ライフサイエンスコーパス: constitutive activation of

1 st turnover tissues, APC loss results in the constitutive activation of a Wnt target gene program tha

2 by elevated miR-34a expression resulting in constitutive activation of acetylated p65 (lysine 310).

3 Although the constitutive activation of adenylyl cyclase (AC) in resp

4 ever, induction of this circuit in mice with constitutive activation of AKT and YAP in bile ducts ind

5 This finding is of interest as constitutive activation of AKT has been described in DLB

6 Constitutive activation of AKT or Bcl-xL rescued the tra

7 Constitutive activation of Akt or inhibition of GSK3beta

8 STRN-ALK leads to constitutive activation of ALK kinase via dimerization m

9 e is most effective in proximal branches via constitutive activation of alpha2 ARs.

10 PKgamma2(RG) in the kidney, linking lifelong constitutive activation of AMPK to a potential risk for

11 ark t(14;18) translocation, which results in constitutive activation of antiapoptotic protein B cell

12 work presented here was to determine whether constitutive activation of autophagy would also block re

13 suggested miR-17 approximately 92's role in constitutive activation of BCR signaling and sensitivity

14 Constitutive activation of beta-catenin in hematopoietic

15 e led to severe cementum hypoplasia, whereas constitutive activation of beta-catenin in the Axin2(+)

16 retion was necessary for GLEI formation, and constitutive activation of beta-catenin in young mice in

17 In addition, the constitutive activation of beta-catenin significantly in

18 omas have mutations in CTNNB1 that result in constitutive activation of beta-catenin, so this molecul

19 ed a mouse model with the germ cell-specific constitutive activation of betacatenin using cre recombi

20 ATE-ZIM DOMAIN protein, thereby resulting in constitutive activation of bHLH05 and mimicking jasmonic

21 esponses such as callose deposition and that constitutive activation of BR signaling in bri1-EMS-supp

22 The constitutive activation of BR signaling, in contrast, en

23 e morphology defects, growth inhibition, and constitutive activation of BR signaling.

24 Because constitutive activation of BRAF leads to proliferation i

25 Specifically, constitutive activation of Ca(2+) entry by expression of

26 identified in human CRC are associated with constitutive activation of calcineurin, whereas nuclear

27 372R) mutations are neomorphic, resulting in constitutive activation of cAMP and Ca(2+) signaling pat

28 Constitutive activation of CaN also decreases immobility

29 In addition, constitutive activation of CaN in vivo favors 5-HT uptak

30 ion and therefore PF-suture closure, whereas constitutive activation of canonical Wnt causes PF-sutur

31 nce of Wnt4, we generated a mouse model with constitutive activation of canonical Wnt/beta-catenin si

32 n the intestinal epithelium was required for constitutive activation of caspase-8 under steady-state

33 Constitutive activation of CD40 in DCs results in inflam

34 Recently, we have shown that constitutive activation of CD40 signaling in B cells ind

35 howed that loss-of-function of BIR1 leads to constitutive activation of cell death and defense respon

36 Constitutive activation of certain stress response netwo

37 res even at 12 h of liquid culture, and near constitutive activation of conidiation, indicating that

38 Constitutive activation of DDR proteins has been observe

39 us actin and stable microtubules, indicating constitutive activation of DIAPH1.

40 Notably, the constitutive activation of DNA damage response genes is

41 d kinases inhibits proliferation, suppresses constitutive activation of downstream signaling pathways

42 EGF/FGF2-independent proliferation exhibited constitutive activation of EGFR, AKT, and STAT3 and sens

43 Constitutive activation of eIF2Bepsilon is sufficient to

44 t deletion of the N-terminal lobe results in constitutive activation of endogenous PIWI domain-based

45 Constitutive activation of endothelial Nrf2 enhanced EC

46 lts suggest that SAM domain deletion induced constitutive activation of EphA2 kinase activity.

47 elial regeneration and cancer growth through constitutive activation of epidermal growth factor recep

48 lular signal-regulated kinase (ERK), whereas constitutive activation of ERK in these cells led to res

49 omotes a mitogenic phenotype associated with constitutive activation of ERK.

50 We hypothesized that constitutive activation of ESX-5 secretion causes attenu

51 -targeted active PTK6 (Palm-PTK6-YF) induces constitutive activation of FAK and cell morphology chang

52 FGF19 amplification corresponded with constitutive activation of FGF receptor 4 (FGFR4)-depend

53 d CKD in mice with either global deletion or constitutive activation of FGFR4.

54 emonstrated a gain-of-function effect due to constitutive activation of G protein downstream signalin

55 hat in addition to Gq, GHS-R1a also promoted constitutive activation of G13.

56 uxin and GA signaling, we show here that the constitutive activation of GA signaling is sufficient to

57 Constitutive activation of Galphaq signaling by mutation

58 cells with increased proliferative capacity, constitutive activation of granulocyte macrophage colony

59 independently of the mTORC1 pathway, whereas constitutive activation of GSK3beta reduces AKT-induced

60 aneous deletion of SSE1 and FES1 resulted in constitutive activation of heat shock protein expression

61 Here, we determined that constitutive activation of hedgehog signaling specifical

62 h-level expression of HRG is associated with constitutive activation of HER3 in SCCHN and thus define

63 Using a genetic model involving constitutive activation of Hh pathway in SF1(+) cells, w

64 ause either inhibition with Hh inhibitors or constitutive activation of Hh signaling activity in tran

65 c mouse models, we show that B-cell-specific constitutive activation of HH/GLI signaling either at th

66 Notably, liver-specific constitutive activation of HIF-2alpha, but not HIF-1alph

67 nhibition of the HIF pathway since ~80% show constitutive activation of HIF.

68 Inactivation of vhl in zebrafish led to constitutive activation of HIF2alpha orthologs and model

69 predispose to paraganglioma tumors that show constitutive activation of hypoxia responses.

70 by loss of the tumor-suppressor VHL, driving constitutive activation of hypoxia-inducible factor-1 (H

71 Notably, constitutive activation of IkappaBalpha/NF-kappaB(p65) i

72 Constitutive activation of IKKbeta in the esophageal epi

73 primary ovarian and breast tumors confirmed constitutive activation of ISGs.

74 cytokines including IL-6 and -13, leading to constitutive activation of JAK/STAT signaling.

75 nitiates an epigenetic switch leading to the constitutive activation of JAK1/STAT3 signalling, which

76 domain and how pathogenic mutations lead to constitutive activation of JAK2.

77 ave an acquired mutation (JAK2V617F) causing constitutive activation of JAK2.

78 e JAK2 c.1849G>T (p.V617F) mutation leads to constitutive activation of Janus kinase (JAK)2 and contr

79 hrombopoietin (TPO) receptor (MPL) to induce constitutive activation of Janus kinase 2 and signal tra

80 Although constitutive activation of Janus kinase 3 (Jak3) leads t

81 kk7 knockout mice (MKK7 cKO), which impaired constitutive activation of JNK in the nervous system.

82 Gclm KO mice also exhibit constitutive activation of liver AMP-activated protein k

83 mas are slow-growing tumours associated with constitutive activation of mammalian target of rapamycin

84 sis complex is a genetic disorder leading to constitutive activation of mammalian target of rapamycin

85 wn genomic alterations in glioma that induce constitutive activation of MAPK are transcriptionally li

86 Furthermore, constitutive activation of master transcription factor X

87 ts within the TSC1 or TSC2 genes, leading to constitutive activation of mechanistic target of rapamyc

88 Interestingly, constitutive activation of miR408 in the spl7 background

89 inhibitor of mitochondrial complex III, and constitutive activation of mitochondrial retrograde sign

90 These data indicate constitutive activation of mitophagy results in reductio

91 We then showed that both inhibition and constitutive activation of mTOR during tutor experiences

92 Here we report that, unexpectedly, constitutive activation of mTOR signalling by Tsc1 delet

93 Constitutive activation of mTORC1 by depletion of tubero

94 st, glucose did not suppress mTORC1, and the constitutive activation of mTORC1 failed to suppress pla

95 ession of cone death during disease and that constitutive activation of mTORC1 in cones is sufficient

96 We show that loss of Tsc1 and constitutive activation of mTORC1 in dopamine neurons ca

97 Recent studies have suggested that constitutive activation of mTORC1 in normal cells could

98 Constitutive activation of mTORC1 preserved cones in 2 m

99 ed mTORC1 signaling in vitro and in vivo The constitutive activation of mTORC1 reduced hepatic lipoge

100 Loss of the PTEN tumor suppressor results in constitutive activation of mTORC1 through the Akt-depend

101 gain of function causes fatty liver through constitutive activation of mTorc1, an effect that is rev

102 bits oncomodulatory properties, elicited via constitutive activation of multiple signaling pathways.

103 In addition, constitutive activation of NEK6 or NEK7 reduced the asso

104 Conversely, constitutive activation of neuronal ALK5 in forebrain ca

105 this epidermal phenotype was associated with constitutive activation of NF-kappaB (RelA) and increase

106 the transglutaminase TG2 has been linked to constitutive activation of NF-kappaB and chemotherapy re

107 ) mouse livers, and this was associated with constitutive activation of NF-kappaB and JNK, along with

108 e/paracrine TLR5 signaling loop resulting in constitutive activation of NF-kappaB both in vitro and i

109 egulatory mechanisms that avoid excessive or constitutive activation of NF-kappaB may be associated w

110 Conversely, constitutive activation of NF-kappaB selectively in wild

111 To model constitutive activation of NF-kappaB, we expressed a tra

112 In contrast, constitutive activation of NFATc1 nullifies the protecti

113 ls to inflammatory signals, and the abnormal constitutive activation of NFkappaB is important for the

114 ts and that this increase is attributable to constitutive activation of nicotinamide adenine dinucleo

115 Here we demonstrate in Arabidopsis that the constitutive activation of NIK1, a leucine-rich repeat r

116 -inactive c-IAP2 mutant (c-IAP2(H570A)) have constitutive activation of non-canonical NF-kappaB, resu

117 e formation of all nephron segments and that constitutive activation of Notch in developing nephrons

118 and Hnf1b Consistent with this, we find that constitutive activation of Notch in mesenchymal nephron

119 es the Notch intracellular domain, while the constitutive activation of Notch reverses the PI3K defic

120 Constitutive activation of Notch signaling fully blocked

121 At the molecular level, constitutive activation of Notch signaling inhibits, whe

122 ptosis in cultured human leukemic cells with constitutive activation of Notch signaling.

123 dation of some of these findings showed that constitutive activation of Notch1 deregulated glutamine

124 Accordingly, constitutive activation of Notch1 prevents SC depletion

125 reactive oxygen species (ROS), arising from constitutive activation of NOX2 oxidase, occurs in >60%

126 enhanced fear memory generalization, whereas constitutive activation of NR neurons decreased memory g

127 Somatic mutations that lead to constitutive activation of NRAS and KRAS proto-oncogenes

128 ibly providing a scenario similar to that of constitutive activation of Nrf2 found in certain human c

129 duct phenotypes could be recapitulated with constitutive activation of Nrf2 signaling in Keap1(F/F):

130 ted the nuclear accumulation of NRF2, led to constitutive activation of NRF2 signaling, and conferred

131 ation of the Nrf2-Keap1 axis, which leads to constitutive activation of Nrf2.

132 elial-mesenchymal transition (EMT), but also constitutive activation of nuclear factor kappa B (NFkap

133 classical Hodgkin lymphoma (cHL), including constitutive activation of nuclear factor kappaB (NF-kap

134 Mechanistically, CB sparks the constitutive activation of oestrogen receptors alpha (ER

135 This coincides with the constitutive activation of one of the downstream effecto

136 ubicin or nutlin-3 results in continuing and constitutive activation of p53, inhibition of XIAP and s

137 Constitutive activation of PDGFRalpha leads to expansion

138 The Pten phenotype is mimicked by constitutive activation of PI3 kinase and is rescued by

139 We further show that constitutive activation of PKB in vivo results in a loss

140 nd premature death, which correlate with the constitutive activation of plant immune responses.

141 ate that the PLCgamma1-R707Q mutation causes constitutive activation of PLCgamma1 and may represent a

142 lterations in MIBC that convergently lead to constitutive activation of PPARgamma/RXRalpha and result

143 vasion phenotypes is mediated in part by the constitutive activation of pro-inflammatory nuclear fact

144 trigger chronic inflammation, which leads to constitutive activation of pro-inflammatory signaling pa

145 Here, we identified constitutive activation of proapoptotic Bax, maintained

146 ominant-negative Rab4 or Rab4 morpholino and constitutive activation of Rab5 decreases the elongation

147 Constitutive activation of Rac1 also led to podocyte det

148 In this study, we demonstrate that constitutive activation of Raf-1 oncogenic signaling ind

149 h the idea that RalGAPA1 deficiency causes a constitutive activation of RalA.

150 RS2, a direct substrate of FGFR1, as well as constitutive activation of RAS-MAPK signaling.

151 Constitutive activation of Ras-mitogen-activated protein

152 st phosphate uptake system component, causes constitutive activation of RegX3.

153 ncreas-specific deletion of IkappaBalpha had constitutive activation of RelA and a gene expression pr

154 Constitutive activation of RelA up-regulates Spi2A, whic

155 protein subunit alpha 13), resulting in the constitutive activation of RhoA (ras homolog family memb

156 Constitutive activation of RhoA in Swap-70(-/-) DCs was

157 Constitutive activation of RhoA led to increased express

158 Moreover, constitutive activation of RhoA restricted three-dimensi

159 eveloped a zebrafish melanoma model in which constitutive activation of ribosomal protein S6 kinase A

160 Additionally, constitutive activation of saeRS (saeRS(C)) enhanced the

161 decreased production of such factors, while constitutive activation of saeRS increases virulence, an

162 rfism, compromised pollen tube guidance, and constitutive activation of salicyclic acid-mediated defe

163 nding site or the ARM-TIR interaction caused constitutive activation of SARM1 and thereby led to axon

164 pendent of their endogenous Sox2 expression, constitutive activation of Shh signaling in CGNPs result

165 ls to tumour development in combination with constitutive activation of SHH signalling.

166 Constitutive activation of signal transducer and activat

167 ogenes and tumor suppressors, leading to the constitutive activation of signaling pathways involved i

168 Constitutive activation of SKN-1 induces a similar trans

169 However, constitutive activation of SKN-1 results in pleiotropic

170 results indicate that oncogenic Kras induces constitutive activation of SOX9 in HPNE and HPDE cells,

171 g-term plasticity, little is known about how constitutive activation of specific kinase isoforms sust

172 cy of both Insigs in enterocytes resulted in constitutive activation of SREBP and HMGR, leading to an

173 In an attempt to achieve constitutive activation of SRK and thus facilitate analy

174 we furthermore show that plasma LPS leads to constitutive activation of STAT1 through autocrine cytok

175 Cs and the Notch pathway, which involves the constitutive activation of STAT3 and NF-kappaB signaling

176 Constitutive activation of STAT3 imparts resistance to a

177 e resulted in phospho-Stat3 accumulation and constitutive activation of Stat3-driven genetic programs

178 r GC cell lines including AGS cells, showing constitutive activation of STAT3.

179 eement with this model, we observed that the constitutive activation of Stat5 cooperates with the los

180 We have detected constitutive activation of STAT5 in malignant B cells de

181 Importantly, primary T-PLL cells exhibited constitutive activation of STAT5, and targeted pharmacol

182 translocation partner in lipoma), induced by constitutive activation of STAT5, but not by transient c

183 In this study, we demonstrated that constitutive activation of STAT6 in KSHV-associated PEL

184 We hypothesize a constitutive activation of stem cell division kinetics s

185 ise to SCLC, and transformation results from constitutive activation of stem cell renewal and inhibit

186 es dysregulation of apoptosis, mainly due to constitutive activation of survival pathways including J

187 stitutive photomorphogenesis associated with constitutive activation of target genes, elevated levels

188 dependent regulation of TERT and elicits the constitutive activation of telomerase.

189 We found that constitutive activation of TFEB is the main driver of th

190 ing mice with either T cell-specific loss or constitutive activation of TGF-beta signaling, we demons

191 , enabling the intestinal flora to trigger a constitutive activation of the anterior midgut immune re

192 llomavirus 31 (HPV31)-positive cells exhibit constitutive activation of the ATM-dependent DNA damage

193 mphocytic leukemia (CLL) is characterized by constitutive activation of the B-cell receptor (BCR) sig

194 that AP-1, like NF-kappaB, was controlled by constitutive activation of the B-cell receptor signaling

195 ve activating mutations in B-Raf, leading to constitutive activation of the B-Raf/MKK/ERK signaling p

196 In chronic myelogenous leukemia, the constitutive activation of the BCR-ABL kinase transforms

197 or the pathogenesis of these tumors, whereby constitutive activation of the cAMP pathway and EZH1 mut

198 Constitutive activation of the canonical and noncanonica

199 This response is attenuated in mutants with constitutive activation of the corticotropin-releasing f

200 ogous expression of STIM1 p.R304W results in constitutive activation of the CRAC channel in vitro, an

201 These results highlight the importance of constitutive activation of the de novo purine synthesis

202 We show that Pten deletion, or constitutive activation of the downstream kinase AKT, ac

203 Constitutive activation of the EGFR is common in cancer

204 of chronic energy deprivation, resulting in constitutive activation of the energy-stress sensor AMPK

205 Constitutive activation of the epidermal growth factor r

206 Constitutive activation of the epidermal growth factor r

207 Constitutive activation of the farnesoid X receptor (FXR

208 erized by frequent loss of PTCH1, leading to constitutive activation of the Hedgehog pathway.

209 findings indicate that MUC1-C contributes to constitutive activation of the HER2 pathway and that tar

210 ippel-Lindau tumor suppressor and subsequent constitutive activation of the hypoxia-inducible factors

211 VHL inactivation results in the constitutive activation of the hypoxia-inducible factors

212 tween the IIS and Rag-TORC1 pathways because constitutive activation of the IIS pathway requires Rag

213 nce of CD37 drives tumor development through constitutive activation of the IL-6 signaling pathway.

214 ation of the IkappaB kinase complex prevents constitutive activation of the immune deficiency pathway

215 One such mechanism may be through constitutive activation of the insulin-like growth facto

216 Constitutive activation of the JAK/STAT pathway downstre

217 All these aberrations lead to the constitutive activation of the JAK/STAT3 pathway, which

218 ise to growth factor-independent clones with constitutive activation of the Janus kinase (JAK)- signa

219 atic human mutation (p.Ser646Phe) inducing a constitutive activation of the Janus kinase (JAK)/STAT p

220 followed by a persistent, ligand-independent constitutive activation of the kappaOR itself.

221 Constitutive activation of the mammalian target of rapam

222 Balloon cells (BCs) in FCDIIB exhibit constitutive activation of the mammalian target of rapam

223 ve fitness normalize GSK3beta activity after constitutive activation of the MAPK pathway, commonly th

224 n BRAF, mainly at codon 600, which result in constitutive activation of the MAPK pathway.

225 vating mutations drive tumorigenesis through constitutive activation of the MAPK pathway.

226 es, elevated baseline expression relied upon constitutive activation of the MAPK pathway.

227 The pathogenic cells are defined by constitutive activation of the MAPK signaling pathway.

228 NCAM1 expression strongly associated with constitutive activation of the MAPK-signaling pathway, r

229 utation in the TSC1 or TSC2 genes leading to constitutive activation of the mechanistic target of rap

230 mutation resembles active LysRS and causes a constitutive activation of the microphthalmia transcript

231 We present evidence that constitutive activation of the mitogen-activated protein

232 Activating BRAF mutations promote constitutive activation of the mitogen-activated protein

233 nes and enhanced freezing tolerance, whereas constitutive activation of the MKK4/5-MPK3/6 cascade in

234 MORPHOPROTEOMIC TUMOR ANALYSES REVEALED CONSTITUTIVE ACTIVATION OF THE MTOR PATHWAY AS EVIDENCED

235 ibition or specific Ship2 inhibition reduced constitutive activation of the mTORC1/ribosomal protein

236 Structural modeling supported constitutive activation of the mutant STING protein base

237 NF-kappaB in hypoxic breast cancer cells and constitutive activation of the NF-kappaB pathway in CAIX

238 DLBCL (ABC-DLBCL), which is characterized by constitutive activation of the NF-kappaB pathway, carry

239 leted in multiple myeloma (MM), resulting in constitutive activation of the noncanonical nuclear fact

240 We address this paradox by identifying the constitutive activation of the NRF2 master antioxidant r

241 Constitutive activation of the nuclear factor-kappa B (N

242 eractions with the targets, thereby enabling constitutive activation of the nuclear factor-kappa B, a

243 glutamate receptor-like proteins (GLRs), or constitutive activation of the P-type H(+)-ATPase AHA1.

244 ononuclear cells from the patients indicated constitutive activation of the pathway that cannot be fu

245 sistance mechanism to anti-HER2 therapies is constitutive activation of the phosphoinositide 3-kinase

246 y, miR-17~92-driven lymphoma cells exhibited constitutive activation of the PI3K and NFkappaB pathway

247 h or without PIK3CA mutations, which lead to constitutive activation of the PI3K pathway.

248 Constitutive activation of the PI3K/mTOR signaling pathw

249 o alters EGF receptor signaling and leads to constitutive activation of the protein kinase Akt.

250 omain-mediated polymerization of EN leads to constitutive activation of the PTK domain and constituti

251 ecked TLR-induced inflammatory responses and constitutive activation of the Pyrin inflammasome.

252 of the cognate sensor QseC leads to robust, constitutive activation of the QseB response regulator b

253 BRAF V600E leads to the constitutive activation of the RAF-MEK-extracellular sig

254 nd/or with PTEN deletion based on the common constitutive activation of the Raf/MEK/ERK and PI3K/AKT

255 JMML pathobiology is characterized by constitutive activation of the Ras signal transduction p

256 There was constitutive activation of the Ras/Raf/ERK pathway p-ERK

257 nal proline-rich motif of FGFR2 inducing the constitutive activation of the receptor, thereby prompti

258 nic mutations in KIT are present, leading to constitutive activation of the receptor, which drives th

259 In contrast, three other mutants showed constitutive activation of the reporter in the roots and

260 rase reporter for monitoring the GSR support constitutive activation of the response in this mutant b

261 Pst phosphate transporter component, causes constitutive activation of the response regulator RegX3,

262 nnoma cells, containing merlin mutations and constitutive activation of the Rho/Rac family of GTPases

263 gly, loss of casein kinase 1 activity causes constitutive activation of the RIM pathway, and, accordi

264 own of ABCC4 expression markedly blunted the constitutive activation of the SHH pathway secondary to

265 Constitutive activation of the signal transducer and act

266 Constitutive activation of the signal transducer and act

267 Here, we show that constitutive activation of the small GTPase ARF6 (ARF6(Q

268 In contrast, constitutive activation of the small GTPase Rap1 restric

269 blastoma consists of four major groups where constitutive activation of the Sonic Hedgehog (SHH) sign

270 This disruption leads to a constitutive activation of the spindle-assembly checkpoi

271 Accordingly, IL6 mediated constitutive activation of the STAT3 pathway, an essenti

272 In conclusion, our studies suggest that constitutive activation of the STAT3-Pim1 pathway repres

273 both adherent and spheroid glioma CSCs show constitutive activation of the STAT3/NF-kappaB signaling

274 when grown in Fe-sufficient condition, and a constitutive activation of the Strategy I Fe uptake gene

275 Constitutive activation of the T-cell leukemia 1A (TCL1A

276 IL6-mediated inflammation programs constitutive activation of the TAK1-NFkappaB signaling c

277 In fact, in CD44+/CD24- cells, constitutive activation of the TGF-beta axis was both ne

278 Moreover, constitutive activation of the TOR-pathway target and li

279 egulation of lysosomal protein expression by constitutive activation of the transcription factor EB (

280 subtype characterized by adverse outcome, is constitutive activation of the transcription factor nucl

281 Constitutive activation of the UPR(mt) by gain of functi

282 Constitutive activation of the Wnt pathway resulting fro

283 Constitutive activation of the Wnt pathway, one of the e

284 Constitutive activation of the Wnt pathway/beta-catenin

285 Constitutive activation of the Wnt/beta-catenin signalin

286 sidues within TM6 and TM7 results in a weak 'constitutive' activation of the pathway.

287 Constitutive activation of this loop in transformed cell

288 Tumor-associated mutants reveal how constitutive activation of this pathway impacts cell's d

289 romotes osteoblast differentiation in vitro, constitutive activation of this pathway impairs bone for

290 Also, constitutive activation of Toll and IMD pathways by knoc

291 The second-site mutations prevent constitutive activation of TpoR W515K/L, while preservin

292 In multiple forms of cancer, constitutive activation of type I IFN signaling is a cri

293 These mutations confer cGAMP-independent constitutive activation of type I interferon signaling t

294 Emerging evidence suggests that constitutive activation of various signaling pathways li

295 ptor-related protein 5 Wnt coreceptor causes constitutive activation of Wnt signaling, and in adenovi

296 Constitutive activation of Wnt-beta-catenin signaling fu

297 Constitutive activation of Wnt/beta-catenin inhibits oli

298 t common mechanisms of misregulation lead to constitutive activation of WT STATs.

299 Here we show that constitutive activation of XBP1 in tumor-associated DCs

300 Overexpression or constitutive activation of YAP leads to transformation a