ライフサイエンスコーパス: connective tissue disease

1 with neurodegeneration and/or cataracts and connective tissue disease.

2 ractions and mechanisms of joint disease and connective tissue disease.

3 try), and had not developed IcSSc or another connective tissue disease.

4 but often fatal, occurrence in patients with connective tissue disease.

5 limited specificity for a single autoimmune connective tissue disease.

6 thematosus and in patients who have no known connective tissue disease.

7 tibodies is associated with undifferentiated connective tissue disease.

8 d related vasculitides even in patients with connective tissue disease.

9 for vasculitis was 99.5% among patients with connective tissue disease.

10 ported on DIF: lichen planus, porphyria, and connective tissue disease.

11 IPF and mycophenolate mofetil for ILD due to connective tissue disease.

12 tests are obtained to screen for an emerging connective tissue disease.

13 gnificantly increased in patients with mixed connective tissue disease.

14 dication at onset, 6 had cancer, and 3 had a connective tissue disease.

15 ssociated with statin medication, cancer, or connective tissue disease.

16 unities and were screened for the absence of connective tissue disease.

17 of prolyl 3-hydroxylation is a mechanism for connective tissue disease.

18 olesterol biosynthesis, liver cirrhosis, and connective tissue disease.

19 entified 586 new instances of vasculitis and connective tissue disease.

20 recessive inheritance of TNX deficiency and connective-tissue disease.

21 cleroderma, is a rare and complex autoimmune connective-tissue disease.

22 shed light on the misfolding of collagen in connective tissue diseases.

23 ic sclerosis, but not in patients with other connective tissue diseases.

24 flammation in transplant organ rejection and connective tissue diseases.

25 es that will help to explain the etiology of connective tissue diseases.

26 n scarring, fibrosis, poor wound healing and connective tissue diseases.

27 thic PAH and are rare in PAH associated with connective tissue diseases.

28 to study autoimmunity in a wider spectrum of connective tissue diseases.

29 us system manifestations of vasculitides and connective tissue diseases.

30 RNP is a prominent target of autoimmunity in connective tissue diseases.

31 uld not be likely to reduce the incidence of connective-tissue diseases.

32 Self-reported connective-tissue diseases.

33 Reasons for RTX initiation included connective tissue disease (38%), systemic vasculitis (36

34 immunodeficiency virus (HIV) infection (45), connective-tissue disease (39), substance abuse (37), th

35 FDG score: 3.27+/-1.22), and 2 patients with connective tissue disease (5.07 and 7.11) compared with

36 was 49+/-14 years, 78% were female, 33% had connective tissue disease, 52% were in New York Heart As

37 ciation between silicone breast implants and connective tissue diseases, a conclusion recently endors

38 es that add to the growing list of monogenic connective tissue disease affecting the arterial wall, a

39 ants specifically, and any of the individual connective-tissue diseases, all definite connective-tiss

40 tyly, and telangiectasias syndrome and mixed connective tissue disease also had significantly higher

41 e risk (RR) of the combined end point of any connective-tissue disease among those who reported breas

42 ard, but do suggest small increased risks of connective-tissue diseases among women with breast impla

43 ase can occur in association with autoimmune connective tissue disease and confound the clinical pict

44 lung cancer screening, screening adults with connective tissue disease and first-degree relatives of

45 resent a case report of a patient with mixed connective tissue disease and non-insulin-dependent diab

46 nus is not associated with increased risk of connective tissue disease and that most patients in the

47 or predisposing factors, particularly among connective tissue diseases and among endocrine diseases.

48 Compared with 5,457 patients with connective tissue diseases and pneumonia due to other or

49 ighest for neoplasms and musculoskeletal and connective tissue diseases and was most accurate for sch

50 rse events (LAEs), consisting of 1 clinical (connective tissue disease) and 4 imaging variables: maxi

51 CAD patients, whereas peptic ulcer disease, connective tissue disease, and lymphoma were less signif

52 medical processes, most commonly infections, connective tissue disease, and pharmacological toxicity.

53 highest cause-specific mortality of all the connective tissue diseases, and the aetiology of this co

54 f P carinii pneumonia (PCP) in patients with connective tissue diseases, and to determine the role th

55 Systemic sclerosis is a rare connective tissue disease; and interstitial lung disease

56 digestive diseases; (6) musculoskeletal and connective tissue diseases; and (7) genitourinary diseas

57 o measure IgG autoantibodies associated with connective tissue diseases, anti-cytokine antibodies, an

58 nsistently identified in associated PAH with connective tissue disease (APAH-CTD).

59 n; and patients with PAH in association with connective tissue disease are identified as a particular

60 Patients with connective tissue disease are known to develop multiple

61 Hereditary connective tissue diseases are associated with mutations

62 Genes important in the connective tissue diseases are being recognized in two b

63 Autoimmune connective tissue diseases are clinically variable, maki

64 Autoimmune connective tissue diseases arise in a stepwise fashion f

65 ral bridges may be pathologically altered in connective tissue disease as evidenced by the ultrastruc

66 Bruck Syndrome is a connective tissue disease associated with inactivating m

67 These mutants may be useful in treating connective tissue diseases associated with increased met

68 To characterize the T cell response to a connective tissue disease-associated autoantigen, this s

69 are how best to define, diagnose, and treat connective tissue disease-associated ILD (CTD-ILD)--diso

70 This phenomenon occurs in both connective tissue disease-associated ILD and, surprising

71 features, 4 hypersensitivity pneumonitis, 5 connective tissue disease-associated ILD, 5 other ILD) a

72 Patients with diagnoses of fibrotic connective tissue disease-associated ILD, fibrotic hyper

73 For connective tissue disease-associated ILD, immunomodulato

74 ied, fHP without an exposure identified, and connective tissue disease-associated interstitial lung d

75 Rationale: Distinguishing connective tissue disease-associated interstitial lung d

76 valent in patients with SSc-PAH (n = 81) and connective tissue disease-associated PAH (n = 110) compa

77 patients with schistosomiasis-associated and connective tissue disease-associated PAH had evidence of

78 patients with schistosomiasis-associated and connective tissue disease-associated PAH was also system

79 levels in men with idiopathic, heritable, or connective tissue disease-associated PAH were compared w

80 ously been a case of PCP in a patient with a connective tissue disease at the same hospital (OR 135,

81 n 1976, and were free from SLE and any other connective tissue disease at the time of enrollment.

82 reported breast implants and 11,805 reported connective-tissue diseases between 1962 and 1991.

83 Calcinosis cutis is common in several connective tissue diseases but rare in systemic lupus er

84 been increasingly reported in patients with connective tissue diseases, but the frequency of this co

85 ell clones were generated from patients with connective tissue disease by using either a recombinant

86 It is often accompanied by statin therapy, connective tissue diseases, cancer, and autoantibodies s

87 Osteogenesis imperfecta (OI) is a heritable connective tissue disease characterized by bone fragilit

88 Systemic sclerosis (SSc) is a destructive connective tissue disease characterized by dysregulation

89 mportant role in systemic sclerosis (SSc), a connective tissue disease characterized by inflammation,

90 or scleroderma (SSc) is a complex autoimmune connective tissue disease characterized by obliterative

91 icans progressiva (FOP) is a rare hereditary connective tissue disease characterized by progressive p

92 sclerosis (SSc) is a multisystem autoimmune connective tissue disease characterized by skin and orga

93 (SSc), also known as scleroderma, is a rare connective tissue disease characterized by vascular and

94 dence interval, 0.65 to 3.11]); all definite connective-tissue diseases combined (0.80; 95 percent co

95 ual connective-tissue diseases, all definite connective-tissue diseases combined, or other autoimmune

96 Loeys-Dietz syndrome (LDS) is a systemic connective tissue disease (CTD) associated with a predis

97 All had connective tissue disease (CTD) serologies, spirometry,

98 To compare self-report of connective tissue disease (CTD) with medical records, su

99 onitis, accounting for 15% of ILD cases, and connective tissue disease (CTD), accounting for 25% of I

100 biopsies from 30 patients with idiopathic or connective tissue disease (CTD)-related ILD and 13 contr

101 al solvent exposure may increase the risk of connective tissue disease (CTD).

102 tricular (RV) failure with worse outcomes in connective tissue disease (CTD).

103 etermine whether anti-Gu antibodies occur in connective tissue diseases (CTD) and, if so, to determin

104 Inflammatory connective tissue diseases (CTD) like lupus and rheumato

105 plication to SV, in both primary disease and connective tissue diseases (CTD), is reviewed here.

106 Patients with connective tissue diseases (CTD), who may be predisposed

107 jogren syndrome or in association with other connective tissue diseases (CTDs), including rheumatoid

108 minantly in genes known to underlie vascular connective tissue diseases (CTDs).

109 id arthritis (RA), and 25 (0.26%) with other connective tissue diseases (CTDs).

110 ly identified as an autoantigen in the human connective tissue disease dermatomyositis [14,15].

111 inimal effect on the number of women in whom connective-tissue diseases develop, and the elimination

112 creased risk: previous high-dose procedures, connective tissue disease, diabetes mellitus, and homozy

113 inosis is a recognized manifestation of many connective-tissue diseases, especially juvenile dermatom

114 c studies has been to exclude large risks of connective-tissue diseases following breast implants.

115 le localized scleroderma stand out among the connective tissue diseases for their multiorgan involvem

116 Connective tissue diseases frequently appear in the diff

117 Renal insufficiency, PAH associated with connective tissue disease, functional class III, mean ri

118 ash with eosinophilia and systemic symptoms, connective tissue disease, hair, oral, and miscellaneous

119 T cell dependence of autoimmune responses in connective tissue diseases has been well established, li

120 Animal models of systemic connective tissue diseases have provided valuable insigh

121 using multivariable Cox regression analysis: connective tissue disease (hazard ratio [HR] 2.94, 95% c

122 complication of systemic conditions, such as connective tissue disease, HIV infection, or chronic liv

123 ated with other medical conditions including connective tissue disease, HIV, and congenital heart dis

124 ics between these patients and patients with connective tissue diseases hospitalized with other types

125 % CI: 0.79-1.25); and 2) PAH associated with connective tissue disease (HR: 0.86; 95% CI: 0.52-1.42).

126 ical forms of inflammatory syndromes such as connective tissue diseases, human immunodeficiency virus

127 the study: 200 (67%) with HP, 49 (16%) with connective tissue disease-ILD, and 48 (16%) with idiopat

128 MDD diagnoses included HP, connective tissue disease-ILD, and idiopathic pulmonary

129 natural history of RP not associated with a connective tissue disease in a large, community-based po

130 Scleroderma is an autoimmune connective tissue disease in which patients make antibod

131 Systemic sclerosis is an autoimmune connective tissue disease in which T cells play a promin

132 familial Mediterranean Fever, and the rarer connective tissue diseases, in particular systemic lupus

133 e individual diseases, the finding for other connective-tissue diseases (including mixed) was statist

134 Exclusion criteria included connective tissue disease, intraperitoneal dialysis, imm

135 ta demonstrate that RP not associated with a connective tissue disease is frequently a transient phen

136 In addition, some children in whom mixed connective tissue disease is initially diagnosed ultimat

137 ne gel in relation to idiopathic or atypical connective tissue disease is not clear.

138 e true prevalence of PAH among patients with connective tissue disease is unknown.

139 lmonary fibrosis occurring in the context of connective tissue diseases is often characterized by a d

140 Scleroderma, a debilitating acquired connective tissue disease, is characterized by fibrosis,

141 s erythematosus, systemic scleroderma, mixed connective tissue disease, juvenile dermatomyositis, juv

142 Recent studies also indicate a possible connective tissue disease-like syndrome with parvoviral

143 t an association between breast implants and connective tissue disease-like syndromes.

144 from controls or patients with other non-SSc connective tissue diseases (lupus, rheumatoid arthritis,

145 roderma (SSc) is a complex and heterogeneous connective tissue disease mainly characterized by autoim

146 protein fibrillin-1, result in the dominant connective tissue disease Marfan syndrome.

147 Mixed connective tissue disease (MCTD) is a rare and complex a

148 Mixed connective tissue disease (MCTD) is a systemic autoimmun

149 A defining feature of mixed connective tissue disease (MCTD) is the presence of anti

150 eroderma (systemic sclerosis [SSc]) or mixed connective tissue disease (MCTD).

151 erythematosus (SLE) and 1 patient with mixed connective tissue disease (MCTD).

152 pe relationship for several classes of human connective tissue diseases, mechanisms of integrin clust

153 ialty studied, with melanoma, psoriasis, and connective tissue diseases most examined.

154 itis, spondyloarthritis, DILS, vasculitides, connective tissue disease, myopathies, and musculoskelet

155 M) (n=102), myositis associated with another connective tissue disease (myositis-CTD overlap syndrome

156 Raynaud phenomenon without previously known connective tissue disease, nailfold capillaroscopy and l

157 Systemic sclerosis (SSc) is an autoimmune connective tissue disease of unknown etiology in which T

158 has indicated that the rate of well-defined connective tissue disease or breast cancer has greatly i

159 PAH patients (idiopathic, or associated with connective tissue disease or congenital heart disease) w

160 hypertension that was idiopathic, related to connective tissue disease or congenital heart disease, w

161 arditis/perimyocarditis; 85% idiopathic, 11% connective tissue disease or inflammatory bowel disease,

162 ut bias due to differential overreporting of connective-tissue diseases or selective participation by

163 esents a single disease entity, namely mixed connective tissue disease, or an undifferentiated autoim

164 R and -ETAR Abs are more frequent in SSc-PAH/connective tissue disease-PAH compared with other forms

165 ucleic acid (NA) binding Ab occur in vivo in connective tissue disease patients and certain inbred st

166 ere used to screen sera from 554 consecutive connective tissue disease patients.

167 These illnesses include connective tissue diseases, portal hypertension, diet an

168 include the use of beta-blocking agents, and connective tissue disease processes such as systemic lup

169 ergency is particularly relevant in the rare connective tissue diseases (rCTDs) communities, as discu

170 terstitial lung disease (RA-ILD) is a common connective tissue disease-related ILD (CTD-ILD) associat

171 cipants with IPF, 42.8% of participants with connective tissue disease-related ILD (CTD-ILD), 44.9% o

172 fibrosis, hypersensitivity pneumonitis, and connective tissue disease-related ILD, and highlights em

173 od for IPF (kappaw=0.71 [IQR 0.64-0.77]) and connective tissue disease-related interstitial lung dise

174 iagnosis of idiopathic pulmonary fibrosis or connective tissue disease-related interstitial lung dise

175 D, with 21.6% and 10.1% having an associated connective tissue disease (rheumatoid arthritis or syste

176 summary adjusted relative risk of individual connective-tissue diseases (rheumatoid arthritis, 1.04 [

177 76 and 2002) in 674 women was confirmed by a connective tissue disease screening questionnaire and bl

178 80 and 2000) was confirmed in 480 women by a connective tissue disease screening questionnaire and me

179 nd point, definite RA, was confirmed using a connective tissue disease screening questionnaire, follo

180 s-Danlos syndrome (vEDS) is a rare inherited connective tissue disease secondary to mutations within

181 r Ehlers-Danlos syndrome is a rare inherited connective tissue disease secondary to mutations within

182 ounterpart adult-onset Still disease (AOSD), connective tissue diseases, sepsis, infection, cancers a

183 anti-SSA/Ro-positive sera from patients with connective tissue diseases showed high reactivity to the

184 disorder, and to a lesser extent, seizures, connective tissue disease signs, sleep disturbance, visi

185 opathic, associated with congenital heart or connective tissue disease) started bosentan with or with

186 factor superfamily member 15 (TNFSFI5) gene; connective tissue diseases such as polycystic kidney dis

187 r contracture and calcification and possibly connective tissue diseases such as scleroderma and rheum

188 se subunits are autoantigens associated with connective tissue diseases such as systemic lupus erythe

189 n and consequently cause the pathogenesis of connective tissue diseases such as tendinopathy and oste

190 ease that presents mixed features with other connective tissue diseases, such as systemic lupus eryth

191 Studies of scleroderma and other defined connective tissue diseases suggest that implant recipien

192 d by a known disorder such as Parkinson's or connective tissue disease, symptoms of gastroparesis wer

193 s, or scleroderma, is an uncommon autoimmune connective tissue disease that results in systemic fibro

194 estimated the annual number of new cases of connective-tissue disease that could be attributed to br

195 CT signs of variant patterns of fibrosis in connective tissue disease (the "anterior upper lobe," "s

196 al blood cells from patients with autoimmune connective tissue diseases, the cell type-specific analy

197 ial hypertension (primary or associated with connective-tissue disease) to receive placebo or to rece

198 era from patients with scleroderma and mixed connective tissue disease, two systemic fibrotic disease

199 tigate the relation between undifferentiated connective tissue disease (UCTD) and solvent exposure in

200 hio who were diagnosed with undifferentiated connective tissue disease (UCTD) to investigate the sign

201 such individuals might have undifferentiated connective tissue disease (UCTD).

202 ase, neutrophilic dermatoses, polyarthritis, connective tissue diseases, vasculitis, and autoimmune c

203 luding patients with heart and lung disease, connective tissue disease was associated with a poorer s

204 A connective tissue disease was diagnosed in 30% and B-cel

205 Two hundred twenty-three patients with connective tissue diseases were diagnosed with PCP in th

206 s (55 healthy, 54 with spondyloarthritis and connective tissue diseases) were studied.

207 this condition is diagnosed in patients with connective tissue diseases who present with pneumonia, s

208 ittle cornea syndrome (BCS2) is an inherited connective tissue disease with a devastating ocular phen

209 c sclerosis (SSc; scleroderma) is a systemic connective tissue disease with an extensive vascular com

210 History A 46-year-old woman with known mixed connective tissue disease with clinical features of scle

211 ystemic sclerosis (SSc) is a rare autoimmune connective tissue disease with multi-organ involvement,

212 i-SSA/Ro Ab-positive sera from patients with connective tissue diseases with the E-pore peptide opens

213 recently published data about calcinosis in connective-tissue diseases with emphasis on the pathogen

214 t multiple genes are involved in each of the connective tissue diseases, with some genes in common th

215 th pulmonary arterial hypertension, 872 with connective tissue diseases without overt pulmonary hyper

216 ents with PAH, idiopathic or associated with connective tissue disease, World Health Organization (WH