コーパス検索結果 (1語後でソート)
通し番号をクリックするとPubMedの該当ページを表示します
1 e and 4.61 nM for the mPEG-glycine-quinidine conjugate).
2 diubiquitin and an ubiquitin-alpha-synuclein conjugate.
3 ng binding modality for use in targeted drug conjugates.
4 increasingly being adapted for antibody-drug conjugates.
5 hrombomodulin (TM), using one-to-one protein conjugates.
6 njugation strategies to prepare antibody-TNM conjugates.
7 tions to provide multi-coloured gold nanorod conjugates.
8 ere identified as the main type of generated conjugates.
9 ition, targeted therapies, and antibody-drug conjugates.
10 king natural-synthetic hybrid structures and conjugates.
11 functionalized C-5 substituents derived from conjugated 1,3-dienyl and cumulated 1,2-dienyl carbamate
13 onsted basicities pK(aH) (i.e., pK(a) of the conjugate acids) of 32 pyrrolidines and imidazolidinones
15 mass spectral library of acylcarnitines and conjugated acylcarnitines from the LC-MS/MS analysis of
18 herapeutic modalities, such as antibody-drug conjugates (ADC), present significant challenges for the
19 of the small molecule payload, antibody-drug conjugates (ADCs) are administered at a much lower dose
21 ticipating the construction of antibody-drug conjugates (ADCs) as the ultimate goal of this research
22 e widely used in the field for antibody drug conjugates (ADCs) containing peptide linkers that are en
28 or the site-selective and diastereoselective conjugate addition of boron-stabilized allylic nucleophi
32 hat the most favorable pathway is a stepwise conjugate addition-Aldol sequence via the dual hydrogen-
33 formations, including allylic substitutions, conjugate additions, proto-boryl additions to alkenes, b
34 linked to a 15-carbon tail that harbors two conjugated all-trans trienes separated by a stereogenic
36 chain Vi generates T-dependent antigens, the conjugates also retain T-independent properties, leading
38 noic acid) is a naturally occurring caffeoyl conjugate and a potent antioxidant found in the phenolic
40 ys a key role in the circulation time of the conjugate and release of the drug for full activity at t
42 compare the methods for preparing chemically conjugated and recombinant A99 to elastin-like polypepti
43 nthesized several ciprofloxacin-carbohydrate conjugates and established a structure-activity relation
45 vy and light chains of a model antibody-drug conjugate, and calculation of the overall DAR of the ADC
47 ned on a DNA-based immunoassay that employed conjugated antibodies for target protein recognition, wh
50 el actively targeted hybrid mAb-polymer-drug conjugate (APDC) containing anti-CD20, anti-CD38 or anti
51 rt a method to generate antibody-siRNA (1:2) conjugates (ARCs) that are structurally defined and easy
56 ex with HIV-1 RT/dsDNA showed binding of the conjugates at the polymerase active site, however, in di
57 a mitochondria-targeted triphenylphosphonium-conjugated ATO with varying alkyl side chains (Mito(4)-A
58 hly unusual three-dimensional packing of the conjugated backbone, which is likely responsible for the
60 -based vaccine, comprising a polymer-peptide conjugate-based nanotransformer and loaded antigenic pep
64 t) in toluene resulted in the formation of a conjugated bis-guanidinate (CBG)-supported aluminum dihy
66 cleavage of a tetrazine-linked antibody-drug conjugate by trans-cyclooctenes, affording efficient dru
67 loading and excellent GRPR selectivity, this conjugate can be considered as a promising boron deliver
69 clododecane-1,4,7,10-tetraacetic acid (DOTA)-conjugated CCK2R ligands with proline substitution at di
71 ere catalytically active, whereas all Type 2 conjugates cleaved RNA target in a sequence-specific man
74 cules including cross-conjugated, half cross-conjugated, conjugation-interrupted and linearly conjuga
75 as small molecule (MMAE) or as antibody-drug conjugate containing non-cleavable auristatin drug paylo
76 S) on single and total polyphenols (free and conjugated) content and antioxidant activity (AOA) of or
77 nthesis has been used to prepare a fully pai-conjugated cyclic porphyrin octamer, composed of both be
79 ansfer through selective excitation of a pai-conjugated diblock oligomeric system featuring tetrathio
80 nditions (argon purging, pH variation) using Conjugated Dienes and Thiobarbituric acid reactive subst
81 ng of a specific IgG antibody to two antigen-conjugated DNA templating strands that triggers a chemic
83 ties of the molecular components, mainly pai-conjugated donor-acceptor (D-A) chromophores, and their
86 are discussed for the development of ligand-conjugated drugs for the specific targeting and treatmen
87 stoichiometric distribution of the number of conjugated drugs present on the mAb), determination of t
91 C induces ubiquitination of the E2 ubiquitin-conjugating enzyme UBE2N by transglutamination, thereby
92 placebo-controlled hormone therapy trials of conjugated equine estrogens (CEE) among posthysterectomy
94 iative Hormone Therapy), treatment with oral conjugated equine estrogens and medroxyprogesterone acet
96 ied lipids increased the accumulation of the conjugated fluorescence probe in the placenta with a tot
97 4,7-triazacyclononane-N,N',N"-triacetic acid conjugated folate ((18)F-FOL) is a PET tracer targeting
99 ile, with human cell lysate, and the protein conjugates formed were identified by affinity chromatogr
100 e), which, in combination with the fully pai-conjugated framework, makes these materials unique among
101 n graphene, two-dimensional (2D) carbon-rich conjugated frameworks (CCFs) have attracted growing rese
102 tal pai functions are unique to sp(2) carbon-conjugated frameworks and cannot be accessible by imine-
104 multichromophoric molecules including cross-conjugated, half cross-conjugated, conjugation-interrupt
105 We investigate the pharmacokinetics of this conjugate in mice and show that the amount of platinum i
107 , we discuss multivalent nucleic acid-ligand conjugates in the context of the biological protein rece
108 ed from docosahexaenoic acid, namely maresin conjugates in tissue regeneration (MCTRs), were recently
109 in which long-chain, but not short-chain, Vi conjugate induced late apoptosis of Vi-specific B cells
110 d contrast, short-chain Vi (9.5 to 42.7 kDa) conjugates induced a response in wild-type mice but not
111 the synergistic effect originating from the conjugated inner wall, the POF material (aperture size 2
112 dical with nitrosopyridine leads to a stable conjugate, installing a label at N6-methyl-adenosine.
113 toxic drug doxorubicin, and we show that the conjugate internalizes specifically into PSMA(+) cells,
114 t 13-fold more efficiently than the branched conjugate into HepG2 cells, as demonstrated by confocal
115 atinum in the brain after treatment with the conjugate is 15-fold greater than with cisplatin after 5
116 ution did not affect CCK2R affinity, and the conjugates labeled with indium-111 and lutetium-177 show
118 ysical studies of CDP-naphthalimide (CDP-NI) conjugates led to the identification of two AIEgenic flu
124 donor-acceptor-donor-acceptor (D-A-D-A) pai-conjugated macrocycle comprised of two U-shaped electron
126 these issues using a thiol-functionalized 2D conjugated metal-organic framework as an electron-extrac
127 red spin in the ground state, open-shell pai-conjugated molecules can achieve optoelectronic properti
130 ecent advances in the development of aptamer-conjugated nanomaterials and their utilization for the d
131 Accordingly, the demand for using aptamer-conjugated nanomaterials for various applications has pr
133 nd directly to the tumor suppressor VHL, and conjugate nedd8 to VHL within a region that is important
134 the zeta potential of the detection probe by conjugating negatively charged DNA oligonucleotides.
135 olite found is isocaproyltaurine, a covalent conjugate of a distinctive C. difficile fermentation pro
136 s of action, we synthesized EC2629, a folate conjugate of a DNA crosslinking agent based on a novel D
137 synthesis of an amphiphilic polymer-prodrug conjugate of an imidazoquinoline TLR7/8 agonist that in
138 m6A enzymatically labelled with a commercial conjugate of streptavidin-peroxidase (Strep-HRP) as trac
139 lar probes for fluorescence microscopy using conjugates of antibodies, growth factors, and nucleic ac
143 ilised mainly for accessing boron containing conjugated organic materials, however recent development
148 ained release of neurotrophin-3 from peptide-conjugated PEG hydrogels resulting from the reversible i
149 with a cocktail of keyhole limpet hemocyanin-conjugated peptides corresponding to the AipA, Asp14, an
152 target liver cells and indicate that GalNAc-conjugated PNAs have possible therapeutic applications.
153 The fluorescently labeled analogs of GalNAc-conjugated PNAs were internalized by HepG2 cells that ex
156 nt of a dendronized pyropheophorbide a (Ppa)-conjugated polymer (DPP) is reported, and a linear Ppa-c
159 ectronic interactions by large modulation of conjugated polymer orientation via solution coating is r
160 ammonium fluoride is simply admixed with the conjugated polymer poly(N,N'-bis(7-glycol)-naphthalene-1
162 phenes, one of the most important classes of conjugated polymer, only limited success has been achiev
163 created by seeded growth of two types of pai-conjugated polymeric building blocks, the triblock copol
166 tudy, the self-assembly of homo- and blended conjugated polymers which are confined in nanostructures
169 ations and experiments on multiple push-pull conjugated polymers, it is argued that the size of the d
170 o optimize the thermoelectric performance of conjugated polymers, thus also providing new insights in
173 lecular structure of 32 semiflexible (mostly conjugated) polymers that differ drastically in aromatic
174 ow often affect cell surface epitopes or mAb conjugates, precluding the evaluation of the phosphoryla
177 based on highly luminescent europium chelate-conjugated probe, which is the key component in sensing
180 of the carriers created following doping of conjugated push-pull polymers with both F(4) TCNQ (2,3,5
181 w that a readily-accessible sugar-polyolefin conjugate quantitatively produces an exceptionally stabl
183 fluorescence imaging revealed that PEG30 kDa-conjugated rhDNase (PEG30-rhDNase) was retained in mouse
184 lence interactions between redox-active, pai-conjugated scaffolds is of interest when developing new
186 ratory experiment in mice, a VHH-PTH peptide conjugate showed biological activity, whereas the corres
187 of trivalent N-acetylgalactosamine (GalNAc)-conjugated siRNAs is the remarkable durability of silenc
191 olecular hydroamination have been limited to conjugated, strained, or terminal alkenes(2-4); only a f
192 ore and after vaccination with the 13-valent-conjugated Streptococcus pneumoniae vaccine were assesse
193 e plays a key role in the formation of a pai-conjugated structure, which facilitates charge transfer
194 eversible redox activity of azo group in pai-conjugated structures, azobenzene-based molecules repres
196 e degradations associated with antibody drug conjugates, such biotransformations of tethered antibody
197 ed in rats that received the PEG-haloperidol conjugate, suggesting that conjugation can effectively p
199 a resonance dipolar structure of the [18]pai-conjugated system as the reduced congener with concomita
201 ugated, conjugation-interrupted and linearly conjugated systems were synthesized and characterized.
202 erview the existing literature on chiral pai-conjugated systems whose thin films have been characteri
203 the role that the bridging units between the conjugated TbT core and the peripheral arylamine units p
204 (melflufen) is a first-in-class peptide-drug conjugate that targets aminopeptidases and rapidly and s
206 a major challenge is the synthesis of stable conjugates that resist aggregation in samples with high
207 P results to other antigens, we successfully conjugated tHBcAg VLPs to the HIV capsid protein P24 in
208 To enhance persulfide delivery to cells, we conjugated the SOPD motif to a short, self-assembling pe
209 o monitor osteogenesis, and was generated by conjugating the drug pamidronate to a NIR fluorescent go
211 modifications via coupling drugs together or conjugating them with various functional molecules such
212 multiscale distribution of the antibody-dye conjugate, this study demonstrates improved microscopic
213 ptors per mum(2) represented by a covalently conjugated TIL region from the beta1-adrenergic receptor
214 ime FRET assay with a thioester linked E2~Ub conjugate to monitor single ubiquitination events and de
215 .6.6]icosan-1-ylamino)-5-oxopentanoic acid), conjugated to (Tyr(3))-octreotate, called (64)Cu-CuSarTA
218 diagnosis based on gold nanoparticles (GNPs) conjugated to an antibody against the ENaC present on pl
220 sitive cyclic peptide c[E(4)W(5)C] pHLIC was conjugated to bifunctional maleimide-NO2A and radiolabel
222 t cells using streptavidin-linked antibodies conjugated to biotinylated saporin, a toxin unable to cr
224 ereupon long K48-linked ubiquitin chains are conjugated to CMG-Mcm7, dependent on multiple replisome
225 netic alphabet, is reminiscent of antibodies conjugated to drugs, which presumably act by this mechan
226 Subsequently, three synthesized glycans were conjugated to DT protein to provide glycoconjugate vacci
228 ion using a specific CD63 aptamer, which was conjugated to horseradish peroxidase (HRP) through bioti
229 otent anti-inflammatory and antioxidant drug conjugated to hydroxyl terminated generation-4 PAMAM den
232 rheumatic targeted drug tocilizumab (TCZ) is conjugated to polymer nanoparticles (PNPs) to develop th
233 G15 is a ubiquitin-like molecule that can be conjugated to proteins but is also released from cells i
238 anomeric aminooxy GM3 trisaccharide was then conjugated to the immunologically relevant zwitterionic
239 n vivo study, the miR-216a mimics/inhibitors conjugated to the nanoparticles were injected into 12-we
240 xes stabilized by etoposide were shown to be conjugated to ubiquitin, and this was reduced by inhibit
241 es facilitate the development of polypeptide conjugates to advance therapeutics, diagnostics, and fun
242 Triene 6pai electrocyclization, wherein a conjugated triene undergoes a concerted stereospecific c
246 included in the pneumococcal polysaccharide conjugate vaccine (PCV) in 2000 before it was expanded i
247 le settings.Fifteen years after pneumococcal conjugate vaccine (PCV) introduction and 5 years post-PC
250 relation to PPV23/non-13-valent pneumococcal conjugate vaccine (PCV13) serotype pneumonia (n = 417 ca
253 mination through the introduction of typhoid conjugate vaccine (TCV), we again need to reconsider the
254 (vaccinated with the 13-valent pneumococcal conjugate vaccine [PCV13] as part of the Expanded Progra
255 le in the clinically relevant polysaccharide conjugate vaccine against Streptococcus pneumoniae (pneu
256 er at 11 months and a 10-valent pneumococcal conjugate vaccine at 2, 4, and 11 months after birth.
257 ntions, including mass vaccination with a Vi-conjugate vaccine coadministered with measles vaccine ar
258 ization prequalification should make typhoid conjugate vaccine more accessible and affordable in low-
261 lth Organization now recommends that typhoid conjugate vaccines (TCV) be used in settings with high t
262 of households, we estimate that pneumococcal conjugate vaccines and live attenuated rotavirus vaccine
263 provide some support for the introduction of conjugate vaccines in Nepal, including outside urban are
268 targeting, an ALPPL2-targeted antibody-drug conjugate was developed and demonstrated potent and spec
275 inding of heteromultivalent DNA-nanoparticle conjugates, where multiple unique oligonucleotides displ
276 es were constructed by rosmarinic acid-lipid conjugates which not only work synergistically with doxo
277 re the conformation of a FRET labelled E2~Ub conjugate, which distinguishes between closed and altern
278 inker, making a monovalent quinidine-polymer conjugate, which was then evaluated for its interactions
279 chnology is extended to microbubble-liposome conjugates, which exhibit a stronger response to the app
282 te group to form the corresponding disulfide conjugate with an EPR spectrum characteristic of the tra
284 two coumarin-caged thymidine compounds, each conjugated with (2) or without (1) an extended, self-imm
288 ess by comparing trastuzumab and trastuzumab conjugated with DM1, following the GlyCLICK procedure.
289 o [isoindoline-1,9'-xanthen] -3-one (BTSIXO) conjugated with Fe(3+)-ions via very simple eco- friendl
290 two alkyne-modified peptoids (PE8 and PE9), conjugated with fluorophore and antibody, to make stable
291 prodrug radiotracer that is intracellularly conjugated with glutathione to form the ABCC1 substrate
292 f an ultra-pH sensitive amphiphilic polymer, conjugated with indocyanine green, which rapidly and irr
294 -binding prodrugs, we developed albumin-drug conjugates with a controlled loading that achieved bette
295 hesis of a library of chromophore-amino acid conjugates with slightly modified and adjustable optical
298 fords quantitative yields of protein-polymer conjugates within 2 h, avoiding damage to the secondary
299 A-binding compound triaminotriazine-acridine conjugate (Z1) functions by targeting T:T mismatches in