improvement over untreated controls and res
178 n contrast, subcutaneous (s.c.) immunization conferred no protection against the p.v. challenge.
180 TP53 mutation varied with genomic subtypes, conferring no effect in the NOTCH2 subtype and poor prog
181 y to reversibly associate and dissociate may confer on them a functional advantage with respect to no
183 impairs attention, but the advantage alpha5 confers on endogenous cholinergic signaling is unknown.
186 , and this is associated with epigenetically conferred phenotypic differences, environmental adaptabi
187 ed as F-type, fails to form spores, does not confer plant growth-promoting effect, and displays alter
189 is a functional riboregulator sufficient to confer posttranscriptional temperature-dependent regulat
190 H1-17/H3-14 antibody which has been shown to confer potent protection to lethal infection in mice des
191 isoproxil fumarate and tenofovir alafenamide conferred potentially cardioprotective properties associ
192 d insula GMV plausibly represent genetically conferred predispositional risk factors for, as opposed
193 action between cells in different EMT states confers properties that are not induced by either EMT pr
194 nt of the circadian clock in beta-cells will confer protection against beta-cell dysfunction under di
195 odies defined in vitro have been proposed to confer protection against HCMV infection, and the virion
197 abetes-associated SNPs that truncate SLC30A8 confer protection from this disease, contradicting this
198 onstrate that P. aeruginosa QS molecules may confer protection to neighboring yeasts against azoles,
201 frequency in sub-Saharan Africa because they conferred protection against pathogenic trypanosomes tha
202 .o. immunization or infection with Chlamydia confers protection against per-vaginal (p.v.) challenge,
203 innate immune memory induced by beta-glucan confers protection against secondary infections, its imp
204 to improve metabolic health in offspring and confers protection against the development of non-alcoho
206 e degree to which the innate immune response confers protection or induces pathogenesis through a dys
208 ether with the hinge domain of HP1gamma that confer protein and nucleic acid-binding ability are suff
210 he polymerase acidic protein-a mutation that confers reduced susceptibility to baloxavir marboxil-fro
211 labels, the structure of the nitroxides must confer reduction resistance to withstand the reductive e
213 ddition of a single or multiple sialic acids conferred remarkable enhancement to the biophysical stab
215 Here we assessed whether miR-218 in the mPFC confers resilience or susceptibility to depression-like
218 y an east-west divide in haplotypes known to confer resistance to chloroquine and sulfadoxine-pyrimet
220 Gly-Ser dipeptides into cross-bridges and to confer resistance to lysostaphin, a secreted bacteriocin
221 idrug resistance loci, encoding enzymes that confer resistance to nonrelated antibiotics, including e
223 enicillins, emergent beta-lactamases can now confer resistance to other beta-lactam drugs, including
227 ctor, increased EGFR protein expression, and conferred resistance to BRAFis both in vitro and in vivo
228 erichia coli in domestic swine in China that conferred resistance to colistin, an antibiotic of last
231 ies are warranted to better define mutations conferring resistance to amoxicillin, tetracycline, and
232 atty acids and nucleotides for biosynthesis, conferring resistance to therapies targeting anabolic pa
234 highly diverse, but how microbial diversity confers resistance or susceptibility to intestinal patho
235 epletion of outer membrane porin OmpT, which confers resistance to host-derived antimicrobial peptide
236 P1 is over-expressed in multiple cancers and confers resistance to ionizing radiation and chemotherap
238 ct on the forskolin response, but the latter conferred responsiveness to arginine-vasopressin (an inh
239 higher activity after prolonged storage and confer reusability for over 100 runs with less than 10%
240 e molecular switch with terminal bromo atoms confers reversible handedness inversion to the helical s
242 estimated that a thousand or more genes may confer risk for ASD when functionally perturbed, however
244 sses may interact with neural alterations to confer risk, and 3) provide recommendations based on con
246 ophy (e.g., refractile drusen), and features conferring risk for atrophy development (e.g., hyperrefl
249 hat physiological regulation mechanisms that confer robustness to growth may be specifically vulnerab
251 ng following antigen stimulation-a mechanism conferring selective advantage during B-cell lymphoma de
252 cancer cells lacking PDE3A is sufficient to confer sensitivity to DNMDP, and substitutions in the PD
254 nti-CfaE and anti-LTB antibody responses and conferred significant reduction of diarrhea compared to
258 isted laparoscopic donor nephrectomy (HALDN) confers significant morbidity to a healthy patient group
261 asmalogens, harbor a vinyl ether double bond conferring special chemical and physical properties.
262 R) T cells, expressing the CD4 ectodomain to confer specificity for the HIV envelope, to mitigate HIV
263 ically deleted cyclin Ds, which activate and confer specificity to CDK4/6, can compensate and prolife
264 rtmentalized signaling of cyclic nucleotides confers specificity to extracellular stimuli and is crit
266 her than with other members of the community-confer stability, mitigating effects of species loss or
267 on, inflammation, and pathology but does not confer sterilizing immunity, as evidenced by detection o
270 ence of graft dysfunction does not appear to confer survival advantage after intestinal transplantati
272 ical functions across a cell population that confers survival benefits; among unicellular bacteria, t
273 ies have established that mutations in LRRK2 confer susceptibility to mycobacterial infection, sugges
275 lates inflammatory genes in DTPs and thereby confers susceptibility to anti-inflammatory glucocortico
276 three HLA-DQ AAs (alpha44, beta57, beta135) conferring T1D risk should sharpen functional and transl
277 our study highlights an important mechanism conferring tamoxifen resistance via both ERalpha depende
279 residues S269 and N472, absent in AAV8, may confer the ability to cross the BBB in AAVrh.10 and AAVr
280 ith stunted growth from Bangladesh, and that confer the capacity to similarly tailor microbiota profi
283 has played a major role in domestication by conferring the free-threshing character and pleiotropica
285 cribe the emergence of a protein domain that confers the capability of interacting with both filament
286 acterized by strongly reduced metabolism and conferred this compromised metabolic state to CD8(+) T c
288 Neuroprotection against those hazards is conferred through fractional inspired oxygen ( FI,O2 ) c
295 cal Wnt signaling in mesoderm is critical to confer trachea mesenchymal identity in human and mouse.
298 opolysaccharides, but this protection is not conferred upon genetic or pharmacological abolition of t
299 the uniqueness of the molecular design which confers useful properties for various potential applicat
300 n at C(7), substitution at benzodioxane C(5) confers very high alpha4beta2/alpha3beta4 selectivity to