ライフサイエンスコーパス: congenital heart defect

1 hydrometrocolpos, post-axial polydactyly and congenital heart defects).

2 genic CHD7 mutation, of whom 220 (74%) had a congenital heart defect.

3 of Fallot (TOF) is the most common cyanotic congenital heart defect.

4 report characterizing ncRNA expression in a congenital heart defect.

5 FQ were included; among offspring, 543 had a congenital heart defect.

6 factors contribute to the presentation of a congenital heart defect.

7 the ductus arteriosus, the third most common congenital heart defect.

8 ntricular septal defects are the most common congenital heart defect.

9 .40%, N = 2,050,491) children had at least 1 congenital heart defect.

10 of individuals, and three individuals had a congenital heart defect.

11 midpregnancy and increased offspring risk of congenital heart defects.

12 type of LQTS, HCM, sudden cardiac death, and congenital heart defects.

13 oxygen species (ROS) levels and the risk of congenital heart defects.

14 short stature, craniofacial dysmorphism, and congenital heart defects.

15 2-8 of pregnancy and their associations with congenital heart defects.

16 highly penetrant and associated with varied congenital heart defects.

17 tened drinks increased the risk of offspring congenital heart defects.

18 ic abnormalities; myopia was correlated with congenital heart defects.

19 ial to mitigate poor growth in children with congenital heart defects.

20 feeding and growth pattern in children with congenital heart defects.

21 elopmental disorder characterized in part by congenital heart defects.

22 also associated with cardiac hypertrophy and congenital heart defects.

23 centers of the German Competence Network for Congenital Heart Defects.

24 cases and 49.06% (35.06-63.16) for all major congenital heart defects.

25 28.57% (14.64-46.30) for all cases of major congenital heart defects.

26 s in FGF3 or FGF10 could contribute to human congenital heart defects.

27 cy of pulse oximetry as a screening test for congenital heart defects.

28 ons with a variety of syndromic and isolated congenital heart defects.

29 sity is associated with an increased risk of congenital heart defects.

30 in the large number of patients affected by congenital heart defects.

31 tus arteriosus and is one of the most common congenital heart defects.

32 s necessary to improve repair strategies for congenital heart defects.

33 deling contribute to the etiology of several congenital heart defects.

34 intricate steps of cardiogenesis can lead to congenital heart defects.

35 erhaps defects in this signal play a role in congenital heart defects.

36 e formation of the OFT can result in serious congenital heart defects.

37 pacing technologies to younger patients with congenital heart defects.

38 lso to genetic and mechanistic insights into congenital heart defects.

39 otect against other birth defects, including congenital heart defects.

40 en found to be responsible for some cases of congenital heart defects.

41 greater understanding of the pathogenesis of congenital heart defects.

42 athic PAH and 2 with PAH in association with congenital heart defects.

43 ght ultimately result in particular types of congenital heart defects.

44 panic disorder), epilepsy, asthma, and some congenital heart defects.

45 d received allograft placement for repair of congenital heart defects.

46 irment could be a significant contributor to congenital heart defects.

47 overing mutations causing a wide spectrum of congenital heart defects.

48 thogenesis of both structural and functional congenital heart defects.

49 wledge about the molecular genetic causes of congenital heart defects.

50 apid identification of disease genes causing congenital heart defects.

51 ecurrence risk for families of children with congenital heart defects.

52 pressed in patients with Down's syndrome and congenital heart defects.

53 atients who underwent open-heart surgery for congenital heart defects.

54 or hemodynamic abnormalities associated with congenital heart defects.

55 ion, providing a framework for investigating congenital heart defects.

56 hanical signaling and MET in the etiology of congenital heart defects.

57 This is relevant to congenital heart defects.

58 have been proposed as a mechanism for human congenital heart defects.

59 on in this process has major implications in congenital heart defects.

60 raction in postnatal cardiac development and congenital heart defects.

61 of women whose pregnancies were affected by congenital heart defects (224 case subjects) or unaffect

62 of women whose pregnancies were affected by congenital heart defects (331 cases) and in a control gr

63 .1 years) because of cardiomyopathy (66%) or congenital heart defects (34%).

64 ardiac abnormalities were diagnosed, such as congenital heart defects (6%), mitral valve abnormalitie

65 Congenital heart defects affect at least 0.8% of newborn

66 pid aortic valve (BAV) is the most prevalent congenital heart defect affecting 1% to 2% of the popula

67 Congenital heart defects also are common in patients wit

68 re not able to demonstrate a higher risk for congenital heart defect among monozygotic twins compared

69 The adjusted OR (aOR) of congenital heart defects among offspring of mothers belo

70 Bicuspid aortic valve (BAV) is a heritable congenital heart defect and an important risk factor for

71 septal defect (ASD) is the most common adult congenital heart defect and can present with wide variat

72 aortic valve (BAV) is the most common adult congenital heart defect and is found in 0.5% to 2.0% of

73 Ten patients with cyanotic congenital heart defects and 10 control subjects were st

74 rovide new insights into the pathogenesis of congenital heart defects and 22q11.2 deletion syndrome p

75 nts of Chromosome 8p23.1 are associated with congenital heart defects and developmental delay.

76 with variable penetrance identified in other congenital heart defects and dilated cardiomyopathy, thi

77 yos, which will enhance our understanding of congenital heart defects and heart disease.

78 der characterized by post-axial polydactyly, congenital heart defects and hydrometrocolpos, a congeni

79 rge pedigree with concomitant LQTS, HCM, and congenital heart defects and identified a novel CACNA1C

80 tion accounts for approximately 30% of human congenital heart defects and manifests frequently in TBX

81 ios (ORs) for associations between offspring congenital heart defects and maternal hypertensive disor

82 conceptional folic acid on the occurrence of congenital heart defects and orofacial clefts is reporte

83 ic acid and a reduction in the occurrence of congenital heart defects and orofacial clefts.

84 iological mechanisms may be involved in some congenital heart defects and preterm preeclampsia.

85 Patients with congenital heart defects and stenotic or occluded IFV/IV

86 he genetic/epigenetic pathways implicated in congenital heart defects and the mechanisms of cardiac t

87 approaches to understanding the etiology of congenital heart defects and the repair of diseased card

88 will be important to understand the basis of congenital heart defects and to derive cardiac regenerat

89 rol study was conducted in infants born with congenital heart defects and unaffected controls from th

90 nts with Holt-Oram syndrome characterized by congenital heart defects and upper limb abnormalities.

91 ns cause Holt-Oram syndrome characterized by congenital heart defects and upper limb deformations.

92 ht ventricular dysplasia; and delineation of congenital heart defects and valvular abnormalities are

93 This mutation causes heterotaxy and complex congenital heart defects and was mapped to a 2.2-Mb inte

94 h six cases were significant, but not major, congenital heart defects, and 40 were other illnesses th

95 abnormalities, hypoplastic corpus callosum, congenital heart defects, and central hypoventilation.

96 of clinical features including growth delay, congenital heart defects, and craniofacial dysmorphism.

97 ith absent speech, hypotonia, brachycephaly, congenital heart defects, and dysmorphic facial features

98 ve malformations with associated aortopathy, congenital heart defects, and genetic syndromes.

99 ral CNS anomalies, ophthalmologic anomalies, congenital heart defects, and genitourinary abnormalitie

100 al-level information on GI and GL, offspring congenital heart defects, and health and lifestyle covar

101 Thirty-six patients (40%) had congenital heart defects, and many (31 [86%]) had associ

102 concern because of its involvement in common congenital heart defects, and the PV is usually the site

103 sed risk of bearing children with a range of congenital heart defects, and the risk increases with in

104 a complex phenotype including LQTS, HCM, and congenital heart defects annotated as cardiac-only Timot

105 Congenital heart defects are a leading cause of morbidit

106 Congenital heart defects are a major cause of perinatal

107 cohort study to determine whether offspring congenital heart defects are associated with an increase

108 Congenital heart defects are more frequent in offspring

109 Children with major congenital heart defects are risking impaired cerebral g

110 Congenital heart defects are the most common birth defec

111 Congenital heart defects are the most common birth defec

112 Congenital heart defects are the most common malformatio

113 Congenital heart defects are the most frequent malformat

114 alve morphogenesis involved in the origin of congenital heart defects associated with reduced NOTCH f

115 nd ventricular septum defect, which resemble congenital heart defects attributed to defects in the NC

116 the largest genome-wide association study of congenital heart defects available (2594 cases and 5159

117 transcription factors cannot only result in congenital heart defects but also alter heart function t

118 ors likely contribute to the pathogenesis of congenital heart defects, but it is unclear whether indi

119 n in neonatal patients with single ventricle congenital heart defects, but this complex procedure car

120 trongest evidence that multivitamins prevent congenital heart defects, but this RCT did not provide e

121 ong women whose pregnancies were affected by congenital heart defects cannot be defined without furth

122 Mothers of 7392 congenital heart defect cases and 56,304 unaffected cont

123 of pulse oximetry for detection of critical congenital heart defects (causing death or requiring inv

124 eening method to detect undiagnosed critical congenital heart defects (CCHD) in asymptomatic newborns

125 Hypoplastic left heart is a severe human congenital heart defect characterized by left ventricula

126 ibrillator (ICD) placement in paediatric and congenital heart defect (CHD) patients.

127 c patent ductus arteriosus (PDA) is a common congenital heart defect (CHD) with both inherited and ac

128 ately 65% of individuals with 22q11DS have a congenital heart defect (CHD), mostly of the conotruncal

129 About half of people with trisomy 21 have a congenital heart defect (CHD), whereas the remainder hav

130 Congenital heart defect (CHD)-related death rates correl

131 n our understanding of the genetic causes of congenital heart defect (CHD).

132 cts (heterotaxy) that were associated with a congenital heart defect (CHD).

133 Congenital heart defects (CHD) are collectively the most

134 Congenital heart defects (CHD) are the leading cause of

135 ing neurocognitive outcomes in children with congenital heart defects (CHD) have focused on high-risk

136 ternal lifestyle during pregnancy related to congenital heart defects (CHD) in Shaanxi province, Nort

137 ion in a patient with pathogenically similar congenital heart defects (CHD) to narrow the putative cr

138 Background In women with congenital heart defects (CHD), changes in blood volume,

139 This study determines the prevalence of Congenital Heart Defects (CHD), diagnosed prenatally or

140 ic modalities and therapeutic strategies for congenital heart defects (CHD), these malformations stil

141 some 21 (Hsa21), is the most common cause of congenital heart defects (CHD), yet the genetic and mech

142 on (AF) is rising in the aging patients with congenital heart defects (CHD).

143 who undergo early cardiac surgery to repair congenital heart defects (CHD).

144 cription factor NKX2.5 as a cause of various congenital heart defects (CHD).

145 ls to the poles of the heart tube results in congenital heart defects (CHD).

146 Nearly one in 100 live births presents with congenital heart defects (CHD).

147 nd distressful comorbidities associated with congenital heart defects (CHD).

148 sociated with an increased risk of offspring congenital heart defects (CHD); however, the causal mech

149 Congenital heart defects (CHDs) affect 2%-3% of newborns

150 en maternal medical conditions/illnesses and congenital heart defects (CHDs) among infants.

151 Congenital heart defects (CHDs) and anomalies in cardiac

152 Congenital heart defects (CHDs) are among the most commo

153 While congenital heart defects (CHDs) are major clinical featu

154 Congenital heart defects (CHDs) are the most common birt

155 Congenital heart defects (CHDs) are the most common deve

156 Congenital heart defects (CHDs) are the most common grou

157 Maternal diabetes is associated with congenital heart defects (CHDs) as a group, but few stud

158 Congenital heart defects (CHDs) have a neonatal incidenc

159 Congenital heart defects (CHDs) have a neonatal incidenc

160 Congenital heart defects (CHDs) have been associated wit

161 rythematosus (SLE) have an increased risk of congenital heart defects (CHDs) in comparison with child

162 patterns with neural tube defects (NTDs) and congenital heart defects (CHDs) in the U.S. National Bir

163 O2, NO2, CO are related to increased risk of congenital heart defects (CHDs) in Wuhan, China.

164 first-trimester screening on the spectrum of congenital heart defects (CHDs) later in pregnancy and o

165 Pregnant women with congenital heart defects (CHDs) may be at increased risk

166 of the results achieved by modern surgery in congenital heart defects (CHDs) over the past 40 years r

167 , there has been a decline in mortality from congenital heart defects (CHDs) over the past several de

168 Studies on congenital heart defects (CHDs) were excluded because of

169 ed States, >1 million adults are living with congenital heart defects (CHDs), but gaps exist in under

170 congenital malformations in humans including congenital heart defects (CHDs), left-right disturbances

171 ease almost always are attributed to complex congenital heart defects (CHDs), reflecting the extreme

172 The etiology of congenital heart defects (CHDs), which are among the mos

173 ide a rationale for attempting prevention of congenital heart defects (CHDs).

174 ed in patients with isolated or nonsyndromic congenital heart defects (CHDs).

175 acid and of folic acid food fortification on congenital heart defects (CHDs).

176 scription factor genes cause human inherited congenital heart defects (CHDs); however, their molecula

177 Congenital heart defects comprise the most common form o

178 ice were subviable, smaller in size, and had congenital heart defects, consistent with the severity o

179 By contrast, complex congenital heart defects continue to require open-heart

180 cal and sub-clinical vascular brain lesions, congenital heart defects, coronary heart disease, psychi

181 Presence of any critical or noncritical congenital heart defect detected in infants at birth, co

182 e recently been reported in association with congenital heart defects, developmental delay, schizophr

183 nical manifestations of this disease include congenital heart defects, developmental delays, distinct

184 fidence interval, 45-82%] increased risk for congenital heart defect for twins).

185 of hCPCs in young patients with nonischemic congenital heart defects for potential use in congenital

186 bance, epilepsy, hypotonia, visual problems, congenital heart defects, gastrointestinal problems, sho

187 In this review, progress in identifying new congenital heart defect genes for specific lesions and i

188 orn prematurely (<37 weeks gestation); had a congenital heart defect; had history in the past 2 weeks

189 The occurrence of a congenital heart defect has long been thought to have a

190 In the recent era, no congenital heart defect has undergone a more dramatic ch

191 Improvement in outcome of infants born with congenital heart defects has been accompanied by an incr

192 though the care of infants and children with congenital heart defects has been revolutionized over th

193 CSCs in very young patients with nonischemic congenital heart defects has not been explored.

194 Bicuspid aortic valve (BAV), the most common congenital heart defect, has been thought to cause frequ

195 egnancies that were affected by nonsyndromic congenital heart defects have alterations in the homocys

196 In severe SMA cases, a growing number of congenital heart defects have been identified upon autop

197 ally significant increased risk of offspring congenital heart defects (highest vs lowest intake-aOR:

198 esting may become standard for many forms of congenital heart defects, improving clinicians' ability

199 Hypoplastic left heart syndrome is a rare congenital heart defect in which the left side of the he

200 We collected information on congenital heart defects in 299 patients with a pathogen

201 Offspring congenital heart defects in a previous pregnancy were al

202 dysmorphia, increased risk of leukemia, and congenital heart defects in approximately 50% of cases.

203 reening method for the detection of critical congenital heart defects in asymptomatic newborn babies.

204 pulse oximetry for the detection of critical congenital heart defects in asymptomatic newborn babies.

205 Allografts used in the repair of congenital heart defects in children induce a persistent

206 Treatment of congenital heart defects in children requiring right ven

207 may be a viable strategy for suppression of congenital heart defects in fetuses of diabetic pregnanc

208 pina bifida, cleft lip, anal atresia, severe congenital heart defects in general, or tetralogy of Fal

209 ations in a Hox mouse model, which mimic the congenital heart defects in HOXA1 syndrome patients.

210 ations in GATA4 and TBX5 are associated with congenital heart defects in humans.

211 he MEF2C and TDGF1 genes are associated with congenital heart defects in humans.

212 The risk of congenital heart defects in infants of women who had pre

213 hypertension, was associated with offspring congenital heart defects in later pregnancies (early pre

214 d mortality after the surgical correction of congenital heart defects in neonatal patients.

215 Screening for critical congenital heart defects in newborn babies can aid in ea

216 f NFAT, suggesting a potential mechanism for congenital heart defects in Noonan syndrome.

217 ted, is associated with an increased risk of congenital heart defects in offspring.

218 intake of methyl nutrients, and the odds of congenital heart defects in offspring.

219 as been associated with an increased risk of congenital heart defects in offspring; however, the resu

220 on genetic cause of cognitive impairment and congenital heart defects in the human population.

221 nd sugar-sweetened beverages and the risk of congenital heart defects in the offspring.

222 on, 316 children with sporadic, nonsyndromic congenital heart defects, including 76 coarctation of th

223 TBX20 are associated with multiple forms of congenital heart defects, including cardiac septal abnor

224 Sema3D morphants have subsequent complex congenital heart defects, including hypertrophic cardiom

225 se mutations are highly penetrant for varied congenital heart defects, including progressive atrioven

226 the cardiac outflow tract (OFT) causes many congenital heart defects, including those associated wit

227 le the survival of infants and children with congenital heart defects, including those with univentri

228 Congenital heart defects, inguinal hernia, or hypospadia

229 omalous pulmonary venous return (TAPVR) is a congenital heart defect inherited via complex genetic an

230 Many congenital heart defects involve anomalies in cardiac se

231 Congenital heart defects involving left-sided lesions (L

232 Congenital heart defect is more common in twins than in

233 Elucidating the causes of congenital heart defects is made difficult by the comple

234 In cases of congenital heart defects, localized ultrastructural disr

235 The type of congenital heart defect, maternal body mass index (BMI;

236 s and many case series reports indicate that congenital heart defects may be more common in monochori

237 d in all 24 probands and three parents, with congenital heart defects most frequent (83%).

238 eview of 1- and 2-year outcomes of a Complex Congenital Heart Defect Neurodevelopmental Follow-Up pro

239 ions such as those with sickle cell disease, congenital heart defects, neutropenia, and indwelling ce

240 some 16, trisomy of which is associated with congenital heart defects observed in Down syndrome.

241 Congenital heart defects occur at a rate of 5% and are t

242 ined that a wide spectrum of the most common congenital heart defects occur in 11q-, including an unp

243 We investigated congenital heart defect occurrence in all twins and 5% o

244 twins compared with dizygotic twins, and the congenital heart defect occurrence was also increased in

245 women (BMI: 19-24.9) to have children with a congenital heart defect [odds ratio (OR): 1.15; 95% CI:

246 sing the SNF1LK locus has been implicated in congenital heart defects often observed in patients with

247 Congenital heart defects often result from improper diff

248 he chance that offspring will be born with a congenital heart defect or an orofacial cleft are review

249 ntified pregnancies complicated by offspring congenital heart defects or early preterm preeclampsia,

250 le-genome sequencing and cardiac RNAseq from congenital heart defect patients from the Pediatric Card

251 Congenital heart defects (persistent truncus arteriosus

252 as a molecular signature that differentiated congenital heart defect phenotypes.

253 Bicuspid aortic valve (BAV) is a common congenital heart defect (population incidence, 1-2%)(1-3

254 ntricular septal defects (AVSD) are a severe congenital heart defect present in individuals with Down

255 Because atrial incisions from repair of congenital heart defects provide a substrate for re-entr

256 This new model for a common congenital heart defect provides novel insights into the

257 tions in live born null mice include complex congenital heart defects, pulmonary reversal or isomeris

258 Some Hug mutants exhibit congenital heart defects ranging from mild pulmonary ste

259 dividuals, a total of 584 twins (1.4%) had a congenital heart defect registered in the Danish Nationa

260 Screening for congenital heart defects relies on antenatal ultrasonogr

261 Congenital heart defects remain a leading cause of infan

262 ntrolling AHF development and their roles in congenital heart defects remain incompletely elucidated.

263 ongenital heart defects for potential use in congenital heart defect repair warrants exploration.

264 Isolated congenital heart defects resulting from isomerisms and d

265 s, a metabolic profile that is predictive of congenital heart defect risk would help to refine curren

266 of Down's syndrome were more likely to list congenital heart defects (SMOR 29.1, 95% CI 27.8-30.4),

267 Notably, in human newborns, congenital heart defects strongly associate with neurode

268 re is a lack of comparable data for specific congenital heart defects such as in repaired tetralogy o

269 included 49 articles that focused on complex congenital heart defects such as tetralogy of Fallot, sy

270 higher in women with pregnancies affected by congenital heart defects than in women without such a hi

271 -5-expressing cells leads to the most common congenital heart defect that is also a subset of abnorma

272 to characterize three patients with 11q- and congenital heart defects that carry interstitial deletio

273 It identifies cases of critical congenital heart defects that go undetected with antenat

274 k suggests a role for the SHF in a subset of congenital heart defects that have overriding aorta and

275 gene(s) that causes at least a subset of the congenital heart defects that occur in 11q-.

276 rnal metabolic risk profile for nonsyndromic congenital heart defects that would enhance current prev

277 It is not clear whether the risk of congenital heart defects, the most common malformations,

278 spectrum of congenital disorders, including congenital heart defects, the primary determinant of mor

279 gation deficiencies lead to life-threatening congenital heart defects, the variables controlling the

280 Although genetic variation contributes to congenital heart defects, their precise molecular bases

281 e being made to prevent fetal hydrops due to congenital heart defects, to recruit hypoplastic ventric

282 D13L), which is mutated in patients with the congenital heart defect transposition of the great arter

283 of pulse oximetry for detection of critical congenital heart defects was 76.5% (95% CI 67.7-83.5).

284 association between GI and GL and offspring congenital heart defects was estimated by logistic regre

285 The absolute prevalence of congenital heart defects was higher for infants of women

286 However, the absolute risk of congenital heart defects was low.

287 and a moderately increased risk of offspring congenital heart defects was observed.

288 alse-positive rate for detection of critical congenital heart defects was particularly low when newbo

289 dditional affected individual with RHD and a congenital heart defect, we found a homozygous loss-of-f

290 In 35 cases, congenital heart defects were already suspected after an

291 ifferent ages undergoing cardiac surgery for congenital heart defects were isolated and cultured unde

292 ifferent ages undergoing cardiac surgery for congenital heart defects were isolated and cultured unde

293 Congenital heart defects were noted in four of the five

294 and infant characteristics, and diagnoses of congenital heart defects were retrieved from nationwide

295 Offspring congenital heart defects were strongly associated with e

296 ight also provide clues to better understand congenital heart defects, which are the most common birt

297 in half of newborn mice mainly associated to congenital heart defects, while Loxl2 overexpression tri

298 ighly significant trend of increasing OR for congenital heart defects with increasing maternal obesit

299 is highly specific for detection of critical congenital heart defects with moderate sensitivity, that

300 We identified 113 candidate genes for congenital heart defects within these CNVs, including BT