ライフサイエンスコーパス: congenital disease

1 primary strategy to reduce the incidence of congenital disease.

2 in utero, likely increasing the severity of congenital disease.

3 ping serious infections due to an underlying congenital disease.

4 iversity with prominent roles in somatic and congenital disease.

5 on of ZIKV and other viruses associated with congenital disease.

6 virus (ZIKV) crosses the placenta and causes congenital disease.

7 oblem because of its ability to cause severe congenital disease.

8 ng fetal therapeutics to efficaciously treat congenital disease.

9 ing over causes infertility, miscarriage and congenital disease.

10 and neck and in the pathophysiology of human congenital disease.

11 nfection is a promising treatment to prevent congenital disease.

12 to have wide relevance in organogenesis and congenital disease.

13 virus (ZIKV) to counteract its potential for congenital disease.

14 ure, valvular disease, coronary disease, and congenital disease.

15 f left-right orientation lead to significant congenital disease.

16 ted malformations exist as a part of complex congenital diseases.

17 ethality or are associated with severe human congenital diseases.

18 thogenetic mechanism that may underlie other congenital diseases.

19 natal investigation of fetal development and congenital diseases.

20 g embryogenesis is crucial for understanding congenital diseases.

21 ocess that promotes tumorigenesis and causes congenital disease(1-4).

22 Congenital diseases account for a large portion of pedia

23 LMNA are associated with the laminopathies, congenital diseases affecting tissue regeneration and ho

24 om several human genetic variants that cause congenital disease and a broad spectrum of chronic human

25 ns of PBX-dependent networks can cause human congenital disease and cancer.

26 ne or a few chromosomes that can cause human congenital disease and cancer.

27 ive changes in these processes underlie both congenital disease and evolutionary change.

28 outflow tract, both in children with complex congenital disease and in adults undergoing the Ross pro

29 directly associated with the development of congenital disease and includes diverse bacteria, viruse

30 lum Apicomplexa and is an important cause of congenital disease and infection in immunocompromised pa

31 megalovirus (CMV), a herpesvirus that causes congenital disease and opportunistic infections in immun

32 ion and impair fetal development, leading to congenital disease and other pregnancy complications.

33 , leading to revealing the complex nature of congenital disease and regenerative medicine.

34 nses were demonstrated both in patients with congenital disease and those with acquired disease, sugg

35 ions in T-box genes are the cause of several congenital diseases and are implicated in cancer.

36 mplex genomic rearrangements associated with congenital diseases and cancers stem from mistakes made

37 coding genes have been associated with human congenital diseases and cancers, respectively.

38 ue homeostasis, and its misregulation causes congenital diseases and cancers.

39 tions of GalNAc-T isoforms and their role in congenital diseases and disorders.

40 athways are important for understanding many congenital diseases and for developing regenerative medi

41 ian embryogenesis and is implicated in human congenital diseases and multiple types of cancer; howeve

42 atresia (CA), which are associated with many congenital diseases and require immediate clinical inter

43 infections have been linked to microcephaly, congenital disease, and Guillain-Barre syndrome.

44 for studying human developmental processes, congenital diseases, and pathogen response mechanisms in

45 with a wide spectrum of disorders, including congenital diseases as well as cancers and neurodegenera

46 t and facilitates the investigation of novel congenital diseases associated with these processes.

47 cations arising from trauma, surgery, and as congenital, disease-associated, or drug-induced blood di

48 is known about how pathogens associated with congenital disease breach the placental barrier to trans

49 chondrial DNA (mtDNA) mutations cause severe congenital diseases but may also be associated with heal

50 Hormone absence or inactivity is common in congenital disease, but hormone antagonism remains contr

51 e caused by GM-CSF autoantibodies and a rare congenital disease caused by CSF2RA mutations.

52 dromes represent a broader spectrum of human congenital diseases caused by genotoxic stress; therefor

53 cally inactive Jumpy mutant, R336Q, found in congenital disease centronuclear myopathy, lost the abil

54 use Shwachman-Diamond Syndrome (SDS), a rare congenital disease characterized by bone marrow failure

55 DiGeorge syndrome (DGS) is a congenital disease characterized by defects in organs an

56 nked myotubular myopathy (XLMTM) is a severe congenital disease characterized by profound muscle weak

57 order of glycosylation type 1a (CDG-1a) is a congenital disease characterized by severe defects in ne

58 The major viral cause of congenital disease, CMV infects the uterine-placental in

59 promising strategy for treating a number of congenital diseases diagnosed shortly after birth as exp

60 tation (P=0.05), female gender (P=0.02), and congenital disease diagnosis (P=0.05).

61 lating downstream signaling for treatment of congenital diseases due to constitutively active GPCRs,

62 y of children in the nonglomerular group was congenital, disease duration equated with age.

63 ly presents a major infectious cause of both congenital disease during pregnancy as well as opportuni

64 ka virus (ZIKV) was identified as a cause of congenital disease during the explosive outbreak in the

65 In some cases, categories of congenital disease familiar to clinicians are not recogn

66 ial syndrome (UFS) is an autosomal recessive congenital disease featuring grimacing and incomplete bl

67 s (HCMV) infection, the most common cause of congenital disease globally, affecting an estimated 1 mi

68 However, microorganisms that cause congenital disease have likely evolved diverse mechanism

69 or study due to their relevance to the human congenital disease Hirschsprung disease (HSCR).

70 induce various gut disorders, including the congenital disease Hirschsprung disease, or various othe

71 oxoplasma gondii, that can cause abortion or congenital disease in a variety of domestic animal hosts

72 Cytomegalovirus (CMV) is a leading cause of congenital disease in newborns, and an effective vaccine

73 al agenesis/atresia (TA) is a rare but fatal congenital disease in which the breathing tube fails to

74 d biliary duct remodeling cause a variety of congenital diseases including Alagille Syndrome and poly

75 erience from other vaccines directed against congenital disease (including rubella and Zika) may be i

76 Human cytomegalovirus - the major cause of congenital disease - infects the uterine wall and the ad

77 omegalovirus (CMV), the major viral cause of congenital disease, infects the uterus and developing pl

78 Thus, a vaccine to prevent HCMV-associated congenital disease is a public health priority.

79 Understanding the molecular mechanisms of congenital diseases is challenging due to their occurren

80 Its genetic mutations are linked to the congenital disease Leber congenital amaurosis Type 2 (LC

81 Ribosomopathies are largely congenital diseases linked to defects in ribosomal prote

82 Although Zika virus (ZIKV)-induced congenital disease occurs more frequently during early s

83 mmune lymphoproliferative syndrome (ALPS), a congenital disease of defective apoptosis and autoimmuni

84 PLD should be considered as congenital diseases of cholangiocyte signaling.

85 h as inversions and translocations can cause congenital disease or cancer by inappropriately rewiring

86 t disease, cardiomyopathy, valvular disease, congenital disease, pericardial disease, and masses.

87 and the use of hiPSC-cardiomyocyte models of congenital disease phenotypes for guiding large-scale sc

88 morphogenesis in 3D, improving insight into congenital disease phenotypes.

89 lized lymphatic anomaly (GLA) is an uncommon congenital disease secondary to the proliferation of lym

90 nd shape and suggested as culprit in several congenital diseases such as CAKUT (Congenital anomalies

91 eletal muscle RyR (RyR1) are associated with congenital diseases such as malignant hyperthermia and c

92 tal development that, when disturbed, causes congenital diseases such as spina bifida and cleft palat

93 Walker-Warburg syndrome (WWS) is a severe congenital disease that is characterized by brain and ey

94 to raise awareness of this sight-threatening congenital disease that manifests as cataract with ocula

95 Lowe syndrome is a rare X-linked congenital disease that presents with congenital catarac

96 ctive therapies for PDH deficiency and other congenital diseases that affect early embryonic developm

97 tabolite profiles to identify rare inherited congenital diseases through newborn screening, but littl

98 since the link between infection and severe congenital disease was announced by Brazilian authoritie

99 ephrin-B1 acts to influence development and congenital disease, we generated mice harboring a series

100 Children with immune deficiencies or congenital diseases were excluded.

101 Wolff-Parkinson-White syndrome and no other congenital disease, were imaged with ECGI a day before a

102 n solid-organ transplant patients as well as congenital disease when administered to pregnant women.

103 responses that underlie the pathogenesis of congenital disease will guide future treatment strategie

104 Human cytomegalovirus (HCMV) causes congenital disease with long-term morbidity.

105 Congenital diseases with significant neurological defect

106 mates among an additional 7000 children with congenital diseases yielded an even stronger statistical