ライフサイエンスコーパス: constant region

1 so stimulate antiviral responses through its constant region.

2 bination (CSR) alters the Ig heavy (H) chain constant region.

3 result from an alteration in the light-chain constant region.

4 f Pref-1 fused to human immunoglobulin-gamma constant region.

5 constant region and extends mutations to the constant region.

6 switch (S) regions that precede exons of the constant region.

7 omatin at the variable region but not at the constant region.

8 each containing heavy chains with the Calpha constant region.

9 human IgG2, IgG3, IgG4, or IgA1 heavy-chain constant region.

10 by replacing the human gamma4 with a gamma2 constant region.

11 n spots corresponding to the IgA heavy chain constant region.

12 and third domains of human IgG1 heavy-chain constant region.

13 CS protection may have resided in the sTCR constant region.

14 in fused in frame to a rabbit immunoglobulin constant region.

15 unded by a specific cassette and a conserved constant region.

16 region replaced by that encoding human kappa constant region.

17 patibility of Dmu with the kappa-joining and constant regions.

18 bodies (MAbs) with human gamma 1 heavy-chain constant regions.

19 complete mAbs with human gamma 1 heavy chain constant regions.

20 o an expression vector containing human IgG1 constant regions.

21 rminal variable regions and carboxy-terminal constant regions.

22 rived from human/humanized monoclonals, with constant regions.

23 man gamma1 heavy chain and kappa light chain constant regions.

24 a or Vbeta regions fused to xenogeneic human constant regions.

25 domains of a cynomolgus macaque mAb to human constant regions.

26 h contain rearranging segmental elements and constant regions.

27 quence discontinuous residues of HIV-1 gp120 constant regions.

28 wild-type or shuffled human IgG heavy-chain constant regions.

29 ctors containing human kappa and IgG1 or IgM constant regions.

30 ntained the human kappa light-chain and IgG1 constant regions.

31 conserved in both alpha and beta TCR chains constant regions.

32 he ABL 364 antibody with human framework and constant regions.

33 gth IgG (MAbs) with human gamma1 heavy chain constant regions.

34 IgG1 and IgG3 mAbs having human IgG1 or IgG3 constant regions.

35 ibodies (MAbs) with human gamma1 heavy-chain constant regions.

36 plicing within the zebrafish "variable" and "constant" regions.

37 ed that targeting T cell receptor beta-chain constant region 1 (TRBC1) can kill cancerous T cells whi

38 HIV-1 Env constant region 1 and 2 (C1C2) monoclonal antibodies (MA

39 oosting in humans on the vaccine-induced Env constant region 1 and 2 (C1C2)-specific antibody reperto

40 ne-for-valine substitution at position 84 in constant region 1 and an isoleucine-for-methionine subst

41 induced HIV-1 envelope variable region 2 and constant region 1 antibodies synergize for recognition o

42 r-methionine substitution at position 434 in constant region 4.

43 conformational V1/V2 and linear V2, V3, and constant region 5 (C5).

44 tracellular domains to antibody hinge and Fc constant regions, adding a stabilizing disulfide bond be

45 trom and 0.76 angstrom for the variable- and constant regions alone.

46 e crossed to mice with disruption of the TCR constant region alpha gene to create animals with a sing

47 racetylation of histones associated with the constant region and extends mutations to the constant re

48 been replaced by that encoding human epsilon constant region and gene segment encoding kappa constant

49 as the junction between the heavy (H) chain constant region and IL-2.

50 ion, while zinc was bound to the heavy chain constant region and iron was not bound with the identifi

51 n which a Vn was associated with the gamma2a constant region and its intervening and immediate flanki

52 terminal SRCR domains interact with the Fcmu constant region and J chain components of the IgM core.

53 in variable (Igh-V) region compared with the constant region and partially transcribed Igh RNAs, sugg

54 nt of the potential restriction sites in the constant regions and 47% of the potential restriction si

55 xpressing a chimeric TCR comprised of murine constant regions and human variable regions specific for

56 antigen binding, or the presence of antibody constant regions and increases, on average, as sequence

57 These studies, like those of porcine Ig constant regions and MHC genes, also indicate unexpected

58 c and rigid core formed by the Cmu4 and Cmu3 constant regions and the J-chain.

59 by TCR adenoviruses required the xenogeneic constant regions and was mediated by CD8+ T cells.

60 n of a second disulfide bond between the TCR constant regions and/or creation of a chimeric protein i

61 To this end, chimerized (rat V domains/mouse constant regions) and murinized (95% mouse sequence) DTA

62 glycosylated at conserved positions in their constant regions, and the presence of carbohydrate can b

63 with targeted deletion of the IgA switch and constant regions are completely deficient in IgA and exh

64 However, omp1 constant regions are rarely sequenced yet, they may cont

65 flanks in immunoglobulin (Ig) genes, whereas constant regions are spared.

66 Preceding antibody constant regions are switch (S) regions varying in lengt

67 containing murine variable regions and human constant regions as calibrators or controls in immunoass

68 ion is not contributed to nor constrained by constant regions; (b) in consequence, the landscape of f

69 ne configuration, the same core variable and constant regions but contains different numbers of uniqu

70 es from the Apo(a)-kringle repeat and Apo(a)-constant regions, but neither of these associations diff

71 u constant region with one of the downstream constant regions by recombination between the donor and

72 s, three J gamma gene segments, and a single constant region C gamma gene were identified in the avia

73 have undergone the unusual class switch from constant region C mu to C delta (C delta-CS).

74 class switch recombination (CSR) replaces Cu constant region (C(H)) exons with one of six downstream

75 d IgH Cmu exons with a set of downstream IgH constant region (C(H)) exons.

76 joining region (J(kappa)) to the kappa-chain constant region (C(kappa)).

77 as well as different length segments of the constant region (C(L)), thus highlighting the relevance

78 be expressed with any one of the downstream constant region (C) genes to encode antibodies with many

79 (CSR) replaces initially expressed Cmu (IgM) constant regions (C(H)) exons with downstream C(H) exons

80 ssociation, reactivity to three peptides (in constant regions C1 and C3 and variable region V3 of gp1

81 Reactivity to six peptides (in constant regions C3, C4, and C5 of gp120 and in gp41) co

82 r domain was fused with a mutated human IgG1 constant region (CD83Ig) and expressed by stable transfe

83 that replaces one immunoglobulin heavy-chain constant region (Ch) gene with another.

84 The Ig heavy chain (IgH) constant region (CH) genes are organized from 5' to 3' i

85 of "switch" transcripts from the heavy chain constant region (CH) genes targeted for rearrangement.

86 s in the expression of different heavy chain constant region (CH) genes without a change in the Ab va

87 junctions of the heavy chain and light chain constant regions (CH1 and CL) of serum IgGk, IgG , IgAk,

88 he second domain of the antibody heavy chain constant region (CH2).

89 The constant region CH3 domain remained unchanged, implying

90 immunoglobulin (MsIg) heavy- and light-chain constant regions chains, respectively.

91 gher than for a murine variable region/human constant region chimeric Fab.

92 les Igh variable region exons upstream of mu constant region (Cmu) exons, which are the first of seve

93 ication of cDNA ends) and a highly conserved constant region consensus amino acid sequence to isolate

94 ether Ig variable regions, in the absence of constant regions, could be immunotherapeutic in this mod

95 of the light chain on different human gamma constant regions (creating inside-out molecules).

96 cine efficacy, and xenogeneic immunoglobulin constant region determinants were required for immunogen

97 mer that bears no resemblance to variable or constant region dimers in an antibody.

98 detect binding of either BiP protein to the constant region domain.

99 Using a panel of human IgA1/IgG1 constant region "domain swap" mutants, the binding site

100 b was joined to either human kappa or lambda constant region domains and expressed with mouse-human c

101 to the tail-piece, structural motifs in the constant region domains are critical for polymer assembl

102 The contribution of all three constant region domains to immunoglobulin half-life may

103 fting the mAb variable regions onto the IgG2 constant region dramatically enhanced the tumor inhibito

104 Replacing the entire 13G5 constant region enhanced its binding and cellular activi

105 ns covalently linked to human immunoglobulin constant regions enhanced mAb MK2-23 immunogenicity in B

106 Its constant region exhibits an elongated shape with flexibi

107 the downstream DQ52-RSS scans the downstream constant region exon-containing 3' Igh subdomain, in whi

108 s immunoglobulin heavy chain locus (Igh) Cmu constant region exons (C(H)s) with one of six C(H)s lyin

109 CSR changes the heavy chain constant region exons (Ch) expressed with a given variab

110 In mice, six additional sets of constant region exons (CHs) lie 100-200 kilobases downst

111 s with one of several sets of downstream IgH constant region exons (e.g., C gamma, C epsilon, or C al

112 B cells can change expressed Ig heavy chain constant region exons by class switch recombination (CSR

113 d end joining of switch regions flanking Igh constant region exons during class-switch recombination,

114 ass switch recombination (CSR) exchanges IgH constant region exons in peripheral B cells.

115 can be altered by changing the expressed IgH constant region exons through IgH class switch recombina

116 ch recombination (CSR) replaces the IgH C mu constant region exons with one of several sets of downst

117 s of duck alpha and mu are each encoded by 4 constant region exons, and the hydrophobic C-terminal re

118 ot detect antisense transcripts from the Cmu constant region exons, which lie between the IgH variabl

119 t lie upstream of the various Ig heavy chain constant region exons.

120 rPcdh1 has both alpha and gamma variable and constant region exons.

121 an intergenic region from Igh Ds, J(H)s, and constant region exons.

122 transcriptional orientation as adjacent Cmu constant region exons.

123 with one VH, two DH, one JH, and one set of constant region exons.

124 that flank immunoglobulin heavy chain (IgH) constant region exons.

125 cellular domains are encoded by three small "constant" region exons located downstream from a tandem

126 ted to the interaction of protein A with the constant region (Fc) and heavy chain variable domain (VH

127 age their targets but also on the antibody's constant region (Fc) and its interactions with Fcgamma r

128 Knockout mice lacking either the antibody constant region (Fc) receptor or the substance P recepto

129 o the asparagine 297 residue in the antibody constant region (Fc).

130 b) and the other present on the conserved HC constant region (Fc).

131 he various effector molecules to which their constant regions (Fc domains) engage.

132 ctures of the complex between immunoglobulin constant regions (Fc) and their Fc-respective receptors

133 d across the NTS, with five occurring in the constant regions flanking the VIR region and two occurri

134 rocess that replaces the immunoglobulin (Ig) constant region for the isotype that can best protect ag

135 with Id proteins modified to include foreign constant regions, foreign constant regions plus GM-CSF,

136 The neonatal constant region fragment (Fc) receptor (FcRn), which is

137 e we show that the VDJ can be expressed with constant regions from different clusters, although IgH g

138 in-specific single-chain antibody, 3A8, with constant regions from the murine IgG1kappa, Guy's 13.

139 To investigate the role of antibody constant region function in toxin neutralization, we gen

140 Ab variants with effector function (IgG1 constant region (G1)) or without effector function (IgG2

141 recombinant IgG antibody containing a novel constant region, G1Deltanab, devoid of in vitro cytotoxi

142 or without effector function (IgG2/G4 fusion constant region (G2G4)) exhibited high antitumor activit

143 the most 3' immunoglobulin (Ig) heavy chain constant region gene (Calpha) contains a series of trans

144 an intrachromosomal deletion whereby the IgM constant region gene (Cmu) is replaced by a downstream c

145 transcription of the germ line (GL) Ig alpha constant region gene and to direct class switching to Ig

146 sion model integrating whole blood TCR gamma constant region gene expression levels and age and sex (

147 TCR gamma constant region gene expression levels and clinical data

148 CRISPR/Cas9 editing of the immunoglobulin M constant region gene inhibits the growth of human RS-PDX

149 stimulate transcription from the GL Ig alpha constant region gene promoter.

150 is induced by transcription of the Ig gamma1 constant region gene segment (Cgamma1).

151 cient mouse by disrupting the gamma3 H chain constant region gene via targeted mutagenesis.

152 eukemia cell line (MEL), the most distal IgH constant region gene, C alpha, replicates early in S; ot

153 eavy chain constant region with a downstream constant region gene, thereby altering the effector func

154 egion gene (Cmu) is replaced by a downstream constant region gene.

155 (S) regions that precede each Ig heavy chain constant region gene.

156 ng the CH1 domain of the gamma 3 heavy-chain constant region gene.

157 , each of which is associated with a H chain constant region gene.

158 d D-region genes, J-region genes, and the mu constant-region gene.

159 riable (AV and BV), joining (AJ and BJ), and constant region genes (AC and BC).

160 ombination and deletion process by which Igh constant region genes are exchanged.

161 bclasses (IgG1 to IgG4), encoded by separate constant region genes within the Ig heavy chain locus (I

162 ha, replicates early in S; other heavy chain constant region genes, joining and diversity segments, a

163 rious switch DNA regions located upstream of constant region genes.

164 s by a regulatory region that lies 3' of the constant region genes.

165 recombination to transgenic gamma and alpha constant region genes.

166 t between micro and gamma, alpha, or epsilon constant region genes.

167 ines, germline transcription of some H chain constant regions genes is severely impaired.

168 orks progress in both directions through the constant-region genes, which is consistent with the acti

169 ogress in one direction through the examined constant-region genes.

170 I strain, whose gene segment encoding gamma1 constant region has been replaced by that encoding human

171 m of ADSF by fusing it to the human IgGgamma constant region (hFc).

172 three Ig domains of VEGF receptor 1 to an Ig constant region; however, this fusion protein has very p

173 ing human gamma4 heavy and kappa light chain constant regions (HuEP5C7.g4).

174 s originating upstream of the immunoglobulin constant region (I transcripts) are required to direct a

175 cation spanning IGHE to IGHA1 within the IGH constant region (IGHC) and, within the IGHV region, an e

176 implications regarding the selection of the constant region in anti-CD200 immunotherapy of cancer pa

177 nduced sterile transcripts from the TCRgamma constant region in cultured thymocytes from IL-7(-/-)RAG

178 umin of nearly all isotypes 3' of the gamma1 constant region in the IgH locus, indicating that class

179 d by targeted deletion of the IgA switch and constant regions in embryonic stem cells.

180 the evolution of switch regions and multiple constant regions in the IgH locus.

181 r human counterparts while leaving the mouse constant regions intact, using a unique in situ humaniza

182 Mb) into the mouse genome, leaving the mouse constant regions intact.

183 The heavy chain constant region is a modified IgG4 containing two single

184 ypermutation or gene conversion, whereas the constant region is altered by class-switch recombination

185 As the Deltanab constant region is uninformative in mice, F(ab')2 B2G1 w

186 changes a glycine to a valine in the lambda1 constant region, is responsible for this defect.

187 These results establish that constant region isotype influences toxin neutralization

188 ows for the expression of different antibody constant region isotypes that optimize the functions of

189 All LAP2 isoforms have the same N-terminal 'constant' region (LAP2-c), which includes the LEM domain

190 e region-like N-terminal domain and three Ig constant region-like domains termed A1, A2, and B2.

191 n, and various amounts of the immunoglobulin constant-region-like domains.

192 e between the human and mouse immunoglobulin constant regions limit the utility of these mice.

193 Regulatory elements within the heavy chain constant region locus are required for Myc translocation

194 We conclude that the heavy chain constant region locus itself includes all of the element

195 at a transgene containing the Ig heavy chain constant region locus, inserted into five different chro

196 arranged VDJ gene and the entire heavy chain constant region locus.

197 anged VDJ gene and the entire murine H chain constant region locus.

198 ing a transgene of the entire murine H chain constant region locus.

199 ed a BAC transgene of the entire heavy chain constant region locus.

200 bodies by grafting full-length proteins into constant region loops of a full-length antibody or an an

201 LL-1; with murine variable regions and human constant regions) MoAb on the growth of various human ly

202 human HPA-1a-specific scFv (B2) with an IgG1 constant region modified to minimize Fcgamma receptor-de

203 all of a cavity within the TCR Ti-alpha/beta constant region module (CalphaCbeta) while the CD and EF

204 ranging gene segments (VH-D1-D2-JH) with one constant region, mu or omega.

205 e transmembrane domain of the mu-heavy-chain constant region (MuMT; B-cell and antibody deficient) or

206 d of the surface domain of EnvJ fused to the constant region of a rabbit IgG and mass spectrometry we

207 ein of subgroup E (RAV-0) virus fused to the constant region of a rabbit immunoglobulin.

208 RG7356 is a humanized antibody targeting the constant region of CD44 that shows antitumor efficacy in

209 l association between anaphylatoxins and the constant region of F(ab)2.

210 s were found to respond to an epitope from a constant region of FliC, enabling them to cross-react wi

211 They are localized on the constant region of gamma1, gamma2, and gamma3 chains.

212 To reduce unwanted side effects, the constant region of hLL1 was changed from gamma1 to gamma

213 e amino terminal portion of SC1/ECM2 and the constant region of human Ig preferentially bound to pre-

214 was constructed containing a portion of the constant region of human IgG1 (Fc) at the amino terminus

215 The CH3-ScFv antibody, which maintains the constant region of human IgG3, has some of the associate

216 expressed amino terminal to the heavy-chain constant region of human immunoglobulin G containing the

217 ave solved the solution NMR structure of the constant region of human LAP2 (residues 1-168).

218 cleave the IgA1 hinge in the context of the constant region of IgA1 or IgA2m(1) but not in the conte

219 ectly for a rabbit Cdelta locus encoding the constant region of IgD, we determined the nucleotide seq

220 tments with the fusion protein consisting of constant region of IgG and extracellular domain of lymph

221 ine traps' consisting of fusions between the constant region of IgG and the extracellular domains of

222 Receptors (FcgammaRs) for the constant region of immunoglobulin G (IgG) are an importa

223 gamma receptors, which are specific for the constant region of immunoglobulin G.

224 mber of the kindred revealed mutation in the constant region of kappa light-chain, with cysteine repl

225 short interfering RNA (siRNA) targeting the constant region of lambda light chains that substantiall

226 at the carboxyl terminus of the heavy-chain constant region of MAb-chB72.3.

227 for this bactericidal activity and that the constant region of the Ab is dispensable.

228 onstrate that introducing cysteines into the constant region of the alpha and beta chains can promote

229 es and do not allow for customization of the constant region of the antibody.

230 work has implicated the third domain of the constant region of the epsilon-heavy chain (Cepsilon3) i

231 recombination process, leads to a change in constant region of the expressed antibody.

232 0, TT833S, were genetically grafted into the constant region of the heavy chain of the humanized anti

233 several racemized amino acid residues in the constant region of the heavy chains of the three IgG sub

234 C6 contains a recombination event within the constant region of the hexon gene.

235 ein identified sequences compatible with the constant region of the immunoglobulin kappa light-chain.

236 meshift mutation in nucleotides encoding the constant region of the molecule.

237 quail Tva extracellular region fused to the constant region of the mouse immunoglobulin G (IgG) prot

238 d to two epitope tags (sTva) or fused to the constant region of the mouse immunoglobulin G heavy chai

239 ng of 28 randomized positions flanked by two constant regions of 22 residues each.

240 g N- linked carbohydrates in the heavy chain constant regions of all isotypes and O-linked carbohydra

241 ge, the first complete reference set for the constant regions of all known isotypes and chain types o

242 t challenges in engineering the variable and constant regions of antibody fragments and full-length a

243 constructed a complete reference set of the constant regions of ferret Ig and TCR isotypes and chain

244 extracellular domain linked to the hinge and constant regions of human IgG gamma 1.

245 afted, respectively, onto genes encoding the constant regions of human Igkappa and human IgG1, transf

246 (CDR) of murine OKT4A and the framework and constant regions of human light (kappa) and heavy chains

247 Given the similarity among constant regions of Ig and MHC molecules, these findings

248 Thus, AID does not gain access to the 5' and constant regions of Ig genes.

249 etermine the aggregation-prone motifs in the constant regions of IgG1 classes of antibodies.

250 s the use of genes encoding the variable and constant regions of immunoglobulin, changing avidity, an

251 Peptides containing constant regions of MOMP were recognized equally by all

252 ns of protein G (which likewise binds to the constant regions of mouse IgG) decreased the affinity of

253 oving conserved N-glycoslyation sites in the constant regions of TCR alpha or beta chains could incre

254 interest can be normalized to those from the constant regions of the immunoglobulins used for the IP.

255 eristics correlated with the position of the constant region on the IgH locus.

256 to include foreign constant regions, foreign constant regions plus GM-CSF, or linkage to keyhole limp

257 Together with IgA quantities and constant region post-translational modifications, repert

258 e region (TCRBV) families were paired with a constant region primer to polymerase chain reaction to a

259 cDNA using the seven VH family-specific and constant region primers.

260 stant region and gene segment encoding kappa constant region replaced by that encoding human kappa co

261 e variable sequences, or the J(H) and the 5' constant regions, respectively.

262 M3 mice with a chimeric IgE containing human constant regions resulted in the development of a robust

263 several joining regions, and are spliced to constant region segments.

264 status of HCL, RNA transcripts of V(H)DJ(H)--constant region sequences from 5 cases of typical HCL, a

265 Based on framework and constant region sequences from full-length cDNAs and int

266 g into expression vectors that contain human constant region sequences.

267 shed germline or novel/modified variable and constant region sequences.

268 ariable region sequences were fused to human constant region sequences.

269 illing and increased avidity via a series of constant region shuffling and subdomain swapping approac

270 Constant region shuffling identified a major CH3 and a m

271 screening strategy to eliminate undesirable constant region-specific antibodies and select for anti-

272 ted that the accessibility of Ig heavy chain constant regions targeted for CSR was established after

273 to the HPA-1a epitope but carries a modified constant region that does not bind to Fcgamma receptors.

274 body was designed as an IgG1 antibody with a constant region that lacks the ability to interact with

275 ficiency resulted in defective CSR to distal constant regions that might reflect an impaired ability

276 in the Igkappa sterile transcript, the kappa constant region, the Ekappai and Ekappa3' enhancers, and

277 gene encodes both human mu and human gamma 1 constant regions, the latter of which is expressed via i

278 over, since the motifs identified are in the constant regions, they are applicable for all antibodies

279 e by comparing HIV-1 sequences in the second constant region through the fifth hypervariable region (

280 imately 700-bp sequences covering the second constant region through the fifth variable region (C2 to

281 es, and the variable regions joined to human constant regions to generate a mAb (h-13F6) appropriate

282 o parse the contributions of both random and constant regions to the secondary structures of more tha

283 n-4 (IL-4) by producing specific germline Ig constant region transcripts and by forming switch region

284 h process in DLBCL, 4 cases of tumor-derived constant region transcripts of all isotypes were investi

285 genome is characterized by variable and more constant regions, unequal nucleotide frequencies, and pr

286 in the immunoglobulin G1 (IgG1) heavy chain constant region, virus neutralization, and natural kille

287 This same Vn, when associated with the mu constant region (Vn/mu), mutated at a 1000-fold lower ra

288 tution in the CH2 domain of the human gamma1 constant region was made by polymerase chain reaction mu

289 chimeric antibodies in which the human IgG1 constant region was paired with three murine fHbp-specif

290 The IgG1 heavy-chain constant region was then replaced with the human IgG2, I

291 ion of a chimeric protein in which the human constant regions were replaced by murine homologs result

292 from DNAs encoding the desired variable and constant regions, which allows antibodies of different i

293 transmembrane component and the heavy chain constant region, while zinc was bound to the heavy chain

294 nation (CSR) replaces the Ig(mu) heavy chain constant region with a downstream constant region gene,

295 ere then class-switched by replacing the IgE constant region with IgG4 while retaining the allergen-s

296 CSR involves the replacement of the mu constant region with one of the downstream constant regi

297 one-pot cell-free system and human antibody constant regions with minimal sialic acid motifs in glyc

298 he same variable regions and different human constant regions with their unique combination of effect

299 a "functional-sidedness" to the alphabetaTCR constant region, with dimerization occurring on the side

300 genetic location, whereas the retained mouse constant regions would allow for optimal interactions an