ライフサイエンスコーパス: conidia

1 vival following inhalation of fungal spores (conidia).

2 kine production in contrast to the wild-type conidia.

3 and an unknown metabolite than the wild type conidia.

4 ng GFP fusions, was present in young, mature conidia.

5 n, hyphal curvature and limited formation of conidia.

6 nd alpha-mannose on Aspergillus and Fusarium conidia.

7 nflammation to repeated inhalation of fungal conidia.

8 elieved to be caused by airborne Aspergillus conidia.

9 after multiple inhalation exposures to live conidia.

10 erved persistence of ungerminated but viable conidia.

11 elopment of the Th2 response to A. fumigatus conidia.

12 4 to day 28 and investigated on day 28 after conidia.

13 via i.t. instillation with live A. fumigatus conidia.

14 halation of the aerosolized spores, known as conidia.

15 ays that are modulated during infection with conidia.

16 esponse to repeated exposure to A. fumigatus conidia.

17 ion during repeated exposure to A. fumigatus conidia.

18 ular conidiophore that bears spores known as conidia.

19 ets differ in their response to A. fumigatus conidia.

20 lity to phagocytose and inhibit A. fumigatus conidia.

21 himeras following infection with Aspergillus conidia.

22 ent times following pulmonary challenge with conidia.

23 equired prolonged exposure with live resting conidia.

24 At least one species produces dematiaceous conidia.

25 BL/6 and gp91(phox)(-/-) mice in response to conidia.

26 ts a critical early response of AM to fungal conidia.

27 atus, with a limit of detection of 1 x 10(2) conidia.

28 ritin, completely abolished activity against conidia.

29 at peribronchiolar sites but no germinating conidia.

30 al in preventing germination of A. fumigatus conidia.

31 4) and IL-13 than T cells responding to live conidia.

32 in worker ants exposed to Beauveria bassiana conidia.

33 were consistent for DNA from both hyphae and conidia.

34 after CLP, with viable Aspergillus fumigatus conidia.

35 ese parameters at all subsequent times after conidia.

36 ly defined minimal medium produced pigmented conidia.

37 ed with CXCR2+/+ mice at various times after conidia.

38 ant reduction in the number and viability of conidia.

39 mentation and multicellular adherence of the conidia.

40 ophil effector activity against inhaled mold conidia.

41 ithout inactivating intracellular A. terreus conidia.

42 after pulmonary challenge with A. fumigatus conidia.

43 inhalation exposure to Aspergillus fumigatus conidia.

44 se and increased beta-(1,3)-glucan levels in conidia.

45 sulting in the production of inter-connected conidia.

46 stronger platelet activation than wild-type conidia.

47 levels of airborne Aspergillus and Fusarium conidia.

48 tection was demonstrated over 5 log units of conidia (10 to 10(5) spores).

49 Large splash droplets contained most conidia (4-5.5 mm splashes averaged 308 conidia), but we

50 days 14 and 28 after challenge with swollen conidia, a finding never observed in their allergic wild

51 Morphologically, smooth, ovoid conidia, a greenish gray colony color, slow growth on al

52 Aspergillus conidia activated CD8(+) T cells upon sorting to the Rab

53 gement of MD-2 by PTX3-opsonized Aspergillus conidia activated the TLR4/Toll/IL-1R domain-containing

54 Macrophages stimulated with conidia alone increased NF-kappaB translocation.

55 driven by the A. fumigatus allergen, viable conidia also stimulated pulmonary arterial remodeling in

56 l upon antigenic challenge with A. fumigatus conidia, although this pathway does not seem to allow fo

57 h narrow and cylindrical-to-slightly clavate conidia and a strong, pungent odor.

58 t the Fgsrp1 deletion mutant rarely produced conidia and caused only limited symptoms on wheat heads

59 e fungi reproduce asexually by production of conidia and chlamydospores and in wild habitats by ascos

60 tion of mcrA resulted in a reduced number of conidia and decreased mRNA levels of brlA, the key asexu

61 cell responses against inhaled A. fumigatus conidia and demonstrates a benefit for systemic GM-CSF a

62 However, maturing A. fumigatus conidia and germ tubes stimulate NF-kappabeta, secretion

63 Caspofungin- or micafungin-treated conidia and germlings induced less secretion of tumor ne

64 In contrast to treated conidia and germlings, echinocandin-treated hyphae stimu

65 itivity for DNA extraction from A. fumigatus conidia and GHE.

66 We examined the interaction between conidia and host cells in a murine bone-marrow-derived m

67 l distinct killing mechanisms of Aspergillus conidia and hyphae by human neutrophils, leading to a co

68 Endocytosed conidia and hyphae caused progressive endothelial cell i

69 ficolin-A significantly binds to Aspergillus conidia and hyphae in a concentration-dependent manner a

70 ry caused by hyphae was not, indicating that conidia and hyphae injure endothelial cells by different

71 ed the interactions of Aspergillus fumigatus conidia and hyphae with endothelial cells in vitro.

72 an platelets were incubated with Aspergillus conidia and hyphae, isolated wall components, or fungal

73 lved in the killing of Aspergillus fumigatus conidia and hyphae, using neutrophils from patients with

74 ides to the surface of Aspergillus fumigatus conidia and hyphae.

75 type-specific mAb, reacts with A. fumigatus conidia and hyphae.

76 re also increased in gp91(phox)(-/-) mice by conidia and in C57BL/6 mice by polystyrene beads, sugges

77 GprH is pre-formed in conidia and is increasingly active during carbon starvat

78 ith resting or swollen Aspergillus fumigatus conidia and monitored for survival and lung inflammatory

79 -(1,3)-Glucan was isolated from A. fumigatus conidia and mycelia cell wall.

80 r macrophages are postulated to kill inhaled conidia and neutrophils are believed to act against hyph

81 Cells were unstimulated or stimulated with conidia and simultaneously treated with DEX, GM-CSF, or

82 el interaction was identified between viable conidia and SMAD2/3.

83 ZmLOX3 expression increased production of conidia and sterigmatocystin in both backgrounds.

84 between high levels of Aspergillus fumigatus conidia and the appearance of new cases of IA or have de

85 that was reduced in production of oxylipins, conidia and the mycotoxin sterigmatocystin.

86 rthermore, the genes are highly expressed in conidia and under conditions that favour sexual developm

87 wn pigments as well as enhanced tolerance of conidia and vegetative hyphae against oxidative and ther

88 These findings indicate that H. capsulatum conidia and yeast can produce melanin or melanin-like co

89 llenged with resting or swollen A. fumigatus conidia, and both groups of mice were analyzed prior to

90 velB deletion strains show reduced number of conidia, and decreased and delayed mRNA accumulation of

91 n demonstrate impaired uptake and killing of conidia, and ECs with CFTR mutation undergo more conidia

92 f diverse cell types in M. oryzae, including conidia, appressoria, and asci.

93 to dormant conidia, responses are similar if conidia are already germinated at the time of monocyte u

94 Here, we show that conidia are capable of germination on ash leaves and in

95 oulds) are ubiquitous soil inhabitants whose conidia are inhaled into the respiratory tract, where th

96 atitis, we developed a murine model in which conidia are injected into the corneal stroma.

97 Once inside the host, conidia are phagocytosed by alveolar macrophages.

98 Even though conidia are the predominant infectious particle for H. c

99 Fungal spores (conidia) are rapidly ingested by ECs derived from bronch

100 ary exposure to viable Aspergillus fumigatus conidia as well as vaccination with crude hyphal extract

101 Larvae were injected with conidia (asexual spores) of two different wild-type stra

102 gh slowly, at alkaline pH, were able to form conidia (asexual spores), and were inhibited by concanam

103 7BL/6 and CXCR2(-/-) mice showed germinating conidia at 6 h but not at 48 h and few inflammatory cell

104 sumed the whole body and grew out to produce conidia at approximately 156 and 204 hpi for C. elegans

105 2 peptide inhibited germination of S. musiva conidia at physiologically relevant low micromolar conce

106 and was transmitted through asexual spores (conidia) at a rate 3 to 8% of that for full-length CHV1-

107 f chronic lung exposure to live A. fumigatus conidia, beta-glucan recognition via Dectin-1 led to the

108 rophages during infection with H. capsulatum conidia but not H. capsulatum yeast cells.

109 signals mainly localized to the cytoplasm in conidia but to the cytoplasm and nucleus in hyphae.

110 most conidia (4-5.5 mm splashes averaged 308 conidia), but were splashed <30 cm horizontal distance.

111 hat is not present on the surface of dormant conidia, but is present after cellular swelling and loss

112 red into quality control compartments within conidia, but not within terminally differentiated infect

113 oth monocyte subsets efficiently phagocytose conidia, but only CD14(+)CD16(-) monocytes inhibit conid

114 Host hemocytes can recognize and ingest its conidia, but this capacity is lost on production of hyph

115 ing of L-ficolin-opsonized live A. fumigatus conidia by flow cytometry and microscopy.

116 GM-CSF could promote resistance to conidia by maintaining proinflammatory responses.

117 ent off-line identification of the separated conidia by matrix-assisted laser desorption/ionization t

118 These experiments suggest that P. citricarpa conidia can be dispersed from infected oranges by splash

119 n immunocompromised individuals, Aspergillus conidia can germinate into tissue-invasive hyphae, disse

120 ffected neither DHN melanin distribution nor conidia cell wall integrity in P. fici.

121 maH resulted in loss of melanin and affected conidia cell wall integrity.

122 After the conidia challenge, mice lacking CCR4 (CCR4-/- mice) exhi

123 monas exotoxin, from days 38 to 44 after the conidia challenge.

124 No mortality was observed in conidia-challenged sham-operated mice.

125 ient mice challenged with resting or swollen conidia compared to TLR9(+/+) mice.

126 e were significantly reduced at day 21 after conidia compared with Stat6+/+ mice, but both groups exh

127 However, 10(2)- and 10(3)-fold higher conidia concentrations were required for 100% lethality.

128 increased exponentially soon after wild-type conidia contacted their host plants .

129 ts repressive role, the mcrA deletion mutant conidia contain more amounts of sterigmatocystin and an

130 ormally high levels of airborne A. fumigatus conidia correlated with new cases of IA, even in patient

131 Humans inhale mold conidia daily and typically experience lifelong asymptom

132 Though the average human inhales hundreds of conidia daily, A. fumigatus invasive infections primaril

133 Following inhalation, Aspergillus conidia deposit in the small airways, where they are lik

134 Autoclave-killed conidia did not elicit a SiTf induction response from wo

135 Swollen conidia did not expedite epithelial transmigration.

136 f complement activation, ficolin-A-opsonized conidia did not lead to lectin pathway-specific C4 depos

137 BDP-PCZ transfer to conidia did not require phagocytosis and was markedly en

138 ation, and repeated exposure to A. fumigatus conidia did not result in hyphal growth or accumulation

139 mutant produced more compact assemblages of conidia, displayed a reduced and delayed spore dispersal

140 /-) mice exhibit an accelerated clearance of conidia during fungal asthma.

141 ophages bind and ingest A. fumigatus resting conidia efficiently, there is little inflammatory respon

142 ake or killing of intracellular A. fumigatus conidia either in vitro or in a murine model of pulmonar

143 When the conidia escape from early killing and germinate, the ext

144 ic cells activated in vitro with Aspergillus conidia expressed higher TNF-alpha, CXCL10, and CXCL2 le

145 independent from DHN-melanin, as A. terreus conidia expressing wA showed no increased intracellular

146 droplets from diseased oranges, which exuded conidia for over one hour during repeated wetting.

147 filamentous fungi involves the formation of conidia, formed on specialized structures called conidio

148 Here, we compared the interaction of conidia from both fungal species with MUTZ-3-derived den

149 dA hydrophobin, and Aspergillus and Fusarium conidia from clinical isolates that were treated with hy

150 Conidia from the DeltapkaR mutant are more sensitive to

151 l responses are critical for clearing fungal conidia from the host airways prior to establishing dise

152 We compared lung immune responses to conidia from two fungal isolates that expressed differen

153 nnate immunity, inhaled A. fumigatus spores (conidia) germinate in the lung, forming hyphae that inva

154 cA was found to be significantly impaired in conidia germination, growth in normoxia and hypoxia, and

155 important role in control of asexual spore (conidia) germination.

156 altered cellular lipid profiles were seen in conidia grown on a variety of substrates including potat

157 ment when grown on solid media, although its conidia had normal pigmentation.

158 nose-only inhalation to A. fumigatus viable conidia, heat-inactivated conidia (HIC), or HEPA-filtere

159 . fumigatus viable conidia, heat-inactivated conidia (HIC), or HEPA-filtered air twice a week for 13

160 At all times after conidia, histological analysis revealed an absence of go

161 q data were generated with RNA isolated from conidia, hyphae, and perithecia.

162 eral hundred to several thousand Aspergillus conidia (i.e., vegetative spores) daily and typically cl

163 te defense against Aspergillus by opsonizing conidia, immobilizing this fungus through enhanced adher

164 ion of SMO1 results in abnormal, nonadherent conidia, impaired in their production of spore tip mucil

165 ne concentration and analysis of Aspergillus conidia in bronchoalveolar lavage fluid using the combin

166 intranasal exposure to Aspergillus fumigatus conidia in C57BL/6 mice results in a chronic pulmonary i

167 ower microscopy demonstrated the presence of conidia in splash droplets from diseased oranges, which

168 resence of glucose, and rapid germination of conidia in the absence of external carbon sources.

169 otent at arresting the growth of Aspergillus conidia in vitro, indicating the presence of a reactive

170 t early transcription in mouse AM exposed to conidia in vivo targets neutrophil recruitment, and that

171 wn about their molecular responses to fungal conidia in vivo.

172 nse to live Aspergillus fumigatus spores, or conidia, in A. fumigatus-sensitized mice.

173 en the lungs are exposed to large numbers of conidia, in addition to the phagocytic activity of AM, e

174 Neither live nor killed conidia increased tissue factor activity of endothelial

175 Thus, A. fumigatus conidia induced a coordinated expression of genes import

176 nstrate that uptake of Aspergillus fumigatus conidia induced drastic spatial redistribution of TLR9 t

177 Live conidia induced more endothelial cell injury than did li

178 corneal infection, we showed that DeltarodA conidia induced significantly higher cytokine production

179 Repeated exposure to A. fumigatus conidia induced T cell activation in the lungs and the c

180 d-dispersed, insect-vectored or water-spread conidia infect ash and may sporulate in planta, as well

181 mice repeatedly challenged with A. fumigatus conidia, inflammation was attenuated (with the most sign

182 n vivo infections, live imaging demonstrated conidia initially phagocytosed by neutrophils were trans

183 flies by injecting them with a standardized conidia inoculum.

184 Following introduction of conidia into the lung, microarray analysis of AM showed

185 is mechanism in AM following introduction of conidia into the mouse lung using transcriptional, lumin

186 Recognition of conidia involves integrin CD11b/CD18 (and not dectin-1),

187 duction in response to Aspergillus fumigatus conidia is antagonized by granulocyte-macrophage colony-

188 opportunistic pathogen Aspergillus fumigatus conidia is essential given the important role they play

189 nature induced in macrophages in response to conidia is independent of Toll-like receptor (TLR) signa

190 ral and biophysical-biological properties of conidia is not fully characterized.

191 ction in a fungal species with multiple cell conidia is poorly understood.

192 ice to viable, resting Aspergillus fumigatus conidia leads to the development of chronic pulmonary in

193 aks of abnormally high A. fumigatus airborne conidia levels (175, 50, 25, 20, 160, and 400 CFUs/m(3))

194 -6 months), the median airborne A. fumigatus conidia levels were 0 colony-forming units (CFUs) per cu

195 velopment leading to the formation of mature conidia may require environmental signals to regulate fl

196 t (USVL531-MDR) watermelon plants with 10(5) conidia ml(-1) of P. xanthii.

197 CD-1 mice showed that infection with 5 x 106 conidia/mouse consistently caused 100% mortality by day

198 Cell surface defects were rectified in the conidia mutated in downstream melanin biosynthetic pathw

199 Moreover, DCs confronted with A. terreus conidia neither produced pro-inflammatory nor T-cell sti

200 Interestingly, at day 3 after conidia, neutrophil recruitment and airway hyperresponsi

201 mained sterile in culture, producing neither conidia nor sexual spores in the mycelial phase, but oft

202 sion in human monocytes (HMCs) infected with conidia of A. fumigatus using DNA microarray analysis.

203 t (DeltacsmA, DeltacsmB, and DeltacsmA/csmB) conidia of A. fumigatus.

204 d at relatively low challenge doses with the conidia of Aspergillus fumigatus administered to recombi

205 suppressed hyphal growth of most germinating conidia of B. cinerea and was eventually lethal to infec

206 genes induced by hard-surface contact of the conidia of Colletotrichum gloeosporioides, chip6, encode

207 Conidia of H. minnesotensis adhered to passing nematodes

208 Furthermore, compared to A. fumigatus, the conidia of N. udagawae require longer incubation periods

209 Conidia of representative Fusarium from the 2004-2006 ke

210 Conidia of selected lines also germinated fifty percent

211 Conidia of the Deltaace2 mutant were larger and had acce

212 Resting conidia of the filamentous fungus are constantly inhaled

213 essed mouse model, intranasally administered conidia of the mutant are significantly less virulent th

214 oscopy (CARS) is performed on single spores (conidia) of the fungus Aspergillus nidulans in order to

215 Airborne spores (conidia) of these filamentous fungi express a surface pr

216 Interestingly, foot cells of mutant conidia often differentiated into conidiogenous cells, r

217 showed reduced germination of DeltaBbcyp52x1 conidia on grasshopper wings as compared with the wild-t

218 germ tubes were produced from individual Bgt conidia on the surface of the Arabidopsis leaves.

219 y little is known at a molecular level about conidia or about their interaction with cells of the hos

220 Aspergillus fumigatus conidia or Candida albicans yeast cells were added to br

221 els of fungal DNA with Aspergillus fumigatus conidia or hyphae.

222 n control experiments, protease treatment of conidia or roots had no effect on growth and development

223 not respond chemotropically to mat A males (conidia) or form mature fruiting bodies (perithecia) or

224 t the Raman signal from Aspergillus nidulans conidia originates in pigment molecules within the cell

225 Aspergilli disseminate via asexual conidia passively travelling through air currents to ger

226 hes were <1 mm diameter but carried only 0-4 conidia per droplet.

227 onary antifungal immune responses to swollen conidia, possibly through the regulation of dectin-1 exp

228 Injection of E. rostratum conidia preexposed to 0.32 mg/mL of methylprednisolone f

229 given intratracheal or s.c. immunization of conidia prior to corneal infection exhibited enhanced fu

230 Conidiation was reduced > 80%; however, conidia produced by the DeltaOhmm strain germinated sign

231 mutant had dysmorphic conidiophores, reduced conidia production and abnormal conidial cell wall archi

232 wn-regulation of growth and up-regulation of conidia production between 18 and 24 hours of growth.

233 Its conidia production is prolific, and so human respiratory

234 A perA null mutant has decreased conidia production, increased susceptibility to triazole

235 ggest that exposure of chitin in germinating conidia promotes eosinophil recruitment and ultimately i

236 migatus and block the growth of A. fumigatus conidia (proportion with growth blocked, 69%).

237 -splash dispersal of Phyllosticta citricarpa conidia (pycnidiospores) from infected oranges was studi

238 After phagocytosis, A. fumigatus conidia rapidly escaped from DCs, whereas A. terreus con

239 rapidly escaped from DCs, whereas A. terreus conidia remained persisting with long-term survival.

240 onocytes differ in their response to dormant conidia, responses are similar if conidia are already ge

241 t masks Dectin-1 and Dectin-2 recognition of conidia, resulting in impaired neutrophil recruitment to

242 as noted irrespective of pH, and DeltaBbpacC conidia showed subtle increases in UV susceptibility.

243 MN-mediated host defenses against infectious conidia (spores) of this organism have yielded conflicti

244 that DeltarodA and hydrofluoric acid-treated conidia stimulate significantly higher NF-kappaB p65 nuc

245 Infection with hyphae, but not with conidia, stimulated endothelial cells to synthesize E-se

246 NF-kappaB to the nucleus in unstimulated and conidia-stimulated macrophages.

247 kappaB degradation by GM-CSF with or without conidia stimulation, with corresponding effects on trans

248 The conidia subsequently germinate and produce a budding yea

249 -deficient mice in response to swollen/fixed conidia, suggesting that immune suppression enhances det

250 Conidia swelled, formed differentiated germination-struc

251 formants sporulated single-cell monokaryotic conidia that were able to grow on media selective for re

252 tosis-like features in Aspergillus fumigatus conidia, the most prevalent human mold pathogen.

253 After nasal instillation of conidia, the survival was 25%, 35%, and 85% for mice in

254 anamorphic (asexual) form produces prolific conidia, thought to function solely as spermatia (male g

255 ombination with their function as spermatia, conidia thus act to maximise gene flow between sympatric

256 When challenged with resting conidia, TLR9(-/-) mice exhibited significantly lower ai

257 and opsonization led to enhanced binding of conidia to A549 airway epithelial cells.

258 The capacity of A. fumigatus conidia to activate platelets is at least partly due to

259 lenged with two inhalation exposures of live conidia to induce airway disease.

260 strated that MAb 4D1 binds to and recognizes conidia to yeast cells' transition inside of a human mon

261 Furthermore, while A. fumigatus conidia triggered expression of DC activation markers su

262 ndependent isolates, which failed to produce conidia under any conditions tested, were only distantly

263 t layers in all three chitin synthase mutant conidia was associated with an activation of human dendr

264 However, endothelial cell injury caused by conidia was dependent on fungal viability, whereas injur

265 Ficolin-A binding to conidia was increased under low-pH conditions, and opson

266 trast, ingestion and killing of A. fumigatus conidia was MyD88 independent.

267 (BAMs) from mice in response to Aspergillus conidia was tested after in vivo administration of salin

268 re challenged intranasally with A. fumigatus conidia weekly, and leukocyte composition, activation, a

269 In this model, Aspergillus fumigatus conidia were administered into the lungs of neutrophil-d

270 At day 0, Aspergillus fumigatus conidia were administered intranasally.

271 phal growth in tissue, Aspergillus fumigatus conidia were allowed to form mycelia in tissue culture m

272 H. capsulatum conidia were also cytotoxic to amoebae.

273 Specifically, germinating A. fumigatus conidia were associated with Clec7a and were predicted t

274 Approximately 99% of A. fumigatus conidia were cleared within 24 h after inoculation, and

275 ally, the fractions containing the separated conidia were collected from the capillary and analyzed b

276 Wild-type conidia were covered with a highly hydrophobic layer of

277 Then the adhered conidia were desorbed, concentrated, and separated using

278 ected from antifungals, whereas A. fumigatus conidia were efficiently cleared.

279 Conidia were endocytosed 2-fold more avidly than hyphae,

280 es to pulmonary instillation of A. fumigatus conidia were examined.

281 In the proposed procedure, conidia were first dynamically adhered onto the roughene

282 se reported earlier: firstly, aerially borne conidia were harvested, and then used for inoculations,

283 Aspergillus fumigatus conidia were incubated in 0.2% glucose RPMI 1640 contain

284 s of airway neutrophils and macrophages, and conidia were more rapidly eliminated from these mice com

285 Within DCs A. terreus conidia were protected from antifungals, whereas A. fumi

286 CD54, MHCII and CCR7, persistent A. terreus conidia were significantly less immunogenic.

287 an fungal pathogen, produces asexual spores (conidia), which are the main mode of propagation, surviv

288 ss of long-term viability of asexual spores (conidia), which is likely associated with the lack of co

289 responses induced by heat-killed Aspergillus conidia, which have minimal beta-glucan expression on th

290 gs and formed oxidase-active aggregates with conidia, which inhibited germination.

291 o, with mycelia in the environment producing conidia, which probably act as infectious propagules upo

292 ther germination nor growth of the resulting conidia, which were single-cell monokaryotic progeny, wa

293 The Fgpal1 mutant produced conidia with fewer septa and more nuclei per compartment

294 unologically inert; however, deletion mutant conidia with modified surfaces could activate human dend

295 t result in hyphal growth or accumulation of conidia with time.

296 Following incubation of conidia with various concentrations of antifungal drug,

297 e fungi is the production of asexual spores (conidia) within fruiting bodies called conidiomata.

298 repeated intranasal exposure to Aspergillus conidia would induce pulmonary arterial remodeling in th

299 onoclonal antibodies (MAb) labeled pigmented conidia, yeast, and the isolated particles as determined

300 sed daily to hundreds of viable A. fumigatus conidia, yet considerable numbers of them survive years