ライフサイエンスコーパス: constrict

1 Contractile rings disassemble as they constrict.

2 smits forces around the organ, causing it to constrict.

3 crovascular networks maintain the ability to constrict.

4 light hits the retina, the pupil reflexively constricts.

5 ein FtsZ into a cytokinetic ring, which then constricts.

6 at nodes of Ranvier, where axons are locally constricted.

7 size, which was enhanced when the cavity was constricted.

8 renaline (NA, non-selective alphaAR agonist) constricted 1A, 2A and 3A with similar potency and effic

9 onventional myosin-II (Myo2) to assemble and constrict a contractile ring of actin filaments.

10 tes accomplish cell division by building and constricting a medial actomyosin-based cytokinetic ring

11 d by active crawling on the substrate and by constricting a supracellular actomyosin cable.

12 mational change that alternately dilates and constricts a collar-like intracellular entrance to the p

13 nanoparticles (NPs) swell below the LCST and constrict above it.

14 Structural and ligand-binding data reveal a constricted active site able to accommodate RDX and smal

15 that a glutamate gatekeeper and a sterically constricted active site confer specificity for N(8)-acet

16 Molecular modeling indicates that the constricted active site of wild-type pol iota becomes mo

17 at 2.9 angstrom resolution, which revealed a constricted adenine-binding pocket, suggesting the reaso

18 and type 2 cysLT receptors (CysLTRs), which constrict airway smooth muscle, but elicits airflow obst

19 articular, DIs are potent bronchodilators of constricted airways in nonasthmatic subjects but not in

20 unidentified intercellular signaling between constricted airways, the parenchyma, and the surrounding

21 ny eukaryotic cells divide by assembling and constricting an actin- and myosin-based contractile ring

22 , arterioles in FGF9-expressing tumors could constrict and dilate in response to adrenergic and nitri

23 role of the actin cytoskeleton in CME is to constrict and elongate the bud neck and drive the endocy

24 Prostaglandins that constrict and relax airways are synthesized in reactions

25 engineered dynamin displayed the capacity to constrict and sever membrane tubes.

26 Dynamin hydrolyzes GTP to constrict and sever membranes.

27 (S)FtsN depended on the ability of cells to constrict and, thus, on the activity of (E)FtsN.

28 d interaction, tumor organoids also actively constricted and displaced vessels.

29 k aquaria assisted the interpretation of the constricted and diverged trophic niches detected in the

30 tion can result in coexisting species having constricted and diverged trophic niches, the competing s

31 Constricted and expanded structures reveal coupled dilat

32 family members, the LasA active site is less constricted and utilizes a different set of metal ligand

33 duces membrane curvature and lipid ordering, constricting and destabilizing the membrane neck, causin

34 mote an iris-like conformational change that constricts and dehydrates the ion pore, creating a 13.5

35 We show that the rate at which the pupil constricts and dilates is matched to the temporal struct

36 g cytokinesis, a contractile actomyosin ring constricts and divides the cell in two.

37 It constricts and rigidifies the DEKA pore to bind Na(+) op

38 The pore constricts and the tyrosine and other pore-related loops

39 An open ring is able to constrict, and rings repair from successive cuts.

40 While LECs are migrating they also constrict apically, and changes in activity of the small

41 roposing that MX1 forms ring structures that constrict around viral nucleoprotein complexes.

42 t vasodilatatory effect on phenylephrine pre-constricted arterial rings, which was partially abolishe

43 Activation of TRPV1 in vascular myocytes constricted arteries, reduced coronary flow in isolated

44 tor that increases extracellular ATP levels, constricted arterioles by 58.0 +/- 3.8% (P < 0.001 for b

45 (2+) levels in arterial smooth muscle cells, constricted arterioles ex vivo and in vivo and increased

46 human VPCs were injected in proximity to the constricted artery.

47 It is striking that Chs2-S217A constricts asymmetrically with the actomyosin ring (AMR)

48 These slowly assembled contractile rings constricted at a normal rate but with more variability,

49 .SIGNIFICANCE STATEMENT Myelinated axons are constricted at nodes of Ranvier, resulting in a marked l

50 Myelinated axons are constricted at nodes of Ranvier.

51 The PKD2 ion permeation pathway is constricted at the selectivity filter and near the cytop

52 The constricted axons increase axial resistance to action po

53 ind that myelin infolding is often linked to constricted axons with signs of impaired axonal transpor

54 The skin is scaled, constricting bands encircle the tail and digits, the foo

55 ss of integrins causes pre-follicle cells to constrict basally, detach from the basement membrane and

56 emerging NSCs remain epithelial and apically constrict before dividing asymmetrically to produce neur

57 the swimmer is suppressed as the channel is constricted below a critical radius, for which the magni

58 hat the permeation pathway in the open state constricts below the gate, restricting the passage to la

59 tioselective synthesis and SAR of sterically constricted benzofurans at RXR.

60 ring around the mitochondrion and appears to constrict both outer and inner mitochondrial membranes.

61 with cognitive decline, amyloid beta (Abeta) constricts brain capillaries at pericyte locations.

62 hich a lateral opening in the barrel wall is constricted, but which is otherwise structurally identic

63 When this adaptive range is constricted by diminished dosage of 22q11 genes, embryos

64 bps (syn purine base, HG hydrogen bonds and constricted C1'-C1' distance across the bp) to search fo

65 ith syn purines lacking HG hydrogen bonds or constricted C1'-C1' distances that are analogous to conf

66 icyte death in rigor, which may irreversibly constrict capillaries and damage the blood-brain barrier

67 eceptor activity causes pericytes to locally constrict capillaries, which reduces blood flow to ische

68 e relative pressure estimates for a range of constricted cardiovascular conditions.

69 Our evidence suggests that Dachs constricts cell-cell junctions to alter the geometry of

70 etermines organ shape, first by mechanically constricting cells and second through recruitment of Per

71 enriched at the apical junctions of apically constricting cells and that MRCK-1 and myosin activity a

72 ablations of actomyosin networks reveal that constricting cells have higher cortical tension, generat

73 ata that confirm that the volume of apically constricting cells is conserved throughout the entire co

74 l) tyrosine kinase depletion causes apically constricting cells to undergo aberrant basal cell extrus

75 embryo dissipates tensile forces required by constricting cells via their neighbors, thereby allowing

76 Myosin II accumulates specifically around constricting cells, and its disruption dysregulates cons

77 cell-cell contact-free surfaces of apically constricting cells, downstream of cell fate determinatio

78 ed TRPM4 currents in smooth muscle cells and constricted cerebral arteries from both groups.

79 Cocaine affects neuronal activity and constricts cerebral blood vessels, making it difficult t

80 trapped at the interface by the increasingly constricted collagen pore network.

81 es on other K(+) channels do not support the constricted conformation as the C-type inactivated state

82 The constricted conformation can be blocked by substituting

83 tivity filter led to the conclusion that the constricted conformation does not correspond to the C-ty

84 However, the functional significance of the constricted conformation has become a matter of debate.

85 revent inactivation, which suggests that the constricted conformation is not the C-type inactivated s

86 tational results support the notion that the constricted conformation of the selectivity filter corre

87 and KvAP channels, we show that blocking the constricted conformation of the selectivity filter does

88 In this study, we address whether the constricted conformation of the selectivity filter is in

89 at low K(+) or in the open state revealed a constricted conformation of the selectivity filter, whic

90 ular gate revealed a selectivity filter in a constricted conformation similar to the structure observ

91 g the buried water molecules stabilizing the constricted conformation.

92 ent the selectivity filter from adopting the constricted conformation.

93 hat this inactivated state corresponds to a "constricted" conformation of the selectivity filter.

94 and change from a cylindrical to an apically constricted, conical shape.

95 y visual flicker, limited to an annulus that constricts content complexity to simple moving grey blob

96 Thus, cardiac pericytes constrict coronary capillaries and reduce microvascular

97 cardiac catheterization suggest that cocaine constricts coronary microvessels, yet direct evidence is

98 been discovered, providing new insight into constricted crystal growth mechanisms underlying confine

99 f-prediction, potentially motivating several constricting defense mechanisms.

100 ons, and ends with the formation of a highly constricted Did2-Ist1 co-polymer that we show is compete

101 lobular adiponectin (gAd) and insulin on pre-constricted distal saphenous arteries.

102 increases mitochondrial-derived H2O2, which constricts ductal smooth muscle cells by raising intrace

103 ive mice have higher [Ca(2+)]i, and are more constricted, due, primarily, to elevated SNA and some in

104 hase, demonstrating that phagocytes actively constrict during late-stage phagocytosis.

105 e FtsZ establishes the cytokinetic ring that constricts during cell division.

106 ted steric hindrance by active site residues constricts entry to the adenosine pocket as compared to

107 cargo to allow centripetal growth of a neck constricting ESCRT-III spiral.

108 clinical findings of reduced visual acuity, constricted fields, and reduced electroretinograms (ERGs

109 isynthetic channel that is unable to adopt a constricted filter but inactivates like WT channels chal

110 ent from K(+) ion binding to channels with a constricted filter, suggesting that the structures of th

111 f channels with conductive, inactivated, and constricted filters using isothermal titration calorimet

112 l cliffs may be glacial relicts whose ranges constricted following the last glacial maximum.

113 orce and to actomyosin-based circumferential constricting forces is mediated by FBN-1, a ZP domain pr

114 Further, we found that a slowly constricting fzlA mutant strain develops 'pointy' poles,

115 chemical basis for sodium selectivity, and a constricted gate suggests a closed pore consistent with

116 potency for LTE(4) than LTC(4) or LTD(4) in constricting guinea pig trachea in vitro and comparable

117 predacious fungi that catch nematodes using constricting hyphal rings.

118 ring closure but does cause the particle to constrict in a two-step process that correlates with the

119 ogical mechanism by which pulmonary arteries constrict in hypoxic lung areas in order to redirect blo

120 re suggested that the helix of dynamin could constrict in order to promote fission of the enclosed me

121 on observed in the normal retina, arterioles constrict in response to an oxygen deficiency.

122 However, rings constrict in some cells in the absence of Myosin-2 activ

123 phila melanogaster embryos, actomyosin rings constrict in two sequential and mechanistically distinct

124 retinal arterioles developed basal tone and constricted in a manner dependent on concentration to ET

125 The residual seeing visual field was constricted in all cases when compared with normative da

126 a helical polymer; second, dynamin oligomer constricts in the presence of GTP; and third, dynamin ca

127 The closed network structure led to constricted information flow in which patients and close

128 ytosolic Ca(2+) levels in potassium chloride-constricted intact arteries isolated from mouse mesenter

129 ex, allowing five of the six VAT subunits to constrict into a tight helix that grips an 80 A stretch

130 Ps into assemblies at the midcell which then constrict inwards as peptidoglycan is synthesised, event

131 K(+)](o) <10 mM dilated and [K(+)](o) >20 mM constricted isolated brain cortex parenchymal arterioles

132 lls normally elongated along the a-p axis to constrict isotropically, which suggests that apical cons

133 s promote individual freedom, whereas others constrict it so as to maintain elites' power and privile

134 impinges on the benzene ring of Y11 so as to constrict its movement and as a consequence, firmly clos

135 elial cells in both mutants fail to apically constrict, leading to craniorachischisis.

136 onformation, while the intracellular-half is constricted, leading to a loss of both water and permean

137 A(D-ala77) channel can adopt an asymmetrical constricted-like nonconductive conformation and that the

138 establish the ability of full-length Drp1 to constrict lipid bilayers through a GTP hydrolysis-depend

139 n C. crescentus and E. coli cells and inside constricting liposomes by means of electron cryomicrosco

140 turkey (Meleagris gallopavo) as a similarly constricted locus, with 34 genes identified within a 0.2

141 a structured scaffold that both expands and constricts lumen shape.

142 ture and fluidity, mediating the scission of constricted membrane necks in multiple biological pathwa

143 udy validates protein-lipid cooperativity in constricting membrane tubules.

144 ble around the necks of budding vesicles and constrict membranes in a GTP-dependent process, resultin

145 ated protein-1 (Drp1) oligomerization, which constricts membranes at endoplasmic reticulum (ER) conta

146 how the core machinery of the ESCRT pathway constricts membranes to promote fission.

147 ochondrial outer membrane; Drp1 then further constricts membranes until mitochondrial fission occurs.

148 Ex vivo, terlipressin relaxed pulmonary and constricted mesenteric arteries.

149 be isolated from the ambient and can move in constricted microcapillary.

150 ss, (ii) the velocity of the cell entering a constricted microchannel (entry velocity), and (iii) the

151 ets a locus in chromosome-1 indeed show that constricted migration delays DNA damage.

152 fuse into regenerating muscle in vivo after constricted migration in vitro, and myodifferentiation i

153 The cell cycle block caused by constricted migration is nonetheless reversible, with a

154 In this study, constricted migration of myoblastic cell types and mesen

155 Here, constricted migration of two human cancer cell types and

156 Phenotypic differences that arise from constricted migration of U2OS clones are further illustr

157 y, knockdown, myosin-II inhibition, and even constricted migration that disrupts and segregates lamin

158 mitosis and the cell cycle are suppressed by constricted migration, consistent with a checkpoint.

159 nucleoplasmic patterns of damage similar to constricted migration.

160 process involving ER tubules encircling and constricting mitochondria.

161 g cytokinesis, although the contractile ring constricts more rapidly in the pkd2 mutant than the wild

162 hich the pupil of a directly illuminated eye constricts more than the pupil of the consensual (not il

163 vides a framework for the larynx and for the constricted, muscularized esophagus, crucial for transpo

164 ontribution of proteins that localize to the constricted neck.

165 into small vesicles connected through highly constricted necks.

166 In contrast, in basally constricted neuroepithelia, a novel formin-dependent pus

167 and distant normal liver tissue primarily by constricting normal distal liver vessels and in turn inc

168 The SF region displayed conductive, constricted, occluded, and dilated states, in qualitativ

169 Accordingly, a poorly constricted OM is believed to link the cell chains forme

170 complex is open on the cytoplasmic side and constricted on the extracellular side.

171 from the mother plugs and passed through the constricted opening of the T-junction.

172 owledge and reveal the presence of gate-like constricted openings that may play a role in sperm selec

173 arized comet tail in association with highly constricted or fully endocytosed CCSs.

174 ring frequently detaches from the cortex and constricts or collapses to one side of the cell, and the

175 and exhibited absence of cardiac looping, a constricted outflow tract, and no cardiac jelly.

176 ole of the linear heart tube, resulting in a constricted outflow tract. Furthermore, mutants lacked b

177 present a molecularly explicit simulation of constricting partially anchored rings as studied in thes

178 c restriction in flies, it did not yield the constricted phenotype.

179 roduced together with FtsX), but these rings constricted poorly.

180 , are stacked in midplane and characterize a constricted pore of 10- to 20-nm diameter.

181 (2+) ion resolved within each monomer with a constricted pore; this is likely to correspond to a clos

182 When cells migrate through constricting pores, they incur DNA damage and develop ge

183 evering process displayed long-lived, highly constricted prefission intermediates that contributed to

184 CaV1.2/CaV3.1, was first shown to depolarize/constrict pressurized rat cerebral arteries; no effect w

185 andibular joint, a flexible spine capable of constricting prey, and the presence of vertebrate remain

186 t immunological memory can 'overfill' and/or constrict prior memory responses.

187 er a corneal flap at the center of the light-constricted pupil created with a femtosecond laser.

188 ously switched between a state of rest and a constricted pupil, and one of active locomotion and a di

189 indicates that, compared to eyes with fully constricted pupils, eyes from A. irradians with fully di

190 old infants' brain responses to dilating and constricting pupils in the context of viewing own-race a

191 s imaged in situ through cranial window also constricted rapidly in response to local application of

192 Its selectivity is largely determined by a constricted region of its open pore known as the selecti

193 ic CO and the CO-releasing molecule (CORM)-3 constricted renal arteries and increased O2*- production

194 by a progressive fall in PrP(C) level, which constricts replication rate and thereby causes the plate

195 Folr1-deficient neural plate cells fail to constrict, resulting in widening of the neural plate mid

196 Myosin II to transition to a compact, fully constricted ring.

197 e centres of septa surrounded by an adjacent constricting ring containing Pbp2b, Pbp1a and regulators

198 brane-anchored complexes called nodes in the constricting ring.

199 sm continuously reassembles and remodels the constricting ring.

200 Myo51 alone cannot constrict rings but increases the constriction rate by M

201 Other actin anchoring schemes failed to constrict rings.

202 Four constricted rings consisting of conserved interior beta-

203 ery to explore the biophysical properties of constricting rings in Caenorhabditis elegans embryos.

204 We show that the constricting rings of Drechslerella doedycoides catch ea

205 with specific structural features including constricting rings, helical scaffolds, and hydrophobic m

206 ads to the rupture of a covalent bond in the constricted section of the axle.

207 The pore contains a constricted selectivity filter that can accommodate seve

208 ls together to generate protein "loops" that constrict separation of the DNA from the histone surface

209 es from that of other PBPs to the centres of constricting septa in mid-to-late divisional cells resol

210 d separate positioning of Pbp2x and Pbp1a in constricting septa, consistent with two separable PG syn

211 I spectrin is necessary for formation of the constricted shape of the spine neck, which in turn contr

212 le cells (FC) from a columnar to an apically constricted shape.

213 cepted pressure-flow theory as they severely constrict sieve tubes.

214 ger loop and ribosomal protein L24 lead to a constricted signal sequence-binding pocket possibly prev

215 1 (yeast/mammals), which form spirals around constricted sites on mitochondria.

216 y a dynamin-related GTPase that assembles at constricted sites on the organelle.

217 red that contractile rings in cps1-191 cells constrict slowly and that an mto2(S338N) mutation is req

218 Burmese pythons, giant constricting snakes native to Asia, now are found throug

219 Bath-applied VP significantly constricted SON arterioles (Delta-41 +/- 7%) via activat

220 contacts form between the ER and endosome at constricted sorting domains, and free diffusion of cargo

221 Cellular migrations through constricted spaces are a crucial aspect of many developm

222 leton are coordinated to move nuclei through constricted spaces.

223 Cortical spreading depolarization constricts sphincters and causes vascular trapping of bl

224 ells, are interrupted by pauses in which the constricted state of the cell apex is maintained.

225 , whereas expression of twist stabilizes the constricted state of the cell apex.

226 ion occupancy at the S1 binding site in the constricted state of the selectivity filter of the KcsA

227 ation compared to loading particles in their constricted state.

228 5 compromised embryos and Rab35 localizes to constricting surfaces.Various stages of tissue morphogen

229 ively, these findings establish that obesity constricts T-cell diversity by accelerating age-related

230 , suggesting a specific action of cocaine to constrict terminal feed arteries.

231 code cells are both longer and less apically constricted than control cells, thereby reducing epithel

232 lid tissues are often sufficiently dense and constricting that nuclei are highly stressed by migratio

233 e amino acid differences in the binding site constrict the A ring binding domain in CeTb, which inter

234 filaments produce force to assemble and then constrict the contractile ring to form a cleavage furrow

235 tile forces are generated inside the cell to constrict the division site or to haul the rear of the c

236 em to require additional molecular motors to constrict the division site.

237 We demonstrate that deletions designed to constrict the DNA-binding ring of Ku80 disrupt nonhomolo

238 A truncated RTNLB3, unable to constrict the ER, was not recruited to the cell plate at

239 These Z rings could constrict the liposomes and in some cases appeared to co

240 Fission requires dynamin to first constrict the membrane.

241 and ESCRT-III proteins function together to constrict the necks of budding vesicles.

242 sue, Hatch and Hetzer show that actin fibers constrict the nucleus, causing chromatin protrusions and

243 ginine residue, both highly conserved, which constrict the permeation pathway.

244 icate that two pore-occluding phenylalanines constrict the pore.

245 resent muscles whose contractions dilate and constrict the pupil, respectively.

246 Ser-132 to Thr and Ala-133 to Ser apparently constricted the active site cavity resulting in producti

247 bstitution of the Ala(286) to Phe apparently constricted the active site cavity, and the A286F mutant

248 Knockout of Khdrbs1 constricted the pool of proliferating NPCs by accelerati

249 d by melanocortin 4 receptor deficiency also constricted the T-cell repertoire diversity, recapitulat

250 t of feedback to cGMP synthesis in spatially constricting the fall of cGMP during the single-photon r

251 assembles a second strand on CHMP1B, further constricting the membrane tube and reducing its diameter

252 However, no role for CLE40/CLV1/ACR4 in constricting the mobility of WOX5 or other fluorescent t

253 , framework or nanoparticle with the hope of constricting the movement of the enzyme and shielding it

254 myosin II rings therefore play a key role in constricting the neck of budding bulk endosomes before d

255 scission by scaffolding the membrane bud and constricting the neck to the point of scission.

256 , we propose a "ring cycle" for dilating and constricting the nuclear pore.

257 n isomerization that controls selectivity by constricting the opening through which acceptors must pa

258 uxtaposed with the DNA target sequence, thus constricting the range of targetable sites.

259 sphincter, facilitates urinary continence by constricting the urethra.

260 nine-residue segment of the pocket edge that constricts the active site opening, or "pore", that siev

261 a chronic Th2 inflammation in the lungs that constricts the airways and presents as coughing and whee

262 ress is as follows: How does the knot, which constricts the backbone as well as forms the SAM-binding

263 ruits, it drives peptidoglycan synthesis and constricts the cell.

264 graphitic nanostructure production not only constricts the conductive pathways but also limits the a

265 tive site hydrophobic loop on ligand binding constricts the entrance to the active site.

266 mRNA latch conformation to a closed one that constricts the mRNA entry channel and narrows the P site

267 selection: an asparagine/histidine ring that constricts the narrow end of the funnel serves as a broa

268 uanosine triphosphatase that polymerizes and constricts the organelle.

269 CRF constricts the small bowel and increases fructose malabs

270 r curcumin dilated, whereas micromolar doses constricted, the arterioles.

271 Subsequently, cardiomyocytes constrict their abluminal surface, moving their cell bod

272 iately precedes invagination, endoderm cells constrict their apices because of Rho/Rho-kinase-depende

273 a gastrulation, the ventral mesodermal cells constrict their apices, undergo a series of coordinated

274 strategies typical of epithelia in order to constrict their dorsal surface membrane during cell inte

275 nduced in TNC knockout and wild-type mice by constricting their abdominal aorta or by infusion of ang

276 in loss enabled nonmitotic cells to apically constrict through mitotic cell stretching.

277 d in the upper common oviduct that relax and constrict throughout sperm storage and egg movement.

278 Contractile rings constrict to a greater degree, resulting in smaller ring

279 +), arterioles lost basal tone and failed to constrict to ET-1.

280 e apical tips of elongating epithelial cells constrict to form an anchor point before fiber cell diff

281 arteriole transitional region differentially constrict to structurally and dynamically determine the

282 ing on their inner surface to form buds that constrict to vesicles.

283 op Placopecten magellanicus have pupils that constrict to ~60% of their fully dilated areas within se

284 s a hypopharynx housing a small, valved pump constricted to a narrow salivary duct supplying outgoing

285 Ni-63 is constricted to a small surface area of the microelectrod

286 to FG repeats, thereby linking the ratio of constricted to dilated nuclear pores to cellular transpo

287 asal tone at 55 cmH(2)O luminal pressure and constricted to ET-1 (0.1 nM) with a 40 +/- 6% reduction

288 tigate how the neck of the budding endosomes constricts to allow efficient recruitment of the fission

289 ry cytoskeletal element of the Z ring, which constricts to divide bacteria, assembles into short, one

290 tsZ and a dozen other division proteins, and constricts to divide the cell.

291 settes, cells are polarized with apical ends constricted towards the rosette center and nuclei basall

292 tivation by A769662 caused phenylephrine pre-constricted UtA from normoxic or hypoxic pregnant mice t

293 ctivation of [Cu(bcppm)H2O] generates a pore-constricted version of the material through concomitant

294 ssure differences across segments, but their constricted waist provides an evident mechanism for comp

295 ity, the current spontaneously and gradually constricts when a device is biased into the negative dif

296 mitosis, where it formed a ring that did not constrict with actomyosin ring (cytokinetic actomyosin r

297 EFS caused vasodilatation in arteries constricted with 1 mum U46619 in the presence of 140 mum

298 sayed in pressurized mesenteric arteries pre-constricted with endothelin-1.

299 cells, strands slowly close into rings that constrict without the normal ~25-min maturation period.

300 a mesoderm, linked epithelial cells apically constrict, without cell extrusion or intercalation, to f