ライフサイエンスコーパス: conformational change

1 er from those favoring activation-associated conformational change.

2 he rocking-bundle mechanism as the driver of conformational change.

3 site in RalA as a result of a switch II loop conformational change.

4 (i.e., the C'D-loop) that undergoes a remote conformational change.

5 ites and coupling between ligand binding and conformational change.

6 rate TPP nor protonation induces large-scale conformational changes.

7 mplementary nucleotides and derived rates of conformational changes.

8 ular rulers for investigating ligand-induced conformational changes.

9 n intrinsic autoinhibitory mechanism through conformational changes.

10 espond to signals from their surroundings by conformational changes.

11 ng that His(232) serves as a pivot point for conformational changes.

12 to characterize the global and peptide-level conformational changes.

13 dimers that are activated by ligand-induced conformational changes.

14 ccompanied by additional function-empowering conformational changes.

15 lglycine, which provides a signal for enzyme conformational changes.

16 e of large proteins that undergo substantial conformational changes.

17 make it difficult to precisely resolve these conformational changes.

18 igands, suggesting a sequential mechanism of conformational changes.

19 onditions, macromolecules undergo continuous conformational changes, a subset of which are functional

20 (but not of NADH) leads to a related global conformational change, accompanied by local re-arrangeme

21 ynamical entities that undergo a plethora of conformational changes, accomplishing their biological f

22 coupled to a ClpA rotation and a network of conformational changes across the seam, suggesting that

23 ADPH binding and mutation of Lys166 causes a conformational change, altering protein structure.

24 PS), binds NLRP6 directly and induces global conformational change and dimerization.

25 e AQP4 carboxyl terminus, causing a specific conformational change and driving AQP4 cell-surface loca

26 toinhibition, allowing it to undergo a large conformational change and interact itself with the membr

27 Upon binding dsRNA, OAS undergoes a conformational change and is activated to polymerize ATP

28 op a detailed thermodynamic model of coupled conformational change and ligand binding.

29 virus surface spike, allowing it to undergo conformational changes and become prone to proteolytic a

30 e V region of IgG could modulate a degree of conformational changes and binding energy of noncovalent

31 that the ACB domain facilitates induced-fit conformational changes and confers high-affinity RNA hai

32 we demonstrate a direct relationship between conformational changes and enzyme activity that is explo

33 To identify the primary steps of these conformational changes and how they are prevented by the

34 Here, we show the detailed patterns of conformational changes and inter-subunit and -domain reo

35 sensitive and robust method to probe protein conformational changes and protein-ligand interactions.

36 t undergoes adenosine triphosphate-dependent conformational changes and recruits MutLalpha.

37 anisms that lie on a continuum between large conformational changes and subtle changes in internal dy

38 ect in the ability of AAV capsids to undergo conformational changes and support efficient vector geno

39 s that Aurora B S227 phosphorylation induces conformational changes and this manifests in a profound

40 solution provides precise information about conformational changes and variations of the interaction

41 ification site K92 of UBE2N undergoes marked conformational change, and Lpg2149 inhibits this ubiquit

42 ar details of ligand binding, agonist-driven conformational changes, and class F receptor activation.

43 cruit multiple SNARE proteins, trigger their conformational changes, and facilitate SNARE assembly.

44 The resulting conformational changes are envisioned to form the basis

45 boundary indicate that cofilin-induced actin conformational changes are local and limited to subunits

46 egulatory hub in Sth1, suggesting that large conformational changes are part of Sth1 regulation and R

47 r than inactivation, although the underlying conformational changes are unknown.

48 se structures provide insights into a unique conformational change associated with donor substrate bi

49 hese three distinct channel states highlight conformational changes associated with an open activatio

50 review how protons are thought to drive the conformational changes associated with ASIC activation a

51 ome, we demonstrate that RF exposure reduces conformational changes associated with biological activi

52 Although conformational changes associated with gating promote cr

53 We observe large conformational changes associated with substrate binding

54 The structures also reveal protein conformational changes associated with the binding of NA

55 Finally, we study the conformational changes associated with the switching of

56 show that Mg.dNTP binding induces an enzyme conformational change at a rate that is independent of f

57 We observed that the mucin mimics undergo a conformational change at high surface densities from a c

58 wed that ATP-DnaA, not ADP-DnaA, undergoes a conformational change at the higher nucleotide concentra

59 ection against glycoxidation-induced protein conformational changes at 100 ug/ml phenolics.

60 In-cell NMR can investigate protein conformational changes at atomic resolution, such as tho

61 ies of apo and holo states demonstrate local conformational changes at specific sites within the loop

62 stalline state, and each accompanies protein conformational changes at the active site.

63 between fluorophore motions and large-scale conformational changes between LIV-BPSS domains.

64 the core domain, and OMP binding results in conformational changes between the core/P1 domains.

65 We also propose a ligand induced conformational change bringing the N-termini of RAR and

66 rane capacitance (reflecting the concomitant conformational change) can be detected in real time even

67 These conformational changes control the path of DNA flanking

68 te that similar organelle- or GTPase-induced conformational changes could regulate the activity of ot

69 We find that while the conformational changes do not significantly affect elect

70 We hypothesize that the conformational changes due to SCoA binding impact the Cd

71 rized state resulting from voltage-dependent conformational changes during a 10-mus-timescale atomist

72 The HIV-1 envelope (Env) undergoes conformational changes during infection.

73 ABC transporters undergo substantial conformational changes during substrate translocation.

74 in which the enzyme choreographs a series of conformational changes during the catalytic cycle.

75 ermal vibrations and dynamics as well as the conformational changes during the chemical reaction of m

76 esis but clashes with longer RNA-DNA trigger conformational changes for the timely release of the pro

77 r covalent inhibitors, MtClpP1P2 undergoes a conformational change from an inactive compact state to

78 A key element of the model is a conformational change from R (relaxed), which is highly

79 We show that the forward conformational change (>6000 s(-1)) is much faster than

80 th large cylindrical pore, while in CALHM6 a conformational change has converted the pore shape into

81 provide a mechanism for nucleotide-dependent conformational change, have been repurposed in septins t

82 of Neuroligin-2 with Collybistin-2 induces a conformational change in Collybistin-2 that promotes its

83 to these residues during transport induces a conformational change in MurJ required to proceed throug

84 osteric mechanism for activation involving a conformational change in one subunit of the complex, whi

85 The first conformational change in our dataset involves rotation o

86 the isoalloxazine ring of FMN and induced a conformational change in residues of the FMN-binding poc

87 ow acylation by the K234R enzyme is due to a conformational change in Ser(130), and this change also

88 Electron microscopy has revealed a distinct conformational change in sigma1 from a compact form on v

89 r longer chain fatty acids is regulated by a conformational change in the C-terminal tail that leads

90 We hypothesize that a conformational change in the DNA aptamer upon specific b

91 r, the binding to ATPgammaS promotes a large conformational change in the entire AAA+ domain that lea

92 echanism is that the mutation predisposes to conformational change in the expressed protein, leading

93 Conformational change in the receptor regulated tightly

94 In addition, varying degrees of conformational change in the setron-5-HT(3A)R structures

95 DEER revealed an agonist-dependent conformational change in which residues of the B'-helix

96 This suggests that simultaneous conformational changes in all ATPase domains at each cat

97 lity that CAP binding may induce substantial conformational changes in all the subunits of RNAP and t

98 outcomes result from drug-induced activating conformational changes in alphaIIbbeta3 but direct proof

99 r lobe of the catalytic domain exhibit large conformational changes in both the GDP- and the GTP-boun

100 surface in the unbound form, and stochastic conformational changes in D1 facilitate initial binding

101 onger mRNA substrates, these clashes prevent conformational changes in DcpS that are required for the

102 Our investigations reveal that conformational changes in EF-Tu coordinate the rate-limi

103 emains active, allowing the visualization of conformational changes in Enterococcus faecalis MDD that

104 806 (here called BMS-806) blocks CD4-induced conformational changes in Env important for entry and is

105 H(+) driven by the proton motive force, and conformational changes in FliG2 driven by CheY3-P allow

106 a2+, and NPC1 binding synergistically induce conformational changes in GP2 and permit virus-liposome

107 based biosensors that detect WNT-induced FZD conformational changes in living cells in order to asses

108 toribosomal subunit, we discover significant conformational changes in MRP mL45 at the nascent polype

109 (EPR) has become an important tool to probe conformational changes in nucleic acids.

110 The early receptor potential is caused by conformational changes in opsins after photoisomerizatio

111 These findings shed light on allosteric conformational changes in PCSK9 required for high-affini

112 ents indicated that antibody binding induces conformational changes in pro- and latent myostatin that

113 onsistent with recent structural findings of conformational changes in PSD-95 and demonstrate how con

114 ninvasive, label-free approach for assessing conformational changes in receptors in living cells at a

115 The Chi-recognized structure shows conformational changes in regions of the protein that co

116 NA elements that regulate gene expression by conformational changes in response to ligand binding.

117 s and torques and the observation of dynamic conformational changes in single motor complexes.

118 for efficient intracellular trafficking and conformational changes in the AAV capsid that support ef

119 ows that inhibitor binding is accompanied by conformational changes in the active site, including the

120 inding to the mini-sensor induces allosteric conformational changes in the Ca(2+) translocation pathw

121 und to the HRMs and to the core, we detected conformational changes in the catalytic core only in one

122 Upon siderophore binding, conformational changes in the CCSSD enable regulated int

123 crease of pH from 8 to 4, we observed marked conformational changes in the ECD-TMD interface and the

124 ceptors, CD4 and CCR5/CXCR4, triggers serial conformational changes in the envelope glycoprotein (Env

125 ates rotation of the central stalk, inducing conformational changes in the F(1) motor that catalyzes

126 in cross-linked residues implicate multiple conformational changes in the GAFa and GAFb domains in f

127 ctivates fusion by facilitating irreversible conformational changes in the glycoprotein.

128 spectroscopy, we show that the drug induced conformational changes in the IFN-gamma molecule.

129 This in turn promotes conformational changes in the kinase domain that result

130 DAGH sheet) are particularly susceptible to conformational changes in the monomeric state.

131 ns helped to propose a plausible sequence of conformational changes in the mu-OR and G(i) system and

132 own about the molecular mechanisms that link conformational changes in the NMDAR to changes in spine

133 ransmembrane stalk of a model protein allows conformational changes in the protein.

134 Additional conformational changes in the region of the Zn2+-binding

135 cordings, we observed a temporal sequence of conformational changes in the S6 bundle crossing and the

136 Dysregulated effector binding due to conformational changes in the switch I-interswitch-switc

137 ng secretion and we propose that a series of conformational changes in the T3SS trigger opening of th

138 ule and structural studies for force-induced conformational changes in the TCR-CD3 complex, for dynam

139 The former invokes termination via conformational changes in the transcription complex and

140 Large force-induced conformational changes in the vinculin head domain, as w

141 Atm1 progresses through the transport cycle, conformational changes in transmembrane helix 6 (TM6) al

142 anistic insights into electrophile-dependent conformational changes in TRPA1.

143 e models; (2) intraspecies identification of conformational changes in Zelda-depleted Drosophila embr

144 acquired during optimization enabled global conformational changes, including high-energy backbone r

145 L) of the serpin, and the serpin undergoes a conformational change, incorporating the amino-terminal

146 ier to partial dehydration in the absence of conformational change indicates Kir channels are not gat

147 Monitoring structural and conformational change induced by environmental perturbat

148 ngineered binder specifically recognizes the conformational changes induced by A1120 in two loop regi

149 nal modifications (PTMs), stoichiometry, and conformational changes induced by ligand binding.

150 e collective opening-closing transitions and conformational changes induced by partner binding.

151 he SNF2 domain is coupled to the DNMT domain conformational changes induced by preferred substrates.

152 g correlates cytoskeletal filament size with conformational changes inferred from molecular dynamics

153 This measure allows mapping of global conformational changes into local side chain proximity a

154 folding and unfolding and determining hidden conformational changes invisible to other methods.

155 r understanding membrane lipid influences on conformational changes involved in GPCR activation.

156 of the bovine and human BBSome reveal that a conformational change is required to recruit the complex

157 But the precise nature of the ATP-induced conformational changes is poorly understood.

158 rotein-based mechanisms of inheritance whose conformational changes lead to the acquisition of divers

159 s that ATP binding to BchL produces specific conformational changes leading to release of the flexibl

160 er showed that extracellular ligands induced conformational changes located in the polar core or ERK

161 which inhibits YfkE transport and interrupts conformational changes mediated by the mini-sensor.

162 loop, and Thr355 in the alpha5-helix, these conformational changes might lead to the deformation of

163 The mAb h5B3.1 blocks the required F conformational change needed to facilitate membrane fusi

164 The staple moieties introduce local conformational changes not only in the replaced position

165 We also measured conformational changes occurring after chemistry and dur

166 the spatiotemporal location and function of conformational changes occurring between the first and t

167 relaxation dispersion measurements report on conformational changes occurring on the mus-ms timescale

168 An intricate combination of conformational changes occurs in both Nef and AP2 to ena

169 rai1 pore opening is accompanied by a global conformational change of all Orai transmembrane domain (

170 The conformational change of dibenzocycloocta-1,5-diene (DBC

171 n microscopy reconstructions, we studied the conformational change of EF-Tu from the guanosine tripho

172 ore efficiently to RIG-I and facilitates the conformational change of RIG-I, leading to enhanced inte

173 by the carotenoid finally leads to the large conformational change of the complex.

174 s on the mus timescale and correlates with a conformational change of the conserved neighbouring hist

175 nhibition to an active, open state, due to a conformational change of the ELMO1 subunit, exposes bind

176 Prions result from a drastic conformational change of the host-encoded cellular prion

177 ORP1 PPR domain-tRNAPhe structure revealed a conformational change of the PPR domain upon tRNA bindin

178 Substrate binding induces a conformational change of the SBP and it is thought that

179 le of the E-DNA sensor is the target induced conformational change of the surface signaling probe (co

180 These findings suggest that conformational changes of actin filaments in cells could

181 ble to induce distinct functionally relevant conformational changes of arrestin.

182 ling (SDSL), is a useful method for studying conformational changes of biomolecules in cells.

183 ecule fluorescence spectroscopy to track the conformational changes of bovine MRP1 (bMRP1) in real ti

184 single molecule technique, sensitive to the conformational changes of DNA.

185 f the l- and d-enantiomers induced different conformational changes of FliY, where the l- enantiomer-

186 or channel and the substrate channel via the conformational changes of its two catalytic residues Cys

187 Conformational changes of linker units in metal-organic

188 Using FRET assays to monitor conformational changes of pol beta with r8-oxo-GTP, we d

189 scattering with contrast variation to detect conformational changes of primary-miR-16-1 in complex wi

190 CIU detects subtle conformational changes of proteins and emerges as an att

191 teasomes modify solvent accessibility due to conformational changes of the beta-rings.

192 Alternatively, Urd may block conformational changes of the holoenzyme required for en

193 Conformational changes of the loops forming the central

194 h cryo-EM and x-ray crystallography, in vivo conformational changes of the NPC remain under-explored.

195 Conformational changes of the photosynthetic antenna com

196 for a seesaw-like movement concomitant with conformational changes of the Sub2 ATPase.

197 e adenosine triphosphate (ATP) hydrolysis to conformational changes of their catalytic core.

198 demonstration of a small molecule affecting conformational changes on a HS oligosaccharide.

199 escale have been structurally characterized, conformational changes on slower timescales remain elusi

200 g multiple cycles of LIV-BPSS clamshell-like conformational changes on the time scale of seconds, exa

201 These switches activate through a conformational change only when all conditions are met,

202 In Kir2.2 channels, the PIP(2)-induced conformational changes open the pore.

203 We also examine how proton-induced conformational changes pose unique challenges to classic

204 ith the mutation disrupting an actin-induced conformational change prior to the power stroke.

205 Exchange processes which include conformational change, protonation/deprotonation, and bi

206 nod, Wyman, and Changeux to include tertiary conformational changes provides a better quantitative de

207 Monoclonal antibody binding inhibits this conformational change, providing a direct means to block

208 for substrate binding and a fidelity-related conformational change referred to as "fingers closing."

209 Although the cause of this conformational change remains elusive, ADAMTS13 is prima

210 ther show that RVC20 blocks the acid-induced conformational change required for membrane fusion.

211 and hydrolyzes ATP, and undergoes a specific conformational change required for nsDNA binding, but it

212 The conformational changes required for activation and K(+)

213 lecular basis for low basal activity and the conformational changes required for activation.

214 of the host receptor toward the large spike conformational changes required for cell fusion.

215 smatched virus was less stable and completed conformational changes required for entry prematurely.

216 domain (RBD) or allosteric interference with conformational changes required for entry.

217 preventing access to the target RNA and the conformational changes required for nuclease activation.

218 t through mimicking the key interactions and conformational changes required for the VKOR catalytic c

219 fide bridge appears to prevent an inhibitory conformational change resulting from proton motive force

220 To assess conformational changes resulting from binding, we applie

221 We prove that a local conformational change spreads omnidirectionally within t

222 IGR IRES to the 40S while ensuring that the conformational change stabilizing the 40S-IRES complex d

223 Transition paths of macromolecular conformational changes such as protein folding are predi

224 a mutant with impaired ACP binding reveal a conformational change, suggesting that ACP may regulate

225 haracterization of the temperature-dependent conformational changes suggests the contribution of the

226 EDD8-dependent interprotein interactions and conformational changes synergistically configure a catal

227 ding of gD to one of its receptors induces a conformational change that allows gD to bind to the regu

228 Moreover, binding to loxP DNA induces a conformational change that dislodges the C terminus, res

229 thosteric ligand-binding pocket enabled by a conformational change that doubles the pocket volume.

230 e depletion, and particularly into the STIM1 conformational change that is the basis for communicatio

231 ner membrane leaflet, which triggers a large conformational change that leads to dilation of the pore

232 indicate that acetylation of Pif1 induces a conformational change that may account for its altered e

233 ral modeling predicts that SY242CS confers a conformational change that mediates stable binding to a

234 T6 but absent from other isoforms, induced a conformational change that resulted in a much stronger a

235 slow unimolecular reaction consistent with a conformational change that stabilized the complex.

236 native environment so that it can undergo a conformational change that switches on its peroxidase ac

237 nt to the peptide binding site, leading to a conformational change that ultimately allows the recepto

238 ding, EF-Tu hydrolyzes GTP, which triggers a conformational change that ultimately results in the rel

239 In addition, our structure shows conformational changes that accompany stages of the ATP-

240 During amyloidogenesis, proteins undergo conformational changes that allow them to aggregate and

241 e the binding event is often associated with conformational changes that are critical to cellular sig

242 ophage T7 undergoes large, substrate-induced conformational changes that are thought to account for h

243 helix-bundle domains of CaM results in major conformational changes that create a potential binding s

244 iochemical data define RNAP and promoter DNA conformational changes that delineate steps on the pathw

245 nation on the channel surface and correlated conformational changes that displace the K(+)-selectivit

246 Here, we identified the unique structure and conformational changes that distinguish clade 4 FabIs.

247 angiotensin-converting enzyme 2, initiating conformational changes that drive membrane fusion.

248 bond, but during catalysis thermally induced conformational changes that enable ET from a cluster iro

249 n of transferrin receptor protein 1 promotes conformational changes that improve noncovalent interact

250 sub-step of F(o) associated with long-range conformational changes that indicates how this flexibili

251 n complexes and receptors, and have revealed conformational changes that occur on receptor binding.

252 cGMP binding produces global conformational changes that open the cavity gate located

253 RNA recognition frequently results in conformational changes that optimize intermolecular bind

254 Both additional states involve conformational changes that orient GLUex away from the e

255 ests receptor binding initiates a cascade of conformational changes that produces expanded particles

256 asugars reveal mechanistic details hidden by conformational changes that the Michaelis complex of the

257 ut signals are converted to the same output: conformational changes that trigger refolding of trimeri

258 avage and the destabilizing mutation trigger conformational changes that turn the LC pathogenic.

259 from the chromophore to the protein to drive conformational changes that ultimately generate an outpu

260 ovides a signal to detect nucleotide-induced conformational changes through equilibrium and stopped-f

261 c, likely driven by a wave of interdependent conformational changes throughout the protein originatin

262 faster than most of labeling-induced protein conformational changes, thus enabling a 'snapshot' of pr

263 bitor, suggesting the protein must undergo a conformational change to bind the inhibitor.

264 revealed that this feature undergoes a large conformational change to participate in covering the NAD

265 m of the active site tunnel, which undergoes conformational changes to accommodate the different cap

266 have focused on residue mobility and global conformational changes to address receptor function.

267 le mechanisms which include oligomerization, conformational changes to aid substrate recognition, and

268 ISVPs undergo further conformational changes to form ISVP*s, resulting in the

269 a target protein, which also undergoes major conformational changes to form the complex with CaM.

270 s-linking and mass spectrometric analysis of conformational changes to GAFab induced upon binding of

271 on, suggesting that packaging motors undergo conformational changes to transition between initiation,

272 steine adducts that induce an open-to-closed conformational change, triggering reduction.

273 le ATP binding and hydrolysis to large-scale conformational changes, ultimately leading to substrate

274 Techniques for capturing the continuous conformational changes underlying function are essential

275 A comparison of these states reveals global conformational changes underlying GlyR channel gating an

276 The molecular conformational changes underpinning ligand activation ar

277 These chains undergo a conformational change upon heating, causing the cage and

278 ined structures of ECF-FolT2 revealed larger conformational changes upon binding of folate than panto

279 ences of proteins can encode a wide range of conformational changes upon binding, including transitio

280 mponents of the NPC are flexible and undergo conformational changes upon engaging with cargo.

281 organization of the stator unit (MotAB), its conformational changes upon ion transport, and how these

282 Conformational changes upon ligand binding illuminate a

283 Catalysis is accompanied by large conformational changes upon peptidoglycan binding, where

284 able to proteins undergoing relatively small conformational changes upon target binding.

285 ermore, we demonstrate that FZDs can undergo conformational changes upon WNT binding without being de

286 tion through SecYEG and (2) communication of conformational changes via SecDF across the periplasm to

287 t with existing structures to understand the conformational changes VqmA undergoes upon DNA binding.

288 Of note, this conformational change was not universally fulfilled by a

289 These conformational changes were consistent with transfer of

290 One limitation has been that global conformational change - which occurs in all conventional

291 rlocked components' submolecular motions and conformational changes, which are triggered by external

292 of ATP, the alpha(3)beta(3) domain undergoes conformational changes while the central stalk (gamma/D)

293 forward and reverse directions to correlate conformational changes with chemical reaction steps.

294 nd viscoelastic properties due to reversible conformational changes with mucin forming a network stru

295 ments of the fingers, and RdRPs use a subtle conformational change within the palm domain to close th

296 overcome the steric block of transmission of conformational changes within EF-G by which FA prevents

297 ctor-triggered and phosphorylation-regulated conformational changes within RRS1 that results in disti

298 ing and Smc1-Smc3 heterodimerization promote conformational changes within the ATPase that are transm

299 energy transfer offers a unique tool to map conformational changes within the protein structure.

300 analyze three diverse biological processes: conformational changes within the soluble protein calmod