ライフサイエンスコーパス: constitutive activation

1 but cannot be dephosphorylated, resulting in constitutive activation.

2 sion results in its nuclear localization and constitutive activation.

3 hosphorylated CaMKII (P<0.01), suggestive of constitutive activation.

4 p phosphorylation-dependent kinase result in constitutive activation.

5 acute myeloid leukemia patients and lead to constitutive activation.

6 eceptors TRKA, TRKB, and TRKC, can result in constitutive activation and aberrant expression of TRK k

7 O-GlcNAcylation has been linked to NF-kappaB constitutive activation and cancer development.

8 small molecule inhibitor BMS-777607 blocked constitutive activation and decreased AKT signaling.

9 rced covalent dimerization did not result in constitutive activation and did not affect the ability o

10 ctional data from miR-155 tg NK cells showed constitutive activation and enhanced target cell conjuga

11 Both constitutive activation and loss of Akt kinase activity

12 Loss of ClpC repression in MD mutants causes constitutive activation and severe cellular toxicity.

13 PKC-iota by site-directed mutagenesis led to constitutive activation and unresponsiveness to PIP3 in

14 fied regulatory mechanism was observed after constitutive activation as well as after receptor tyrosi

15 Constitutive activation can result in interferonopathies

16 ls, 3C(pro) targets Q167 and Q189 within the constitutive activation domain, resulting in cleavage of

17 Somatic SMO mutations that result in constitutive activation have been described in several t

18 n of SYK activity eliminated features of the constitutive activation in these cells and partly restor

19 tal arrest and presenting as GC B cells with constitutive activation-induced cytidine deaminase (AID)

20 NF-kappaB constitutive activation is a major factor for the apopto

21 er, our studies indicate that stress-induced constitutive activation is a novel mechanism of kappaOR

22 endocrine therapy via mutation of ERs whose constitutive activation is associated with shorter patie

23 nt, the data suggest that controlled but not constitutive activation is required for gonococcal infec

24 High SYK expression by itself drives the constitutive activation observed in these B cells, which

25 st turnover tissues, APC loss results in the constitutive activation of a Wnt target gene program tha

26 by elevated miR-34a expression resulting in constitutive activation of acetylated p65 (lysine 310).

27 Although the constitutive activation of adenylyl cyclase (AC) in resp

28 ever, induction of this circuit in mice with constitutive activation of AKT and YAP in bile ducts ind

29 This finding is of interest as constitutive activation of AKT has been described in DLB

30 Constitutive activation of AKT or Bcl-xL rescued the tra

31 Constitutive activation of Akt or inhibition of GSK3beta

32 STRN-ALK leads to constitutive activation of ALK kinase via dimerization m

33 e is most effective in proximal branches via constitutive activation of alpha2 ARs.

34 PKgamma2(RG) in the kidney, linking lifelong constitutive activation of AMPK to a potential risk for

35 ark t(14;18) translocation, which results in constitutive activation of antiapoptotic protein B cell

36 work presented here was to determine whether constitutive activation of autophagy would also block re

37 suggested miR-17 approximately 92's role in constitutive activation of BCR signaling and sensitivity

38 Constitutive activation of beta-catenin in hematopoietic

39 e led to severe cementum hypoplasia, whereas constitutive activation of beta-catenin in the Axin2(+)

40 retion was necessary for GLEI formation, and constitutive activation of beta-catenin in young mice in

41 In addition, the constitutive activation of beta-catenin significantly in

42 omas have mutations in CTNNB1 that result in constitutive activation of beta-catenin, so this molecul

43 ed a mouse model with the germ cell-specific constitutive activation of betacatenin using cre recombi

44 ATE-ZIM DOMAIN protein, thereby resulting in constitutive activation of bHLH05 and mimicking jasmonic

45 esponses such as callose deposition and that constitutive activation of BR signaling in bri1-EMS-supp

46 The constitutive activation of BR signaling, in contrast, en

47 e morphology defects, growth inhibition, and constitutive activation of BR signaling.

48 identified in human CRC are associated with constitutive activation of calcineurin, whereas nuclear

49 372R) mutations are neomorphic, resulting in constitutive activation of cAMP and Ca(2+) signaling pat

50 Constitutive activation of CaN also decreases immobility

51 ion and therefore PF-suture closure, whereas constitutive activation of canonical Wnt causes PF-sutur

52 nce of Wnt4, we generated a mouse model with constitutive activation of canonical Wnt/beta-catenin si

53 n the intestinal epithelium was required for constitutive activation of caspase-8 under steady-state

54 Constitutive activation of CD40 in DCs results in inflam

55 Recently, we have shown that constitutive activation of CD40 signaling in B cells ind

56 howed that loss-of-function of BIR1 leads to constitutive activation of cell death and defense respon

57 Constitutive activation of certain stress response netwo

58 res even at 12 h of liquid culture, and near constitutive activation of conidiation, indicating that

59 Constitutive activation of DDR proteins has been observe

60 us actin and stable microtubules, indicating constitutive activation of DIAPH1.

61 Notably, the constitutive activation of DNA damage response genes is

62 EGF/FGF2-independent proliferation exhibited constitutive activation of EGFR, AKT, and STAT3 and sens

63 Constitutive activation of eIF2Bepsilon is sufficient to

64 t deletion of the N-terminal lobe results in constitutive activation of endogenous PIWI domain-based

65 Constitutive activation of endothelial Nrf2 enhanced EC

66 lts suggest that SAM domain deletion induced constitutive activation of EphA2 kinase activity.

67 elial regeneration and cancer growth through constitutive activation of epidermal growth factor recep

68 omotes a mitogenic phenotype associated with constitutive activation of ERK.

69 We hypothesized that constitutive activation of ESX-5 secretion causes attenu

70 -targeted active PTK6 (Palm-PTK6-YF) induces constitutive activation of FAK and cell morphology chang

71 FGF19 amplification corresponded with constitutive activation of FGF receptor 4 (FGFR4)-depend

72 d CKD in mice with either global deletion or constitutive activation of FGFR4.

73 emonstrated a gain-of-function effect due to constitutive activation of G protein downstream signalin

74 hat in addition to Gq, GHS-R1a also promoted constitutive activation of G13.

75 Constitutive activation of Galphaq signaling by mutation

76 cells with increased proliferative capacity, constitutive activation of granulocyte macrophage colony

77 independently of the mTORC1 pathway, whereas constitutive activation of GSK3beta reduces AKT-induced

78 aneous deletion of SSE1 and FES1 resulted in constitutive activation of heat shock protein expression

79 Here, we determined that constitutive activation of hedgehog signaling specifical

80 h-level expression of HRG is associated with constitutive activation of HER3 in SCCHN and thus define

81 Using a genetic model involving constitutive activation of Hh pathway in SF1(+) cells, w

82 ause either inhibition with Hh inhibitors or constitutive activation of Hh signaling activity in tran

83 c mouse models, we show that B-cell-specific constitutive activation of HH/GLI signaling either at th

84 Notably, liver-specific constitutive activation of HIF-2alpha, but not HIF-1alph

85 Inactivation of vhl in zebrafish led to constitutive activation of HIF2alpha orthologs and model

86 predispose to paraganglioma tumors that show constitutive activation of hypoxia responses.

87 by loss of the tumor-suppressor VHL, driving constitutive activation of hypoxia-inducible factor-1 (H

88 Notably, constitutive activation of IkappaBalpha/NF-kappaB(p65) i

89 Constitutive activation of IKKbeta in the esophageal epi

90 cytokines including IL-6 and -13, leading to constitutive activation of JAK/STAT signaling.

91 nitiates an epigenetic switch leading to the constitutive activation of JAK1/STAT3 signalling, which

92 domain and how pathogenic mutations lead to constitutive activation of JAK2.

93 ave an acquired mutation (JAK2V617F) causing constitutive activation of JAK2.

94 e JAK2 c.1849G>T (p.V617F) mutation leads to constitutive activation of Janus kinase (JAK)2 and contr

95 hrombopoietin (TPO) receptor (MPL) to induce constitutive activation of Janus kinase 2 and signal tra

96 Although constitutive activation of Janus kinase 3 (Jak3) leads t

97 kk7 knockout mice (MKK7 cKO), which impaired constitutive activation of JNK in the nervous system.

98 Gclm KO mice also exhibit constitutive activation of liver AMP-activated protein k

99 mas are slow-growing tumours associated with constitutive activation of mammalian target of rapamycin

100 sis complex is a genetic disorder leading to constitutive activation of mammalian target of rapamycin

101 wn genomic alterations in glioma that induce constitutive activation of MAPK are transcriptionally li

102 Furthermore, constitutive activation of master transcription factor X

103 ts within the TSC1 or TSC2 genes, leading to constitutive activation of mechanistic target of rapamyc

104 Interestingly, constitutive activation of miR408 in the spl7 background

105 inhibitor of mitochondrial complex III, and constitutive activation of mitochondrial retrograde sign

106 These data indicate constitutive activation of mitophagy results in reductio

107 We then showed that both inhibition and constitutive activation of mTOR during tutor experiences

108 Here we report that, unexpectedly, constitutive activation of mTOR signalling by Tsc1 delet

109 Constitutive activation of mTORC1 by depletion of tubero

110 st, glucose did not suppress mTORC1, and the constitutive activation of mTORC1 failed to suppress pla

111 ession of cone death during disease and that constitutive activation of mTORC1 in cones is sufficient

112 We show that loss of Tsc1 and constitutive activation of mTORC1 in dopamine neurons ca

113 Recent studies have suggested that constitutive activation of mTORC1 in normal cells could

114 Constitutive activation of mTORC1 preserved cones in 2 m

115 ed mTORC1 signaling in vitro and in vivo The constitutive activation of mTORC1 reduced hepatic lipoge

116 Loss of the PTEN tumor suppressor results in constitutive activation of mTORC1 through the Akt-depend

117 gain of function causes fatty liver through constitutive activation of mTorc1, an effect that is rev

118 bits oncomodulatory properties, elicited via constitutive activation of multiple signaling pathways.

119 In addition, constitutive activation of NEK6 or NEK7 reduced the asso

120 Conversely, constitutive activation of neuronal ALK5 in forebrain ca

121 this epidermal phenotype was associated with constitutive activation of NF-kappaB (RelA) and increase

122 the transglutaminase TG2 has been linked to constitutive activation of NF-kappaB and chemotherapy re

123 ) mouse livers, and this was associated with constitutive activation of NF-kappaB and JNK, along with

124 e/paracrine TLR5 signaling loop resulting in constitutive activation of NF-kappaB both in vitro and i

125 egulatory mechanisms that avoid excessive or constitutive activation of NF-kappaB may be associated w

126 Conversely, constitutive activation of NF-kappaB selectively in wild

127 In contrast, constitutive activation of NFATc1 nullifies the protecti

128 ls to inflammatory signals, and the abnormal constitutive activation of NFkappaB is important for the

129 Here we demonstrate in Arabidopsis that the constitutive activation of NIK1, a leucine-rich repeat r

130 -inactive c-IAP2 mutant (c-IAP2(H570A)) have constitutive activation of non-canonical NF-kappaB, resu

131 e formation of all nephron segments and that constitutive activation of Notch in developing nephrons

132 and Hnf1b Consistent with this, we find that constitutive activation of Notch in mesenchymal nephron

133 es the Notch intracellular domain, while the constitutive activation of Notch reverses the PI3K defic

134 Constitutive activation of Notch signaling fully blocked

135 At the molecular level, constitutive activation of Notch signaling inhibits, whe

136 ptosis in cultured human leukemic cells with constitutive activation of Notch signaling.

137 dation of some of these findings showed that constitutive activation of Notch1 deregulated glutamine

138 Accordingly, constitutive activation of Notch1 prevents SC depletion

139 reactive oxygen species (ROS), arising from constitutive activation of NOX2 oxidase, occurs in >60%

140 Somatic mutations that lead to constitutive activation of NRAS and KRAS proto-oncogenes

141 ibly providing a scenario similar to that of constitutive activation of Nrf2 found in certain human c

142 duct phenotypes could be recapitulated with constitutive activation of Nrf2 signaling in Keap1(F/F):

143 ted the nuclear accumulation of NRF2, led to constitutive activation of NRF2 signaling, and conferred

144 ation of the Nrf2-Keap1 axis, which leads to constitutive activation of Nrf2.

145 elial-mesenchymal transition (EMT), but also constitutive activation of nuclear factor kappa B (NFkap

146 classical Hodgkin lymphoma (cHL), including constitutive activation of nuclear factor kappaB (NF-kap

147 Mechanistically, CB sparks the constitutive activation of oestrogen receptors alpha (ER

148 This coincides with the constitutive activation of one of the downstream effecto

149 ubicin or nutlin-3 results in continuing and constitutive activation of p53, inhibition of XIAP and s

150 Constitutive activation of PDGFRalpha leads to expansion

151 The Pten phenotype is mimicked by constitutive activation of PI3 kinase and is rescued by

152 We further show that constitutive activation of PKB in vivo results in a loss

153 nd premature death, which correlate with the constitutive activation of plant immune responses.

154 ate that the PLCgamma1-R707Q mutation causes constitutive activation of PLCgamma1 and may represent a

155 lterations in MIBC that convergently lead to constitutive activation of PPARgamma/RXRalpha and result

156 vasion phenotypes is mediated in part by the constitutive activation of pro-inflammatory nuclear fact

157 trigger chronic inflammation, which leads to constitutive activation of pro-inflammatory signaling pa

158 ominant-negative Rab4 or Rab4 morpholino and constitutive activation of Rab5 decreases the elongation

159 Constitutive activation of Rac1 also led to podocyte det

160 In this study, we demonstrate that constitutive activation of Raf-1 oncogenic signaling ind

161 h the idea that RalGAPA1 deficiency causes a constitutive activation of RalA.

162 RS2, a direct substrate of FGFR1, as well as constitutive activation of RAS-MAPK signaling.

163 Constitutive activation of Ras-mitogen-activated protein

164 st phosphate uptake system component, causes constitutive activation of RegX3.

165 ncreas-specific deletion of IkappaBalpha had constitutive activation of RelA and a gene expression pr

166 protein subunit alpha 13), resulting in the constitutive activation of RhoA (ras homolog family memb

167 Constitutive activation of RhoA led to increased express

168 Moreover, constitutive activation of RhoA restricted three-dimensi

169 eveloped a zebrafish melanoma model in which constitutive activation of ribosomal protein S6 kinase A

170 Additionally, constitutive activation of saeRS (saeRS(C)) enhanced the

171 decreased production of such factors, while constitutive activation of saeRS increases virulence, an

172 rfism, compromised pollen tube guidance, and constitutive activation of salicyclic acid-mediated defe

173 nding site or the ARM-TIR interaction caused constitutive activation of SARM1 and thereby led to axon

174 pendent of their endogenous Sox2 expression, constitutive activation of Shh signaling in CGNPs result

175 ls to tumour development in combination with constitutive activation of SHH signalling.

176 Constitutive activation of signal transducer and activat

177 ogenes and tumor suppressors, leading to the constitutive activation of signaling pathways involved i

178 Constitutive activation of SKN-1 induces a similar trans

179 However, constitutive activation of SKN-1 results in pleiotropic

180 results indicate that oncogenic Kras induces constitutive activation of SOX9 in HPNE and HPDE cells,

181 g-term plasticity, little is known about how constitutive activation of specific kinase isoforms sust

182 cy of both Insigs in enterocytes resulted in constitutive activation of SREBP and HMGR, leading to an

183 In an attempt to achieve constitutive activation of SRK and thus facilitate analy

184 we furthermore show that plasma LPS leads to constitutive activation of STAT1 through autocrine cytok

185 Cs and the Notch pathway, which involves the constitutive activation of STAT3 and NF-kappaB signaling

186 Constitutive activation of STAT3 imparts resistance to a

187 e resulted in phospho-Stat3 accumulation and constitutive activation of Stat3-driven genetic programs

188 r GC cell lines including AGS cells, showing constitutive activation of STAT3.

189 eement with this model, we observed that the constitutive activation of Stat5 cooperates with the los

190 We have detected constitutive activation of STAT5 in malignant B cells de

191 Importantly, primary T-PLL cells exhibited constitutive activation of STAT5, and targeted pharmacol

192 translocation partner in lipoma), induced by constitutive activation of STAT5, but not by transient c

193 In this study, we demonstrated that constitutive activation of STAT6 in KSHV-associated PEL

194 We hypothesize a constitutive activation of stem cell division kinetics s

195 ise to SCLC, and transformation results from constitutive activation of stem cell renewal and inhibit

196 es dysregulation of apoptosis, mainly due to constitutive activation of survival pathways including J

197 We found that constitutive activation of TFEB is the main driver of th

198 ing mice with either T cell-specific loss or constitutive activation of TGF-beta signaling, we demons

199 llomavirus 31 (HPV31)-positive cells exhibit constitutive activation of the ATM-dependent DNA damage

200 mphocytic leukemia (CLL) is characterized by constitutive activation of the B-cell receptor (BCR) sig

201 that AP-1, like NF-kappaB, was controlled by constitutive activation of the B-cell receptor signaling

202 or the pathogenesis of these tumors, whereby constitutive activation of the cAMP pathway and EZH1 mut

203 This response is attenuated in mutants with constitutive activation of the corticotropin-releasing f

204 ogous expression of STIM1 p.R304W results in constitutive activation of the CRAC channel in vitro, an

205 These results highlight the importance of constitutive activation of the de novo purine synthesis

206 We show that Pten deletion, or constitutive activation of the downstream kinase AKT, ac

207 Constitutive activation of the EGFR is common in cancer

208 of chronic energy deprivation, resulting in constitutive activation of the energy-stress sensor AMPK

209 Constitutive activation of the epidermal growth factor r

210 Constitutive activation of the epidermal growth factor r

211 Constitutive activation of the farnesoid X receptor (FXR

212 erized by frequent loss of PTCH1, leading to constitutive activation of the Hedgehog pathway.

213 findings indicate that MUC1-C contributes to constitutive activation of the HER2 pathway and that tar

214 ippel-Lindau tumor suppressor and subsequent constitutive activation of the hypoxia-inducible factors

215 VHL inactivation results in the constitutive activation of the hypoxia-inducible factors

216 tween the IIS and Rag-TORC1 pathways because constitutive activation of the IIS pathway requires Rag

217 nce of CD37 drives tumor development through constitutive activation of the IL-6 signaling pathway.

218 ation of the IkappaB kinase complex prevents constitutive activation of the immune deficiency pathway

219 Constitutive activation of the JAK/STAT pathway downstre

220 All these aberrations lead to the constitutive activation of the JAK/STAT3 pathway, which

221 ise to growth factor-independent clones with constitutive activation of the Janus kinase (JAK)- signa

222 followed by a persistent, ligand-independent constitutive activation of the kappaOR itself.

223 Constitutive activation of the mammalian target of rapam

224 ve fitness normalize GSK3beta activity after constitutive activation of the MAPK pathway, commonly th

225 n BRAF, mainly at codon 600, which result in constitutive activation of the MAPK pathway.

226 es, elevated baseline expression relied upon constitutive activation of the MAPK pathway.

227 The pathogenic cells are defined by constitutive activation of the MAPK signaling pathway.

228 NCAM1 expression strongly associated with constitutive activation of the MAPK-signaling pathway, r

229 utation in the TSC1 or TSC2 genes leading to constitutive activation of the mechanistic target of rap

230 mutation resembles active LysRS and causes a constitutive activation of the microphthalmia transcript

231 Activating BRAF mutations promote constitutive activation of the mitogen-activated protein

232 We present evidence that constitutive activation of the mitogen-activated protein

233 nes and enhanced freezing tolerance, whereas constitutive activation of the MKK4/5-MPK3/6 cascade in

234 MORPHOPROTEOMIC TUMOR ANALYSES REVEALED CONSTITUTIVE ACTIVATION OF THE MTOR PATHWAY AS EVIDENCED

235 ibition or specific Ship2 inhibition reduced constitutive activation of the mTORC1/ribosomal protein

236 Structural modeling supported constitutive activation of the mutant STING protein base

237 NF-kappaB in hypoxic breast cancer cells and constitutive activation of the NF-kappaB pathway in CAIX

238 DLBCL (ABC-DLBCL), which is characterized by constitutive activation of the NF-kappaB pathway, carry

239 leted in multiple myeloma (MM), resulting in constitutive activation of the noncanonical nuclear fact

240 We address this paradox by identifying the constitutive activation of the NRF2 master antioxidant r

241 Constitutive activation of the nuclear factor-kappa B (N

242 eractions with the targets, thereby enabling constitutive activation of the nuclear factor-kappa B, a

243 glutamate receptor-like proteins (GLRs), or constitutive activation of the P-type H(+)-ATPase AHA1.

244 ononuclear cells from the patients indicated constitutive activation of the pathway that cannot be fu

245 sistance mechanism to anti-HER2 therapies is constitutive activation of the phosphoinositide 3-kinase

246 h or without PIK3CA mutations, which lead to constitutive activation of the PI3K pathway.

247 Constitutive activation of the PI3K/mTOR signaling pathw

248 o alters EGF receptor signaling and leads to constitutive activation of the protein kinase Akt.

249 ecked TLR-induced inflammatory responses and constitutive activation of the Pyrin inflammasome.

250 BRAF V600E leads to the constitutive activation of the RAF-MEK-extracellular sig

251 nd/or with PTEN deletion based on the common constitutive activation of the Raf/MEK/ERK and PI3K/AKT

252 JMML pathobiology is characterized by constitutive activation of the Ras signal transduction p

253 There was constitutive activation of the Ras/Raf/ERK pathway p-ERK

254 nal proline-rich motif of FGFR2 inducing the constitutive activation of the receptor, thereby prompti

255 rase reporter for monitoring the GSR support constitutive activation of the response in this mutant b

256 Pst phosphate transporter component, causes constitutive activation of the response regulator RegX3,

257 nnoma cells, containing merlin mutations and constitutive activation of the Rho/Rac family of GTPases

258 gly, loss of casein kinase 1 activity causes constitutive activation of the RIM pathway, and, accordi

259 own of ABCC4 expression markedly blunted the constitutive activation of the SHH pathway secondary to

260 Constitutive activation of the signal transducer and act

261 Constitutive activation of the signal transducer and act

262 Here, we show that constitutive activation of the small GTPase ARF6 (ARF6(Q

263 This disruption leads to a constitutive activation of the spindle-assembly checkpoi

264 Accordingly, IL6 mediated constitutive activation of the STAT3 pathway, an essenti

265 In conclusion, our studies suggest that constitutive activation of the STAT3-Pim1 pathway repres

266 both adherent and spheroid glioma CSCs show constitutive activation of the STAT3/NF-kappaB signaling

267 when grown in Fe-sufficient condition, and a constitutive activation of the Strategy I Fe uptake gene

268 Constitutive activation of the T-cell leukemia 1A (TCL1A

269 IL6-mediated inflammation programs constitutive activation of the TAK1-NFkappaB signaling c

270 In fact, in CD44+/CD24- cells, constitutive activation of the TGF-beta axis was both ne

271 Moreover, constitutive activation of the TOR-pathway target and li

272 egulation of lysosomal protein expression by constitutive activation of the transcription factor EB (

273 subtype characterized by adverse outcome, is constitutive activation of the transcription factor nucl

274 Constitutive activation of the UPR(mt) by gain of functi

275 Constitutive activation of the Wnt pathway resulting fro

276 Constitutive activation of the Wnt pathway, one of the e

277 Constitutive activation of the Wnt pathway/beta-catenin

278 Constitutive activation of the Wnt/beta-catenin signalin

279 Constitutive activation of this loop in transformed cell

280 Tumor-associated mutants reveal how constitutive activation of this pathway impacts cell's d

281 romotes osteoblast differentiation in vitro, constitutive activation of this pathway impairs bone for

282 Also, constitutive activation of Toll and IMD pathways by knoc

283 In multiple forms of cancer, constitutive activation of type I IFN signaling is a cri

284 These mutations confer cGAMP-independent constitutive activation of type I interferon signaling t

285 Emerging evidence suggests that constitutive activation of various signaling pathways li

286 ptor-related protein 5 Wnt coreceptor causes constitutive activation of Wnt signaling, and in adenovi

287 Constitutive activation of Wnt-beta-catenin signaling fu

288 Constitutive activation of Wnt/beta-catenin inhibits oli

289 t common mechanisms of misregulation lead to constitutive activation of WT STATs.

290 Here we show that constitutive activation of XBP1 in tumor-associated DCs

291 Overexpression or constitutive activation of YAP leads to transformation a

292 sidues within TM6 and TM7 results in a weak 'constitutive' activation of the pathway.

293 Aberration in STAT3 activity due to constitutive activation or mutations leads to diseases s

294 We propose that constitutive activation results from a lessened intrinsi

295 receptor, which leads to ligand-independent constitutive activation that is not inhibited by anti-an

296 showed that different JAK3 mutations induce constitutive activation through distinct mechanisms, poi

297 nd Q61L, suggests that these mutations cause constitutive activation through two different mechanisms

298 lpha-dependent, but mutations usually confer constitutive activation to the hormone receptor, renderi

299 is essential for effective innate immunity, constitutive activation typically causes harmful autoimm

300 This constitutive activation was abrogated by ex vivo treatme