ライフサイエンスコーパス: conjugate base

1 to prevent parasitic capture of CO(2) by its conjugate base.

2 rmation to proton transfer to the catalyst's conjugate base.

3 complex and a chiral phosphoric acid or its conjugate base.

4 f their higher charge density at the anionic conjugate base.

5 to oxidize H2 in the presence of a suitable conjugate base.

6 complexes that are kappa(2)-chelated by the conjugate base.

7 o stabilize a partial negative charge in the conjugate base.

8 r-electron interactions in the singlet-state conjugate bases.

9 ected viability rather than the pH itself or conjugate bases.

10 d cocrystallizes with two of its monoanionic conjugated bases.

11 resonance stabilization of the corresponding conjugate bases 1, 2 and 3, respectively.

12 2 and the lithium salt of the corresponding conjugate base 3 were decomposed by photolysis.

13 the identity proton transfer of 3H-O to its conjugate base (3(-)-O) and of 3H-S to 3(-)-S have been

14 The respective conjugate bases, 3--O and 3--S, represent benzofuran and

15 Both 3a and its conjugate base 3a(-) are present in aqueous solution und

16 on of base to 2 at -85 degrees C elicits its conjugate base 6 with a novel O horizontal lineFe(IV)-O-

17 by tetramethylcyclam via protonation of its conjugate base and characterized it in detail using vari

18 ce existed to ascertain the structure of the conjugate base and the aromatic character of the boron-c

19 yrate are produced not as acids but as their conjugate bases, and acetone is neither an acid nor a ba

20 boxylic acids, which adsorb as their anionic conjugate bases, and proceeds indirectly by dissolution

21 the importance of the chemical stability of conjugate base anions in attaining high acidity and sugg

22 the kinetic and thermodynamic effects of the conjugate base are not accounted for properly.

23 ex interplay between the dissociated ions or conjugate bases available as compared to the acid and wa

24 ole occurs through the formation of a chiral conjugate base/bicyclic quaternary N-acyliminium ion pai

25 lization of the charged oxygen center in the conjugate base by three hydrogen bonds and another 6.3 k

26 Based on natural population analysis, the conjugate bases can be thought of as salts between a pol

27 Its conjugate base, CHB(11)Cl(11)(-), was found by photoelec

28 ions is generally believed to be HOCl or its conjugate base, ClO-.

29 e ligands in the 5-, 6-, 7-, or 8-coordinate conjugate base complex of the hydride or dihydrogen comp

30 preferentially at the phenolic site, and the conjugate base consists of a 70:30 mixture of phenoxide

31 al landscape can be explored with the aid of conjugate-based direction integrated into a specific sea

32 Since the radical anion conjugate base does not undergo ring opening as fast as

33 We describe polymer-based, lipid-based, and conjugate-based drug delivery systems, differentiating b

34 irreversible first-order elimination from a conjugate base (E1cB(I)) mechanism with acetoxy ester 3,

35 of not only acid strength but also inherent conjugate base electron density.

36 and shear-thinning behavior were observed in conjugate-based emulsions.

37 Various polymer-drug conjugates based, for example, on polyethylene glycol (P

38 While HSNO and HSSNO are elusive, their conjugate bases form isolable zinc complexes (Ph,Me) TpZ

39 hift in the equilibrium between the acid and conjugate base forms of glutamic acid due to other amino

40 The conjugate base, however, has not been structurally chara

41 The counteranion, that is the conjugate base, in these systems is often too nucleophil

42 TfOH's conjugate base is also found to rearrange H atoms and al

43 lloproteins, yet the role of the imidazolate conjugate base is often neglected, despite its potential

44 H6X6) (where X = chlorine or bromine), whose conjugate base is the exceptionally inert CB11H6X6- carb

45 acid to form a tetravalent trihydroxyborate conjugate base, it has been proposed that pseudoaromatic

46 ute interactions of the excited acid and its conjugate base leads to a pronounced fluorosolvatochromi

47 isilazane (HMDS) additive and TMS(2)S by the conjugate base, lithium bis(trimethylsilyl)amide (LiN(Si

48 bined with N-acetylgalactosamine ligands for conjugate-based liver delivery.

49 be replaced by an arginine, disfavoring the conjugate base mechanism, distinguishing between these t

50 eversed nucleophilicity of the corresponding conjugate bases N(-) and O(-).

51 -based vaccine, comprising a polymer-peptide conjugate-based nanotransformer and loaded antigenic pep

52 are available for de-escalated antibody-drug conjugate-based neoadjuvant therapy without conventional

53 d within a cationic Ru complex by the chiral conjugate base of (R)-1-phenylethanol.

54 uilibrium state since decarboxylation of the conjugate base of 12 takes place and, at the end of the

55 ts the greater aromatic stabilization of the conjugate base of 6H-S (thiophene derivative) compared t

56 adiabatic electron detachment energy of the conjugate base of a small covalent polyol model compound

57 th an initially less stable anion (i.e., the conjugate base of a weaker acid), and is negligible for

58 elimination of the C1-mesyloxy group by the conjugate base of adenine or thymine to give two diaster

59 er transform mass spectrometer to afford the conjugate base of benzocyclobutadiene (1a).

60 give thiocarbamate-S-oxide (H2NC(=O)SO-, the conjugate base of carbamothioperoxoic acid) via a mechan

61 zed in good yields, by Michael addition of a conjugate base of core-substituted phenylacetones to sub

62 exchange experiments were carried out on the conjugate base of cysteine with four different deuterate

63 nucleophilic substitution reaction where the conjugate base of Pro-1 functions as the nucleophile and

64 d ring opening followed by alkylation of the conjugate base of Pro-1.

65 rst modified by deposition of a layer of the conjugate base of sulfanilic acid and then with quaterni

66 cals appear to remain H-bonded to the chiral conjugate base of the Bronsted acid during the course of

67 e of synthesis and low molecular weight, the conjugate base of triethylurea (TEU(-)) was of primary f

68 The computed relative stabilities of the conjugate bases of 1 are as follows: beta > gamma > alph

69 First, conjugate bases of 1,3-dicarbonyls were oxidized to neut

70 y basic anions (A(-)), many of which are the conjugate bases of known strong acids and superacids.

71 addition, PB microcubes will react with the conjugate bases of metal oxide based weak acids, generat

72 (3) Conjugate bases of organolithiums are stable with respec

73 The dissociated anionic conjugate bases of PFCAs have negligible air-water parti

74 The structures of the conjugate bases of saccharin and iso-saccharin were also

75 t(2), [(BDI)V=C(t)Bu(OTf)] (2-OTf), with the conjugated base of phenylacetylene, lithium phenylacetyl

76 at total concentrations (uncharged acid plus conjugate base) of 257 and 27.1 mM, respectively.

77 ation of a novel, targeted, nanobiopolymeric conjugate based on biodegradable, nontoxic, and nonimmun

78 hesized a novel small-molecule PSMA-targeted conjugate based on the monomethyl auristatin E.

79 We have synthesized new protein conjugates based on 4-(2-pyridylazo) ligands.

80 trategy for the synthesis of polymer-protein conjugates based on discrete, chiral polymers synthesize

81 E. coli ATCC 33475 (ent-) revealed that six conjugates based on L-Ent having relatively small cargos

82 approach may lead to a new class of antibody conjugates based on peptide-tags that have minimal effec

83 A survey of several antibody drug conjugates based on the same IgG framework and small mol

84 rgeted by MOJPs as they form neutrophil-MOJP conjugates, based on multivariate multifrequency electri

85 and the carbonate radical anion form an acid/conjugate base pair.

86 calization of hydronium near a counterion or conjugate base reduces the Eigen and Zundel configuratio

87 ion to benzene and of cyclopentadiene to its conjugate base, reflecting the smaller aromatic stabiliz

88 change reaction involving the binding of the conjugate base RX(-) and the desorption of 1 equiv of al

89 more easily cleaved from DNA by AlkA (their conjugate bases should be better leaving groups).

90 HSNO and HSSNO with their conjugate bases (-) SNO and (-) SSNO form in the reactio

91 terface is determined by changes in acid and conjugate base solvation and that the acidity decreases

92 the neutral inorganic halamines, the anionic conjugate base species, and the cationic conjugate acid

93 igned to the catalytic base Tyr-411 with the conjugate base stabilized by interaction with the guanid

94 A readily accessible conjugate-base-stabilized carboxylic acid (CBSCA) cataly

95 from these three tautomers produces the same conjugate base structure.

96 critical requirement is the strength of the conjugate base such that an equilibrium exists between p

97 citation energies of the poly-ynes and their conjugate bases suggest that the alkynyl groups are inte

98 We report here a novel conjugate-based targeting method to enhance tissue-speci

99 the triplet excited state and yields the pHP conjugate base that, upon reprotonation, regenerates the

100 ls as the H-atom donor or protonation of its conjugate base, the Co(III)(2)(u-O)(2) complex 1a.

101 found to be easily distinguishable from its conjugate base, the N1-deprotonated radical, G*(-H)*.

102 tions, pyruvic acid deprotonates to form its conjugate base, the photochemistry of which is essential

103 rm the development of the next generation of conjugate-based therapies.

104 e as a Bronsted acid and favor the boron oxy conjugate base, thereby avoiding the disruption of cycli

105 o act as Bronsted acids and form a boron oxy conjugate base, thereby avoiding the disruption of ring

106 ution," and "Unimolecular elimination by the conjugate base." They were associated with the most ance

107 the reaction that leads to the most aromatic conjugate base (thiophene derivative) has a lower intrin

108 erived from stabilization of the carboxylate conjugate base through intramolecular anion-binding to a

109 the boron centre to stabilise the [NH(2)](-) conjugate base through N-to-B pai bonding.

110 yl ether polymerization and acts as a chiral conjugate base to direct the stereochemistry of monomer

111 Herein, we report a coumarin-quinoline (CQ) conjugate-based turn-on near-infrared (NIR) fluorescence

112 ic hydroxyquinone ionizes, and the resulting conjugate base undergoes cycloaddition preferentially to

113 ost likely residue to which the ubiquitin is conjugated, based upon fitting atomic structures of acti

114 ic acid as well as its water-soluble anionic conjugate base valproate.

115 nts of the carbon acids and their respective conjugate bases were also determined which helped in und

116 c sites (NH and OH) for the formation of the conjugate base, which reacts with the electrophile, and

117 e Diels-Alder reactions of tropolone and its conjugate base with N-methylmaleimide have been explored

118 se of stronger acids, which form more stable conjugate bases with lower charge densities.

119 reactions between 21 acids, Y-X-H, and their conjugate bases, (-)X-Y, were studied according to the r

120 ic oxides (those having weaker corresponding conjugate bases) yield stronger surface organometallic e